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Article ; Online: Diminished LAG3

Hu, Suiyuan / Tao, Yuting / Hu, Fanlei / Liu, Xu

2023 Volume 55, Issue 1, Page(s) 2208373

Abstract: Background: Lymphocyte activation gene-3 (LAG3) positive B cells have been identified as a novel regulatory B cell subset, while the role of LAG3: Materials and methods: Peripheral blood mononuclear cells (PBMCs) from RA, osteoarthritis (OA) patients ...

Abstract	Background: Lymphocyte activation gene-3 (LAG3) positive B cells have been identified as a novel regulatory B cell subset, while the role of LAG3 Materials and methods: Peripheral blood mononuclear cells (PBMCs) from RA, osteoarthritis (OA) patients and healthy volunteers were collected for flow cytometry staining of LAG3 Results: A significant decrease of LAG3 Conclusions: Impairment of LAG3
MeSH term(s)	Animals ; Humans ; Mice ; Arthritis, Experimental/pathology ; Arthritis, Rheumatoid ; Leukocytes, Mononuclear
Chemical Substances	Lag3 protein, human ; Lag3 protein, mouse
Language	English
Publishing date	2023-05-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004226-x
ISSN	1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
ISSN (online)	1365-2060 ; 1651-2219
ISSN	0785-3890 ; 1743-1387
DOI	10.1080/07853890.2023.2208373
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Article ; Online: Diminished LAG3+ B cells correlate with exacerbated rheumatoid arthritis

Suiyuan Hu / Yuting Tao / Fanlei Hu / Xu Liu

Annals of Medicine, Vol 55, Iss

2023 Volume 1

Abstract: AbstractBackground Lymphocyte activation gene-3 (LAG3) positive B cells have been identified as a novel regulatory B cell subset, while the role of LAG3+ B cells in the pathogenesis of rheumatoid arthritis (RA) remains elusive.Materials and methods ... ...

Abstract	AbstractBackground Lymphocyte activation gene-3 (LAG3) positive B cells have been identified as a novel regulatory B cell subset, while the role of LAG3+ B cells in the pathogenesis of rheumatoid arthritis (RA) remains elusive.Materials and methods Peripheral blood mononuclear cells (PBMCs) from RA, osteoarthritis (OA) patients and healthy volunteers were collected for flow cytometry staining of LAG3+ B cells. Their correlation with RA patient clinical and immunological features were analyzed. Moreover, the frequencies of LAG3+ B cells in collagen-induced arthritis (CIA) mice and naive mice were also detected.Results A significant decrease of LAG3+ B cells was observed in RA patients as compared with healthy individuals and OA patients. Notably, the frequencies of LAG3+ B cells were negatively correlated with tender joint count (r = −0.4301, p = .0157) and DAS28-ESR (r = −0.4018, p = .025) in RA patients. In CIA mice, LAG3+ B cell frequencies were also decreased and negatively correlated with the CIA arthritis score.Conclusions Impairment of LAG3+ B cells potentially contributes to RA development. Reconstituting LAG3+ B cells might provide novel therapeutic strategies for the persistent disease.Key messagesLAG3+ B cells have been identified as a novel regulatory B cell subset. However, its role in the pathogenesis of RA remains unknown.This study revealed the decreased frequency of LAG3+ B cells in RA patients. Notably, LAG3+ B cells were negatively correlated with RA disease activity including the tender joint count and DAS28-ESR.In CIA mice, LAG3+ B cell frequencies were also decreased and negatively correlated with the CIA arthritis score.Reconstitution of LAG3+ B cells might provide novel therapeutic strategies for disease perpetuation.
Keywords	Immunotherapy ; LAG3 ; rheumatoid arthritis ; regulatory B cells ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of polydimethylsiloxane surface morphology on osteogenic differentiation of mesenchymal stem cells through SIRT1 signalling pathway.

Hu, Zezun / Yang, Fanlei / Xiang, Pan / Luo, Zongping / Liang, Ting / Xu, Hao

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

2024 , Page(s) 9544119241242964

Abstract: Constructing surface topography with a certain roughness is a widely used, non-toxic, cost-effective and effective method for improving the microenvironment of cells, promoting the proliferation and osteogenic differentiation of mesenchymal stem cells ( ... ...

Abstract	Constructing surface topography with a certain roughness is a widely used, non-toxic, cost-effective and effective method for improving the microenvironment of cells, promoting the proliferation and osteogenic differentiation of mesenchymal stem cells (MSCs), and promoting the osseointegration of grafts and further improving their biocompatibility under clinical environmental conditions. SIRT1 plays an important regulatory role in the osteogenic differentiation of bone marrow-derived MSCs (BM-MSCs). However, it remains unknown whether SIRT1 plays an important regulatory role in the osteogenic differentiation of BM-MSCs with regard to surface morphology. Polydimethylsiloxane (PDMS) with different surface morphologies were prepared using different grits of sandpaper. The value for BMSCs added on different surfaces was detected by cell proliferation assays. RT-qPCR and Western blotting were performed to detect SIRT1 activation and osteogenic differentiation of MSCs. Osteogenesis of MSCs was detected by alkaline phosphatase (ALP) and alizarin red S staining. SIRT1 inhibition experiments were performed to investigate the role of SIRT1 in the osteogenic differentiation of MSCs induced by surface morphology. We found that BM-MSCs have better value and osteogenic differentiation ability on a surface with roughness of PDMS-1000M. SIRT1 showed higher gene and protein expression on a PDMS-1000M surface with a roughness of 13.741 ± 1.388 µm. The promotion of the osteogenic differentiation of MSCs on the PDMS-1000M surface was significantly decreased after inhibiting SIRT1 expression. Our study demonstrated that a surface morphology with certain roughness can activate the SIRT1 pathway of MSCs and promote the osteogenic differentiation of BMSCs via the SIRT1 pathway.
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1065942-0
ISSN	2041-3033 ; 0046-2039 ; 0954-4119
ISSN (online)	2041-3033
ISSN	0046-2039 ; 0954-4119
DOI	10.1177/09544119241242964
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Article ; Online: Raman spectroscopy as a promising diagnostic method for rheumatoid arthritis.

Cao, Lulu / Zheng, Xi / Han, Peng / Ren, Limin / Jing Wang / Hu, Fanlei / Li, Zhanguo

Analytical methods : advancing methods and applications

2023 Volume 15, Issue 6, Page(s) 709–718

Abstract: ... ...

Abstract	Background
MeSH term(s)	Humans ; Spectrum Analysis, Raman ; Arthritis, Rheumatoid/diagnosis ; Rheumatoid Factor ; Autoantibodies ; Anti-Citrullinated Protein Antibodies
Chemical Substances	Rheumatoid Factor (9009-79-4) ; Autoantibodies ; Anti-Citrullinated Protein Antibodies
Language	English
Publishing date	2023-02-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/d2ay01904c
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Article ; Online: Double-negative (DN) B cells: an under-recognized effector memory B cell subset in autoimmunity.

Li, Yuzi / Li, Zhanguo / Hu, Fanlei

Clinical and experimental immunology

2021 Volume 205, Issue 2, Page(s) 119–127

Abstract: Human B cells could be divided into four classical subsets based on CD27 and immunoglobulin (Ig)D expression. Distinct from the other three well-studied subsets, ... ...

Abstract	Human B cells could be divided into four classical subsets based on CD27 and immunoglobulin (Ig)D expression. Distinct from the other three well-studied subsets, CD27
MeSH term(s)	Animals ; Autoimmune Diseases/immunology ; B-Lymphocyte Subsets/immunology ; Humans ; Immunoglobulin D/immunology ; Immunologic Memory/immunology
Chemical Substances	Immunoglobulin D
Language	English
Publishing date	2021-06-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	218531-3
ISSN	1365-2249 ; 0009-9104 ; 0964-2536
ISSN (online)	1365-2249
ISSN	0009-9104 ; 0964-2536
DOI	10.1111/cei.13615
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Article ; Online: Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy.

Xie, Yang / Jia, Yuan / Li, Zhanguo / Hu, Fanlei

Expert opinion on therapeutic targets

2022 Volume 26, Issue 5, Page(s) 461–477

Abstract: Introduction: Scavenger receptor A (SR-A) is reported to be involved in innate and adaptive immunity and in recent years, the soluble form of SR-A has also been identified. Intriguingly, SR-A displays double-edged sword features in different diseases. ... ...

Abstract	Introduction: Scavenger receptor A (SR-A) is reported to be involved in innate and adaptive immunity and in recent years, the soluble form of SR-A has also been identified. Intriguingly, SR-A displays double-edged sword features in different diseases. Moreover, targeted therapy on SR-A, including genetic modulation, small molecule inhibitor, inhibitory peptides, fucoidan, and blocking antibodies, provides potential strategies for treatment. Currently, therapeutics targeting SR-A are in preclinical studies and clinical trials, revealing great perspectives in future immunotherapy. Areas covered: Through searching PubMed (January 1979-March 2022) and clinicaltrials.gov, we review most of the research and clinical trials involving SR-A. This review briefly summarizes recent study advances on SR-A, with particular concern on its role in immunity and autoimmune diseases. Expert opinion: Given the emerging evidence of SR-A in immunity, its targeted therapy has been studied in various diseases, especially autoimmune diseases. However, many challenges still remain to be overcome, such as the double-sworded effects and the specific isoform targeting. For further clinical success of SR-A targeted therapy, the crystal structure illustration and the dual function discrimination of SR-A should be further investigated. Nevertheless, although challenging, targeting SR-A would be a potential effective strategy in the treatment of autoimmune diseases and other immune-related diseases.
MeSH term(s)	Adaptive Immunity ; Autoimmune Diseases/drug therapy ; Humans ; Immunotherapy ; Receptors, Scavenger
Chemical Substances	Receptors, Scavenger
Language	English
Publishing date	2022-05-12
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2055208-7
ISSN	1744-7631 ; 1472-8222
ISSN (online)	1744-7631
ISSN	1472-8222
DOI	10.1080/14728222.2022.2072729
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Article: Research hotspots and trends on acupuncture treatment for headache: a bibliometric analysis from 2003 to 2023.

Zhao, Shun / Hu, Songfeng / Luo, Yujing / Li, Wangjun / Zhao, Fenfen / Wang, Changkang / Meng, Fanlei / He, Xingwei

Frontiers in neuroscience

2024 Volume 18, Page(s) 1338323

Abstract: Background: While acupuncture treatment has gained extensive usage in addressing headaches, there remains a notable gap in the literature analysis for this field. Therefore, this study aims to conduct a literature review using Citespace, VOSviewer, and ... ...

Abstract	Background: While acupuncture treatment has gained extensive usage in addressing headaches, there remains a notable gap in the literature analysis for this field. Therefore, this study aims to conduct a literature review using Citespace, VOSviewer, and Bibliometrix, aiming to examine the current status, strengths, and potential future directions in the utilization of acupuncture for headache treatment. Methods: Relevant literature on acupuncture treatment for headaches between 2003 and 2023 was retrieved from the Web of Science (WoS) core database. Utilizing CiteSpace 6.1.R6, VOSviewer 1.6.18, and Bibliometrix 4.1.4, we conducted bibliometric analyses across various categories, including countries/regions, institutions, authors, journals, references, and keywords. Results: A total of 808 research reports were included. China and the United States have significantly contributed to this field. Chengdu University of Chinese Medicine holds the record for the highest number of published papers. Liu Lu has the highest publication output, while Linde K has the highest citation rate. Conclusion: Acupuncture treatment for headaches has established a stable trend with a promising developmental trajectory. Research in this field mainly focuses on different acupuncture prevention and treatment for various types of headaches, the safety and efficacy of acupuncture, etc. Research on the mechanism of action mainly focuses on interpreting bidirectional and holistic regulation between pain and emotion by acupuncture and the regulation of brain function connection and neuroimaging technology by acupuncture. Future research should expand on the advantages and indications of acupuncture treatment for different headaches and their modern mechanisms.
Language	English
Publishing date	2024-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2024.1338323
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Article ; Online: Soluble CD24 is an inflammatory biomarker in early and seronegative rheumatoid arthritis.

Zheng, Xi / Wang, Ping / Song, Jing / Tang, Yundi / Xie, Yang / Jin, Xu / Zhu, Danxue / Fang, Xiangyu / Wei, Chaonan / Li, Ru / Hu, Fanlei / Li, Zhanguo

Annals of medicine

2023 Volume 55, Issue 2, Page(s) 2246370

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Arthritis, Rheumatoid/diagnosis ; Rheumatic Diseases ; Biomarkers ; Clinical Relevance ; Enzyme-Linked Immunosorbent Assay ; CD24 Antigen
Chemical Substances	Biomarkers ; CD24 protein, human ; CD24 Antigen
Language	English
Publishing date	2023-08-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004226-x
ISSN	1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
ISSN (online)	1365-2060 ; 1651-2219
ISSN	0785-3890 ; 1743-1387
DOI	10.1080/07853890.2023.2246370
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Article ; Online: Elevated expression of hsa_circ_0000479 in neutrophils correlates with features of systemic lupus erythematosus.

Yao, Ranran / Xu, Liling / Cheng, Gong / Wang, Ziye / Liang, Ruyu / Pei, Wenwen / Cao, Lulu / Jia, Yuan / Ye, Hua / Hu, Fanlei / Su, Yin

Annals of medicine

2024 Volume 56, Issue 1, Page(s) 2309607

Abstract: Objective: Accumulating evidence suggests that differentially expressed circular RNAs (circRNAs) play critical roles in immune cells of systemic lupus erythematosus (SLE) patients. Hsa_circ_0000479 has been studied in the field of cancer and infection, ... ...

Abstract	Objective: Accumulating evidence suggests that differentially expressed circular RNAs (circRNAs) play critical roles in immune cells of systemic lupus erythematosus (SLE) patients. Hsa_circ_0000479 has been studied in the field of cancer and infection, whereas seldom studied in autoimmune diseases. The aim of this study was to investigate the role and clinical value of neutrophil hsa_circ_0000479 in SLE. Methods: The expression levels of hsa_circ_0000479 in both healthy individuals and SLE patients' neutrophils were detected by qPCR and compared with those in peripheral blood mononuclear cells (PBMCs) . In addition, the correlation of hsa_circ_0000479 levels in neutrophils with the clinical and immunological features of SLE patients was also analysed. Results: The expression levels of hsa_circ_0000479 in the patients with SLE were significantly higher in neutrophils than that of PBMCs, and also significantly higher than that in healthy controls (HCs). Moreover, the expression levels of hsa_circ_0000479 in neutrophils were negatively associated with absolute neutrophil count and complement 3 (C3), whereas positively correlated with anti-dsDNA and anti-nucleosome antibodies in SLE. In addition, SLE patients with higher levels of hsa_circ_0000479 demonstrated more several clinical manifestations, including Raynaud's phenomenon, alopecia and leucopenia. Conclusions: Hsa_circ_0000479 is up-regulated in neutrophils of SLE patients, and is also associated with several important laboratory indicators and clinical manifestations, suggesting that hsa_circ_0000479 in neutrophils was one of probable factors involved in the pathogenesis of SLE with potential clinical value.
MeSH term(s)	Humans ; Neutrophils/metabolism ; Leukocytes, Mononuclear/metabolism ; RNA, Circular/metabolism ; Lupus Erythematosus, Systemic/genetics ; Leukocyte Count
Chemical Substances	RNA, Circular
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004226-x
ISSN	1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
ISSN (online)	1365-2060 ; 1651-2219
ISSN	0785-3890 ; 1743-1387
DOI	10.1080/07853890.2024.2309607
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Article ; Online: B cell subsets in adult-onset Still's disease: potential candidates for disease pathogenesis and immunophenotyping.

Fang, Xiangyu / Ye, Hua / Xie, Yang / Wei, Chaonan / Liu, Shuyan / Yao, Haihong / Li, Zhanguo / Jia, Yuan / Hu, Fanlei

Arthritis research & therapy

2023 Volume 25, Issue 1, Page(s) 104

Abstract: Background: Adult-onset Still's disease (AOSD) is a systemic autoinflammatory disorder of unknown etiology. B cells are critical participants in different rheumatic diseases, and their roles in AOSD are rarely investigated. This study aimed to unveil ... ...

Abstract	Background: Adult-onset Still's disease (AOSD) is a systemic autoinflammatory disorder of unknown etiology. B cells are critical participants in different rheumatic diseases, and their roles in AOSD are rarely investigated. This study aimed to unveil the B cell subset features in AOSD and provide evidence for B cell-based diagnosis and targeted therapies of AOSD. Methods: B cell subsets in the peripheral blood of AOSD patients and healthy controls (HCs) were detected by flow cytometry. Firstly, the frequencies of B cell subsets were compared. Then, the correlation analysis was performed to explore the correlation between B cell subsets and clinical manifestations in AOSD. Finally, unbiased hierarchical clustering was performed to divide AOSD patients into three groups with different B cell subset features, and the clinical characteristics of the three groups were compared. Results: The frequencies of B cell subsets were altered in AOSD patients. Disease-promoting subsets (such as naïve B cells, double negative B cells (DN B cells), and plasmablasts) increased, and potential regulatory subsets (such as unswitched memory B cells (UM B cells) and CD24 Conclusions: B cell subsets are significantly altered in AOSD patients, potentially contributing to the disease pathogenesis. These findings would inspire B cell-based diagnosis and targeted therapies for this refractory disease.
MeSH term(s)	Adult ; Humans ; Still's Disease, Adult-Onset ; B-Lymphocyte Subsets ; Immunophenotyping ; Plasma Cells
Language	English
Publishing date	2023-06-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/s13075-023-03070-2
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