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Book ; Online: A model-independent Dalitz plot analysis of $B^\pm \to D K^\pm$ with $D \to K^0_{\rm S} h^+h^-$ ($h=\pi, K$) decays and constraints on the CKM angle $\gamma$

LHCb collaboration / Aaij, R. / Beteta, C. Abellan / Adametz, A. / Adeva, B. / Adinolfi, M. / Adrover, C. / Affolder, A. / Ajaltouni, Z. / Albrecht, J. / Alessio, F. / Alexander, M. / Ali, S. / Alkhazov, G. / Cartelle, P. Alvarez / Alves Jr, A. A. / Amato, S. / Amhis, Y. / Anderlini, L. /

Anderson, J. / Appleby, R. B. / Gutierrez, O. Aquines / Archilli, F. / Artamonov, A. / Artuso, M. / Aslanides, E. / Auriemma, G. / Bachmann, S. / Back, J. J. / Baesso, C. / Baldini, W. / Barlow, R. J. / Barschel, C. / Barsuk, S. / Barter, W. / Bates, A. / Bauer, Th. / Bay, A. / Beddow, J. / Bediaga, I. / Belogurov, S. / Belous, K. / Belyaev, I. / Ben-Haim, E. / Benayoun, M. / Bencivenni, G. / Benson, S. / Benton, J. / Berezhnoy, A. / Bernet, R. / Bettler, M. -O. / van Beuzekom, M. / Bien, A. / Bifani, S. / Bird, T. / Bizzeti, A. / Bjørnstad, P. M. / Blake, T. / Blanc, F. / Blanks, C. / Blouw, J. / Blusk, S. / Bobrov, A. / Bocci, V. / Bondar, A. / Bondar, N. / Bonivento, W. / Borghi, S. / Borgia, A. / Bowcock, T. J. V. / Bozzi, C. / Brambach, T. / Brand, J. van den / Bressieux, J. / Brett, D. / Britsch, M. / Britton, T. / Brook, N. H. / Brown, H. / Büchler-Germann, A. / Burducea, I. / Bursche, A. / Buytaert, J. / Cadeddu, S. / Callot, O. / Calvi, M. / Gomez, M. Calvo / Camboni, A. / Campana, P. / Carbone, A. / Carboni, G. / Cardinale, R. / Cardini, A. / Carson, L. / Akiba, K. Carvalho / Casse, G. / Cattaneo, M. / Cauet, Ch. / Charles, M. / Charpentier, Ph. / Chen, P. / Chiapolini, N. / Chrzaszcz, M. / Ciba, K. / Vidal, X. Cid / Ciezarek, G. / Clarke, P. E. L. / Clemencic, M. / Cliff, H. V. / Closier, J. / Coca, C. / Coco, V. / Cogan, J. / Cogneras, E. / Collins, P. / Comerma-Montells, A. / Contu, A. / Cook, A. / Coombes, M. / Corti, G. / Couturier, B. / Cowan, G. A. / Craik, D. / Cunliffe, S. / Currie, R. / D'Ambrosio, C. / David, P. / David, P. N. Y. / De Bonis, I. / De Bruyn, K. / De Capua, S. / De Cian, M. / De Miranda, J. M. / De Paula, L. / De Simone, P. / Decamp, D. / Deckenhoff, M. / Degaudenzi, H. / Del Buono, L. / Deplano, C. / Derkach, D. / Deschamps, O. / Dettori, F. / Di Canto, A. / Dickens, J. / Dijkstra, H. / Batista, P. Diniz / Bonal, F. Domingo / Donleavy, S. / Dordei, F. / Suárez, A. Dosil / Dossett, D. / Dovbnya, A. / Dupertuis, F. / Dzhelyadin, R. / Dziurda, A. / Dzyuba, A. / Easo, S. / Egede, U. / Egorychev, V. / Eidelman, S. / van Eijk, D. / Eisenhardt, S. / Ekelhof, R. / Eklund, L. / Rifai, I. El / Elsasser, Ch. / Elsby, D. / Pereira, D. Esperante / Falabella, A. / Färber, C. / Fardell, G. / Farinelli, C. / Farry, S. / Fave, V. / Albor, V. Fernandez / Rodrigues, F. Ferreira / Ferro-Luzzi, M. / Filippov, S. / Fitzpatrick, C. / Fontana, M. / Fontanelli, F. / Forty, R. / Francisco, O. / Frank, M. / Frei, C. / Frosini, M. / Furcas, S. / Torreira, A. Gallas / Galli, D. / Gandelman, M. / Gandini, P. / Gao, Y. / Garnier, J-C. / Garofoli, J. / Garosi, P. / Tico, J. Garra / Garrido, L. / Gaspar, C. / Gauld, R. / Gersabeck, E. / Gersabeck, M. / Gershon, T. / Ghez, Ph. / Gibson, V. / Gligorov, V. V. / Göbel, C. / Golubkov, D. / Golutvin, A. / Gomes, A. / Gordon, H. / Gándara, M. Grabalosa / Diaz, R. Graciani / Cardoso, L. A. Granado / Graugés, E. / Graziani, G. / Grecu, A. / Greening, E. / Gregson, S. / Grünberg, O. / Gui, B. / Gushchin, E. / Guz, Yu. / Gys, T. / Hadjivasiliou, C. / Haefeli, G. / Haen, C. / Haines, S. C. / Hall, S. / Hampson, T. / Hansmann-Menzemer, S. / Harnew, N. / Harnew, S. T. / Harrison, J. / Harrison, P. F. / Hartmann, T. / He, J. / Heijne, V. / Hennessy, K. / Henrard, P. / Morata, J. A. Hernando / van Herwijnen, E. / Hicks, E. / Hill, D. / Hoballah, M. / Hopchev, P. / Hulsbergen, W. / Hunt, P. / Huse, T. / Hussain, N. / Hutchcroft, D. / Hynds, D. / Iakovenko, V. / Ilten, P. / Imong, J. / Jacobsson, R. / Jaeger, A. / Hussein, M. Jahjah / Jans, E. / Jansen, F. / Jaton, P. / Jean-Marie, B. / Jing, F. / John, M. / Johnson, D. / Jones, C. R. / Jost, B. / Kaballo, M. / Kandybei, S. / Karacson, M. / Karbach, T. M. / Keaveney, J. / Kenyon, I. R. / Kerzel, U. / Ketel, T. / Keune, A. / Khanji, B. / Kim, Y. M. / Kochebina, O. / Komarov, V. / Koopman, R. F. / Koppenburg, P. / Korolev, M. / Kozlinskiy, A. / Kravchuk, L. / Kreplin, K. / Kreps, M. / Krocker, G. / Krokovny, P. / Kruse, F. / Kucharczyk, M. / Kudryavtsev, V. / Kvaratskheliya, T. / La Thi, V. N. / Lacarrere, D. / Lafferty, G. / Lai, A. / Lambert, D. / Lambert, R. W. / Lanciotti, E. / Lanfranchi, G. / Langenbruch, C. / Latham, T. / Lazzeroni, C. / Gac, R. Le / van Leerdam, J. / Lees, J. -P. / Lefèvre, R. / Leflat, A. / Lefrançois, J. / Leroy, O. / Lesiak, T. / Li, Y. / Gioi, L. Li / Liles, M. / Lindner, R. / Linn, C. / Liu, B. / Liu, G. / von Loeben, J. / Lopes, J. H. / Asamar, E. Lopez / Lopez-March, N. / Lu, H. / Luisier, J. / Mac Raighne, A. / Machefert, F. / Machikhiliyan, I. V. / Maciuc, F. / Maev, O. / Magnin, J. / Maino, M. / Malde, S. / Manca, G. / Mancinelli, G. / Mangiafave, N. / Marconi, U. / Märki, R. / Marks, J. / Martellotti, G. / Martens, A. / Martin, L. / Sánchez, A. Martín / Martinelli, M. / Santos, D. Martinez / Massafferri, A. / Mathe, Z. / Matteuzzi, C. / Matveev, M. / Maurice, E. / Mazurov, A. / McCarthy, J. / McGregor, G. / McNulty, R. / Meissner, M. / Merk, M. / Merkel, J. / Milanes, D. A. / Minard, M. -N. / Rodriguez, J. Molina / Monteil, S. / Moran, D. / Morawski, P. / Mountain, R. / Mous, I. / Muheim, F. / Müller, K. / Muresan, R. / Muryn, B. / Muster, B. / Mylroie-Smith, J. / Naik, P. / Nakada, T. / Nandakumar, R. / Nasteva, I. / Needham, M. / Neufeld, N. / Nguyen, A. D. / Nguyen-Mau, C. / Nicol, M. / Niess, V. / Nikitin, N. / Nikodem, T. / Nomerotski, A. / Novoselov, A. / Oblakowska-Mucha, A. / Obraztsov, V. / Oggero, S. / Ogilvy, S. / Okhrimenko, O. / Oldeman, R. / Orlandea, M. / Goicochea, J. M. Otalora / Owen, P. / Pal, B. K. / Palano, A. / Palutan, M. / Panman, J. / Papanestis, A. / Pappagallo, M. / Parkes, C. / Parkinson, C. J. / Passaleva, G. / Patel, G. D. / Patel, M. / Patrick, G. N. / Patrignani, C. / Pavel-Nicorescu, C. / Alvarez, A. Pazos / Pellegrino, A. / Penso, G. / Altarelli, M. Pepe / Perazzini, S. / Perego, D. L. / Trigo, E. Perez / Yzquierdo, A. Pérez-Calero / Perret, P. / Perrin-Terrin, M. / Pessina, G. / Petridis, K. / Petrolini, A. / Phan, A. / Olloqui, E. Picatoste / Valls, B. Pie / Pietrzyk, B. / Pilař, T. / Pinci, D. / Playfer, S. / Casasus, M. Plo / Polci, F. / Polok, G. / Poluektov, A. / Polycarpo, E. / Popov, D. / Popovici, B. / Potterat, C. / Powell, A. / Prisciandaro, J. / Pugatch, V. / Navarro, A. Puig / Qian, W. / Rademacker, J. H. / Rakotomiaramanana, B. / Rangel, M. S. / Raniuk, I. / Rauschmayr, N. / Raven, G. / Redford, S. / Reid, M. M. / Reis, A. C. dos / Ricciardi, S. / Richards, A. / Rinnert, K. / Molina, V. Rives / Romero, D. A. Roa / Robbe, P. / Rodrigues, E. / Perez, P. Rodriguez / Rogers, G. J. / Roiser, S. / Romanovsky, V. / Vidal, A. Romero / Rouvinet, J. / Ruf, T. / Ruiz, H. / Sabatino, G. / Silva, J. J. Saborido / Sagidova, N. / Sail, P. / Saitta, B. / Salzmann, C. / Sedes, B. Sanmartin / Sannino, M. / Santacesaria, R. / Rios, C. Santamarina / Santinelli, R. / Santovetti, E. / Sapunov, M. / Sarti, A. / Satriano, C. / Satta, A. / Savrie, M. / Schaack, P. / Schiller, M. / Schindler, H. / Schleich, S. / Schlupp, M. / Schmelling, M. / Schmidt, B. / Schneider, O. / Schopper, A. / Schune, M. -H. / Schwemmer, R. / Sciascia, B. / Sciubba, A. / Seco, M. / Semennikov, A. / Senderowska, K. / Sepp, I. / Serra, N. / Serrano, J. / Seyfert, P. / Shapkin, M. / Shapoval, I. / Shatalov, P. / Shcheglov, Y. / Shears, T. / Shekhtman, L. / Shevchenko, O. / Shevchenko, V. / Shires, A. / Coutinho, R. Silva / Skwarnicki, T. / Smith, N. A. / Smith, E. / Smith, M. / Sobczak, K. / Soler, F. J. P. / Soomro, F. / Souza, D. / De Paula, B. Souza / Spaan, B. / Sparkes, A. / Spradlin, P. / Stagni, F. / Stahl, S. / Steinkamp, O. / Stoica, S. / Stone, S. / Storaci, B. / Straticiuc, M. / Straumann, U. / Subbiah, V. K. / Swientek, S. / Szczekowski, M. / Szczypka, P. / Szumlak, T. / T'Jampens, S. / Teklishyn, M. / Teodorescu, E. / Teubert, F. / Thomas, C. / Thomas, E. / van Tilburg, J. / Tisserand, V. / Tobin, M. / Tolk, S. / Tonelli, D. / Topp-Joergensen, S. / Torr, N. / Tournefier, E. / Tourneur, S. / Tran, M. T. / Tsaregorodtsev, A. / Tsopelas, P. / Tuning, N. / Garcia, M. Ubeda / Ukleja, A. / Urner, D. / Uwer, U. / Vagnoni, V. / Valenti, G. / Gomez, R. Vazquez / Regueiro, P. Vazquez / Vecchi, S. / Velthuis, J. J. / Veltri, M. / Veneziano, G. / Vesterinen, M. / Viaud, B. / Videau, I. / Vieira, D. / Vilasis-Cardona, X. / Visniakov, J. / Vollhardt, A. / Volyanskyy, D. / Voong, D. / Vorobyev, A. / Vorobyev, V. / Voss, H. / Voß, C. / Waldi, R. / Wallace, R. / Wandernoth, S. / Wang, J. / Ward, D. R. / Watson, N. K. / Webber, A. D. / Websdale, D. / Whitehead, M. / Wicht, J. / Wiedner, D. / Wiggers, L. / Wilkinson, G. / Williams, M. P. / Williams, M. / Wilson, F. F. / Wishahi, J. / Witek, M. / Witzeling, W. / Wotton, S. A. / Wright, S. / Wu, S. / Wyllie, K. / Xie, Y. / Xing, F. / Xing, Z. / Yang, Z. / Young, R. / Yuan, X. / Yushchenko, O. / Zangoli, M. / Zavertyaev, M. / Zhang, F. / Zhang, L. / Zhang, W. C. / Zhang, Y. / Zhelezov, A. / Zhong, L. / Zvyagin, A.

2012

Abstract: ... 43}_{\,-38})^\circ$, with a second solution at $\gamma \to \gamma + 180^\circ$, and $r_B = 0.07 \pm 0 ... 04$, where $r_B$ is the ratio between the suppressed and favoured B decay amplitudes. ... Comment: 26 ...

Abstract	A binned Dalitz plot analysis of $B^\pm \to D K^\pm$ decays, with $D \to K^0_{\rm S} \pi^+\pi^-$ and $D \to K^0_{\rm S} K^+ K^-$, is performed to measure the CP-violating observables $x_{\pm}$ and $y_{\pm}$ which are sensitive to the CKM angle $\gamma$. The analysis exploits 1.0 $\rm fb^{-1}$ of data collected by the LHCb experiment. The study makes no model-based assumption on the variation of the strong phase of the D decay amplitude over the Dalitz plot, but uses measurements of this quantity from CLEO-c as input. The values of the parameters are found to be $x_- = (0.0 \pm 4.3 \pm 1.5 \pm 0.6) \times 10^{-2}$, $y_- = (2.7 \pm 5.2 \pm 0.8 \pm 2.3) \times 10^{-2}$, $x_+ = (-10.3 \pm 4.5 \pm 1.8 \pm 1.4)\times 10^{-2}$ and $y_+ = (-0.9 \pm 3.7 \pm 0.8 \pm 3.0)\times 10^{-2}$. The first, second, and third uncertainties are the statistical, the experimental systematic, and the error associated with the precision of the strong-phase parameters measured at CLEO-c, respectively. These results correspond to $\gamma = (44^{\,+43}_{\,-38})^\circ$, with a second solution at $\gamma \to \gamma + 180^\circ$, and $r_B = 0.07 \pm 0.04$, where $r_B$ is the ratio between the suppressed and favoured B decay amplitudes. Comment: 26 pages,7 figures; this revision with additional author information uploaded
Keywords	High Energy Physics - Experiment
Subject code	612
Publishing date	2012-09-26
Publishing country	us
Document type	Book ; Online
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Article ; Online: New HST data and modeling reveal a massive planetesimal collision around Fomalhaut.

Gáspár, András / Rieke, George H

Proceedings of the National Academy of Sciences of the United States of America

2020 Volume 117, Issue 18, Page(s) 9712–9722

Abstract: ... However, subsequent observations of Fomalhaut b raised questions about its status: Unlike other exoplanets, it is ... yields results consistent with the observations. Fomalhaut b appears to be a directly imaged catastrophic ...

Abstract	The apparent detection of an exoplanet orbiting Fomalhaut was announced in 2008. However, subsequent observations of Fomalhaut b raised questions about its status: Unlike other exoplanets, it is bright in the optical and nondetected in the infrared, and its orbit appears to cross the debris ring around the star without the expected gravitational perturbations. We revisit previously published data and analyze additional Hubble Space Telescope (HST) data, finding that the source is likely on a radial trajectory and has faded and become extended. Dynamical and collisional modeling of a recently produced dust cloud yields results consistent with the observations. Fomalhaut b appears to be a directly imaged catastrophic collision between two large planetesimals in an extrasolar planetary system. Similar events should be very rare in quiescent planetary systems of the age of Fomalhaut, suggesting that we are possibly witnessing the effects of gravitational stirring due to the orbital evolution of hypothetical planet(s) around the star.
Language	English
Publishing date	2020-04-20
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1912506117
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Article: Stylomandibular False Ankylosis: An Unusual Complication After Vascularized Iliac Crest Flap for Mandibular Reconstruction.

Morgado, Bruno / Poleri, Filipa / Gaspar, Carolina / Costa, Horácio / Zenha, Horácio

Cureus

2023 Volume 15, Issue 4, Page(s) e37615

Abstract: Stylomandibular fusion is a poorly documented and rare complication of maxillofacial surgical procedures. This case report describes a patient presenting with stylomandibular false ankylosis following mandibular reconstruction. A 59-year-old female ... ...

Abstract	Stylomandibular fusion is a poorly documented and rare complication of maxillofacial surgical procedures. This case report describes a patient presenting with stylomandibular false ankylosis following mandibular reconstruction. A 59-year-old female patient underwent segmental mandibular resection and reconstruction for a defect resulting from ameloblastoma surgery using an iliac crest free flap. A styloid fracture was detected postoperatively, and the patient was managed conservatively. In the third postoperative year, the patient presented with marked limitation of oral gape. A diagnosis of stylomandibular false ankylosis was made, and the patient underwent an ostectomy of the aberrant bone, with improved mouth opening. The abnormal union between the styloid process and the mandible is a previously unreported complication in the use of iliac crest free flaps. This case report emphasizes the importance of being vigilant for stylomandibular false ankylosis, especially when there is a restriction of oral aperture postoperatively following reconstructive procedures involving bone flaps.
Language	English
Publishing date	2023-04-15
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.37615
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Article ; Online: Secondary infections and long-term outcomes among hospitalized elderly and non-elderly patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and treated with baricitinib: a comparative study from the national centre of Hungary.

Gáspár, Zsófia / Szabó, Bálint Gergely / Andrikovics, Hajnalka / Ceglédi, Andrea / Rajmon, Martin / Ábrahám, Anita / Várnai, Zsuzsanna / Kiss-Dala, Noémi / Szlávik, János / Sinkó, János / Vályi-Nagy, István / Lakatos, Botond

GeroScience

2024 Volume 46, Issue 3, Page(s) 2863–2877

Abstract: Baricitinib is considered a first-line treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected adult patients with an associated cytokine storm syndrome (CSS). Our objective was to compare rates of secondary infections and ... ...

Abstract	Baricitinib is considered a first-line treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected adult patients with an associated cytokine storm syndrome (CSS). Our objective was to compare rates of secondary infections and long-term outcomes of elderly and non-elderly patients who received baricitinib for COVID-19. We conducted a single-centre observational study between November 2020 and September 2023, focusing on hospitalized adult SARS-CoV-2 patients with CSS, categorized as elderly (≥ 65 years) and non-elderly (< 65 years). Enrolment, severity stratification, and diagnosis of infectious complications followed predefined criteria. Outcomes of all-cause mortality and rates of non-severe and severe secondary infections were assessed at 1-year post-treatment initiation. Kaplan-Meier analysis was performed for survival analysis. In total, 490 patients were enrolled (median age 65 ± 23 (21-100) years (years, median ± IQR, min-max); 49.18% elderly; 59.59% male). Elderly patients were admitted to the hospital significantly earlier (7 ± 5 days vs. 8 ± 4 days; p = 0.02), experienced a higher occurrence of severe COVID-19 (121/241, 50.21% vs. 98/249, 39.36%; p = 0.02), and required the use of non-invasive ventilation at baseline (167/225, 74.22% vs. 153/236, 64.83%; p = 0.03). At 1 year, all-cause mortality was significantly higher in the elderly subgroup (111/241, 46.06% vs. 29/249, 11.65%; p < 0.01). At 90 days and 1 year, rates of any severe secondary infection were also more prevalent among the elderly (56/241, 23.24% vs. 37/249 14.86%; p = 0.02 and 58/241, 24.07% vs. 39/249, 15.66%; p = 0.02). In conclusion, elderly SARS-CoV-2-infected patients experience a more severe clinical course, higher secondary infection rates, and increased risk for long-term mortality, regardless of immunomodulatory therapy.
MeSH term(s)	Humans ; Male ; Aged ; Middle Aged ; Aged, 80 and over ; Female ; SARS-CoV-2 ; COVID-19 ; Coinfection ; Hungary ; COVID-19 Drug Treatment ; Azetidines ; Purines ; Pyrazoles ; Sulfonamides
Chemical Substances	baricitinib (ISP4442I3Y) ; Azetidines ; Purines ; Pyrazoles ; Sulfonamides
Language	English
Publishing date	2024-02-17
Publishing country	Switzerland
Document type	Observational Study ; Journal Article
ZDB-ID	2886586-8
ISSN	2509-2723 ; 2509-2715
ISSN (online)	2509-2723
ISSN	2509-2715
DOI	10.1007/s11357-024-01099-y
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Article ; Online: Short paired-end reads trump long single-end reads for expression analysis.

Freedman, Adam H / Gaspar, John M / Sackton, Timothy B

BMC bioinformatics

2020 Volume 21, Issue 1, Page(s) 149

Abstract: Background: Typical experimental design advice for expression analyses using RNA-seq generally assumes that single-end reads provide robust gene-level expression estimates in a cost-effective manner, and that the additional benefits obtained from paired- ...

Abstract	Background: Typical experimental design advice for expression analyses using RNA-seq generally assumes that single-end reads provide robust gene-level expression estimates in a cost-effective manner, and that the additional benefits obtained from paired-end sequencing are not worth the additional cost. However, in many cases (e.g., with Illumina NextSeq and NovaSeq instruments), shorter paired-end reads and longer single-end reads can be generated for the same cost, and it is not obvious which strategy should be preferred. Using publicly available data, we test whether short-paired end reads can achieve more robust expression estimates and differential expression results than single-end reads of approximately the same total number of sequenced bases. Results: At both the transcript and gene levels, 2 × 40 paired-end reads unequivocally provide expression estimates that are more highly correlated with 2 × 125 than 1 × 75 reads; in nearly all cases, those correlations are also greater than for 1 × 125, despite the greater total number of sequenced bases for the latter. Across an array of metrics, differential expression tests based upon 2 × 40 consistently outperform those using 1 × 75. Conclusion: Researchers seeking a cost-effective approach for gene-level expression analysis should prefer short paired-end reads over a longer single-end strategy. Short paired-end reads will also give reasonably robust expression estimates and differential expression results at the isoform level.
MeSH term(s)	Gene Expression/genetics ; Gene Expression Profiling/methods
Language	English
Publishing date	2020-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2041484-5
ISSN	1471-2105 ; 1471-2105
ISSN (online)	1471-2105
ISSN	1471-2105
DOI	10.1186/s12859-020-3484-z
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Article ; Online: How We Manage Adenosine Deaminase-Deficient Severe Combined Immune Deficiency (ADA SCID).

Kohn, Donald B / Gaspar, H Bobby

Journal of clinical immunology

2017 Volume 37, Issue 4, Page(s) 351–356

Abstract: Adenosine deaminase-deficient severe combined immune deficiency (ADA SCID) accounts for 10-15% of cases of human SCID. From what was once a uniformly fatal disease, the prognosis for infants with ADA SCID has improved greatly based on the development of ... ...

Abstract	Adenosine deaminase-deficient severe combined immune deficiency (ADA SCID) accounts for 10-15% of cases of human SCID. From what was once a uniformly fatal disease, the prognosis for infants with ADA SCID has improved greatly based on the development of multiple therapeutic options, coupled with more frequent early diagnosis due to implementation of newborn screening for SCID. We review the various treatment approaches for ADA SCID including allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen-matched sibling or family member or from a matched unrelated donor or a haplo-identical donor, autologous HSCT with gene correction of the hematopoietic stem cells (gene therapy-GT), and enzyme replacement therapy (ERT) with polyethylene glycol-conjugated adenosine deaminase. Based on growing evidence of safety and efficacy from GT, we propose a treatment algorithm for patients with ADA SCID that recommends HSCT from a matched family donor, when available, as a first choice, followed by GT as the next option, with allogeneic HSCT from an unrelated or haplo-identical donor or long-term ERT as other options.
MeSH term(s)	Adenosine Deaminase/deficiency ; Adenosine Deaminase/therapeutic use ; Agammaglobulinemia/diagnosis ; Agammaglobulinemia/therapy ; Algorithms ; Early Diagnosis ; Enzyme Replacement Therapy ; Genetic Therapy ; HLA Antigens/genetics ; HLA Antigens/immunology ; Hematopoietic Stem Cell Transplantation ; Histocompatibility ; Humans ; Infant, Newborn ; Neonatal Screening ; Severe Combined Immunodeficiency/diagnosis ; Severe Combined Immunodeficiency/therapy
Chemical Substances	HLA Antigens ; Adenosine Deaminase (EC 3.5.4.4)
Language	English
Publishing date	2017-02-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-017-0373-y
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Article ; Online: Farmers' willingness to invest in mechanized maize shelling and potential financial benefits

Kotu, B.H. / Manda, J. / Mutungi, C. / Fischer, G. / Gaspar, A.

Agribusiness

evidence from Tanzania

2023

Abstract: Open Access Article ... Sub-Saharan Africa has the least mechanized agriculture in the world due to various reasons including low effective demand at farm level, low policy attention, and ineffective mechanization strategies. However, the situation has ... ...

Abstract	Open Access Article Sub-Saharan Africa has the least mechanized agriculture in the world due to various reasons including low effective demand at farm level, low policy attention, and ineffective mechanization strategies. However, the situation has changed since recently in favor of mechanization while limited empirical evidence is available on how mechanization can be enhanced among smallholder farmers. In this study, we explore farmers' willingness to invest in mechanization services by considering the group business model (GBM) and the individual business model (IBM) of mechanized maize shelling in Tanzania. Moreover, we analyze the potential financial benefit for those farmers who would like to invest in mechanized maize shelling. We use data mainly collected through a household survey and apply econometric and mathematical models for analysis. The results show that about 65% of the sample farmers are willing to invest in mechanized maize shelling within the GBM, while about 10% of them would like to do so within the IBM. Moreover, the results show that investment in mechanized maize shelling is profitable considering both small-scale (4 and 7 HP engine capacity) machines and medium-scale (16 and 20 HP engine capacity) machines. The results show that expanding agricultural mechanization in Tanzania through investments coming from smallholder farmers, as also experienced elsewhere, is possible while they suggest that policy instruments such as targeted loan programs, entrepreneurial and technical trainings, and smart subsidies or tax exemptions are important to encourage and enable smallholder farmers to participate in the mechanization supply chain. [EconLit Citations: Q120, Q130, D250].
Keywords	maize ; shelling ; mechanization ; profitability ; tanzania
Language	English
Publishing date	2023-02-21T07:53:22Z
Publisher	Wiley
Publishing country	fr
Document type	Article ; Online
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Article ; Online: Association between Bilateral Selective Antegrade Cerebral Perfusion and Postoperative Ischemic Stroke in Patients with Emergency Surgery for Acute Type A Aortic Dissection-Single Centre Experience.

Robu, Mircea / Marian, Diana Romina / Margarint, Irina / Radulescu, Bogdan / Știru, Ovidiu / Iosifescu, Andrei / Voica, Cristian / Cacoveanu, Mihai / Ciomag Ianula, Raluca / Gașpar, Bogdan Severus / Dorobanțu, Lucian / Iliescu, Vlad Anton / Moldovan, Horațiu

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 8

Abstract: ... on the operating table or within 48 h after surgery, from whom the postoperative neurological status could not be ...

Abstract	Acute type A aortic dissection (ATAAD) is a surgical emergency with a mortality of 1-2% per hour. Since its discovery over 200 years ago, surgical techniques for repairing a dissected aorta have evolved, and with the introduction of hypothermic circulatory arrest and cerebral perfusion, complex techniques for replacing the entire aortic arch were possible. However, postoperative neurological complications contribute significantly to mortality in this group of patients. The aim of this study was to determine the association between different bilateral selective antegrade cerebral perfusion (ACP) times and the incidence of postoperative ischemic stroke in patients with emergency surgery for ATAAD. Patients with documented hemorrhagic or ischemic stroke, clinical signs of stroke or neurological dysfunction prior to surgery, that died on the operating table or within 48 h after surgery, from whom the postoperative neurological status could not be assessed, and with incomplete medical records were excluded from this study. The diagnosis of postoperative stroke was made using head computed tomography imaging (CT) when clinical suspicion was raised by a neurologist in the immediate postoperative period. For selective bilateral antegrade cerebral perfusion, we used two balloon-tipped cannulas inserted under direct vision into the innominate artery and the left common carotid artery. Each cannula is connected to a separate pump with an independent pressure line. Near-infrared spectroscopy was used in all cases for cerebral oxygenation monitoring. The circulatory arrest was initiated after reaching a target core temperature of 25-28 °C. In total, 129 patients were included in this study. The incidence of postoperative ischemic stroke documented on a head CT was 24.8% (31 patients), and postoperative death was 20.9% (27 patients). The most common surgical technique performed was supravalvular ascending aorta and Hemiarch replacement with a Dacron graft in 69.8% (90 patients). The mean cardiopulmonary bypass time was 210 +/- 56.874 min, the mean aortic cross-clamp time was 114.775 +/- 34.602 min, and the mean cerebral perfusion time was 37.837 +/- 18.243 min. Using logistic regression, selective ACP of more than 40 min was independently associated with postoperative ischemic stroke (OR = 3.589; 95%CI = 1.418-9.085;
MeSH term(s)	Humans ; Ischemic Stroke ; Perfusion ; Aortic Dissection/surgery ; Stroke/epidemiology ; Stroke/etiology ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Cerebrovascular Circulation
Language	English
Publishing date	2023-07-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59081365
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Article ; Online: Using spatiotemporal ratio analyses to quantitatively estimate water quality recovery of the Rio Doce.

Wild, Michael / Rouhani, Shahrokh / Oehrig, Jacob / Alves, Pedro H G / Odle, William / Gaspar, Diogo F A

Integrated environmental assessment and management

2023 Volume 20, Issue 1, Page(s) 74–86

Abstract: ... measure for water quality recovery; (b) chemical parameters associated with the tailings, like manganese ...

Abstract	The Fundão Dam breached on 5 November 2015 (the "Event"), resulting in the release of tailings, water, scoured sediment and/or soil, and other debris to downstream watercourses. Statistical analyses using historical and recent water quality measurements were conducted to assess the extent to which water quality in the Rio Doce was recovering to baseline conditions. A review of station- and/or parameter-specific water quality time series in the Rio Doce revealed two challenges: pre-Event data imbalance and seasonality. Due to the combined effects of these two factors, data gathered from Rio Doce water quality stations before the Event likely underestimated concentration ranges and limited the usefulness of common recovery assessment techniques such as times series and water quality standard exceedance analyses. These challenges were addressed by calculating quarterly and watershed-specific river-to-tributary ratios. R code was used to produce spatiotemporal time series for 44 investigated parameters that were measured both before and after the Event. The water quality recovery durations shown by the parameter- and/or region-specific river-to-tributary ratio time series indicated that (a) turbidity provides the most conservative measure for water quality recovery; (b) chemical parameters associated with the tailings, like manganese and iron recovered faster than turbidity; and (c) other investigated parameters unrelated to the tailings showed either no discernable impact or rapid recovery after the Event. The resulting parameter- and/or region-specific river-to-tributary ratio time series provided reliable and quantifiable estimates of water quality recovery durations. The water quality in the region furthest from Fundão Dam, in Espírito Santo, recovered one year after the Event, while water quality in the closest region to Fundão Dam, upstream of Risoleta Neves (Candonga) Dam, recovered 4.2 years after the Event. Integr Environ Assess Manag 2024;20:74-86. © 2023 Newfields Companies, LLC. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
MeSH term(s)	Water Quality ; Water Pollutants, Chemical/analysis ; Environmental Monitoring ; Iron/analysis ; Rivers ; Brazil
Chemical Substances	Water Pollutants, Chemical ; Iron (E1UOL152H7)
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2234931-5
ISSN	1551-3793 ; 1551-3777
ISSN (online)	1551-3793
ISSN	1551-3777
DOI	10.1002/ieam.4813
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Article ; Online: TEMPO-conjugated tobacco mosaic virus as a magnetic resonance imaging contrast agent for detection of superoxide production in the inflamed liver.

Lumata, Jenica L / Hagge, Laurel M / Gaspar, Miguel A / Trashi, Ikeda / Ehrman, Ryanne N / Koirala, Shailendra / Chiev, Alyssa C / Wijesundara, Yalini H / Darwin, Cary B / Pena, Salvador / Wen, Xiaodong / Wansapura, Janaka / Nielsen, Steven O / Kovacs, Zoltan / Lumata, Lloyd L / Gassensmith, Jeremiah J

Journal of materials chemistry. B

2024 Volume 12, Issue 13, Page(s) 3273–3281

Abstract: Superoxide, an anionic dioxygen molecule, plays a crucial role in redox regulation within the body but is implicated in various pathological conditions when produced excessively. Efforts to develop superoxide detection strategies have led to the ... ...

Abstract	Superoxide, an anionic dioxygen molecule, plays a crucial role in redox regulation within the body but is implicated in various pathological conditions when produced excessively. Efforts to develop superoxide detection strategies have led to the exploration of organic-based contrast agents for magnetic resonance imaging (MRI). This study compares the effectiveness of two such agents, nTMV-TEMPO and kTMV-TEMPO, for detecting superoxide in a mouse liver model with lipopolysaccharide (LPS)-induced inflammation. The study demonstrates that kTMV-TEMPO, with a strategically positioned lysine residue for TEMPO attachment, outperforms nTMV-TEMPO as an MRI contrast agent. The enhanced sensitivity of kTMV-TEMPO is attributed to its more exposed TEMPO attachment site, facilitating stronger interactions with water protons and superoxide radicals. EPR kinetics experiments confirm kTMV-TEMPO's faster oxidation and reduction rates, making it a promising sensor for superoxide in inflamed liver tissue.
MeSH term(s)	Mice ; Animals ; Superoxides ; Contrast Media/chemistry ; Tobacco Mosaic Virus ; Lipopolysaccharides ; Magnetic Resonance Imaging/methods ; Liver
Chemical Substances	Superoxides (11062-77-4) ; Contrast Media ; Lipopolysaccharides
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb02765a
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