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  1. Book ; Online: OliVe

    Guo, Cong / Tang, Jiaming / Hu, Weiming / Leng, Jingwen / Zhang, Chen / Yang, Fan / Liu, Yunxin / Guo, Minyi / Zhu, Yuhao

    Accelerating Large Language Models via Hardware-friendly Outlier-Victim Pair Quantization

    2023  

    Abstract: ... quantization benefits. We propose OliVe, an algorithm/architecture co-designed solution that adopts an outlier ... performance gains. The key insight of OliVe is that outliers are important while the normal values next ... accelerators like systolic array and tensor core. As a result, OliVe-based accelerator surpasses the existing ...

    Abstract Transformer-based large language models (LLMs) have achieved great success with the growing model size. LLMs' size grows by $240\times$ every two years, which outpaces the hardware progress and makes model inference increasingly costly. Model quantization is a promising approach to mitigate the widening gap between LLM size and hardware capacity. However, the existence of outliers, values with significant magnitudes, in LLMs makes existing quantization methods less effective. Prior outlier-aware quantization schemes adopt sparsity encoding techniques to separate outliers from normal values where the process requires global coordination (e.g., a global sparsity coordination list). This incurs complex encoding/decoding hardware logics and an extra orchestration controller for the computation between outlier and normal values. As such, it is not hardware-efficient and hence only achieves sub-optimal quantization benefits. We propose OliVe, an algorithm/architecture co-designed solution that adopts an outlier-victim pair (OVP) quantization and handles outlier values locally with low hardware overheads and high performance gains. The key insight of OliVe is that outliers are important while the normal values next to them are not. Thus those normal values (called victims) can be sacrificed to accommodate outliers. This enables a memory-aligned OVP encoding scheme, which can be efficiently integrated to the existing hardware accelerators like systolic array and tensor core. As a result, OliVe-based accelerator surpasses the existing outlier-aware accelerator, GOBO, by 4.5$\times$ speedup and 4.0$\times$ energy reduction, respectively, with a superior model accuracy.

    Comment: ISCA 2023
    Keywords Computer Science - Hardware Architecture
    Subject code 005
    Publishing date 2023-04-15
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Dietary supplementation with olive oil co-products rich in polyphenols: a novel nutraceutical approach in monogastric animal nutrition.

    Ferlisi, Flavia / Tang, Jiayong / Cappelli, Katia / Trabalza-Marinucci, Massimo

    Frontiers in veterinary science

    2023  Volume 10, Page(s) 1272274

    Abstract: ... with co-products derived from the extraction of olive oil (i.e., olive pomace, olive mill wastewater ... olive cake and olive leaf) in diet has been widely considered in recent decades, because these wastes ... strategy. Olive oil co-products are characterized by various bioactive molecules such as polyphenols ...

    Abstract In recent years, the increased demand for agri-food products to feed livestock species has stimulated research to identify novel solutions for the valorization of natural waste, according to the modern concept of a circular economy. Numerous studies have shown the use of plant-derived and agro-industrial co-products that are sources of bioactive molecules for preparing animal feeds. Supplementation with co-products derived from the extraction of olive oil (i.e., olive pomace, olive mill wastewater, olive cake and olive leaf) in diet has been widely considered in recent decades, because these wastes are produced in high quantity and their re-use represents an innovative economic and environmental strategy. Olive oil co-products are characterized by various bioactive molecules such as polyphenols, carbohydrates, proteins, and lipids. Among them, polyphenols are the nutraceuticals most studied, showing to promote health effects in both humans and animals. Olive oil co-products and their phenolic extracts have shown many beneficial and promising effects when added to the diets of monogastric animals, by improving performance parameters and maintaining the oxidative status of meat and derived products. This review provides an update on the use of olive co-products in monogastric animal (swine, poultry and rabbit) diets and their effects on the productive performance, meat quality characteristics and gut health status.
    Language English
    Publishing date 2023-10-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2023.1272274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Untargeted LC-MS metabolomics reveals the metabolic responses in olive flounder subjected to hirame rhabdovirus infection.

    Gu, Bingyu / Pan, Fenghuang / Wang, Hongxiang / Zou, Zhiyi / Song, Junya / Xing, Jing / Tang, Xiaoqian / Zhan, Yuanchao

    Frontiers in immunology

    2023  Volume 14, Page(s) 1148740

    Abstract: Hirame novirhabdovirus (HIRRV), which mainly infects the olive flounder ( ...

    Abstract Hirame novirhabdovirus (HIRRV), which mainly infects the olive flounder (
    MeSH term(s) Animals ; Flounder ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Metabolomics ; Rhabdoviridae Infections/veterinary ; Glutathione ; Novirhabdovirus
    Chemical Substances Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2023-08-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1148740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Dietary supplementation with olive oil co-products rich in polyphenols

    Flavia Ferlisi / Jiayong Tang / Katia Cappelli / Massimo Trabalza-Marinucci

    Frontiers in Veterinary Science, Vol

    a novel nutraceutical approach in monogastric animal nutrition

    2023  Volume 10

    Abstract: ... with co-products derived from the extraction of olive oil (i.e., olive pomace, olive mill wastewater ... olive cake and olive leaf) in diet has been widely considered in recent decades, because these wastes ... strategy. Olive oil co-products are characterized by various bioactive molecules such as polyphenols ...

    Abstract In recent years, the increased demand for agri-food products to feed livestock species has stimulated research to identify novel solutions for the valorization of natural waste, according to the modern concept of a circular economy. Numerous studies have shown the use of plant-derived and agro-industrial co-products that are sources of bioactive molecules for preparing animal feeds. Supplementation with co-products derived from the extraction of olive oil (i.e., olive pomace, olive mill wastewater, olive cake and olive leaf) in diet has been widely considered in recent decades, because these wastes are produced in high quantity and their re-use represents an innovative economic and environmental strategy. Olive oil co-products are characterized by various bioactive molecules such as polyphenols, carbohydrates, proteins, and lipids. Among them, polyphenols are the nutraceuticals most studied, showing to promote health effects in both humans and animals. Olive oil co-products and their phenolic extracts have shown many beneficial and promising effects when added to the diets of monogastric animals, by improving performance parameters and maintaining the oxidative status of meat and derived products. This review provides an update on the use of olive co-products in monogastric animal (swine, poultry and rabbit) diets and their effects on the productive performance, meat quality characteristics and gut health status.
    Keywords antimicrobials ; antioxidants ; feed supplementation ; monogastric ; olive oil co-products ; polyphenols ; Veterinary medicine ; SF600-1100
    Subject code 330
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Antioxidant Behavior Affected by Polarity in the Olive Oil

    Jie Tang / Guohua You / Lu Ruan / Yi Lu / Bianying Wen / Sizhu Wu

    ACS Omega, Vol 6, Iss 10, Pp 7119-

    Experimental and Molecular Simulation Investigations

    2021  Volume 7126

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Clinical outcomes of an olive wire and external fixator versus a metallic screw in the treatment of inferior tibiofibular syndesmosis injuries in ankle fractures.

    Jin-Tao, Qu / Mei, Wang / Chao-Jun, Li / Zi-Tian, Wang / Guang, Peng / Hao, Yang / Yu-Quan, Jiang / Yu, Tang

    Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons

    2023  Volume 29, Issue 3, Page(s) 233–238

    Abstract: ... We have provided an alternative with an olive wire and external fixator(OWEF) used for syndesmotic ...

    Abstract Background: Metal screws are the most widely used in treating syndesmotic injuries, but failure and the rigidity of the screws can threaten the success of the treatment and increase the cost of care. We have provided an alternative with an olive wire and external fixator(OWEF) used for syndesmotic fixation.
    Methods: A retrospective longitudinal follow-up study was conducted. From February 2011 to January 2018, 58 of 72 patients with ankle fractures and associated syndesmotic disruption were treated with either screw or OWEF fixation. The costs, complications, and clinical outcomes using Olerud-Molander score and Visual Analog score in screw and OWEF fixation group were compared.
    Results: We found the severity of the injury, BMI of the patients and the different fixation methods were determinants of the complications and clinical outcomes. But if no malreduction of the syndesmosis was present, no difference in clinical result was detected.
    Conclusion: The OWEF method appeared to be at least equally functional and effective to screw fixation while maintaining possible lower complication rate.
    Levels of clinical evidence: Level 3.
    MeSH term(s) Humans ; Ankle Fractures/diagnostic imaging ; Ankle Fractures/surgery ; Olea ; Follow-Up Studies ; Retrospective Studies ; Ankle Joint/surgery ; Fracture Fixation, Internal/methods ; Treatment Outcome ; Bone Screws ; External Fixators
    Language English
    Publishing date 2023-01-27
    Publishing country France
    Document type Journal Article
    ZDB-ID 1424533-4
    ISSN 1460-9584 ; 1268-7731
    ISSN (online) 1460-9584
    ISSN 1268-7731
    DOI 10.1016/j.fas.2023.01.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Antioxidant Behavior Affected by Polarity in the Olive Oil: Experimental and Molecular Simulation Investigations.

    Tang, Jie / You, Guohua / Ruan, Lu / Lu, Yi / Wen, Bianying / Wu, Sizhu

    ACS omega

    2021  Volume 6, Issue 10, Page(s) 7119–7126

    Abstract: ... by polarity in the olive oil were systematically investigated by experimental and computational methods ...

    Abstract Natural antioxidants are essential potential sources for protecting the oxidation of food oils. However, until now, the mechanisms are still not very clear, especially from the quantitatively theoretical level to analyze the antioxidant behavior. In this work, the micromechanisms of the antioxidant behavior affected by polarity in the olive oil were systematically investigated by experimental and computational methods. The results showed that the polarity of antioxidants decreased with the growth of the alkyl chains, which had multiple impacts on the effectiveness of antioxidants. The excessive polarity gap between the antioxidant and oil molecules would cause the antioxidant to be dispersed at the oil-air interface, which could enhance their antioxidant ability. Meanwhile, the antioxidants with longer alkyl chains had lower polarity and better dispersibility but decreased mobility. Hence, compared with other antioxidants, medium polarity antioxidants presented both good dispersion and relatively suitable migration, indicating that they would have an optimal antioxidant effect.
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c00120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: NMR-based metabolomics for olive oil cultivar classification: A comparison with standard targeted analysis of fatty acids and triglycerides

    Tang, Fenfen / Polari, Juan J. / Green, Hilary S. / Wang, Selina C. / Hatzakis, Emmanuel

    Food control. 2022 July, v. 137

    2022  

    Abstract: ... classification of olive oil, while NMR is another powerful technique. In this paper we used NMR for the first ... time to classify olive oil produced by four cultivars, namely ‘Arbequina’, ‘Arbosana’, ‘Koroneiki’, and ...

    Abstract Chromatographic techniques such as GC and HPLC are traditionally used for the analysis and classification of olive oil, while NMR is another powerful technique. In this paper we used NMR for the first time to classify olive oil produced by four cultivars, namely ‘Arbequina’, ‘Arbosana’, ‘Koroneiki’, and ‘Sikitita’, planted in super-high-density frames in California, United States. We compared the results with the targeted analysis of fatty acids and triglycerides obtained by GC-FID and UHPLC-CAD, respectively. All three techniques were able to distinguish between cultivars, with fatty acids from GC-FID generating the best models. GC-FID require time-consuming sample preparation; both GC-FID and UHPLC-CAD require lengthy analysis time and protocols for different classes of compounds, while NMR is rapid and able to conduct a simultaneous broad-spectrum analysis of compounds, which led to the discovery of more biomarkers. In addition, NMR was in a good agreement with GC-FID for the determination of fatty acids, as found by Bland-Altman analysis, although in several cases it was not able to distinguish among individual fatty acids.
    Keywords biomarkers ; cultivars ; food safety ; metabolomics ; olive oil ; California
    Language English
    Dates of publication 2022-07
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1027805-9
    ISSN 0956-7135
    ISSN 0956-7135
    DOI 10.1016/j.foodcont.2022.108939
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Effect of Variety and Maturity Index on the Physicochemical Parameters Related to Virgin Olive Oil from Wudu (China)

    Tang, Fengxia / Li, Chuan / Yang, Xiaoran / Lei, Jiandu / Chen, Hongxia / Zhang, Changwei / Wang, Chengzhang

    Foods. 2022 Dec. 20, v. 12, no. 1

    2022  

    Abstract: ... and oxidative stability associated with virgin olive oil (VOO) from ten varieties in Wudu, China, were ...

    Abstract Physical parameters (i.e., extraction yield, oil content), chemicals (i.e., fatty acids, phenolics) and oxidative stability associated with virgin olive oil (VOO) from ten varieties in Wudu, China, were analyzed as a function of maturity index and variety by multivariate analysis models. Most of the analytical parameters were significantly affected by the variety and maturity index, and the former was more influential than the latter. Phenolics were the principal factor dividing the ten varieties into four groups. High phenolic levels were observed in the ‘Koroneiki’ group and ‘Manzanilla’ group, but the oil extractability index differentiated between them, being the highest and lowest, respectively. The ‘Koroneiki’ group demonstrated high oil productivity and oil quality, which was worthy of promotion in large-scale cultivation. High amounts of linoleic enhanced the VOO health benefits of ‘Ascolana tenera, Arbequina and Zhongshan24’ group, but brought the risk of shortening the shelf-life. The ‘Ulliri Bardhe, Empeltre, Ezhi8, Yuntai14 and Picual’ group clustered for the higher relative value of oleic acid. The maturity index had significant negative effects on the content of total phenolics, oleacein, oleocanthal, and oleic acid, but had a positive effect on the extractability index, which suggested that varieties with low phenolics and oleic acid levels should be harvested early.
    Keywords lipid content ; multivariate analysis ; oleic acid ; oleocanthal ; oxidative stability ; risk ; shelf life ; virgin olive oil ; China
    Language English
    Dates of publication 2022-1220
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12010007
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: The Early Peritoneal Cavity Immune Response to Vibrio Anguillarum Infection and to Inactivated Bacterium in Olive Flounder ( Paralichthys olivaceus )

    Xueyan Shi / Heng Chi / Yuanyuan Sun / Xiaoqian Tang / Jing Xing / Xiuzhen Sheng / Wenbin Zhan

    Microorganisms, Vol 10, Iss 2175, p

    2022  Volume 2175

    Abstract: ... of peritoneal cavity cells (PerC cells) and their composition in flounder ( Paralichthys olivaceus ). Flow cytometric ...

    Abstract The peritoneal cavity plays an important role in the immune response, and intraperitoneal administration is an ideal vaccination route in fish. However, immune responses in the peritoneal cavity of teleost fish are still not completely characterized. This study characterized the morphology of peritoneal cavity cells (PerC cells) and their composition in flounder ( Paralichthys olivaceus ). Flow cytometric analysis of the resident PerC cells revealed two populations varying in granularity and size. One population, approximately 15.43% ± 1.8%, was smaller with a lower granularity, designated as lymphocytes. The other population of the cells, about 78.17% ± 3.52%, was larger with higher granularity and was designated as myeloid cells. The results of cytochemical staining and transmission electron microscopy indicated that peritoneal cavity in flounder normally contains a resident population of leukocytes dominated by granulocytes, macrophages, dendritic cells, and lymphocytes. The percentages of IgM + , CD4 + , G-CSFR + , MHCII + , and CD83 + leukocytes among PerC cells determined by flow cytometry were 3.13% ± 0.4%, 2.83% ± 0.53%, 21.12% ± 1.44%, 27.11% ± 3.30%, and 19.64% ± 0.31%, respectively. Further, the changes in IgM + , CD4 + , G-CSFR + , MHCII + , and CD83 + leukocytes in flounder after Vibrio anguillarum infection and immunization were compared. The composition changed rapidly after the infection or vaccination treatment and included two stages, a non-specific stage dominated by phagocytes and a specific immune stage dominated by lymphocytes. Due to the virulence effectors of bacteria, the infected group exhibited a more intense and complicated PerC cells immune response than that of the immunization group. Following our previous study, this is the first report on the morphology and composition of PerC cells and the early activation of PerC cells in flounder response to V. anguillarum infection and vaccination.
    Keywords peritoneal cavity cells ; cell composition ; infection ; vaccination ; fish ; Biology (General) ; QH301-705.5
    Subject code 333
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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