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Article: Amelioration of amyloid beta (Aβ

Alihosseini, Tahereh / Azizi, Monireh / Abbasi, Nasser / Mohammadpour, Shahram / Bagheri, Maryam

Iranian journal of basic medical sciences

2023 Volume 26, Issue 7, Page(s) 791–798

Abstract: Objectives: Alzheimer's disease (AD), the most common cause of dementia, is one of the leading causes of morbidity and death in the world. Currently, treatment mostly used to slow down the disease progression. Herbal remedies are considered by many in ... ...

Abstract	Objectives: Alzheimer's disease (AD), the most common cause of dementia, is one of the leading causes of morbidity and death in the world. Currently, treatment mostly used to slow down the disease progression. Herbal remedies are considered by many in the community as a natural and safe treatment with fewer side effects. Silibinin, the active ingredient of Materials and methods: Forty eight male Wistar rats were randomly divided into sham, lesion; Aβ Results: Different concentrations of silibinin improved behavioral performance in animals. Higher doses of Silibinin could improve memory and learning function through MWM. Also, increasing the concentration of silibinin resulted in decreased ROS and NO production in a dose-dependent manner. Conclusion: Consequently, silibinin may act as a potential candidate for alleviating symptoms of AD.
Language	English
Publishing date	2023-06-26
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2500485-2
ISSN	2008-3874 ; 2008-3866
ISSN (online)	2008-3874
ISSN	2008-3866
DOI	10.22038/IJBMS.2023.66831.14665
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Investigation of wavy microchannel ability on electronic devices cooling with the case study of choosing the most efficient microchannel pattern.

Ghorbani, Nima / Targhi, Mohammad Zabetian / Heyhat, Mohammad Mahdi / Alihosseini, Yousef

Scientific reports

2022 Volume 12, Issue 1, Page(s) 5882

Abstract: A numerical study was conducted to investigate the ability of wavy microchannels to damp the temperature fluctuations generates in electronic devices. Five wavy patterns are considered with the amplitude and wavelength in the ranges of 62.5 to 250 μm and ...

Abstract	A numerical study was conducted to investigate the ability of wavy microchannels to damp the temperature fluctuations generates in electronic devices. Five wavy patterns are considered with the amplitude and wavelength in the ranges of 62.5 to 250 μm and 1250 to 5000 μm, respectively to study the effect of governing phenomena of flow within wavy patterns on thermal-hydraulic performance. The flow regime is laminar and the Reynolds number is in the range of 300 to 900, and a relatively high heat flux of 80 W/cm
Language	English
Publishing date	2022-04-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-09859-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evaluation of gallbladder contractility and Doppler findings in patients with irritable bowel syndrome; a case-control study.

Alihosseini, Samin / Khodaei, Farzaneh / Jaberinezhad, Mehran / Azari, Mojtaba / Ezzati Khatab, Maghsoud / Akhlaghi, Hedieh / Ghanini, Nima / Tarzamni, Mohammad Kazem / Eghbali, Elham

Scandinavian journal of gastroenterology

2023 Volume 59, Issue 3, Page(s) 344–351

Abstract: Background: Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder causing abdominal pain, altered bowel habits and bloating without structural issues. Gallbladder dysfunction may be linked to IBS due to disrupted cholecystokinin release. ... ...

Abstract	Background: Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder causing abdominal pain, altered bowel habits and bloating without structural issues. Gallbladder dysfunction may be linked to IBS due to disrupted cholecystokinin release. This study aims to assess gallbladder function and related hemodynamic parameters using Doppler ultrasound in IBS before and after meals. Method: In this case-control study, we investigated gallbladder function differences between constipation-predominant IBS (C-IBS) patients and healthy volunteers. Participants underwent ultrasonography to measure gallbladder parameters before and after consuming a predefined meal. Gallbladder volume, wall thickness and resistance index (RI) of cystic and superior mesenteric arteries (SMA) were assessed. Student t-test and paired t-test were used to compare case and control groups and pre- and post-meal data, respectively. Results: A total of 34 people (18 C-IBS and 16 healthy control) were included. The mean (Standard deviation) of gallbladder fasting volume was measured 24.74 (8.85) and 29.73 (9.65) cubic millimeter for case and controls, respectively. Postprandial volume was 11.34 (5.66) and 16.9 (6.16) cubic millimeter for case and controls respectively. We observed a statistically significant difference in emptying fractions (EF) between groups (p value = 0.009). IBS patients had a smaller fasting SMA RI (p value = 0.016) but the fraction of change after meal was not significant (p value = 0.10). The cystic artery RI did not reach statistical significance between the fasting and post-meal values (p value = 0.067). Conclusion: IBS patients have a higher emptying fraction and lower change in SMA RI compared to healthy controls. Further studies with larger sample size, inclusion of patients with different coexisting conditions and subtypes of IBS and combining colon transit study with gallbladder ejection fraction evaluation can be used to further provide more meaning to this study.
MeSH term(s)	Humans ; Abdominal Pain/etiology ; Case-Control Studies ; Gallbladder/diagnostic imaging ; Irritable Bowel Syndrome/complications ; Irritable Bowel Syndrome/diagnostic imaging ; Ultrasonography, Doppler/methods
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Journal Article
ZDB-ID	82042-8
ISSN	1502-7708 ; 0036-5521
ISSN (online)	1502-7708
ISSN	0036-5521
DOI	10.1080/00365521.2023.2287989
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Article: Analysis of Dynamics Targeting CNT-Based Drug Delivery through Lung Cancer Cells: Design, Simulation, and Computational Approach.

Sohrabi, Nafiseh / Alihosseini, Afshar / Pirouzfar, Vahid / Pedram, Maysam Zamani

Membranes

2020 Volume 10, Issue 10

Abstract: Nowadays, carbon nano (CN) structures and specifically carbon nanotubes (CNTs), because of the nanotube's nanoscale shape, are widely used in carrier and separation applications. The conjugation of CNTs with polysaccharide, proteins, drugs, and magnetic ... ...

Abstract	Nowadays, carbon nano (CN) structures and specifically carbon nanotubes (CNTs), because of the nanotube's nanoscale shape, are widely used in carrier and separation applications. The conjugation of CNTs with polysaccharide, proteins, drugs, and magnetic nanoparticles provides a chance for smart targeting and trajectory manipulation, which are used in the crucial field of life science applications, including for cancer disease diagnostics and treatments. Providing an optimal procedure for delivering a drug to a specific area based on mathematical criteria is key in systemic delivery design. Trajectory guidance and applied force control are the main parameters affected by systemic delivery. Moreover, a better understanding of the tissue parameters and cell membrane molecular behaviour are other factors that can be indirectly affected by the targeted delivery. Both sides are an essential part of successful targeting. The lung is one of the challenging organs for drug delivery inside the human body. It has a large surface area with a thin epithelium layer. A few severe diseases directly involve human lung cells, and optimal and successful drug delivery to the lung for the treatment procedure is vital. In this paper, we studied functionalized CNTs' targeted delivery via crossing through the lung cell membrane. Molecular dynamics (MD) software simulated all the interaction forces. Mathematical modelling of the cell membrane and proposed delivery system based on the relation of velocity and force has been considered. Dynamics equations for CNTs were defined in the time and frequency domain using control theory methods. The proposed delivery system consists of two main parts: crossing through the cell membrane and targeting inside the cell. For both steps, a mathematical model and a proper magnetic field profile have been proposed. The designed system provides criteria for crossing through the cell membrane within 30 s to 5 min and a translocation profile of 1 to 100 Å.
Language	English
Publishing date	2020-10-14
Publishing country	Switzerland
Document type	Journal Article
ISSN	2077-0375
ISSN	2077-0375
DOI	10.3390/membranes10100283
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Article ; Online: Effect of Melatonin on Endoplasmic Reticulum-Mitochondrial Crosstalk in Stroke.

Abolhasanpour, Nasrin / Alihosseini, Samin / Golipourkhalili, Sevda / Badalzadeh, Reza / Mahmoudi, Javad / Hosseini, Leila

Archives of medical research

2021 Volume 52, Issue 7, Page(s) 673–682

Abstract: Ischemic stroke has remained a principal cause of mortality and neurological disabilities worldwide. Blood flow resumption, reperfusion, in the cerebral ischemia prompts a cascade in the brain characterized by various cellular mechanisms like ... ...

Abstract	Ischemic stroke has remained a principal cause of mortality and neurological disabilities worldwide. Blood flow resumption, reperfusion, in the cerebral ischemia prompts a cascade in the brain characterized by various cellular mechanisms like mitochondrial dysfunction, oxidative stresses, endoplasmic reticulum (ER) stress, and excitotoxicity, finally resulting in programmed cell death. Any changes in the ER-mitochondria axis are probably responsible for both the onset and progression of central nervous system diseases. Melatonin, a neurohormone secreted by the pineal gland, has antioxidative, anti-inflammatory, and anti-apoptotic properties. Most studies have shown that it exerts neuroprotective effects against ischemic stroke. It was observed that melatonin therapy after the stroke not only leads to reduce mitochondrial dysfunction but also cause to alleviate ER stress and inflammation. This review discusses the impact of melatonin on mitochondrial, ER function, and on the crosstalk between two organelles as a therapeutic target for stroke. Given that the influences of melatonin on each organelle separately, its effects on mechanisms of crosstalk between ER and mitochondria are discussed.
MeSH term(s)	Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress ; Humans ; Melatonin/metabolism ; Melatonin/pharmacology ; Melatonin/therapeutic use ; Mitochondria ; Stroke/drug therapy
Chemical Substances	Melatonin (JL5DK93RCL)
Language	English
Publishing date	2021-04-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1156844-6
ISSN	1873-5487 ; 0188-4409 ; 0188-0128
ISSN (online)	1873-5487
ISSN	0188-4409 ; 0188-0128
DOI	10.1016/j.arcmed.2021.04.002
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Article: EFFECT OF PROBIOTIC FERMENTED MILK (KEFIR) ON SERUM LEVEL OF INSULIN AND HOMOCYSTEINE IN TYPE 2 DIABETES PATIENTS.

Alihosseini, N / Moahboob, S A / Farrin, N / Mobasseri, M / Taghizadeh, A / Ostadrahimi, A R

Acta endocrinologica (Bucharest, Romania : 2005)

2019 Volume 13, Issue 4, Page(s) 431–436

Abstract: Background: Probiotic fermented milk is one of the most beneficial foods. The main purpose of this study was to investigate the effect of probiotic fermented milk on the serum level of insulin and homocysteine in the type 2 diabetes patients.: Methods! ...

Abstract	Background: Probiotic fermented milk is one of the most beneficial foods. The main purpose of this study was to investigate the effect of probiotic fermented milk on the serum level of insulin and homocysteine in the type 2 diabetes patients. Methods: This study was done in 60 patients with type 2 diabetes. The intervention group received 600 mL of probiotic fermented milk (kefir) daily and control group received 600 mL of conventional fermented milk daily for 8 weeks. Food intake, anthropometric indices, serum parameters were assessed at the beginning and at the end of the study. The statistical analysis was done by the use of SPSS software (Ver.13). Results: The mean of serum insulin level did not reduce significantly after the intervention in probiotic fermented milk group, and there was no significant difference between the two groups. The mean of HOMA-IR decreased significantly in probiotic fermented milk group after intervention and there was a significant difference between the two groups after intervention. The mean of quickie increased in probiotic fermented milk group, but this increase was not significant. Also, there was not significant difference between the two groups after intervention. The mean of homocysteine level decresead significantly in patients with probiotic fermented milk and conventional fermented milk consumption. Conclusions: By considering the effect of probiotic fermented milk on some risk factors of cardiovascular disease in diabetic patients, probiotic foods may be useful as an adjuvant therapy in diabetic patients.
Language	English
Publishing date	2019-05-27
Publishing country	Romania
Document type	Journal Article
ZDB-ID	1433812-9
ISSN	1843-066X ; 1841-0987
ISSN (online)	1843-066X
ISSN	1841-0987
DOI	10.4183/aeb.2017.431
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Book ; Online: Jointly Measuring Diversity and Quality in Text Generation Models

Montahaei, Ehsan / Alihosseini, Danial / Baghshah, Mahdieh Soleymani

2019

Abstract: ... using n-gram based measures. Then, a feature-based measure which is based on a recent highly deep model ...

Abstract	Text generation is an important Natural Language Processing task with various applications. Although several metrics have already been introduced to evaluate the text generation methods, each of them has its own shortcomings. The most widely used metrics such as BLEU only consider the quality of generated sentences and neglect their diversity. For example, repeatedly generation of only one high quality sentence would result in a high BLEU score. On the other hand, the more recent metric introduced to evaluate the diversity of generated texts known as Self-BLEU ignores the quality of generated texts. In this paper, we propose metrics to evaluate both the quality and diversity simultaneously by approximating the distance of the learned generative model and the real data distribution. For this purpose, we first introduce a metric that approximates this distance using n-gram based measures. Then, a feature-based measure which is based on a recent highly deep model trained on a large text corpus called BERT is introduced. Finally, for oracle training mode in which the generator's density can also be calculated, we propose to use the distance measures between the corresponding explicit distributions. Eventually, the most popular and recent text generation models are evaluated using both the existing and the proposed metrics and the preferences of the proposed metrics are determined.
Keywords	Computer Science - Machine Learning ; Computer Science - Computation and Language ; Statistics - Machine Learning
Subject code	006
Publishing date	2019-04-08
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Erratum to "Nanotechnology in Wound Healing; Semisolid Dosage Forms Containing Curcumin-Ampicillin Solid Lipid Nanoparticles,

Ghaffari, Solmaz / Alihosseini, Faezeh / Rezayat Sorkhabadi, Seyed Mahdi / Arbabi Bidgoli, Sepideh / Mousavi, Seyyedeh Elaheh / Haghighat, Setareh / Afshar Nasab, Ahoo / Kianvash, Nooshin

Advanced pharmaceutical bulletin

2020 Volume 11, Issue 1, Page(s) 204

Abstract: This corrects the article DOI: 10.15171/apb.2018.046.]. ...

Abstract	[This corrects the article DOI: 10.15171/apb.2018.046.].
Language	English
Publishing date	2020-11-07
Publishing country	Iran
Document type	Published Erratum
ZDB-ID	3018440-X
ISSN	2251-7308 ; 2228-5881
ISSN (online)	2251-7308
ISSN	2228-5881
DOI	10.34172/apb.2021.088
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Article: Nanotechnology in Wound Healing; Semisolid Dosage Forms Containing Curcumin-Ampicillin Solid Lipid Nanoparticles,

Ghaffari, Solmaz / Alihosseini, Faezeh / Rezayat Sorkhabadi, Seyed Mahdi / Arbabi Bidgoli, Sepideh / Mousavi, Seyyedeh Elaheh / Haghighat, Setareh / Afshar Nasab, Ahoo / Kianvash, Nooshin

Advanced pharmaceutical bulletin

2018 Volume 8, Issue 3, Page(s) 395–400

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2018-08-29
Publishing country	Iran
Document type	Journal Article
ZDB-ID	3018440-X
ISSN	2251-7308 ; 2228-5881
ISSN (online)	2251-7308
ISSN	2228-5881
DOI	10.15171/apb.2018.046
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Article: Correlation between Endoscopic and Histopathological Findings in Dogs with Chronic Gastritis.

Çolakoğlu, Ekrem Ç / Börkü, Kazım / Haydardedeoğlu, Ali E / Alihosseini, Hadi / Şenel, Oytun O / Yumuşak, Nihat / Özen, Doğukan / Baş, Bülent / Uğurlu, Levent

Journal of veterinary research

2017 Volume 61, Issue 3, Page(s) 351–355

Abstract: Introduction: Chronic gastritis is a common diagnosis in dogs with signs of chronic vomiting. However, there is no data concerning endoscopic and histopathological agreement in dogs with chronic gastritis. Thus, a question should be raised whether ... ...

Abstract	Introduction: Chronic gastritis is a common diagnosis in dogs with signs of chronic vomiting. However, there is no data concerning endoscopic and histopathological agreement in dogs with chronic gastritis. Thus, a question should be raised whether taking gastroduodenal biopsies in dogs with chronic gastritis is necessary or not. Consequently, the purpose of the study was to compare the endoscopic and histopathological agreement in dogs with chronic gastritis. Material and methods: A total of 22 non-pregnant client-owned dogs with the signs of chronic gastritis were enrolled in this prospective study. Procedures including clinical examination, blood analysis, and diagnostic imaging were performed before anaesthesia. Biopsies obtained from gastroduodenal sites were histopathologically evaluated. A total of 110 gastroduodenal samples were examined. Results: Sixty-eight samples had abnormal histopathology and endoscopy while 11 showed normal histopathological and endoscopic evidence. Conclusion: The obtained data demonstrated that it is not necessary to take extra gastroduodenal biopsies in dogs with evidence of endoscopic gastroduodenitis. We also believe that further prospective studies, including cost and time effectiveness and more specific comparison between endoscopic appearance and histopathology, are necessary to make final recommendations regarding the need of using both procedures for definitive diagnosis.
Language	English
Publishing date	2017-09-19
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2855010-9
ISSN	2450-8608 ; 2450-7393
ISSN (online)	2450-8608
ISSN	2450-7393
DOI	10.1515/jvetres-2017-0046
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