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  1. Article ; Online: Cyclic Diguanylate G-Quadruplex Inducer-Nitric Oxide Donor Conjugate as a Bifunctional Antibiofilm Agent and Antibacterial Synergist against

    Lin, Qian-Wen / Lu, Jin-Qiang / Huang, Ye-Si / Liu, Jie-Jiao / Chen, Wei-Min / Lin, Jing

    Journal of medicinal chemistry

    2023  Volume 66, Issue 17, Page(s) 11927–11939

    Abstract: Antibiotic resistance caused by biofilm formation is a clinical challenge. Nitric oxide (NO) can effectively disperse a mature biofilm and can also synergistically influence the level of cyclic diguanylate (c-di-GMP), a universal secondary messenger that ...

    Abstract Antibiotic resistance caused by biofilm formation is a clinical challenge. Nitric oxide (NO) can effectively disperse a mature biofilm and can also synergistically influence the level of cyclic diguanylate (c-di-GMP), a universal secondary messenger that plays an important role in biofilm formation in bacteria. Based on our previous finding that c-di-GMP G-quadruplex inducers are effective biofilm formation inhibitors, we designed and synthesized a c-di-GMP G-quadruplex inducer-NO donor conjugate (
    MeSH term(s) Animals ; Nitric Oxide Donors/pharmacology ; Pseudomonas aeruginosa ; Anti-Bacterial Agents/pharmacology ; Tobramycin/pharmacology ; Nitric Oxide ; Biofilms ; Caenorhabditis elegans ; Phenotype
    Chemical Substances Nitric Oxide Donors ; Anti-Bacterial Agents ; Tobramycin (VZ8RRZ51VK) ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2023-08-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c00516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
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  2. Article ; Online: Author Correction: Catalytic enantioselective reductive alkynylation of amides enables one-pot syntheses of pyrrolidine, piperidine and indolizidine alkaloids.

    Xu, Fang-Fang / Chen, Jin-Quan / Shao, Dong-Yang / Huang, Pei-Qiang

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1836

    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46252-5
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  3. Article: Effects of human umbilical cord blood mononuclear cells on ovalbumin-induced asthma in mice.

    Luo, Yu-Long / Li, Yun-Feng / Zhu, Yi-Ping / Liang, Jin-Qiang / Chen, Di-Fei / Chen, Huan-Jie / Huang, Chu-Qing / Li, Jing / Li, Shi-Yue

    Journal of thoracic disease

    2023  Volume 15, Issue 10, Page(s) 5454–5465

    Abstract: Background: Umbilical cord blood mononuclear cells (UCMNCs) show broad immune-modulation effects, which may be helpful for treating asthma. Effects of UCMNCs on asthma were investigated with mouse model in present study.: Methods: Asthma was induced ... ...

    Abstract Background: Umbilical cord blood mononuclear cells (UCMNCs) show broad immune-modulation effects, which may be helpful for treating asthma. Effects of UCMNCs on asthma were investigated with mouse model in present study.
    Methods: Asthma was induced in BALB/c mice by ovalbumin (OVA) immunization and challenge. Asthmatic mice were then treated on days 7 and 20 with intravenous injections of UCMNCs in doses of 4×10
    Results: Compared with the model group, AHR in the UCMNC
    Conclusions: UCMNCs can modulate AHR, T-helper (Th)2 inflammation, and airway injury in experimental asthma at appropriate dose.
    Language English
    Publishing date 2023-09-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-22-1669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Study on the Effect of "3D-rGO" Buffer Layer on the Microstructure and Properties of SiO

    Liu, Peng / Ma, Qiang / Chen, Yongwei / Chen, Shujin / Zhu, Jie / He, Peng / Chen, Xiaojiang / Jin, Xiao / Zheng, Bin

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 6

    Abstract: Brazing a ... ...

    Abstract Brazing a SiO
    Language English
    Publishing date 2024-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17061394
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  5. Article ; Online: Efficient Solar-Driven CO

    Wang, Huiling / Li, Qiang / Chen, Jin / Chen, Jing / Jia, Hongpeng

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 34, Page(s) e2304406

    Abstract: Solar-driven photothermal conversion of carbon dioxide ( ... ...

    Abstract Solar-driven photothermal conversion of carbon dioxide (CO
    Language English
    Publishing date 2023-10-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202304406
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  6. Article ; Online: Structures of multinuclear U(VI) species on the hydroxylated α-SiO

    Gao, Pengyuan / Jin, Qiang / Chen, Zongyuan / Wang, Dongqi / Tournassat, Christophe / Guo, Zhijun

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 5, Page(s) 4125–4134

    Abstract: Multinuclear U(VI) species may be dominant in aqueous solutions under environmental conditions, while the structures of the multinuclear U(VI) species on mineral surfaces remain unclear. This work reports the structural and bonding properties of the ... ...

    Abstract Multinuclear U(VI) species may be dominant in aqueous solutions under environmental conditions, while the structures of the multinuclear U(VI) species on mineral surfaces remain unclear. This work reports the structural and bonding properties of the possible surface complexes of three aqueous multinuclear U(VI) species,
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp04941h
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  7. Article ; Online: Efficient destruction of basic organo-nitrogenous compounds in liquid hydrocarbon fuel using ascorbic acid/H

    Jin, Xin / Du, Xiaohu / Liu, Guangrong / Jin, Bangheng / Cao, Kaihong / Chen, Fangyue / Huang, Qiang

    Journal of hazardous materials

    2023  Volume 459, Page(s) 132242

    Abstract: Due to the limitations of the conventional refinery methods, development of a new method such as oxidative denitrogenation (ODN) is highly desirable. This study described a novel ODN to remove organo-nitrogenous compounds (ONCs) in liquid fuel by ... ...

    Abstract Due to the limitations of the conventional refinery methods, development of a new method such as oxidative denitrogenation (ODN) is highly desirable. This study described a novel ODN to remove organo-nitrogenous compounds (ONCs) in liquid fuel by ascorbic acid (AscH
    Language English
    Publishing date 2023-08-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2023.132242
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  8. Article ; Online: DNMT1-mediated epigenetic suppression of FBXO32 expression promoting cyclin dependent kinase 9 (CDK9) survival and esophageal cancer cell growth.

    Song, Xian-Qiang / Chen, Bin-Bin / Jin, Yong-Mei / Wang, Chang-Yong

    Cell cycle (Georgetown, Tex.)

    2024  Volume 23, Issue 3, Page(s) 262–278

    Abstract: Esophageal cancer (EC) is a common and serious form of cancer, and while DNA methyltransferase-1 (DNMT1) promotes DNA methylation and carcinogenesis, the role of F-box protein 32 (FBXO32) in EC and its regulation by DNMT1-mediated methylation is still ... ...

    Abstract Esophageal cancer (EC) is a common and serious form of cancer, and while DNA methyltransferase-1 (DNMT1) promotes DNA methylation and carcinogenesis, the role of F-box protein 32 (FBXO32) in EC and its regulation by DNMT1-mediated methylation is still unclear. FBXO32 expression was examined in EC cells with high DNMT1 expression using GSE163735 dataset. RT-qPCR assessed FBXO32 expression in normal and EC cells, and impact of higher FBXO32 expression on cell proliferation, migration, and invasion was evaluated, along with EMT-related proteins. The xenograft model established by injecting EC cells transfected with FBXO32 was used to evaluate tumor growth, apoptosis, and tumor cells proliferation and metastasis. Chromatin immunoprecipitation (ChIP) assay was employed to study the interaction between DNMT1 and FBXO32. HitPredict, co-immunoprecipitation (Co-IP), and Glutathione-S-transferase (GST) pulldown assay analyzed the interaction between FBXO32 and cyclin dependent kinase 9 (CDK9). Finally, the ubiquitination assay identified CDK9 ubiquitination, and its half-life was measured using cycloheximide and confirmed through western blotting. DNMT1 negatively correlated with FBXO32 expression in esophageal cells. High FBXO32 expression was associated with better overall survival in patients. Knockdown of DNMT1 in EC cells increased FBXO32 expression and suppressed malignant phenotypes. FBXO32 repressed EC tumor growth and metastasis in mice. Enrichment of DNMT1 in FBXO32 promoter region led to increased DNA methylation and reduced transcription. Mechanistically, FBXO32 degraded CDK9 through promoting its ubiquitination.
    MeSH term(s) Esophageal Neoplasms/pathology ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/mortality ; Esophageal Neoplasms/metabolism ; Humans ; DNA (Cytosine-5-)-Methyltransferase 1/metabolism ; DNA (Cytosine-5-)-Methyltransferase 1/genetics ; Animals ; Cell Proliferation/genetics ; F-Box Proteins/metabolism ; F-Box Proteins/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Epigenesis, Genetic/genetics ; Mice ; Mice, Nude ; DNA Methylation/genetics ; Ubiquitination ; Cell Movement/genetics ; Apoptosis/genetics ; Mice, Inbred BALB C ; Cell Survival/genetics ; Female ; Male
    Chemical Substances DNA (Cytosine-5-)-Methyltransferase 1 (EC 2.1.1.37) ; F-Box Proteins ; DNMT1 protein, human (EC 2.1.1.37)
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15384101.2024.2309022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5881: Show issues Location:
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  9. Article ; Online: Porcine platelet lysates exert the efficacy of chondroregeneration and SMAD2-mediated anti-chondrofibrosis on knee osteoarthritis.

    Xiao, Xiujuan / Xu, Jiaan / Wang, Chen / Jin, Zhijiang / Qiang Yuan / Zhou, Li / Shan, Letian

    International immunopharmacology

    2024  Volume 128, Page(s) 111509

    Abstract: Background: The lack of self-repairability in cartilage and the formation of fibrocartilage pose significant challenges in treating knee osteoarthritis, and there is still no ideal solution. Autologous platelet lysates have been clinically applied to ... ...

    Abstract Background: The lack of self-repairability in cartilage and the formation of fibrocartilage pose significant challenges in treating knee osteoarthritis, and there is still no ideal solution. Autologous platelet lysates have been clinically applied to treat kOA and exert satisfactory cartilage-repair efficacy, but the preparation of human PL brings damage to patients and is hardly standardized.
    Methods: In this study, porcine PL was developed to replace hPL, and its chondroregenerative and anti-chondrofibrosis effects were explored. Enzyme-Linked Immunosorbent Assay was applied to qualify the PL products. In vivo, partial-thickness cartilage defects were created on rats as a kOA model, and the von Frey test, histopathological observation, immunohistochemical analysis, and western blot analysis were conducted. In vitro, CCK-8 assay, real-time PCR analysis, immunofluorescence test, and WB analysis were conducted for the mechanism study of pPL.
    Results: The in vivo data showed that pPL significantly repaired the cartilage defect by improving matrix synthesis and also ameliorated the pain response in the kOA model of rats. In addition, pPL exerted an anti-fibrosis effect on cartilage by suppressing the expressions of COL1, COL3, α-SMA, VIMENTIN, SMAD2, p-SMAD2, and CTGF in cartilage. The in vitro data verified these effects and indicated that the SMAD2 pathway mediated the anti-fibrosis mechanism of pPL. Moreover, the comparable effects between pPL and rat PL indicate that there is no immune rejection from pPL.
    Conclusions: This study firstly demonstrated the anti-kOA effects of pPL on both cartilage-repair and anti-chondrofibrosis. It developed pPL as a promising alternative to autologous PL for clinical applications.
    MeSH term(s) Humans ; Rats ; Swine ; Animals ; Osteoarthritis, Knee/therapy ; Cartilage ; Smad2 Protein
    Chemical Substances SMAD2 protein, human ; Smad2 Protein
    Language English
    Publishing date 2024-01-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2024.111509
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  10. Article ; Online: Macrophysical properties of specific cloud types from radiosonde and surface active remote sensing measurements over the ARM Southern Great Plains site

    Jin-Qiang ZHANG / Hong-Bin CHEN

    Atmospheric and Oceanic Science Letters, Vol 10, Iss 1, Pp 29-

    2017  Volume 35

    Abstract: Accurate observation of clouds is challenging because of the high variability and complexity of cloud types and occurrences. By using the long-term cloud data collected during the ARM program at the Southern Great Plains central facility during 2001–2010, ...

    Abstract Accurate observation of clouds is challenging because of the high variability and complexity of cloud types and occurrences. By using the long-term cloud data collected during the ARM program at the Southern Great Plains central facility during 2001–2010, the consistencies and differences in the macrophysical properties of clouds between radiosonde and ground-based active remote sensing are quantitatively evaluated according to six cloud types: low; mid-low (ML); high-mid-low; mid; high-mid (HM); and high. A similar variability trend is exhibited by the radiosonde and surface observations for the cloud fractions of the six cloud types. However, the magnitudes of the differences between the two methods are different among the six cloud types, with the largest difference seen in the high clouds. The distribution of the cloud-base height of the ML, mid, and HM clouds agrees in both methods, whereas large differences are seen in the cloud-top height for the ML and high clouds. The cloud thickness variations generally agree between the two datasets for the six cloud types.
    Keywords Cloud macrophysical properties ; cloud types ; radiosonde ; remote sensing ; Environmental sciences ; GE1-350 ; Oceanography ; GC1-1581
    Subject code 520
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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