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  1. Book: Mucins

    McGuckin, Michael A. / Thornton, David J.

    methods and protocols

    (Methods in molecular biology ; 842 ; Springer protocols)

    2012  

    Author's details ed. by Michael A. McGuckin ; David J. Thornton
    Series title Methods in molecular biology ; 842
    Springer protocols
    Collection
    Language English
    Size XI, 329 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017139925
    ISBN 978-1-61779-512-1 ; 1-61779-512-7 ; 9781617795138 ; 1617795135
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 863 order for loan Magazin

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  2. Article ; Online: Structural alignment of ZnO columns across multiple monolayer MoS

    Wang, Xuejing / Kim, Kyungtae / Derby, Benjamin K / McGuckin, Terrence / Calderón, Gabriel A / Pettes, Michael T / Hwang, Jinwoo / Kim, Yeonhoo / Park, Jeongwon / Chen, Aiping / Kang, Kibum / Yoo, Jinkyoung

    Nanoscale

    2024  

    Abstract: Understanding the behavior of materials in multi-dimensional architectures composed of atomically thin two-dimensional (2D) materials and three-dimensional (3D) materials has become mandatory for progress in materials ... ...

    Abstract Understanding the behavior of materials in multi-dimensional architectures composed of atomically thin two-dimensional (2D) materials and three-dimensional (3D) materials has become mandatory for progress in materials preparation
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d4nr00724g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Robotic-Assisted Navigation for Stereotactic Neurosurgery: A Cadaveric Investigation of Accuracy, Time, and Radiation.

    Anderson, William / Ponce, Francisco A / Kinsman, Michael J / Sani, Sepehr / Hwang, Brian / Ghinda, Diana / Kogan, Michael / Mahoney, Jonathan M / Amin, Dhara B / Van Horn, Margaret / McGuckin, Joshua P / Razo-Castaneda, Dominic / Bucklen, Brandon S

    Operative neurosurgery (Hagerstown, Md.)

    2023  

    Abstract: Background and objectives: Despite frequent use, stereotactic head frames require manual coordinate calculations and manual frame settings that are associated with human error. This study examines freestanding robot-assisted navigation (RAN) as a means ... ...

    Abstract Background and objectives: Despite frequent use, stereotactic head frames require manual coordinate calculations and manual frame settings that are associated with human error. This study examines freestanding robot-assisted navigation (RAN) as a means to reduce the drawbacks of traditional cranial stereotaxy and improve targeting accuracy.
    Methods: Seven cadaveric human torsos with heads were tested with 8 anatomic coordinates selected for lead placement mirrored in each hemisphere. Right and left hemispheres of the brain were randomly assigned to either the traditional stereotactic arc-based (ARC) group or the RAN group. Both target accuracy and trajectory accuracy were measured. Procedural time and the radiation required for registration were also measured.
    Results: The accuracy of the RAN group was significantly greater than that of the ARC group in both target (1.2 ± 0.5 mm vs 1.7 ± 1.2 mm, P = .005) and trajectory (0.9 ± 0.6 mm vs 1.3 ± 0.9 mm, P = .004) measurements. Total procedural time was also significantly faster for the RAN group than for the ARC group (44.6 ± 7.7 minutes vs 86.0 ± 12.5 minutes, P < .001). The RAN group had significantly reduced time per electrode placement (2.9 ± 0.9 minutes vs 5.8 ± 2.0 minutes, P < .001) and significantly reduced radiation during registration (1.9 ± 1.1 mGy vs 76.2 ± 5.0 mGy, P < .001) compared with the ARC group.
    Conclusion: In this cadaveric study, cranial leads were placed faster and with greater accuracy using RAN than those placed with conventional stereotactic arc-based technique. RAN also required significantly less radiation to register the specimen's coordinate system to the planned trajectories. Clinical testing should be performed to further investigate RAN for stereotactic cranial surgery.
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1227/ons.0000000000001024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1424 -ON-: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: MUC13 Cell Surface Mucin Limits Salmonella Typhimurium Infection by Protecting the Mucosal Epithelial Barrier.

    McGuckin, Michael A / Davies, Julie M / Felgner, Pascal / Wong, Kuan Yau / Giri, Rabina / He, Yaowu / Moniruzzaman, Md / Kryza, Thomas / Sajiir, Haressh / Hooper, John D / Florin, Timothy H / Begun, Jakob / Oussalah, Abderrahim / Hasnain, Sumaira Z / Hensel, Michael / Sheng, Yong H

    Cellular and molecular gastroenterology and hepatology

    2023  Volume 16, Issue 6, Page(s) 985–1009

    Abstract: Background & aims: MUC13 cell surface mucin is highly expressed on the mucosal surface throughout the intestine, yet its role against bacterial infection is unknown. We investigated how MUC13 impacts Salmonella typhimurium (S Tm) infection and ... ...

    Abstract Background & aims: MUC13 cell surface mucin is highly expressed on the mucosal surface throughout the intestine, yet its role against bacterial infection is unknown. We investigated how MUC13 impacts Salmonella typhimurium (S Tm) infection and elucidated its mechanisms of action.
    Methods: Muc13
    Results: S Tm-infected Muc13
    Conclusions: We show for the first time that MUC13 plays a critical role in antimicrobial defense against pathogenic S Tm at the intestinal mucosal surface by both acting as a releasable decoy limiting bacterial invasion and reducing pathogen-induced cell death. This further implicates the cell surface mucin family in mucosal defense from bacterial infection.
    MeSH term(s) Animals ; Mice ; Bacterial Infections/genetics ; Bacterial Infections/metabolism ; Epithelial Cells/metabolism ; Intestinal Mucosa/pathology ; Mucins/metabolism ; Salmonella typhimurium/metabolism
    Chemical Substances Mucins ; Ly64 protein, mouse
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2023.08.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Oxidative and endoplasmic reticulum stress in respiratory disease.

    Chen, Alice C-H / Burr, Lucy / McGuckin, Michael A

    Clinical & translational immunology

    2018  Volume 7, Issue 6, Page(s) e1019

    Abstract: Oxidative stress and endoplasmic reticulum (ER) stress are related states that can occur in cells as part of normal physiology but occur frequently in diseases involving inflammation. In this article, we review recent findings relating to the role of ... ...

    Abstract Oxidative stress and endoplasmic reticulum (ER) stress are related states that can occur in cells as part of normal physiology but occur frequently in diseases involving inflammation. In this article, we review recent findings relating to the role of oxidative and ER stress in the pathophysiology of acute and chronic nonmalignant diseases of the lung, including infections, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. We also explore the potential of drugs targeting oxidative and ER stress pathways to alleviate disease.
    Language English
    Publishing date 2018-06-13
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2694482-0
    ISSN 2050-0068
    ISSN 2050-0068
    DOI 10.1002/cti2.1019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells.

    Moniruzzaman, Md / Rahman, M Arifur / Wang, Ran / Wong, Kuan Yau / Chen, Alice C-H / Mueller, Alexandra / Taylor, Steven / Harding, Alexa / Illankoon, Thishan / Wiid, Percival / Sajiir, Haressh / Schreiber, Veronika / Burr, Lucy D / McGuckin, Michael A / Phipps, Simon / Hasnain, Sumaira Z

    The Journal of experimental medicine

    2023  Volume 220, Issue 11

    Abstract: Major histocompatibility complex (MHC) II is dynamically expressed on mucosal epithelial cells and is induced in response to inflammation and parasitic infections, upon exposure to microbiota, and is increased in chronic inflammatory diseases. However, ... ...

    Abstract Major histocompatibility complex (MHC) II is dynamically expressed on mucosal epithelial cells and is induced in response to inflammation and parasitic infections, upon exposure to microbiota, and is increased in chronic inflammatory diseases. However, the regulation of epithelial cell-specific MHC II during homeostasis is yet to be explored. We discovered a novel role for IL-22 in suppressing epithelial cell MHC II partially via the regulation of endoplasmic reticulum (ER) stress, using animals lacking the interleukin-22-receptor (IL-22RA1), primary human and murine intestinal and respiratory organoids, and murine models of respiratory virus infection or with intestinal epithelial cell defects. IL-22 directly downregulated interferon-γ-induced MHC II on primary epithelial cells by modulating the expression of MHC II antigen A α (H2-Aα) and Class II transactivator (Ciita), a master regulator of MHC II gene expression. IL-22RA1-knockouts have significantly higher MHC II expression on mucosal epithelial cells. Thus, while IL-22-based therapeutics improve pathology in chronic disease, their use may increase susceptibility to viral infections.
    MeSH term(s) Humans ; Animals ; Mice ; Major Histocompatibility Complex ; Interleukins ; Endoplasmic Reticulum Stress ; Epithelial Cells ; Interleukin-22
    Chemical Substances Interleukins
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20230106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 45: Show issues

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  7. Article ; Online: Lubrication by biomacromolecules: mechanisms and biomimetic strategies.

    Pradal, Clementine / Yakubov, Gleb E / Williams, Martin A K / McGuckin, Michael A / Stokes, Jason R

    Bioinspiration & biomimetics

    2019  Volume 14, Issue 5, Page(s) 51001

    Abstract: Biomacromolecules play a key role in protecting human biointerfaces from friction and wear, and thus enable painless motion. Biomacromolecules give rise to remarkable tribological properties that researchers have been eager to emulate. In this review, we ...

    Abstract Biomacromolecules play a key role in protecting human biointerfaces from friction and wear, and thus enable painless motion. Biomacromolecules give rise to remarkable tribological properties that researchers have been eager to emulate. In this review, we examine how molecules such as mucins, lubricin, hyaluronic acid and other components of biotribological interfaces provide a unique set of rheological and surface properties that leads to low friction and wear. We then highlight how researchers have used some of the features of biotribological contacts to create biomimetic systems. While the brush architecture of the glycosylated molecules present at biotribological interfaces has inspired some promising polymer brush systems, it is the recent advance in the understanding of synergistic interaction between biomacromolecules that is showing the most potential in producing surfaces with a high lubricating ability. Research currently suggests that no single biomacromolecule or artificial polymer successfully reproduces the tribological properties of biological contacts. However, by combining molecules, one can enhance their anchoring and lubricating capacity, thus enabling the design of surfaces for use in biomedical applications requiring low friction and wear.
    MeSH term(s) Biomimetic Materials/chemistry ; Biomimetics ; Humans ; Lubrication ; Macromolecular Substances/chemistry ; Rheology ; Viscosity
    Chemical Substances Macromolecular Substances
    Language English
    Publishing date 2019-07-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2235670-8
    ISSN 1748-3190 ; 1748-3182
    ISSN (online) 1748-3190
    ISSN 1748-3182
    DOI 10.1088/1748-3190/ab2ac6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Interleukin (IL)-22 from IL-20 Subfamily of Cytokines Induces Colonic Epithelial Cell Proliferation Predominantly through ERK1/2 Pathway.

    Moniruzzaman, Md / Wang, Ran / Jeet, Varinder / McGuckin, Michael A / Hasnain, Sumaira Z

    International journal of molecular sciences

    2019  Volume 20, Issue 14

    Abstract: The interleukin (IL)-20 subfamily of cytokines consists of IL-19, IL-20, IL-22, IL-24, and IL-26, and the expression of IL-20, IL-22, and IL-24 is reported to be higher in the colon of patients with ulcerative colitis. Although the receptors for these ... ...

    Abstract The interleukin (IL)-20 subfamily of cytokines consists of IL-19, IL-20, IL-22, IL-24, and IL-26, and the expression of IL-20, IL-22, and IL-24 is reported to be higher in the colon of patients with ulcerative colitis. Although the receptors for these cytokines are highly expressed in the colon epithelium, their effects on epithelial renewal are not clearly understood. This study evaluated the effects of IL-20, IL-22, and IL-24 in epithelial renewal using the LS174T human colon cancer epithelial cell line. LS174T cells were treated with IL-20, IL-22, and IL-24 (25, 50, and 100 ng/mL) and a live-cell imaging system was used to evaluate the effects on cell proliferation. Following treatment, the signaling pathways contributing to cell proliferation were investigated through Western blotting in LS174T cells and downstream transcriptional changes through qRT-PCR in LS174T cells, and RNA-Seq in primary murine intestinal epithelial cells. Our results demonstrated that only IL-22 promoted LS174T cell proliferation, mediated via extracellular-signal-regulated kinase (ERK)1/2-mediated downstream regulation of p90RSK, c-Jun, and transcriptional changes of
    MeSH term(s) Animals ; Cell Line, Tumor ; Cell Proliferation ; Cells, Cultured ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; Enterocytes/metabolism ; Enterocytes/physiology ; Humans ; Interleukins/genetics ; Interleukins/metabolism ; MAP Kinase Signaling System ; Mice ; Mice, Inbred C57BL ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism
    Chemical Substances Interleukins ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24)
    Language English
    Publishing date 2019-07-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20143468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Secreted NF-κB suppressive microbial metabolites modulate gut inflammation.

    Giri, Rabina / Hoedt, Emily C / Khushi, Shamsunnahar / Salim, Angela A / Bergot, Anne-Sophie / Schreiber, Veronika / Thomas, Ranjeny / McGuckin, Michael A / Florin, Timothy H / Morrison, Mark / Capon, Robert J / Ó Cuív, Páraic / Begun, Jakob

    Cell reports

    2022  Volume 39, Issue 2, Page(s) 110646

    Abstract: Emerging evidence suggests that microbiome-host crosstalk regulates intestinal immune activity and predisposition to inflammatory bowel disease (IBD). NF-κB is a master regulator of immune function and a validated target for the treatment of IBD. Here, ... ...

    Abstract Emerging evidence suggests that microbiome-host crosstalk regulates intestinal immune activity and predisposition to inflammatory bowel disease (IBD). NF-κB is a master regulator of immune function and a validated target for the treatment of IBD. Here, we identify five Clostridium strains that suppress immune-mediated NF-κB activation in epithelial cell lines, PBMCs, and gut epithelial organoids from healthy human subjects and patients with IBD. Cell-free culture supernatant from Clostridium bolteae AHG0001 strain, but not the reference C. bolteae BAA-613 strain, suppresses inflammatory responses and endoplasmic reticulum stress in gut epithelial organoids derived from Winnie mice. The in vivo responses to Clostridium bolteae AHG0001 and BAA-613 mirror the in vitro activity. Thus, using our in vitro screening of bacteria capable of suppressing NF-κB in the context of IBD and using an ex vivo organoid-based approach, we identify a strain capable of alleviating colitis in a relevant pre-clinical animal model of IBD.
    MeSH term(s) Animals ; Clostridiales ; Colitis/metabolism ; Humans ; Inflammation/metabolism ; Inflammatory Bowel Diseases/metabolism ; Intestinal Mucosa/metabolism ; Mice ; NF-kappa B/metabolism
    Chemical Substances NF-kappa B
    Language English
    Publishing date 2022-04-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.110646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Influence of the MUC1 Cell Surface Mucin on Gastric Mucosal Gene Expression Profiles in Response to

    Sheng, Yong H / Ng, Garrett Z / Summers, Kim M / Every, Alison L / Price, Gareth / Hasnain, Sumaira Z / Sutton, Philip / McGuckin, Michael A

    Frontiers in cellular and infection microbiology

    2020  Volume 10, Page(s) 343

    Abstract: The cell surface mucin MUC1 is an important host factor ... ...

    Abstract The cell surface mucin MUC1 is an important host factor limiting
    MeSH term(s) Animals ; Gastric Mucosa ; Helicobacter Infections ; Helicobacter pylori ; Mice ; Mucin-1/genetics ; Transcriptome
    Chemical Substances Mucin-1 ; muc1 protein, mouse
    Language English
    Publishing date 2020-07-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2020.00343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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