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  1. Book ; Thesis: Frey Syndrom nach lateraler Parotidektomie bei benignen Tumoren

    Horstmann, Luisa / Grosheva, Maria V. / Angelov, Dojčin N.

    Prävalenz und Risikofaktoren

    2019  

    Institution Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
    Author's details vorgelegt von Luisa Horstmann ; 1. Berichterstatterin: Privatdozentin Dr. med. M. Grosheva, 2. Berichterstatter: Professor Dr. med. (BG) D.N. Angelov ; aus der Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde der Universität zu Köln
    Subject code 610]
    Language German
    Size 76 Seiten, Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2019
    HBZ-ID HT020027222
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 D 464 order for loan Magazin

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  2. Article ; Online: The effects of a green Rooibos (

    Kotzé-Hörstmann, L M / Bedada, D T / Johnson, R / Mabasa, L / Sadie-Van Gijsen, H

    Food & function

    2022  

    Abstract: Current pharmaceutical treatments addressing obesity are plagued by high costs, low efficacy and adverse side effects. Natural extracts are popular alternatives, but evidence for their anti-obesity properties is scant. We assessed the efficacy of a green ...

    Abstract Current pharmaceutical treatments addressing obesity are plagued by high costs, low efficacy and adverse side effects. Natural extracts are popular alternatives, but evidence for their anti-obesity properties is scant. We assessed the efficacy of a green (minimally-oxidized) Rooibos (
    Language English
    Publishing date 2022-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d2fo02440c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

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  3. Article ; Online: Quantification of [

    Horstmann, Maximilian / Quarles, C Derrick / Happel, Steffen / Sperling, Michael / Faust, Andreas / Rahbar, Kambiz / Clases, David / Karst, Uwe

    Analytical and bioanalytical chemistry

    2024  Volume 416, Issue 11, Page(s) 2849–2858

    Abstract: To sensitively ... ...

    Abstract To sensitively determine
    MeSH term(s) Humans ; Mass Spectrometry/methods ; Spectrum Analysis ; Chromatography ; Anions ; Indicators and Reagents
    Chemical Substances Anions ; Indicators and Reagents
    Language English
    Publishing date 2024-01-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-024-05149-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  4. Article ; Online: On the Behavior of the Ethylene Glycol Components of Polydisperse Polyethylene Glycol PEG200.

    Hoffmann, Markus M / Too, Matthew D / Paddock, Nathaniel A / Horstmann, Robin / Kloth, Sebastian / Vogel, Michael / Buntkowsky, Gerd

    The journal of physical chemistry. B

    2023  Volume 127, Issue 5, Page(s) 1178–1196

    Abstract: Molecular dynamics (MD) simulations are reported for [polyethylene glycol (PEG)200], a polydisperse mixture of ethylene glycol oligomers with an average molar weight of 200 g· ... ...

    Abstract Molecular dynamics (MD) simulations are reported for [polyethylene glycol (PEG)200], a polydisperse mixture of ethylene glycol oligomers with an average molar weight of 200 g·mol
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.2c06773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Free-breathing 3D Stack-of-Stars Gradient Echo Sequence in MR-guided Percutaneous Liver Interventions: Evaluation of Workflow and Diagnostic Quality.

    Glandorf, Julian / Horstmann, Dominik / Düx, Daniel Markus / Wacker, Frank / Gutberlet, Marcel / Hensen, Bennet

    Cardiovascular and interventional radiology

    2023  Volume 46, Issue 2, Page(s) 274–279

    Abstract: Purpose: To evaluate workflow efficiency and diagnostic quality of a free-breathing 3D stack-of-stars gradient echo (Radial GRE) sequence compared to a breath-hold 3D Cartesian gradient echo (Cartesian GRE) sequence for needle position control in MR- ... ...

    Abstract Purpose: To evaluate workflow efficiency and diagnostic quality of a free-breathing 3D stack-of-stars gradient echo (Radial GRE) sequence compared to a breath-hold 3D Cartesian gradient echo (Cartesian GRE) sequence for needle position control in MR-guided liver interventions.
    Materials and methods: 12 MR-guided liver interventions were performed on a 1.5 T Siemens Aera and analyzed retrospectively. 15 series of the Radial GRE sequence were compared to 14 series of the Cartesian GRE sequence regarding the time interval between two consecutive live-scans for needle tracking (Tracking-2-Tracking-Time). The quality of both sequences was compared by the SNR within comparable slices in liver and tumor ROIs. The CNR was calculated by subtraction of the SNR values. Subjective image quality scores of three radiologists were assessed and inter-rater reliability was tested by Fleiss' kappa. Values are given as mean ± SD. P-values < 0.05 were considered as significant.
    Results: The median Tracking-2-Tracking-Time was significantly shorter for the Radial GRE sequence, 185 ± 42 s vs. 212 ± 142 s (p = 0.04) and the median SNR of the liver and tumor ROIs were significantly higher in the Radial GRE sequence, 249 ± 92 vs. 109 ± 67 (p = 0.03) and 165 ± 74 vs. 77 ± 43 (p = 0.02). CNR between tumor and liver ROIs showed a tendency to be higher for the Radial GRE sequence without significance, 68 ± 48 vs. 49 ± 32 (p = 0.28). Mean subjective image quality was 3.33 ± 1.08 vs. 2.62 ± 0.95 comparing Radial and Cartesian GRE with a Fleiss' kappa of 0.39 representing fair inter-rater reliability.
    Conclusion: A free-breathing 3D stack-of-stars gradient echo sequence can simplify the workflow and reduce intervention time, while providing superior image quality. Under local anesthesia, it increases patient comfort and reduces potential risks for needle dislocations in MR-guided liver interventions by avoiding respiratory arrests for needle position control.
    MeSH term(s) Humans ; Retrospective Studies ; Reproducibility of Results ; Workflow ; Contrast Media ; Magnetic Resonance Imaging/methods ; Imaging, Three-Dimensional/methods ; Liver/diagnostic imaging ; Liver/surgery
    Chemical Substances Contrast Media
    Language English
    Publishing date 2023-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-022-03350-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1378: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Enhancing pre-clinical research with simplified intestinal cell line models.

    Fey, Christina / Truschel, Theresa / Nehlsen, Kristina / Damigos, Spyridon / Horstmann, Julia / Stradal, Theresia / May, Tobias / Metzger, Marco / Zdzieblo, Daniela

    Journal of tissue engineering

    2024  Volume 15, Page(s) 20417314241228949

    Abstract: Two-dimensional culture remains widely employed to determine the bioavailability of orally delivered drugs. To gain more knowledge about drug uptake mechanisms and risk assessment for the patient after oral drug admission, intestinal in vitro models ... ...

    Abstract Two-dimensional culture remains widely employed to determine the bioavailability of orally delivered drugs. To gain more knowledge about drug uptake mechanisms and risk assessment for the patient after oral drug admission, intestinal in vitro models demonstrating a closer similarity to the in vivo situation are needed. In particular, Caco-2 cell-based Transwell® models show advantages as they are reproducible, cost-efficient, and standardized. However, cellular complexity is impaired and cell function is strongly modified as important transporters in the apical membrane are missing. To overcome these limitations, primary organoid-based human small intestinal tissue models were developed recently but the application of these cultures in pre-clinical research still represents an enormous challenge, as culture setup is complex as well as time- and cost-intensive. To overcome these hurdles, we demonstrate the establishment of primary organoid-derived intestinal cell lines by immortalization. Besides exhibiting cellular diversity of the organoid, these immortalized cell lines enable a standardized and more cost-efficient culture. Further, our cell line-based Transwell®-like models display an organ-specific epithelial barrier integrity, ultrastructural features and representative transport functions. Altogether, our novel model systems are cost-efficient with close similarity to the in vivo situation, therefore favoring their use in bioavailability studies in the context of pre-clinical screenings.
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2573915-3
    ISSN 2041-7314
    ISSN 2041-7314
    DOI 10.1177/20417314241228949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Gesundheitserleben von Lehrkräften im inklusiven Unterricht - Analysen unter besonderer Berücksichtigung der Schulform. Perceived teacher health in inclusive schooling - analyses with special consideration to of the type of school

    Peperkorn, M. / Horstmann, D.

    Prävention und Gesundheitsförderung

    2019  Volume 14, Issue 2, Page(s) 183

    Language German
    Document type Article
    ZDB-ID 2233659-X
    ISSN 1861-6755
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6434: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Stearic acid (C18:0) reduces the expression of lipogenic genes and productivity in latelactating dairy ewes

    Horstmann, R / de Aguiar, G.C / Ribeiro, C.V.D.M / Oliveira, D.E

    Small ruminant research. 2021 Feb., v. 195

    2021  

    Abstract: ... of milk/day. The treatments were: Control and C18 (28 g/animal/d of C18:0). When compared with Control ...

    Abstract The objective of this study was to evaluate stearic acid supplementation (C18:0) on the production, composition, fatty acid profile and the expression of lipogenic genes in the mammary gland of late lactating ewes. We used 30 primiparous and multiparous Lacaune ewes with a mean body weight (BW) of 66.5 ± 9.4 kg and body condition score (BCS) of 3.0 ± 0.5 at late lactation (122 ± 12 DEL), producing 1.0 ± 0.3 kg of milk/day. The treatments were: Control and C18 (28 g/animal/d of C18:0). When compared with Control, C18:0 reduced silage dry matter intake (DMI) by 13.1 % (P = 0.0003), milk production by 8.1 % (P = 0.05), lactose production by 3.3 % (P = 0.0004), and lactose content by 3.4 % (P = 0.0002). There was no treatment effect on the production and content of fat, protein, and total solids. The gene expression of acetyl-CoA carboxylase alpha promoter 2 (ACACA PII) and fatty acid synthase (FASN) were reduced by 30 % (P = 0.02) and 26.1 % (P = 0.04), respectively. The C18:0 supplementation is not effective in increasing the fat content in late lactating dairy ewes and reduces DMI, milk production, lactose levels, and gene expression involved in fatty acid synthesis.
    Keywords acetyl-CoA carboxylase ; body condition ; body weight ; dry matter intake ; fatty acid composition ; fatty-acid synthase ; gene expression ; lactose ; late lactation ; lipid content ; mammary glands ; milk ; milk production ; research ; silage ; stearic acid
    Language English
    Dates of publication 2021-02
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 286928-7
    ISSN 0921-4488
    ISSN 0921-4488
    DOI 10.1016/j.smallrumres.2020.106296
    Database NAL-Catalogue (AGRICOLA)

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    Z 4801: Show issues

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  9. Book ; Online: SIGNAL -- The SAP Signavio Analytics Query Language

    Kampik, Timotheus / Lücke, Andre / Horstmann, Jörn / Wheeler, Mark / Eickhoff, David

    2023  

    Abstract: This paper provides an introduction to and discussion of SIGNAL, an industry-scale process data querying language and engine for large-scale cloud-based systems that is developed by SAP Signavio. SIGNAL is optimized for fast read access to process data ... ...

    Abstract This paper provides an introduction to and discussion of SIGNAL, an industry-scale process data querying language and engine for large-scale cloud-based systems that is developed by SAP Signavio. SIGNAL is optimized for fast read access to process data in event log format and utilizes an in-memory columnar store to this end. To facilitate usability, SIGNAL uses an SQL-like syntax with additional domain-specific querying features and in particular row-pattern matching-based temporal operators. Also, the paper highlights research challenges related to process querying that are informed by the implementation and application of SIGNAL.
    Keywords Computer Science - Databases ; Computer Science - Software Engineering
    Publishing date 2023-04-13
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article: Foreword.

    Horstmann, D M

    The Yale journal of biology and medicine

    2011  Volume 34, Issue 3-4, Page(s) 161.b1–162

    Language English
    Publishing date 2011-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 200515-3
    ISSN 1551-4056 ; 0044-0086
    ISSN (online) 1551-4056
    ISSN 0044-0086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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