Article ; Online: ET-traps: Potential therapeutics for preeclampsia.
2023 Volume 28, Issue 11, Page(s) 103787
Abstract: Elevated endothelin-1 (ET-1) has been implicated in several diseases including preeclampsia, where it causes the induction of hypertension, oxidative stress, endoplasmic reticulum stress, microvascular dysfunction and tissue damage in different organs. ... ...
Abstract | Elevated endothelin-1 (ET-1) has been implicated in several diseases including preeclampsia, where it causes the induction of hypertension, oxidative stress, endoplasmic reticulum stress, microvascular dysfunction and tissue damage in different organs. ET-traps are Fc-fusion proteins with a design based on the physiological receptors of ET-1. This paper discusses the potential use of ET-traps as a therapeutic for preeclampsia. ET-traps potently bind and sequester pathologically elevated ET-1 to significantly reduce different markers of pathology to non-disease levels with no toxicity. |
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MeSH term(s) | Pregnancy ; Female ; Humans ; Pre-Eclampsia ; Endothelin-1 ; Hypertension ; Oxidative Stress |
Chemical Substances | Endothelin-1 |
Language | English |
Publishing date | 2023-09-22 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 1324988-5 |
ISSN | 1878-5832 ; 1359-6446 |
ISSN (online) | 1878-5832 |
ISSN | 1359-6446 |
DOI | 10.1016/j.drudis.2023.103787 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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