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  1. Article: Endobronchial Ultrasound Using Guide Sheath-Guided Transbronchial Lung Biopsy in Ground-Glass Opacity Pulmonary Lesions without Fluoroscopic Guidance.

    Park, Jongsoo / Kim, Changwoon / Jang, Jong Geol / Lee, Seok Soo / Hong, Kyung Soo / Ahn, June Hong

    Cancers

    2024  Volume 16, Issue 6

    Abstract: Diagnosing ground-glass opacity (GGO) pulmonary lesions poses challenges. This study evaluates the utility of radial probe endobronchial ultrasound-guided transbronchial lung biopsy (RP-EBUS-TBLB) in diagnosing GGO pulmonary lesions. A total of 1651 RP- ... ...

    Abstract Diagnosing ground-glass opacity (GGO) pulmonary lesions poses challenges. This study evaluates the utility of radial probe endobronchial ultrasound-guided transbronchial lung biopsy (RP-EBUS-TBLB) in diagnosing GGO pulmonary lesions. A total of 1651 RP-EBUS procedures were performed during the study period. This study analyzed 115 GGO lesions. The EBUS visualization yield was 80.1%. Of 115 lesions, 69 (60%) were successfully diagnosed. The average size of diagnosed lesions was significantly larger than that of undiagnosed lesions (21.9 ± 7.3 vs. 17.1 ± 6.6 mm,
    Language English
    Publishing date 2024-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16061203
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  2. Article: Response to Letter Regarding Article, Trends in Prevalence of Hypertriglyceridemia and Related Factors in Korean Adults: A Serial Cross-Sectional Study.

    Park, Kye-Yeung / Hong, Sangmo / Kim, Kyung-Soo / Han, Kyungdo / Park, Cheol-Young

    Journal of lipid and atherosclerosis

    2024  Volume 13, Issue 1, Page(s) 82–85

    Language English
    Publishing date 2024-01-22
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3016001-7
    ISSN 2288-2561 ; 2287-2892
    ISSN (online) 2288-2561
    ISSN 2287-2892
    DOI 10.12997/jla.2024.13.1.82
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  3. Article ; Online: Daidzein Inhibits Human Platelet Activation by Downregulating Thromboxane A

    Hong, Hyun-Jin / Nam, Gi-Suk / Nam, Kyung-Soo

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: Platelets play crucial roles in cardiovascular diseases (CVDs) by regulating hemostasis and blood coagulation at sites of blood vessel damage. Accumulating evidence indicates daidzein inhibits platelet activation, but the mechanism involved has not been ... ...

    Abstract Platelets play crucial roles in cardiovascular diseases (CVDs) by regulating hemostasis and blood coagulation at sites of blood vessel damage. Accumulating evidence indicates daidzein inhibits platelet activation, but the mechanism involved has not been elucidated. Thus, in this study, we investigated the mechanism responsible for the inhibition of collagen-induced platelet aggregation by daidzein. We found that in collagen-induced platelets, daidzein suppressed the production of thromboxane A
    MeSH term(s) Humans ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Activation ; Platelet Aggregation ; Blood Platelets/metabolism ; Phosphorylation ; Thromboxanes/metabolism ; Collagen/metabolism
    Chemical Substances daidzein (6287WC5J2L) ; Platelet Aggregation Inhibitors ; Thromboxanes ; Collagen (9007-34-5)
    Language English
    Publishing date 2023-07-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241511985
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  4. Article ; Online: Nonfamilial VACTERL-H Syndrome in a Dizygotic Twin: Prenatal Ultrasound and Postnatal 3D CT Findings.

    Hong, Seol Young / Kim, Soo Jung / Park, Mi-Hye / Lee, Kyung A

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 8

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Pregnancy ; Humans ; Female ; Male ; Adult ; Child ; Twins, Dizygotic ; Tracheoesophageal Fistula ; Polyhydramnios ; Hydrocephalus/diagnostic imaging ; Hydrocephalus/genetics ; Ultrasonography, Prenatal ; Dextrocardia
    Language English
    Publishing date 2023-07-28
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59081387
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  5. Article ; Online: Association of non-alcoholic fatty liver disease with cardiovascular disease and all cause death in patients with type 2 diabetes mellitus: nationwide population based study.

    Kim, Kyung-Soo / Hong, Sangmo / Han, Kyungdo / Park, Cheol-Young

    BMJ (Clinical research ed.)

    2024  Volume 384, Page(s) e076388

    Abstract: Objective: To investigate the risk of non-alcoholic fatty liver disease (NAFLD) for cardiovascular disease and all cause death in patients with type 2 diabetes mellitus (T2DM).: Design: Nationwide population based study.: Setting: Longitudinal ... ...

    Abstract Objective: To investigate the risk of non-alcoholic fatty liver disease (NAFLD) for cardiovascular disease and all cause death in patients with type 2 diabetes mellitus (T2DM).
    Design: Nationwide population based study.
    Setting: Longitudinal cohort study in Korea.
    Participants: 7 796 763 participants in the National Health Screening Programme in 2009 were divided into three groups based on NAFLD status: no NAFLD (fatty liver index<30); grade 1 NAFLD (30≤fatty liver index<60); and grade 2 NAFLD (fatty liver index≥60). Median follow-up was 8.13 years.
    Main outcome measures: The primary outcome was incident cardiovascular disease (myocardial infarction, ischaemic stroke) or all cause death.
    Results: Of 7 796 763 participants, 6.49% (n=505 763) had T2DM. More patients with T2DM had grade 1 NAFLD (34.06%) and grade 2 NAFLD (26.73%) than those without T2DM (grade 1 NAFLD: 21.20%; grade 2 NAFLD: 10.02%). The incidence rate (per 1000 person years) of cardiovascular disease and all cause death increased in the order of no NAFLD, grade 1 NAFLD, and grade 2 NAFLD, and the incidence rates in patients with T2DM were higher than those in patients without T2DM. The five year absolute risk for cardiovascular disease and all cause death increased in the order of no NAFLD, grade 1 NAFLD, and grade 2 NAFLD in patients without and with T2DM (no NAFLD, without T2DM: 1.03, 95% confidence interval 1.02 to 1.04, and 1.25, 1.24 to 1.26, respectively; grade 1 NAFLD, without T2DM: 1.23, 1.22 to 1.25, and 1.50, 1.48 to 1.51, respectively; grade 2 NAFLD, without T2DM: 1.42, 1.40 to 1.45, and 2.09, 2.06 to 2.12, respectively; no NAFLD, with T2DM: 3.34, 3.27 to 3.41, and 3.68, 3.61 to 3.74, respectively; grade 1 NAFLD, with T2DM: 3.94, 3.87 to 4.02, and 4.25, 4.18 to 4.33, respectively; grade 2 NAFLD, with T2DM: 4.66, 4.54 to 4.78, and 5.91, 5.78 to 6.05, respectively). Patients with T2DM and without NAFLD had a higher five year absolute risk for cardiovascular disease and all cause death than those without T2DM and with grade 2 NAFLD. Risk differences for cardiovascular disease and all cause death between no NAFLD and grade 1 or grade 2 NAFLD were higher in patients with T2DM than in those without T2DM.
    Conclusions: NAFLD in patients with T2DM seems to be associated with a higher risk of cardiovascular disease and all cause death, even in patients with mild NAFLD. Risk differences for cardiovascular disease and all cause death between the no NAFLD group and the grade 1 or grade 2 NAFLD groups were higher in patients with T2DM than in those without T2DM.
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/diagnosis ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/diagnosis ; Risk Factors ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/complications ; Longitudinal Studies ; Brain Ischemia/complications ; Stroke/complications
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj-2023-076388
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    In stock of ZB MED Cologne/Königswinter

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  6. Article: Anthocyanin Oligomers Induce Apoptosis and Autophagy by Inhibiting the mTOR Signaling Pathway in Human Breast Cancer Cells.

    Lee, Min-Gu / Hong, Hyun-Jin / Nam, Kyung-Soo

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 17, Issue 1

    Abstract: Anthocyanin oligomers (AOs) are phytochemicals synthesized by fermenting anthocyanins extracted from grape skins and are more biologically active than monomeric anthocyanins. In this study, we evaluate the effects of an AO on triple-negative MDA-MB-231 ... ...

    Abstract Anthocyanin oligomers (AOs) are phytochemicals synthesized by fermenting anthocyanins extracted from grape skins and are more biologically active than monomeric anthocyanins. In this study, we evaluate the effects of an AO on triple-negative MDA-MB-231 and HER2-overexpressing SK-BR-3 breast cancer cells. The cell viability of MDA-MB-231 and SK-BR-3 cells was significantly inhibited in a concentration-dependent manner by AO treatment for 24 h, while delphinidin (a monomeric anthocyanin) had no effect on cell viability. In addition, the AO increased H2A.X phosphorylation (a marker of DNA damage), reduced RAD51 (a DNA repair protein) and survivin (a cell survival factor) protein levels, and induced apoptosis by caspase-3-dependent PARP1 cleavage in both cell lines. Surprisingly, the AO induced autophagy by increasing intracellular LC3-II puncta and LC3-II and p62 protein levels. In addition, the AO inhibited the mTOR pathway in MDA-MB-231 and SK-BR-3 cells by suppressing the HER2, EGFR1, and AKT pathways. These results demonstrate that the anti-cancer effect of the AO was due to the induction of apoptosis and autophagy via cleaved caspase-3-mediated PARP1 cleavage and mTOR pathway inhibition, respectively. Furthermore, our results suggest that anthocyanin oligomers could be considered potential candidates for breast cancer treatment.
    Language English
    Publishing date 2023-12-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17010024
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  7. Article ; Online: Underreporting of workers' injuries or illnesses and contributing factors: a systematic review.

    Kyung, MinJung / Lee, Soo-Jeong / Dancu, Caroline / Hong, OiSaeng

    BMC public health

    2023  Volume 23, Issue 1, Page(s) 558

    Abstract: Background: Accurate identification of work-related health problems is important to understand workplace safety issues and develop appropriate interventions. Although workers' reporting of work-related injuries or illnesses is the very first step of the ...

    Abstract Background: Accurate identification of work-related health problems is important to understand workplace safety issues and develop appropriate interventions. Although workers' reporting of work-related injuries or illnesses is the very first step of the reporting process, many workers may encounter challenges in reporting them to their management or workers' compensation (WC) programs. This systematic review aimed to identify the level of workers' underreporting of work-related injuries and illnesses and the contributing factors and reasons for underreporting among US workers.
    Methods: This study searched PubMed (Medline), PsycINFO (ProQuest), CINAHL (EBSCOhost), EMBASE (Embase.com), and Social Science Citation Index (Web of Science) using search terms related to underreporting of work-related injury or illness.
    Results: Twenty studies (17 quantitative and three mixed methods studies) were identified. The studies investigated reporting to management (n = 12), WC programs (n = 6), multiple organizations (n = 1), and not specified (n = 1). The timeframe used to measure reporting prevalence varied from three months to entire careers of workers, with the most common timeframe of 12 months. This review indicated that 20-91% of workers did not report their injuries or illnesses to management or WC programs. From quantitative studies, contributing factors for injury or illness underreporting were categorized as follows: injury type and severity, sociodemographic factors (e.g., age, gender, education, and race/ethnicity), general health and functioning, worker's knowledge on reporting, job and employment characteristics (e.g., work hour, job tenure, work shift, type of occupation, and physical demand), psychosocial work environment (e.g., supervisor support, coworker support, and safety climate), and health care provider factors. From the review of qualitative studies, the reasons for underreporting included the following: fear or concern, cumbersome time and effort in the reporting process, lack of knowledge regarding reporting, perceptions of injuries as not severe or part of the job, and distrust of reporting consequences.
    Conclusions: The review findings indicated that low wage earners, racial/ethnic minority workers, and workers who perceive a poor psychosocial work environment encounter more barriers to reporting a work-related injury or illness. This review also identified variations in the measurement of work-related injury reporting across studies and a lack of standardized measurement.
    Trial registration: The review was registered in the PROSPERO, an international database of prospectively registered systematic reviews in health and social care (CRD42021284685).
    MeSH term(s) Humans ; Occupational Injuries/epidemiology ; Occupational Diseases/epidemiology ; Ethnicity ; Minority Groups ; Workplace ; Workers' Compensation
    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-023-15487-0
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  8. Article ; Online: Clinical and radiological outcomes of non-window-type bioactive glass-ceramic cage in single-level ACDF versus PEEK cage filled with autologous bone.

    Kwon, Ji-Won / Lee, Yong Ho / Lee, Byung Ho / Kim, Jae Hong / Suk, Kyung Soo

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 4035

    Abstract: Bioactive glass-ceramic (BGC) cage is a substitute for polyether ether ketone (PEEK) cages in anterior cervical discectomy and fusion (ACDF). Only a few comparative studies exist using PEEK and non-window-type BGC cages (CaO- ... ...

    Abstract Bioactive glass-ceramic (BGC) cage is a substitute for polyether ether ketone (PEEK) cages in anterior cervical discectomy and fusion (ACDF). Only a few comparative studies exist using PEEK and non-window-type BGC cages (CaO-SiO
    MeSH term(s) Humans ; Silicon Dioxide ; Retrospective Studies ; Polyethylene Glycols ; Benzophenones ; Ketones ; Diskectomy/methods ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/surgery ; Ceramics ; Treatment Outcome ; Spinal Fusion/methods ; Polymers
    Chemical Substances polyetheretherketone (31694-16-3) ; Silicon Dioxide (7631-86-9) ; Polyethylene Glycols (3WJQ0SDW1A) ; Benzophenones ; Ketones ; Polymers
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-54786-3
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  9. Article ; Online: 우측기관주위의 종격동 종괴로 나타난 상피양 혈관내피종: 증례 보고.

    Hong, Pa / Lee, Jae Seok / Lee, Kyung Soo

    Journal of the Korean Society of Radiology

    2022  Volume 83, Issue 6, Page(s) 1373–1379

    Abstract: Epithelioid hemangioendothelioma (EHE) is a low-grade malignant vascular neoplasm that can occur anywhere in the body. EHE has a low annual incidence (0.38/ ... ...

    Title translation Epithelioid Hemangioendothelioma Presenting as a Right Paratracheal Mass: A Case Report.
    Abstract Epithelioid hemangioendothelioma (EHE) is a low-grade malignant vascular neoplasm that can occur anywhere in the body. EHE has a low annual incidence (0.38/10
    Language Korean
    Publishing date 2022-09-05
    Publishing country Korea (South)
    Document type Case Reports ; English Abstract
    ISSN 2951-0805
    ISSN (online) 2951-0805
    DOI 10.3348/jksr.2022.0057
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  10. Article ; Online: Pulmonary Heterotopic Ossification Simulating a Pulmonary Hamartoma: Imaging and Pathologic Findings and Differential Diagnosis.

    Hong, Pa / Lee, Jae Seok / Lee, Kyung Soo

    Korean journal of radiology

    2022  Volume 23, Issue 6, Page(s) 688–690

    MeSH term(s) Diagnosis, Differential ; Diagnostic Imaging/methods ; Hamartoma/diagnostic imaging ; Hamartoma/surgery ; Humans ; Lung Neoplasms/diagnosis ; Ossification, Heterotopic/diagnostic imaging ; Ossification, Heterotopic/surgery
    Language English
    Publishing date 2022-05-23
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2046981-0
    ISSN 2005-8330 ; 1229-6929
    ISSN (online) 2005-8330
    ISSN 1229-6929
    DOI 10.3348/kjr.2022.0156
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