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  1. Article ; Online: Four Patterns of Canine Wei Syndrome Treated with Traditional Chinese Medicine.

    Wang, Binxue / Liu, Yuting / Xiehe, Shuangyi / Ju, Xiao / Fan, Yunpeng / Liu, Yingqiu / Zhang, Weimin / Song, Xiaoping / Ma, Wuren

    Complementary medicine research

    2023  Volume 30, Issue 2, Page(s) 174–180

    Abstract: ... this is known as wei syndrome (WS). According to TCM, the etiology of WS can be (1) lung heat and fluid ...

    Abstract Atrophy and weakness of the limbs is a common condition in animals, especially dogs. It typically presents with flaccidity and weakness of the limbs, especially the hind legs, muscle atrophy, and the inability to walk. In Traditional Chinese Medicine (TCM) and Traditional Chinese Veterinary Medicine (TCVM), this is known as wei syndrome (WS). According to TCM, the etiology of WS can be (1) lung heat and fluid consumption; (2) insufficiency of the liver and kidneys; (3) dampness-heat invasion; (4) damage to the spleen and stomach, which are also the patterns of WS. This report aims to provide an alternative option for the treatment of canine paralysis. Four dogs with different WS patterns were treated with acupuncture, moxibustion, and Chinese herbs based on the guidelines of the TCM literature. Three patients recovered normal functioning. The fourth patient could walk normally after 2 weeks of treatment, but his hind limbs became weak again 3 months later. Weekly acupuncture treatment was resumed until his death 18 months later. TCM application of acupuncture, moxibustion, and Chinese herbs can be an effective treatment for canine WS. It is hoped that this case report will broaden the treatment options of other veterinarians when patients present with this condition.
    MeSH term(s) Dogs ; Animals ; Medicine, Chinese Traditional ; Acupuncture Therapy ; Moxibustion ; Acupuncture ; Spleen
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2885931-5
    ISSN 2504-2106 ; 2504-2092
    ISSN (online) 2504-2106
    ISSN 2504-2092
    DOI 10.1159/000528047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Network pharmacology-based analysis of Jin-Si-Wei on the treatment of Alzheimer's disease.

    Zhi, Jiayi / Yin, Li / Zhang, Zhoudong / Lv, Yaozhong / Wu, Fan / Yang, Yang / Zhang, Enming / Li, Huanqiu / Lu, Ning / Zhou, Mengze / Hu, Qinghua

    Journal of ethnopharmacology

    2023  Volume 319, Issue Pt 3, Page(s) 117291

    Abstract: Ethnopharmacological relevance: Jin-Si-Wei (JSW), a traditional Chinese medicine (TCM) formula ...

    Abstract Ethnopharmacological relevance: Jin-Si-Wei (JSW), a traditional Chinese medicine (TCM) formula, have cognitive enhancing effect and delay the memory decline in an animal model of AD, which has been reported. However, the therapeutic mechanism of JSW in the treatment of AD remains unclear.
    Aim of the study: This study aimed to verify the pharmacodynamics of JSW in the treatment of AD, and to explore its potential mechanism based on network pharmacology, molecular docking and experimental validation both in vitro and in vivo.
    Materials and methods: In this study, the underlying mechanism of JSW against AD was investigated by the integration of network pharmacology. Then, the core pathways and biological process of JSW were verified by experiment, including behavioral test and pathological and biochemical assays with 6-month-old APP
    Results: A Drug-Ingredient-Target network was established, which included 363 ingredients and 116 targets related to the JSW treatment of AD. The main metabolic pathway of JSW treatment for AD is neuroactive ligand-receptor interaction pathway, and biological processes are mainly involved in Aβ metabolic process. In vivo experiments, compared with APP/PS1 mice, the cognitive and memory ability of mice was significantly improved after JSW administration. In brain tissue of APP/PS1 mice, JSW could increase the contents of low-density lipoprotein receptor-related protein 1 (LRP-1), enkephalinase (NEP) and Acetyl choline (ACh), and decrease the contents of Aβ
    Conclusions: JSW improves AD in APP/PS1 mice, and this therapeutic effect may be achieved in part by altering the neuroactive ligand-receptor interaction pathway.
    MeSH term(s) Humans ; Animals ; Mice ; Alzheimer Disease/drug therapy ; Ligands ; Molecular Docking Simulation ; Network Pharmacology ; Neuroblastoma ; Amyloid beta-Protein Precursor/genetics ; Amyloid Precursor Protein Secretases
    Chemical Substances Ligands ; Amyloid beta-Protein Precursor ; Amyloid Precursor Protein Secretases (EC 3.4.-)
    Language English
    Publishing date 2023-11-02
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Wei Chang An pill regulates gastrointestinal motility in a bidirectional manner.

    Jia, Sitong / Chai, Lijuan / Zhang, Jing / Zhang, Min / Li, Lin / Qi, Yaxin / Pang, Yafen / Chen, Xi / Fan, Nana / Wang, Lin / Wang, Yujing / Song, Jixiang / Sun, Yingjie / Wang, Yi / Miao, Lin / Zhang, Han

    Pharmaceutical biology

    2021  Volume 59, Issue 1, Page(s) 1452–1463

    Abstract: Context: Wei Chang An (WCA) is a commercial prescription developed for the coordination ...

    Abstract Context: Wei Chang An (WCA) is a commercial prescription developed for the coordination of gastrointestinal movement.
    Objective: To investigate the role of WCA in the regulation of diarrhoea and constipation in rats.
    Material and methods: The diarrhoea and constipation models were prepared by gavage of
    Results: Data from Bristol stool form scale, diarrhoea index, visceral sensitivity, defaecation time, and intestinal propulsive rate showed that WCA protected rats against diarrhoea and constipation (
    Conclusions: WCA has both antidiarrhea and anti-constipation effects, suggesting its bidirectional role in gastrointestinal modulation, and providing evidence of WCA for irritable bowel syndrome treatment.
    MeSH term(s) Animals ; Constipation/drug therapy ; Constipation/physiopathology ; Diarrhea/drug therapy ; Diarrhea/physiopathology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Gastrointestinal Motility/drug effects ; Irritable Bowel Syndrome/drug therapy ; Irritable Bowel Syndrome/physiopathology ; Male ; Myosin-Light-Chain Kinase/genetics ; Rats ; Rats, Wistar ; rho-Associated Kinases/genetics
    Chemical Substances Drugs, Chinese Herbal ; Weichang'an ; ROCK1 protein, rat (EC 2.7.11.1) ; rho-Associated Kinases (EC 2.7.11.1) ; Myosin-Light-Chain Kinase (EC 2.7.11.18)
    Language English
    Publishing date 2021-10-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440131-9
    ISSN 1744-5116 ; 1388-0209
    ISSN (online) 1744-5116
    ISSN 1388-0209
    DOI 10.1080/13880209.2021.1991383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A Systems Pharmacology Approach for Identifying the Multiple Mechanisms of Action of the Wei Pi Xiao Decoction for the Treatment of Gastric Precancerous Lesions.

    Yang, Liangjun / Liu, Wei / Hu, Zhipeng / Yang, Maoyi / Li, Jiali / Fan, Xiangzhen / Pan, Huafeng

    Evidence-based complementary and alternative medicine : eCAM

    2019  Volume 2019, Page(s) 1562707

    Abstract: The Wei Pi Xiao (WPX) decoction, based on the theory of traditional Chinese medicine, has been ...

    Abstract The Wei Pi Xiao (WPX) decoction, based on the theory of traditional Chinese medicine, has been widely used for the treatment of gastric precancerous lesions (GPL). Although WPX is known to be effective for the treatment of GPL, its active ingredients, cellular targets, and the precise molecular mechanism of action are not known. This study aimed to identify the multiple mechanisms of action of the WPX decoction in the treatment of GPL. The active compounds, drug targets, and the key pathways involved in the therapeutic effect of WPX in the treatment of GPL were analyzed by an integrative analysis pipeline. The information pertaining to the compounds present in WPX and their disease targets was obtained from TCMSP and GeneCards, respectively. The mechanisms underlying the therapeutic effect of WPX were investigated with gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. A total of 82 bioactive compounds and 146 related targets were identified in this study. Following target analyses, the targets were further mapped to 26 key biological processes and 21 related pathways to construct a target-pathway network and an integrated GPL pathway. The study demonstrated that the WPX formula primarily treats the dysfunctions of GPL arising from cell proliferation, apoptosis, and mucosal inflammation, which offered a novel insight into the pathogenesis of GPL and revealed the molecular mechanism underlying the therapeutic effects of the WPX formula in GPL. This study offers a novel approach for the systematic investigation of the mechanisms of action of herbal medicines, which will provide an impetus to the GPL drug development pipeline.
    Language English
    Publishing date 2019-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2019/1562707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Microplastics in surface waters and sediments of the Wei River, in the northwest of China.

    Ding, Ling / Mao, Ruo Fan / Guo, Xuetao / Yang, Xiaomei / Zhang, Qian / Yang, Chen

    The Science of the total environment

    2019  Volume 667, Page(s) 427–434

    Abstract: ... especially in northwest China. We investigated the occurrence and characteristics of microplastics in the Wei ... River Basin, which is located in northwestern China. The Wei River is the largest tributary ... of the Yellow River and runs through three major provinces. In the Wei River, the concentration of microplastics ...

    Abstract Microplastic pollution is an increasingly important environment problem. Many studies show the occurrence of microplastics in our environmental system. However, the freshwater system is less understood, especially in northwest China. We investigated the occurrence and characteristics of microplastics in the Wei River Basin, which is located in northwestern China. The Wei River is the largest tributary of the Yellow River and runs through three major provinces. In the Wei River, the concentration of microplastics in the surface waters varied from 3.67 to 10.7 items /L and in the sediments, the abundance of microplastics varied from 360 to 1320 items/kg. Fiber (50.1%)was the dominant types in water samples and sediments. The small size (<0.5 mm)(68.1%)were the main size of microplastics in Wei River. The types of microplastics were polyethylene, Polyvinyl chloride and polystyrene, as identified using a Fourier transform infrared spectrometer. This study could be a valuable reference for better understanding the microplastics pollution in inland northwestern China.
    Language English
    Publishing date 2019-02-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2019.02.332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Wei Chang An pill regulates gastrointestinal motility in a bidirectional manner

    Jia, Sitong / Chai, Lijuan / Zhang, Jing / Zhang, Min / Li, Lin / Qi, Yaxin / Pang, Yafen / Chen, Xi / Fan, Nana / Wang, Lin / Wang, Yujing / Song, Jixiang / Sun, Yingjie / Wang, Yi / Miao, Lin / Zhang, Han

    Pharmaceutical Biology. 2021 Jan. 1, v. 59, no. 1 p.1450-1461

    2021  

    Abstract: Wei Chang An (WCA) is a commercial prescription developed for the coordination of gastrointestinal ...

    Abstract Wei Chang An (WCA) is a commercial prescription developed for the coordination of gastrointestinal movement. To investigate the role of WCA in the regulation of diarrhoea and constipation in rats. The diarrhoea and constipation models were prepared by gavage of Folium senna and diphenoxylate hydrochloride. Rats were randomized equally (n = 6) into the normal group given saline daily, the positive group given Pinaverium Bromide (13.5 mg/kg) or Sennoside A (0.1 mg/kg) and three WCA-treated groups (22, 44, and 88 mg/kg) by gavage daily for 7 consecutive days. The effects of WCA were assessed by a series of faecal symptoms and histopathology. Gastrointestinal parameters were determined by ELISA. The effect of WCA on gastrointestinal tissues was evaluated by strip assay. Expression of ROCK-1 and MLCK was measured by RT-PCR and Western blotting. Data from Bristol stool form scale, diarrhoea index, visceral sensitivity, defaecation time, and intestinal propulsive rate showed that WCA protected rats against diarrhoea and constipation (p < 0.01). The up-regulation of Substance P and 5-hydroxytryptamine in diarrhoea rats and down-regulation of Substance P and vasoactive intestinal polypeptide in constipation rats were inhibited by WCA (p < 0.05). WCA stimulated the gastrointestinal strip contractions but inhibited ACh-induced contractions (p < 0.01). The decreased ROCK-1 and MLCK expression in diarrhoea rats and increased in constipation rats were suppressed by WCA (p < 0.01). WCA has both antidiarrhea and anti-constipation effects, suggesting its bidirectional role in gastrointestinal modulation, and providing evidence of WCA for irritable bowel syndrome treatment.
    Keywords constipation ; defecation ; diarrhea ; gastrointestinal motility ; histopathology ; intestines ; irritable bowel syndrome ; sennosides ; serotonin ; substance P ; vasoactive intestinal peptide ; Diarrhoea ; Rho-associated coiled-coil forming protein kinase-1 (ROCK-1) ; myosin light chain kinase (MLCK) ; irritable bowel syndrome (IBS)
    Language English
    Dates of publication 2021-0101
    Size p. 1450-1461.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 1440131-9
    ISSN 1744-5116 ; 1388-0209
    ISSN (online) 1744-5116
    ISSN 1388-0209
    DOI 10.1080/13880209.2021.1991383
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Active Ingredients and Anti-Arthritic Mechanisms of Ba-Wei-Long-Zuan Granule Revealed by

    Fan, Gang / Li, Qi / Li, Hai-Jiao / Zhang, Yun-Sen / Xu, Xin-Mei / Fang, Gang / Ge, Yi-Man / Du, Lei-Lei

    Chemistry & biodiversity

    2020  Volume 17, Issue 6, Page(s) e2000122

    Abstract: Ba-Wei-Long-Zuan granule (BWLZ) is a traditional herbal preparation. It has been widely used ...

    Abstract Ba-Wei-Long-Zuan granule (BWLZ) is a traditional herbal preparation. It has been widely used for the treatment of rheumatoid arthritis (RA). However, its active ingredients and mechanisms of action are still unclear. The present study aims to reveal the active compounds and anti-arthritic mechanisms of BWLZ against collagen-induced arthritis (CIA) by using
    MeSH term(s) Animals ; Antirheumatic Agents/chemistry ; Antirheumatic Agents/metabolism ; Antirheumatic Agents/pharmacology ; Arthritis, Experimental/chemically induced ; Arthritis, Experimental/drug therapy ; Binding Sites ; Biomarkers/blood ; Biomarkers/metabolism ; Cytochrome P-450 CYP1A2/chemistry ; Cytochrome P-450 CYP1A2/metabolism ; Discriminant Analysis ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/metabolism ; Drugs, Chinese Herbal/therapeutic use ; Hesperidin/chemistry ; Hesperidin/metabolism ; Hesperidin/therapeutic use ; Isoquinolines/chemistry ; Isoquinolines/metabolism ; Isoquinolines/therapeutic use ; Magnetic Resonance Spectroscopy ; Male ; Medicine, Chinese Traditional ; Metabolomics ; Molecular Docking Simulation ; Principal Component Analysis ; Protein Structure, Tertiary ; Rats ; Rats, Wistar
    Chemical Substances Antirheumatic Agents ; Biomarkers ; Drugs, Chinese Herbal ; Isoquinolines ; coclaurine (CW1576313Y) ; Hesperidin (E750O06Y6O) ; Cytochrome P-450 CYP1A2 (EC 1.14.14.1)
    Language English
    Publishing date 2020-05-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202000122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A Systems Pharmacology Approach for Identifying the Multiple Mechanisms of Action of the Wei Pi Xiao Decoction for the Treatment of Gastric Precancerous Lesions

    Liangjun Yang / Wei Liu / Zhipeng Hu / Maoyi Yang / Jiali Li / Xiangzhen Fan / Huafeng Pan

    Evidence-Based Complementary and Alternative Medicine, Vol

    2019  Volume 2019

    Abstract: The Wei Pi Xiao (WPX) decoction, based on the theory of traditional Chinese medicine, has been ...

    Abstract The Wei Pi Xiao (WPX) decoction, based on the theory of traditional Chinese medicine, has been widely used for the treatment of gastric precancerous lesions (GPL). Although WPX is known to be effective for the treatment of GPL, its active ingredients, cellular targets, and the precise molecular mechanism of action are not known. This study aimed to identify the multiple mechanisms of action of the WPX decoction in the treatment of GPL. The active compounds, drug targets, and the key pathways involved in the therapeutic effect of WPX in the treatment of GPL were analyzed by an integrative analysis pipeline. The information pertaining to the compounds present in WPX and their disease targets was obtained from TCMSP and GeneCards, respectively. The mechanisms underlying the therapeutic effect of WPX were investigated with gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. A total of 82 bioactive compounds and 146 related targets were identified in this study. Following target analyses, the targets were further mapped to 26 key biological processes and 21 related pathways to construct a target-pathway network and an integrated GPL pathway. The study demonstrated that the WPX formula primarily treats the dysfunctions of GPL arising from cell proliferation, apoptosis, and mucosal inflammation, which offered a novel insight into the pathogenesis of GPL and revealed the molecular mechanism underlying the therapeutic effects of the WPX formula in GPL. This study offers a novel approach for the systematic investigation of the mechanisms of action of herbal medicines, which will provide an impetus to the GPL drug development pipeline.
    Keywords Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: [A multicenter randomized controlled study of bismuth-containing quadruple therapy followed by Jing-Hua-Wei-Kang in the treatment of patients newly diagnosed with

    Ma, P P / Meng, L N / Wang, M T / Jin, H F / Fan, Y H / Zha, A S / Huo, X H / Chen, D F / Cao, Z Q / Tang, X F / Yang, P / Shi, Z H / Li, T W / Meng, J / Gan, C / Chen, G X / Sha, W H / Du, Q / Li, Y /
    Lyu, B

    Zhonghua yi xue za zhi

    2021  Volume 101, Issue 26, Page(s) 2060–2065

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Amoxicillin/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Bismuth/therapeutic use ; China ; Drug Therapy, Combination ; Dyspepsia/drug therapy ; Female ; Helicobacter Infections/drug therapy ; Helicobacter pylori ; Humans ; Male ; Middle Aged ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents ; Amoxicillin (804826J2HU) ; Bismuth (U015TT5I8H)
    Language Chinese
    Publishing date 2021-07-18
    Publishing country China
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 132513-9
    ISSN 0376-2491
    ISSN 0376-2491
    DOI 10.3760/cma.j.cn112137-20210305-00563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Jia-Wei-Si-Miao-Wan alleviates acute gouty arthritis by targeting NLRP3 inflammasome.

    Yuan, X / Fan, Y S / Xu, L / Xie, G Q / Feng, X H / Qian, K

    Journal of biological regulators and homeostatic agents

    2019  Volume 33, Issue 1, Page(s) 63–71

    Abstract: ... complications. Jia-Wei-Si-Miao-Wan is a newly developed drug for treating acute gouty arthritis ... of Jia-Wei-Si-Miao-Wan on NLRP3 inflammasome and TLR/NF-κB signaling, which are two important ... Colchicine and Jia-Wei-Si-Miao-Wan were administrated by gavage. The circumference of the knee was measured ...

    Abstract Gout is a common metabolic disease and acute gouty arthritis (AGA) is one of the important complications. Jia-Wei-Si-Miao-Wan is a newly developed drug for treating acute gouty arthritis, but the molecular mechanism has not been completely clarified. Thus, this study was aimed to explore the regulation of Jia-Wei-Si-Miao-Wan on NLRP3 inflammasome and TLR/NF-κB signaling, which are two important signaling pathways in inflammation. AGA rat model was established by injecting monosodium urate into the right knee. Colchicine and Jia-Wei-Si-Miao-Wan were administrated by gavage. The circumference of the knee was measured. IL-1β and IL-18 level in the flushing fluid was detected by enzyme linked immunosorbent assay (ELISA). Western blot, immunohistochemistry and quantitative real-time RT-PCR were used to detect the protein and mRNA expression of TLR4, NLRP3, ASC, caspase-1, NF-κB and p-NF-κB. The results showed that IL-1β and IL-18 level in the flushing fluid was increased and TLR4, NLRP3, ASC, caspase-1, NF-κB and p-NF-κB expressions were up-regulated after the establishment of AGA rat model. Colchicine and Jia-Wei-Si-Miao-Wan administration could alleviate the inflammation in the knee by inhibiting NLRP3 inflammasome and TLR/NF-κB signaling. In vivo data showed that the therapeutic effect of Jia-Wei-Si-Miao-Wan could be comparable with colchicine but had lower hepatic and renal toxicity. In conclusion, Targeting NLRP3 inflammasome and TLR/NF-κB signaling by Jia-Wei-Si-Miao-Wan could be effective in treating AGA.
    MeSH term(s) Animals ; Arthritis, Gouty/drug therapy ; Caspase 1/metabolism ; Drugs, Chinese Herbal/pharmacology ; Inflammasomes/drug effects ; Interleukin-1beta/metabolism ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Rats ; Signal Transduction ; Toll-Like Receptor 4/metabolism
    Chemical Substances Drugs, Chinese Herbal ; Inflammasomes ; Interleukin-1beta ; NF-kappa B ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, rat ; Tlr4 protein, rat ; Toll-Like Receptor 4 ; Caspase 1 (EC 3.4.22.36)
    Language English
    Publishing date 2019-02-20
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 639196-5
    ISSN 1724-6083 ; 0393-974X
    ISSN (online) 1724-6083
    ISSN 0393-974X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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