LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 147

Search options

  1. Article ; Online: ET-traps: Potential therapeutics for preeclampsia.

    Jain, Arjun / Jain, Ira

    Drug discovery today

    2023  Volume 28, Issue 11, Page(s) 103787

    Abstract: Elevated endothelin-1 (ET-1) has been implicated in several diseases including preeclampsia, where it causes the induction of hypertension, oxidative stress, endoplasmic reticulum stress, microvascular dysfunction and tissue damage in different organs. ... ...

    Abstract Elevated endothelin-1 (ET-1) has been implicated in several diseases including preeclampsia, where it causes the induction of hypertension, oxidative stress, endoplasmic reticulum stress, microvascular dysfunction and tissue damage in different organs. ET-traps are Fc-fusion proteins with a design based on the physiological receptors of ET-1. This paper discusses the potential use of ET-traps as a therapeutic for preeclampsia. ET-traps potently bind and sequester pathologically elevated ET-1 to significantly reduce different markers of pathology to non-disease levels with no toxicity.
    MeSH term(s) Pregnancy ; Female ; Humans ; Pre-Eclampsia ; Endothelin-1 ; Hypertension ; Oxidative Stress
    Chemical Substances Endothelin-1
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2023.103787
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Telehealth Expansion, Internet Speed, and Primary Care Access Before and During COVID-19.

    Tilhou, Alyssa Shell / Jain, Arjun / DeLeire, Thomas

    JAMA network open

    2024  Volume 7, Issue 1, Page(s) e2347686

    Abstract: Importance: Primary care (PC) receipt is associated with better health outcomes. How telehealth expansion and internet speed are associated with PC use is unclear.: Objective: To examine the association of telehealth and internet speed with PC use ... ...

    Abstract Importance: Primary care (PC) receipt is associated with better health outcomes. How telehealth expansion and internet speed are associated with PC use is unclear.
    Objective: To examine the association of telehealth and internet speed with PC use across sociodemographic determinants of health.
    Design, setting, and participants: This cohort study performed difference-in-differences regression of the change in in-person and telehealth PC visits between pre-COVID-19 public health emergency (PHE) (June 1, 2019, to February 29, 2020) and an initial (March 1, 2020, to May 31, 2020) and prolonged (March 1, 2020, to December 31, 2021) PHE period among continuously enrolled nonpregnant, nondisabled Wisconsin Medicaid beneficiaries aged 18 to 64 years. Data were analyzed from March 2022 to March 2023.
    Exposure: PHE-induced telehealth expansion.
    Main outcomes and measures: Change in PC telehealth (using Current Procedural Terminology codes) visits: (1) count; (2) visit share completed by telehealth; (3) percentage of PHE-induced visit decline offset by telehealth. High-speed internet (HSI) defined as living in a census block group with a median block maximum download speed of 940 megabits per second or greater (June 2020 Federal Communications Commission broadband data); other census block groups classified as low-speed internet (LSI).
    Results: In the total cohort of 172 387 participants, 102 989 (59.7%) were female, 103 848 (60.2%) were non-Hispanic White, 34 258 (19.9%) were non-Hispanic Black, 15 020 (8.7%) were Hispanic, 104 239 (60.5%) were aged 26 to 45 years, and 112 355 (66.0%) lived in urban counties. A total of 142 433 (82.6%) had access to HSI; 72 524 (42.1%) had a chronic condition. There was a mean (SD) of 0.138 (0.261) pre-PHE PC visits per month. In the pre-PHE period, visit rates were significantly higher for female than male participants, non-Hispanic White than non-Hispanic Black individuals, urban than rural residents, those with HSI than LSI, and patients with chronic disease than patients without. In the initial PHE period, female participants had a greater increase in telehealth visits than male participants (43.1%; 95% CI, 37.02%-49.18%; P < .001), share (2.20 percentage point difference [PPD]; 95% CI, 1.06-3.33 PPD; P < .001) and offset (6.81 PPD; 95% CI, 3.74-9.87 PPD; P < .001). Non-Hispanic Black participants had a greater increase in share than non-Hispanic White participants (5.44 PPD; 95% CI, 4.07-6.81 PPD; P < .001) and offset (15.22 PPD; 95% CI, 10.69-19.75 PPD; P < .001). Hispanic participants had a greater increase in telehealth visits than Non-Hispanic White participants (35.60%; 95% CI, 25.55%-45.64%; P < .001), share (8.50 PPD; 95% CI, 6.75-10.26 PPD; P < .001) and offset (12.93 PPD; 95% CI, 6.25-19.60 PPD; P < .001). Urban participants had a greater increase in telehealth visits than rural participants (63.87%; 95% CI, 52.62%-75.11%; P < .001), share (9.13 PPD; 95% CI, 7.84-10.42 PPD; P < .001), and offset (13.31 PPD; 95% CI; 9.62-16.99 PPD; P < .001). Participants with HSI had a greater increase in telehealth visits than those with LSI (55.23%; 95% CI, 42.26%-68.20%; P < .001), share (6.61 PPD; 95% CI, 5.00-8.23 PPD; P < .001), and offset (6.82 PPD; 95% CI, 2.15-11.49 PPD; P = .004). Participants with chronic disease had a greater increase in telehealth visits than those with none (188.07%; 95% CI, 175.27%-200.86%; P < .001), share (4.50 PPD; 95% CI, 3.58-5.42 PPD; P < .001), and offset (9.03 PPD; 95% CI, 6.01-12.04 PPD; P < .001). Prolonged PHE differences were similar. Differences persisted among those with HSI.
    Conclusions and relevance: In this cohort study of Wisconsin Medicaid beneficiaries, greater telehealth uptake occurred in groups with higher pre-PHE utilization, except for high uptake among Hispanic and non-Hispanic Black individuals despite low pre-PHE utilization. HSI did not moderate disparities. These findings suggest telehealth and HSI may boost PC receipt, but will generally not close utilization gaps.
    MeSH term(s) United States/epidemiology ; Humans ; Female ; Male ; COVID-19/epidemiology ; Cohort Studies ; Telemedicine ; Internet ; Chronic Disease ; Primary Health Care
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.47686
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: Piscis: a novel loss estimator of the F1 score enables accurate spot detection in fluorescence microscopy images via deep learning.

    Niu, Zijian / O'Farrell, Aoife / Li, Jingxin / Reffsin, Sam / Jain, Naveen / Dardani, Ian / Goyal, Yogesh / Raj, Arjun

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Single-molecule RNA ... ...

    Abstract Single-molecule RNA fluorescence
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.31.578123
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Enhancement in thermal performance of solar dryer through conduction mode for drying of agricultural produces

    Rupal Jain / Arjun Sanjay Paul / Deepak Sharma / Narayan Lal Panwar

    Energy Nexus, Vol 9, Iss , Pp 100182- (2023)

    2023  

    Abstract: This paper presents the development and performance analysis of a solar conduction dryer (SCD) used for drying agricultural produce. Compared with other conventional solar dryers, which are mostly based on convection mode, it was found to be more ... ...

    Abstract This paper presents the development and performance analysis of a solar conduction dryer (SCD) used for drying agricultural produce. Compared with other conventional solar dryers, which are mostly based on convection mode, it was found to be more efficient in terms of thermal efficiency, drying time, and drying rate. In addition to increasing the dryer's aperture area, reflectors were placed on both sides, which enhanced its thermal performance. Furthermore, reflectors can also be used as a closing cover to enhance the life of the covering material against rainstorms, hailstones, etc., when the dryer will not be used. The maximum temperature inside the dryer was 77.4 °C and 61.2 °C with and without the use of reflectors during no load conditions, while maximum temperatures inside the dryer with and without the use of reflectors measured 59.1 °C and 51.8 °C respectively during full load conditions. With and without reflectors, the drying efficiency of the developed solar dryer was found to be 59.4% and 50.09% respectively, which are much higher than that of other general solar dryers (∼35%). However, the drying rate varied between 1.525 to 0.005 g of water evaporated per gram of dry matter per hour when reflectors were used and 1.397 to 0.005 g without reflectors. A cost analysis showed that the capital invested for the development of SCD could be recovered in 1.02 years.
    Keywords Solar conduction dryer ; Dryer efficiency ; Drying rate ; Thermal performance of the dryer ; Renewable energy sources ; TJ807-830 ; Agriculture (General) ; S1-972
    Subject code 660
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  5. Article: Evaluation of the Function of Vitamin D in Treating Oral Lichen Planus.

    Abdulcader Riyaz, Ss Mohamed / Torwane, Nilesh Arjun / Almuntashri, Ahmed Ali / Priyadarshini, Smita R / Jain, Amol / Bala, Deepak / Ramaiah, Vardharajula Venkata

    Journal of pharmacy & bioallied sciences

    2024  Volume 16, Issue Suppl 1, Page(s) S714–S716

    Abstract: Objectives: The objective of the current research was to evaluate the role of vitamin D in the management of oral lichen planus.: Materials and method: Based on their vitamin D levels, 90 individuals with oral lichen planus were equally divided into ... ...

    Abstract Objectives: The objective of the current research was to evaluate the role of vitamin D in the management of oral lichen planus.
    Materials and method: Based on their vitamin D levels, 90 individuals with oral lichen planus were equally divided into three groups. Deficient subjects received oral vitamin D supplementation.
    Result: The majority of improvements were observed in patients who were taking vitamin D supplements. It was discovered that the data comparison was statistically considerable.
    Conclusion: It was determined that vitamin D was crucial for the management of oral lichen planus.
    Language English
    Publishing date 2024-02-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.jpbs_961_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: ET-traps offer a potential therapeutic tool for use in different autoimmune diseases.

    Jain, Arjun / Johnson, Martin H

    Drug discovery today

    2020  Volume 25, Issue 7, Page(s) 1142–1145

    Abstract: Research shows that endothelin (ET)-traps are a potential therapy for diabetes. Given that type 1 diabetes mellitus (T1DM) is an autoimmune disorder, ET-traps could also have an efficacious, therapeutic effect on other autoimmune diseases associated with ...

    Abstract Research shows that endothelin (ET)-traps are a potential therapy for diabetes. Given that type 1 diabetes mellitus (T1DM) is an autoimmune disorder, ET-traps could also have an efficacious, therapeutic effect on other autoimmune diseases associated with pathologically elevated ET-1. Here, we describe those different autoimmune diseases that might benefit from a tool such as ET-traps, which potently sequester these elevated levels of ET-1. We also discuss the current use of ET receptor (ETR) antagonists and the associated adverse effects, and how ET-traps are associated with no toxicity and potentially offer a superior alternative. ET-traps could be used against different autoimmune diseases and, therefore, are a novel therapeutic tool for such conditions.
    MeSH term(s) Autoimmune Diseases/drug therapy ; Autoimmune Diseases/metabolism ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/metabolism ; Endothelin Receptor Antagonists/therapeutic use ; Endothelins/metabolism ; Humans ; Receptors, Endothelin/metabolism
    Chemical Substances Endothelin Receptor Antagonists ; Endothelins ; Receptors, Endothelin
    Language English
    Publishing date 2020-04-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2020.04.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Endothelin-1: a potential pathological factor in Parkinson's disease?--From endoplasmic reticulum stress to beyond.

    Jain, Arjun

    Journal of the neurological sciences

    2014  Volume 344, Issue 1-2, Page(s) 236–237

    MeSH term(s) Endoplasmic Reticulum Stress/physiology ; Endothelin-1/metabolism ; Humans ; Parkinson Disease/metabolism ; Parkinson Disease/pathology
    Chemical Substances Endothelin-1
    Language English
    Publishing date 2014-09-15
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2014.06.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: ET-traps as a potential treatment for COVID-19

    Jain, Arjun / Mehrotra, Vidhi

    Medicine in Drug Discovery

    2020  Volume 7, Page(s) 100054

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2590-0986
    DOI 10.1016/j.medidd.2020.100054
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  9. Article ; Online: ET-traps as a potential treatment for COVID-19

    Arjun Jain / Vidhi Mehrotra

    Medicine in Drug Discovery, Vol 7, Iss , Pp 100054- (2020)

    2020  

    Abstract: The ET-traps are Fc-fusion proteins that have shown a therapeutic potential in the diabetes disease space. Previous studies have also discussed the potential use of ET-traps for other diseases, including HIV / AIDS. These diseases are all associated with ...

    Abstract The ET-traps are Fc-fusion proteins that have shown a therapeutic potential in the diabetes disease space. Previous studies have also discussed the potential use of ET-traps for other diseases, including HIV / AIDS. These diseases are all associated with pathologically elevated endothelin −1 (ET-1) levels. This paper discusses the potential use of ET-traps for the COVID-19 pandemic, which previous studies have shown involves high cytokine levels. Research has also shown that ET-1 is a stimulus for the induction of these pro-inflammatory cytokines. Hence, the ET-traps would likely be effective in patients suffering from COVID-19. If successful at the preclinical and clinical testing, the ET- traps would provide a much-awaited therapy.
    Keywords Pharmacy and materia medica ; RS1-441 ; covid19
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  10. Article: Comparison of Effectiveness of Audio and VR Distraction Techniques in Managing Pediatric Dental Patients.

    Shams, Saleh A / Reddy, Arjun / Vaghela, Lilavanti L / Jain, Meena / Naik, Harshit / Krishnan, Pratibha

    Journal of pharmacy & bioallied sciences

    2023  Volume 16, Issue Suppl 1, Page(s) S504–S506

    Abstract: Aim: In order to manage pediatric dental patients, this study set out to assess the effectiveness of two distraction techniques: audio and virtual reality (VR) with tell, show, and do technique (TSD).: Materials and methods: Forty-five children aged ... ...

    Abstract Aim: In order to manage pediatric dental patients, this study set out to assess the effectiveness of two distraction techniques: audio and virtual reality (VR) with tell, show, and do technique (TSD).
    Materials and methods: Forty-five children aged 6-10 years were selected for the present randomized control trial. They were split into three groups at random. Group 1 control group: tell-show-do, Group 2: audio distraction, and Group 3: VR distraction. Both pretreatment and postoperative anxiety levels were measured by modified Venham's anxiety rating scale (MVARS).
    Results: In each of the three groups, there was a statistically significant difference between the child's pre- and post-treatment anxiety levels. VR distraction group experienced the greatest reduction in anxiety.
    Conclusion: All three methods were similarly successful at lowering anxiety while virtual reality distraction outperformed compared to other techniques.
    Language English
    Publishing date 2023-11-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.jpbs_831_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top