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  1. Article ; Online: C(3)1-TAg in C57BL/6 J background as a model to study mammary tumor development.

    Sena, Isadora F G / Rocha, Beatriz G S / Picoli, Caroline C / Santos, Gabryella S P / Costa, Alinne C / Gonçalves, Bryan O P / Garcia, Ana Paula V / Soltani-Asl, Maryam / Coimbra-Campos, Leda M C / Silva, Walison N / Costa, Pedro A C / Pinto, Mauro C X / Amorim, Jaime H / Azevedo, Vasco A C / Resende, Rodrigo R / Heller, Debora / Cassali, Geovanni D / Mintz, Akiva / Birbrair, Alexander

    Histochemistry and cell biology

    2021  Volume 156, Issue 2, Page(s) 165–182

    Abstract: ... studies are done in mice with C57BL/6 J background, we aimed to define the histological alterations in C3 ... 1)-TAg C57BL/6 J animals. Our results showed that C3(1)-TAg animals with C57BL/6 J background ... in the C57BL/6 J background when compared with the FVB strain, providing a better model to study the different ...

    Abstract Diagnosis and prognosis of breast cancer is based on disease staging identified through histopathological and molecular biology techniques. Animal models are used to gain mechanistic insights into the development of breast cancer. C(3)1-TAg is a genetically engineered mouse model that develops mammary cancer. However, carcinogenesis caused by this transgene was characterized in the Friend Virus B (FVB) background. As most genetic studies are done in mice with C57BL/6 J background, we aimed to define the histological alterations in C3(1)-TAg C57BL/6 J animals. Our results showed that C3(1)-TAg animals with C57BL/6 J background develop solid-basaloid adenoid cystic carcinomas with increased fibrosis, decreased area of adipocytes, and a high proliferative index, which are triple-negative for progesterone, estrogen, and human epidermal growth factor receptor 2 (HER2) receptors. Our results also revealed that tumor development is slower in the C57BL/6 J background when compared with the FVB strain, providing a better model to study the different stages in breast cancer progression.
    MeSH term(s) Animals ; Antigens, Viral, Tumor/genetics ; Antigens, Viral, Tumor/immunology ; Breast Neoplasms/genetics ; Breast Neoplasms/immunology ; Breast Neoplasms/pathology ; Carcinoma, Adenoid Cystic/genetics ; Carcinoma, Adenoid Cystic/immunology ; Carcinoma, Adenoid Cystic/pathology ; Female ; Friend murine leukemia virus/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Models, Genetic
    Chemical Substances Antigens, Viral, Tumor
    Language English
    Publishing date 2021-05-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1222930-1
    ISSN 1432-119X ; 0301-5564 ; 0948-6143
    ISSN (online) 1432-119X
    ISSN 0301-5564 ; 0948-6143
    DOI 10.1007/s00418-021-01995-w
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  2. Article: [Rezension von: Auerbach, A. J., ..., Dynamic fiscal policy]

    Mintz, Jack M / Auerbach, A. J

    Journal of economics 1989 = Vol. 50, No. 2, S. 182-184

    1989  Volume 50, Issue 2

    Author's details J. M. Mintz
    Keywords 40;49
    Language English
    Publisher Springer
    Publishing place Wien [u.a.]
    Document type Article
    ZDB-ID 635037-9 ; 1476543-3
    ISSN 1617-7134 ; 0931-8658
    ISSN (online) 1617-7134
    ISSN 0931-8658
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  3. Article ; Online: Mycobacterium avium

    Mintz, Michael J / Lukin, Dana J

    Translational gastroenterology and hepatology

    2023  Volume 8, Page(s) 28

    Abstract: Crohn's disease (CD) in humans and Johne's disease (JD) in ruminants share numerous clinical and pathologic similarities. ... ...

    Abstract Crohn's disease (CD) in humans and Johne's disease (JD) in ruminants share numerous clinical and pathologic similarities. As
    Language English
    Publishing date 2023-07-25
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2415-1289
    ISSN (online) 2415-1289
    DOI 10.21037/tgh-23-16
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  4. Book: Orthopaedic pathology

    Vigorita, Vincent J. / Ghelman, Bernard / Mintz, Douglas

    2016  

    Author's details Vincent J. Vigorita with Bernard Ghelman ; Douglas Mintz
    Keywords Bone Diseases / pathology ; Bone and Bones / pathology ; Musculoskeletal system/Diseases
    Subject code 616.707
    Language English
    Size XI, 895 S. : zahlr. Ill., graph. Darst., 26cm
    Edition 3. ed.
    Publisher Wolters Kluwer
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    Accompanying material Zugang zu Internetausgabe über Code
    HBZ-ID HT018817382
    ISBN 978-1-4511-9202-5 ; 1-4511-9202-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2015 A 3981 available for loan (reading room) Lesesaal EG
    Zugang zu Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  5. Article ; Online: Estimation and interpretation problems and solutions when using proportion covariates in linear regression models.

    Valle, Denis / Mintz, Jeffrey / Brack, Ismael Verrastro

    Ecology

    2024  Volume 105, Issue 4, Page(s) e4256

    Abstract: Proportion variables, also known as compositional data, are very common in ecology. Unfortunately, few scientists are aware of how compositional data, when used as covariates, can adversely impact statistical analysis. We describe here how proportion ... ...

    Abstract Proportion variables, also known as compositional data, are very common in ecology. Unfortunately, few scientists are aware of how compositional data, when used as covariates, can adversely impact statistical analysis. We describe here how proportion covariates result in multicollinearity and parameter identifiability problems. Using simulated data on bird species richness as a function of land use, we show how these problems manifest when fitting a wide range of models in R, both in a frequentist and Bayesian framework. In particular, we show that similar models can often generate substantially different parameter estimates, leading to very different conclusions. Dropping a covariate or the intercept from the model can solve the multicollinearity and parameter identifiability problems. Unfortunately, these solutions do not fix the inherent challenges associated with interpreting parameter estimates. To this end, we propose focusing the interpretation on the difference of slope parameters to avoid the inherent unidentifiability of individual parameters. We also propose conditional plots with two x-axes and marginal plots as visualization techniques that can help users better interpret their modeling results. We illustrate these problems and proposed solutions using empirical data from the North American Breeding Bird Survey. The practical and straightforward approaches suggested in this article will help the fitting of linear models and interpretation of its results when some of the covariates are proportions.
    MeSH term(s) Linear Models ; Bayes Theorem ; Models, Statistical
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010140-5
    ISSN 1939-9170 ; 0012-9658
    ISSN (online) 1939-9170
    ISSN 0012-9658
    DOI 10.1002/ecy.4256
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  6. Article ; Online: Predictive Modeling of Postpartum Blood Pressure Spikes.

    Infusino, Scott / Tao, Jinxin / Mintz, Yonatan / Hoppe, Kara K

    American journal of obstetrics & gynecology MFM

    2024  , Page(s) 101301

    Abstract: Background: Hypertensive disorders of pregnancy (HDP) are one of the leading causes of maternal morbidity and mortality worldwide. Management of these conditions can pose many clinical dilemmas, and can be particularly challenging during the immediate ... ...

    Abstract Background: Hypertensive disorders of pregnancy (HDP) are one of the leading causes of maternal morbidity and mortality worldwide. Management of these conditions can pose many clinical dilemmas, and can be particularly challenging during the immediate postpartum period. Models for predicting and managing postpartum hypertension are necessary to help address this clinical challenge.
    Objective: To evaluate predictive models of blood pressure (BP) spikes postpartum (PP) and investigate clinical management strategies to optimize care.
    Methods: A retrospective cohort study of PP women participating in remote BP monitoring. Postpartum BP spike was defined as BP ≥ 140/ 90 if on an antihypertensive and BP ≥ 150/100 if not on an antihypertensive. We identified 3 risk level patient clusters (low, medium, and high) in predicting patient risk of BP spike PP days 3-7. The variables used in defining these clusters were peak systolic blood pressure (SBP) before discharge, BMI, patient SBP per-trimester, heart rate, gestational age, maternal age, chronic hypertension and gestational hypertension. For each risk cluster, we focused on two treatments: 1) PP length of stay < or >/= 3 days and 2) discharge with or without BP medications. We evaluated the effectiveness of the treatments on different subgroups of patients by estimating the conditional average treatment effect (CATE) values in each cluster respectively using a causal forest. Moreover, for all patients, we considered discharge with medication policies depending on different discharge BP thresholds. We used a doubly robust policy evaluation method to compare the effectiveness of the policies.
    Results: 413 patients were included, of which 267 (64.6%) had a PP BP spike. The treatments for patients at medium and high risk were considered beneficial, the 95% confidence intervals of constant marginal average treatment effect for antihypertensive use at discharge were (-3.482, 4.840) and (-5.539, 4.315); and for a longer stay were (-5.544, 3.866) and (-7.200, 4.302). For patients at low risk, the treatments were not critical in preventing a BP spike with 95% confidence intervals of constant marginal average treatment effect (1.074, 15.784) and (-2.913, 9.021) respectively. We considered the option to discharge with antihypertensive use at different BP thresholds a) ≥ 130 mmHg and/or ≥ 80, b) ≥ 140 mmHg and/or ≥ 90, c) ≥ 150 mmHg and/or ≥ 100, or d) ≥ 160 mmHg and/or ≥ 110, we found that policy (b) was the best option at P<0.05.
    Conclusions: We identified 3 possible strategies to prevent outpatient BP spikes PP: 1) medium and high-risk patients should be considered for a longer PP stay or participate in daily home monitoring, 2) medium and high-risk patients should be prescribed antihypertensives at discharge, and 3) antihypertensive treatment should be prescribed if patients are discharged with BP ≥ 140/90.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2024.101301
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  7. Article ; Online: The use of nanotechnology to combat liver cancer: Progress and perspectives.

    Mintz, Keenan J / Leblanc, Roger M

    Biochimica et biophysica acta. Reviews on cancer

    2021  Volume 1876, Issue 2, Page(s) 188621

    Abstract: Liver cancer is one of the most common cancers worldwide and is also one of the most difficult cancers to treat, resulting in almost one million deaths per year, and the danger of this cancer is compounded when the tumor is nonresectable. Hepatocellular ... ...

    Abstract Liver cancer is one of the most common cancers worldwide and is also one of the most difficult cancers to treat, resulting in almost one million deaths per year, and the danger of this cancer is compounded when the tumor is nonresectable. Hepatocellular carcinoma (HCC) is the most common type of liver cancer and has the third highest mortality rate worldwide. Considering the morbid statistics surrounding this cancer it is a popular research topic to target for better therapy practices. This review summarizes the role of nanotechnology in these endeavors. Nanoparticles (NPs) are a very broad class of material and many different kinds have been used to potentially combat liver cancer. Gold, silver, platinum, metal oxide, calcium, and selenium NPs as well as less common materials are all inorganic NPs that have been used as a therapeutic, carrier, or imaging agent in drug delivery systems (DDS) and these efforts are described. Carbon-based NPs, including polymeric, polysaccharide, and lipid NPs as well as carbon dots, have also been widely studied for this purpose and the role they play in DDS for the treatment of liver cancer is illustrated in this review. The multifunctional nature of many NPs described herein, allows these systems to display high anticancer activity in vitro and in vivo and highlights the advantage of and need for combinatorial therapy in treating this difficult cancer. These works are summarized, and future directions are presented for this promising field.
    MeSH term(s) Disease Progression ; Drug Delivery Systems/methods ; Humans ; Liver Neoplasms/therapy ; Nanotechnology/methods
    Language English
    Publishing date 2021-08-27
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2918802-7
    ISSN 1879-2561 ; 0304-419X
    ISSN (online) 1879-2561
    ISSN 0304-419X
    DOI 10.1016/j.bbcan.2021.188621
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  8. Article: [Besprechung von:] Prichard, J. Robert S.: Crown corporations in Canada. The calculus of instrument choice. 1983

    Mintz, Jack / Prichard, J. Robert S

    The Canadian journal of economics Vol. 18, No. 3 , p. 685-688

    1985  Volume 18, Issue 3, Page(s) 685–688

    Author's details Jack Mintz
    Publisher Blackwell
    Publishing place Boston, Mass. [u.a.]
    Document type Article
    ZDB-ID 218117-4
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  9. Article ; Online: Regulation of adhesin synthesis in Aggregatibacter actinomycetemcomitans.

    Tristano, Jake / Danforth, David R / Wargo, Matthew J / Mintz, Keith P

    Molecular oral microbiology

    2023  Volume 38, Issue 3, Page(s) 237–250

    Abstract: Aggregatibacter actinomycetemcomitans is a gram-negative bacterium associated with periodontal disease and a variety of disseminated extra-oral infections. Tissue colonization is mediated by fimbriae and non-fimbriae adhesins resulting in the formation ... ...

    Abstract Aggregatibacter actinomycetemcomitans is a gram-negative bacterium associated with periodontal disease and a variety of disseminated extra-oral infections. Tissue colonization is mediated by fimbriae and non-fimbriae adhesins resulting in the formation of a sessile bacterial community or biofilm, which confers enhanced resistance to antibiotics and mechanical removal. The environmental changes experienced by A. actinomycetemcomitans during infection are detected and processed by undefined signaling pathways that alter gene expression. In this study, we have characterized the promoter region of the extracellular matrix protein adhesin A (EmaA), which is an important surface adhesin in biofilm biogenesis and disease initiation using a series of deletion constructs consisting of the emaA intergenic region and a promotor-less lacZ sequence. Two regions of the promoter sequence were found to regulate gene transcription and in silico analysis indicated the presence of multiple transcriptional regulatory binding sequences. Analysis of four regulatory elements, CpxR, ArcA, OxyR, and DeoR, was undertaken in this study. Inactivation of arcA, the regulator moiety of the ArcAB two-component signaling pathway involved in redox homeostasis, resulted in a decrease in EmaA synthesis and biofilm formation. Analysis of the promoter sequences of other adhesins identified binding sequences for the same regulatory proteins, which suggests that these proteins are involved in the coordinate regulation of adhesins required for colonization and pathogenesis.
    MeSH term(s) Aggregatibacter actinomycetemcomitans/metabolism ; Adhesins, Bacterial/genetics ; Adhesins, Bacterial/metabolism ; Biofilms ; Protein Binding ; Anti-Bacterial Agents
    Chemical Substances Adhesins, Bacterial ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-15
    Publishing country Denmark
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2537726-7
    ISSN 2041-1014 ; 2041-1006
    ISSN (online) 2041-1014
    ISSN 2041-1006
    DOI 10.1111/omi.12410
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  10. Article ; Online: Why and Where to Fund Carbon Capture and Storage.

    Mintz-Woo, Kian / Lane, Joe

    Science and engineering ethics

    2021  Volume 27, Issue 6, Page(s) 70

    Abstract: This paper puts forward two claims about funding carbon capture and storage. The first claim is that there are moral justifications supporting strategic investment into ... ...

    Abstract This paper puts forward two claims about funding carbon capture and storage. The first claim is that there are moral justifications supporting strategic investment into CO
    MeSH term(s) Carbon ; Carbon Dioxide ; Climate Change ; Financial Management ; Social Justice
    Chemical Substances Carbon Dioxide (142M471B3J) ; Carbon (7440-44-0)
    Language English
    Publishing date 2021-11-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2136491-6
    ISSN 1471-5546 ; 1353-3452
    ISSN (online) 1471-5546
    ISSN 1353-3452
    DOI 10.1007/s11948-021-00344-3
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