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  1. Audio / Video ; Online: Agripreneurship insights and lessons from Agrocenta (Ghana)

    Ocansey, Michael

    2019  

    Abstract: Michael Ocansey, CEO of Agrocenta (Ghana) shares how his initiative is helping farmers by linking ...

    Abstract Michael Ocansey, CEO of Agrocenta (Ghana) shares how his initiative is helping farmers by linking them to large companies that can buy all their products, thus eliminating the middleman and fetch higher prices for their produce.
    Language English
    Publishing date 2019-03-21T07:24:18Z
    Publisher Technical Centre for Agricultural and Rural Cooperation
    Publishing country fr
    Document type Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Biallelic DNAJC3 variants in a neuroendocrine developmental disorder with insulin dysregulation.

    Ocansey, Sharon / Pullen, Debbie / Atkinson, Patricia / Clarke, Antonia / Hadonou, Medard / Crosby, Charlene / Short, John / Lloyd, Ian Christopher / Smedley, Damian / Assunta, Albanese / Shah, Pratik / McEntagart, Meriel

    Clinical dysmorphology

    2021  Volume 31, Issue 1, Page(s) 11–17

    Abstract: ... Examples include Marinesco-Sjogren and Wolcott-Rallison syndromes that share similar clinical features ...

    Abstract DNAJC3, a co-chaperone of BiP, is a member of the heat shock protein family. These proteins are produced in the endoplasmic reticulum (ER) to counter cell stress resulting from healthy functional protein processing. Dysregulation of unfolded proteins within the ER is implicated as a mechanism of genetic disease. Examples include Marinesco-Sjogren and Wolcott-Rallison syndromes that share similar clinical features, manifesting neurodegenerative disease and endocrine dysfunction. Recently, loss of function mutations in DNAJC3 was associated with syndromic diabetes mellitus in three families. The full phenotype included neurodegeneration, ataxia, deafness, neuropathy, adolescent-onset diabetes mellitus, growth hormone deficiency and hypothyroidism. A subsequent report of two unrelated individuals extended the phenotype to include early-onset hyperinsulinaemic hypoglycaemia. Here, we describe two siblings that recapitulate this extended phenotype in association with a homozygous novel mutation in the final exon of DNAJC3 [c.1367_1370delAGAA (p.Lys456SerfsTer85)] resulting in protein elongation predicted to abrogate the functional J domain. This report confirms DNAJC3 as a cause of syndromic congenital hyperinsulinaemic hypoglycaemia. Currently, PanelApp only includes this gene on diabetes mellitus panels. We propose DNAJC3 should be promoted from a red to a green gene on a wider number of panels to improve the diagnosis of this rare condition.
    MeSH term(s) Adolescent ; Child ; Developmental Disabilities ; Diabetes Mellitus, Type 1 ; HSP40 Heat-Shock Proteins/genetics ; Humans ; Insulin ; Mutation ; Neurodegenerative Diseases
    Chemical Substances DNAJC3 protein, human ; HSP40 Heat-Shock Proteins ; Insulin
    Language English
    Publishing date 2021-10-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1121482-x
    ISSN 1473-5717 ; 0962-8827
    ISSN (online) 1473-5717
    ISSN 0962-8827
    DOI 10.1097/MCD.0000000000000397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3528: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Mesenchymal stem cell-gut microbiota interaction in the repair of inflammatory bowel disease: an enhanced therapeutic effect.

    Ocansey, Dickson Kofi Wiredu / Wang, Li / Wang, Jingyan / Yan, Yongmin / Qian, Hui / Zhang, Xu / Xu, Wenrong / Mao, Fei

    Clinical and translational medicine

    2019  Volume 8, Issue 1, Page(s) 31

    Abstract: ... MSCs and gut microbiota.: Conclusion: The two therapies share several points of connection ...

    Abstract Background: Several investigations affirm that, patients with inflammatory bowel disease (IBD) exhibit dysbiosis characterized by restricted biodiversity and imbalanced bacterial composition intertwined with immune dysregulation. The interaction between stem cells and gut microbiota is a novel and highly promising field that could add up to a better understanding of the gut physiology, as well as therapeutic improvement towards diseases like IBD. Through direct contact or release of products and/or metabolites, gut bacteria regulate gut homeostasis, damage repair, regeneration and differentiation of stem cells. In the same way, mesenchymal stem cells (MSCs) produce similar effects including restoration of gut-microbiome composition. BODY: We reviewed the anti-inflammatory, antimicrobial, pathogenic bacterial clearance, proliferation and tissue remodeling effects of mesenchymal stem cells (MSCs) and fecal microbiota transplantation (FMT) as separate transplants in IBD, and the outcome of the interaction between MSCs and gut microbiota.
    Conclusion: The two therapies share several points of connection in therapeutics with enhanced functionalities in their interaction with each other. Focused investigations of MSC-gut bacteria interactions could lead to a novel discovery in therapeutics. We also anticipate an improved clinical remission rate in a combined FMT-MSC transplantation approach in IBD than the current single FMT or MSC approach.
    Language English
    Publishing date 2019-12-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2697013-2
    ISSN 2001-1326
    ISSN 2001-1326
    DOI 10.1186/s40169-019-0251-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Capacity assessment of selected health care facilities for the pilot implementation of Package for Essential Non-communicable Diseases (PEN) intervention in Ghana.

    Nyarko, Kofi Mensah / Ameme, Donne Kofi / Ocansey, Dennis / Commeh, Efua / Markwei, Mehitabel Tori / Ohene, Sally-Ann

    The Pan African medical journal

    2016  Volume 25, Issue Suppl 1, Page(s) 16

    Abstract: ... share common modifiable risk factors. In order to prevent and control NCDs, Ghana has adopted ...

    Abstract Introduction: Non-communicable diseases (NCDs) continue to pose threats to human health and development worldwide. Though preventable, NCDs kill more people annually than all other diseases combined. The four major NCDs namely cardiovascular diseases, chronic respiratory diseases, diabetes and cancers share common modifiable risk factors. In order to prevent and control NCDs, Ghana has adopted the World Health Organisation Package for Essential NCD (WHO-PEN) intervention, to be piloted in selected districts before a nationwide scale-up. We assessed the capacity of these facilities for the implementation of the WHO-PEN pilot.
    Methods: We conducted a cross-sectional health facility-based survey using a multistage sampling technique. We collected data on human resource, equipment, service utilization, medicines availability and health financing through interviews and observation. Descriptive data analysis was performed and expressed in frequencies and relative frequencies.
    Results: In all, 23 health facilities comprising two regional hospitals, three district hospitals, nine health centres and nine Community-based Health Planning and Services (CHPS) compounds from three regions were surveyed. All the hospitals had medical officers whilst 4 (44.4%) of the health centres had physician assistants. Health financing is mainly by the National Health Insurance Scheme (NHIS). None of the health facilities had spacers and only one health centre had oxygen cylinder, glucometer and nebulizer.
    Conclusion: Gaps exist in the human resource capacity and service delivery at the primary care levels, the focus of WHO-PEN intervention. Adequately equipping the primary health care level with trained health workers, basic equipment, medications and diagnostics will optimize the performance of WHO-PEN intervention when implemented.
    MeSH term(s) Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Chronic Disease ; Cross-Sectional Studies ; Delivery of Health Care/organization & administration ; Diabetes Mellitus/etiology ; Diabetes Mellitus/prevention & control ; Ghana ; Health Facilities ; Health Personnel/organization & administration ; Healthcare Financing ; Humans ; Neoplasms/etiology ; Neoplasms/prevention & control ; Pilot Projects ; Primary Health Care/organization & administration ; Respiratory Tract Diseases/etiology ; Respiratory Tract Diseases/prevention & control ; Risk Factors
    Language English
    Publishing date 2016-10-01
    Publishing country Uganda
    Document type Journal Article
    ZDB-ID 2514347-5
    ISSN 1937-8688 ; 1937-8688
    ISSN (online) 1937-8688
    ISSN 1937-8688
    DOI 10.11604/pamj.supp.2016.25.1.6252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Mesenchymal stem cell–gut microbiota interaction in the repair of inflammatory bowel disease

    Dickson Kofi Wiredu Ocansey / Li Wang / Jingyan Wang / Yongmin Yan / Hui Qian / Xu Zhang / Wenrong Xu / Fei Mao

    Clinical and Translational Medicine, Vol 8, Iss 1, Pp 1-

    an enhanced therapeutic effect

    2019  Volume 17

    Abstract: ... MSCs and gut microbiota. Conclusion The two therapies share several points of connection ...

    Abstract Abstract Background Several investigations affirm that, patients with inflammatory bowel disease (IBD) exhibit dysbiosis characterized by restricted biodiversity and imbalanced bacterial composition intertwined with immune dysregulation. The interaction between stem cells and gut microbiota is a novel and highly promising field that could add up to a better understanding of the gut physiology, as well as therapeutic improvement towards diseases like IBD. Through direct contact or release of products and/or metabolites, gut bacteria regulate gut homeostasis, damage repair, regeneration and differentiation of stem cells. In the same way, mesenchymal stem cells (MSCs) produce similar effects including restoration of gut–microbiome composition. Body We reviewed the anti-inflammatory, antimicrobial, pathogenic bacterial clearance, proliferation and tissue remodeling effects of mesenchymal stem cells (MSCs) and fecal microbiota transplantation (FMT) as separate transplants in IBD, and the outcome of the interaction between MSCs and gut microbiota. Conclusion The two therapies share several points of connection in therapeutics with enhanced functionalities in their interaction with each other. Focused investigations of MSC–gut bacteria interactions could lead to a novel discovery in therapeutics. We also anticipate an improved clinical remission rate in a combined FMT–MSC transplantation approach in IBD than the current single FMT or MSC approach.
    Keywords Mesenchymal stem cell therapy ; Fecal microbiota transplant ; Inflammatory bowel disease ; MSC–gut bacteria interaction ; Combined therapy ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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