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  1. Book ; Online: Sepsis Management in Resource-limited Settings

    Dondorp, Arjen M. / Dünser, Martin W. / Schultz, Marcus J.

    2019  

    Keywords General practice ; Clinical & internal medicine ; Anaesthetics ; Accident & emergency medicine ; Intensive care medicine ; Surgery ; Medicine ; Emergency medicine ; Critical care medicine ; Anesthesiology ; Internal medicine ; General practice (Medicine)
    Size 1 electronic resource (216 pages)
    Publisher Springer Nature
    Publishing place Cham
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021029802
    ISBN 978-3-030-03143-5 ; 3-030-03143-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Sepsis Management in Resource-limited Settings

    Dondorp, Arjen M. / Dünser, Martin W. / Schultz, Marcus J.

    2019  

    Author's details edited by Arjen M. Dondorp, Martin W. Dünser, Marcus J. Schultz
    Keywords Emergency medicine ; Critical care medicine ; Anesthesiology ; Internal medicine ; Surgery ; Family medicine
    Subject code 616.025
    Language English
    Size 1 Online-Ressource (XV, 216 p. 8 illus., 6 illus. in color)
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT019993194
    ISBN 978-3-030-03143-5 ; 9783030031428 ; 9783030031442 ; 3-030-03143-8 ; 303003142X ; 3030031446
    DOI 10.1007/978-3-030-03143-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Prevalence and genetic diversity of simian malaria in wild macaque populations across Thailand: Implications for human health.

    Karnchaisri, Kriangkrai / Day, Nicholas P J / Dondorp, Arjen M / Malaivijitnond, Suchinda / Imwong, Mallika

    Acta tropica

    2024  Volume 254, Page(s) 107187

    Abstract: ... and between M. fascicularis subspecies, and the genetic composition of these pathogens. Blood samples ... were collected from 82 M. mulatta and 690 M. fascicularis across 15 locations in Thailand, as well ... malaria infection was observed exclusively in M. fascicularis and not in M. mulatta (P = 0.0002 ...

    Abstract Over the past year, P. falciparum infections have declined in Thailand, yet nonhuman primate malaria infections have correspondingly increased, including Plasmodium knowlesi and P. cynomolgi. Nevertheless, little is known about simian malaria in its natural macaque hosts, Macaca mulatta and Macaca fascicularis. This study aims to address several research questions, including the prevalence and distribution of simian malaria in these two Thai wild macaque species, variations in infection between different macaque species and between M. fascicularis subspecies, and the genetic composition of these pathogens. Blood samples were collected from 82 M. mulatta and 690 M. fascicularis across 15 locations in Thailand, as well as two locations in Vietnam and Myanmar. We employed quantitative real-time PCR targeting the Plasmodium genus-specific 18S ribosomal RNA (rRNA) gene to detect malaria infection, with a limit of detection set at 1,215.98 parasites per mL. We genotyped eight microsatellite markers, and the P. cynomolgi dihydrofolate reductase gene (DHFR) was sequenced (N = 29). In total, 100 of 772 samples (13 %) tested positive for malaria, including 45 (13 %) for P. cynomolgi, 37 (13 %) for P. inui, 16 (5 %) for P. coatneyi, and 2 (0.25 %) for Hepatocystis sp. in Saraburi, central and Ranong, southern Thailand. Notably, simian malaria infection was observed exclusively in M. fascicularis and not in M. mulatta (P = 0.0002). Particularly, P. cynomolgi was detected in 21.7 % (45/207) of M. f. fascicularis living in Wat Tham Phrapothisat, Saraburi Province. The infection with simian malaria was statistically different between M. fascicularis and M. mulatta (P = 0.0002) but not within M. fascicularis subspecies (P = 0.78). A haplotype network analysis revealed that P. cynomolgi shares a lineage with reference strains obtained from macaques. No mutation in the predicted binding pocket of PcyDHFR to pyrimethamine was observed. This study reveals a significant prevalence of simian malaria infection in M. fascicularis. The clonal genotypes of P. cynomolgi suggest in-reservoir breeding. These findings raise concerns about the potential spread of nonhuman primate malaria to humans and underscore the need for preventive measures.
    MeSH term(s) Animals ; Thailand/epidemiology ; Malaria/epidemiology ; Malaria/parasitology ; Malaria/veterinary ; Macaca fascicularis/parasitology ; Prevalence ; RNA, Ribosomal, 18S/genetics ; Genetic Variation ; Macaca mulatta/parasitology ; Genotype ; Microsatellite Repeats/genetics ; Monkey Diseases/parasitology ; Monkey Diseases/epidemiology ; Humans ; Myanmar/epidemiology ; Tetrahydrofolate Dehydrogenase/genetics ; Plasmodium knowlesi/genetics ; Plasmodium knowlesi/isolation & purification ; Plasmodium/genetics ; Plasmodium/classification ; Plasmodium/isolation & purification ; Vietnam/epidemiology ; DNA, Protozoan/genetics ; Plasmodium cynomolgi/genetics ; Plasmodium cynomolgi/classification ; Real-Time Polymerase Chain Reaction
    Chemical Substances RNA, Ribosomal, 18S ; Tetrahydrofolate Dehydrogenase (EC 1.5.1.3) ; DNA, Protozoan
    Language English
    Publishing date 2024-03-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 210415-5
    ISSN 1873-6254 ; 0001-706X
    ISSN (online) 1873-6254
    ISSN 0001-706X
    DOI 10.1016/j.actatropica.2024.107187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: WHO should accelerate, not stall, rectal artesunate deployment for pre-referral treatment of severe malaria.

    Peto, Thomas J / Watson, James A / White, Nicholas J / Dondorp, Arjen M

    Transactions of the Royal Society of Tropical Medicine and Hygiene

    2023  Volume 117, Issue 7, Page(s) 536–538

    Abstract: The recent World Health Organization moratorium on rectal artesunate (RAS) for pre-referral treatment of severe childhood malaria is costing young lives. The decision was based on disappointing findings from a large observational study that provided RAS ... ...

    Abstract The recent World Health Organization moratorium on rectal artesunate (RAS) for pre-referral treatment of severe childhood malaria is costing young lives. The decision was based on disappointing findings from a large observational study that provided RAS to community health workers with little training and supervision. This non-randomized, operational research has provided useful information to guide the implementation of RAS but is subject to bias and confounding and cannot be used to assess treatment effects. Parenteral artesunate reduces severe malaria mortality and a large body of evidence also shows RAS has lifesaving efficacy. There is now more than a decade of delay in conducting the necessary engagement and training required for successful deployment of RAS. Further delays will result in more preventable deaths.
    MeSH term(s) Humans ; Child ; Artesunate/therapeutic use ; Antimalarials/therapeutic use ; Artemisinins/therapeutic use ; Administration, Rectal ; Malaria/drug therapy ; Referral and Consultation ; World Health Organization
    Chemical Substances Artesunate (60W3249T9M) ; Antimalarials ; Artemisinins
    Language English
    Publishing date 2023-01-28
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 441375-1
    ISSN 1878-3503 ; 0035-9203
    ISSN (online) 1878-3503
    ISSN 0035-9203
    DOI 10.1093/trstmh/trad002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Early Lessons on the Importance of Lung Imaging in Novel Coronavirus Disease (COVID-19).

    Dondorp, Arjen M / Schultz, Marcus J

    The American journal of tropical medicine and hygiene

    2020  Volume 102, Issue 5, Page(s) 917–918

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Walking
    Keywords covid19
    Language English
    Publishing date 2020-04-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.20-0225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Comment on Weitzman et al. Resistance to Antimalarial Monotherapy Is Cyclic.

    van der Pluijm, Rob W / Visser, Benjamin J / Dondorp, Arjen M

    Journal of clinical medicine

    2022  Volume 11, Issue 10

    Abstract: Weitzman et al. used PubMed text mining to determine the trends of antimalarial resistance over the last 40 years [ ... ] ...

    Abstract Weitzman et al. used PubMed text mining to determine the trends of antimalarial resistance over the last 40 years [...]
    Language English
    Publishing date 2022-05-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11102934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: New genetic marker for piperaquine resistance in Plasmodium falciparum.

    Dondorp, Arjen M

    The Lancet. Infectious diseases

    2016  Volume 17, Issue 2, Page(s) 119–121

    MeSH term(s) Antimalarials ; Drug Resistance/drug effects ; Genetic Markers ; Humans ; Malaria, Falciparum ; Plasmodium falciparum/drug effects ; Quinolines
    Chemical Substances Antimalarials ; Genetic Markers ; Quinolines ; piperaquine (A0HV2Q956Y)
    Language English
    Publishing date 2016-11-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(16)30414-5
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    Zs.A 5743: Show issues Location:
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  8. Article ; Online: Going Micro in Leptospirosis Kidney Disease.

    Chancharoenthana, Wiwat / Leelahavanichkul, Asada / Schultz, Marcus J / Dondorp, Arjen M

    Cells

    2022  Volume 11, Issue 4

    Abstract: Leptospirosis is a zoonotic and waterborne disease worldwide. It is a neglected infectious disease caused ... ...

    Abstract Leptospirosis is a zoonotic and waterborne disease worldwide. It is a neglected infectious disease caused by
    MeSH term(s) Acute Kidney Injury ; Animals ; Kidney ; Leptospira ; Leptospirosis/diagnosis ; Renal Insufficiency, Chronic
    Language English
    Publishing date 2022-02-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11040698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Recommendations for the Management of COVID-19 in Low- and Middle-Income Countries.

    Dondorp, Arjen M / Papali, Alfred C / Schultz, Marcus J

    The American journal of tropical medicine and hygiene

    2021  Volume 104, Issue 3_Suppl, Page(s) 1–2

    MeSH term(s) COVID-19/epidemiology ; COVID-19/mortality ; COVID-19/prevention & control ; Developing Countries ; Disease Management ; Humans ; Income ; Practice Guidelines as Topic
    Language English
    Publishing date 2021-01-06
    Publishing country United States
    Document type Editorial
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.20-1597
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  10. Article ; Online: Falciparum malaria mortality in sub-Saharan Africa in the pretreatment era.

    Watson, James A / White, Nicholas J / Dondorp, Arjen M

    Trends in parasitology

    2021  Volume 38, Issue 1, Page(s) 11–14

    Abstract: Driven by the malaria-protective effect of sickle-cell trait, balancing selection results in hemoglobin S equilibrium allele frequencies of between 15% and 20% in areas of high Plasmodium falciparum transmission in sub-Saharan Africa. From this we ... ...

    Abstract Driven by the malaria-protective effect of sickle-cell trait, balancing selection results in hemoglobin S equilibrium allele frequencies of between 15% and 20% in areas of high Plasmodium falciparum transmission in sub-Saharan Africa. From this we estimate that the malaria-attributable childhood mortality in the pretreatment era was between 15% and 24%.
    MeSH term(s) Africa South of the Sahara/epidemiology ; Child ; Humans ; Malaria ; Malaria, Falciparum/epidemiology ; Malaria, Falciparum/prevention & control ; Plasmodium falciparum ; Sickle Cell Trait
    Language English
    Publishing date 2021-12-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2021.10.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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