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Book ; Online: Prosthetic Joint Infection: The Challenges of Prevention, Diagnosis and Treatment and Opportunities for Future Research

Benito, Natividad / Murillo, Óscar / Lora-Tamayo, Jaime

2023

Keywords	Medicine ; Epidemiology & medical statistics ; prosthetic joint infection ; arthroplasty infection ; prosthetic joint infection functional outcome ; prosthetic joint infection ambulatory outcome ; tedizolid ; prosthetic joint infections ; prolonged oral treatment ; tolerance ; compliance ; surgical antimicrobial prophylaxis ; knee arthroplasty ; hip arthroplasty ; surgical site infection prevention ; prosthetic joint infection prevention ; intraoperative cultures ; antibiotic levels ; serum bactericidal titer ; oxazolidinones ; osteoarticular infections ; diabetic foot infections ; drug-drug interaction ; Staphylococcus aureus ; implant removal ; outcome ; rifampin ; biofilm ; knee ; total knee arthroplasty ; infection ; intra-articular injection ; surgical site infection ; epidemiology ; risk factors ; multidrug-resistant Gram-negative bacteria ; extensively drug-resistant ; hematoma ; hip hemiarthroplasty ; proximal femur fracture ; antibiotic prophylaxis ; periprosthetic joint infection ; decolonization ; daptomycin ; eosinophilic pneumonia ; Candida spp. ; fungus ; antifungal-loaded cement spacer ; two-stage exchange surgery ; Cutibacterium acnes ; surgical and medical treatment ; dalbavancin ; gram-positive ; sol-gel ; anidulafungin ; Candida albicans ; suppressive antibiotic treatment ; prolonged antibiotic
Language	English
Size	1 electronic resource (184 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030374708
ISBN	9783036579368 ; 3036579362
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: The clinical meaning of biofilm formation ability: The importance of context.

Lora-Tamayo, Jaime / Meléndez-Carmona, Mª Ángeles

Enfermedades infecciosas y microbiologia clinica (English ed.)

2022 Volume 40, Issue 8, Page(s) 415–417

MeSH term(s)	Biofilms ; Terminology as Topic
Language	English
Publishing date	2022-09-10
Publishing country	Spain
Document type	Editorial ; Comment
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2022.02.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Appropriate Duration of Antimicrobial Treatment for Prosthetic Joint Infections: A Narrative Review.

Lora-Tamayo, Jaime / Mancheño-Losa, Mikel / Meléndez-Carmona, María Ángeles / Hernández-Jiménez, Pilar / Benito, Natividad / Murillo, Oscar

Antibiotics (Basel, Switzerland)

2024 Volume 13, Issue 4

Abstract: Prosthetic joint infections are considered difficult to treat they needing aggressive surgery and long antimicrobial treatments. However, the exact duration of these therapies has been established empirically. In the last years, several studies have ... ...

Abstract	Prosthetic joint infections are considered difficult to treat they needing aggressive surgery and long antimicrobial treatments. However, the exact duration of these therapies has been established empirically. In the last years, several studies have explored the possibility of reducing the length of treatment in this setting, with conflicting results. In this narrative review, we critically appraise the published evidence, considering the different surgical approaches (implant retention [DAIR] and one-step and two-step exchange procedures) separately. In patients managed with DAIR, usually treated for at least 12 weeks, a large, randomized trial failed to show that 6 weeks were non-inferior. However, another randomized clinical trial supports the use of 8 weeks, as long as the surgical conditions are favorable and antibiotics with good antibiofilm activity can be administered. In patients managed with a two-step exchange procedure, usually treated during 6 weeks, a randomized clinical trial showed the efficacy of a 4-week course of antimicrobials. Also, the use of local antibiotics may allow the use of even shorter treatments. Finally, in the case of one-step exchange procedures, there is a trend towards reducing the length of therapy, and the largest randomized clinical trial supports the use of 6 weeks of therapy.
Language	English
Publishing date	2024-03-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics13040293
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Article ; Online: Early switch from intravenous to oral antibiotic treatment in bone and joint infections.

Sendi, Parham / Lora-Tamayo, Jaime / Cortes-Penfield, Nicolas W / Uçkay, Ilker

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2023 Volume 29, Issue 9, Page(s) 1133–1138

Abstract: Objectives: The timing of the switch from intravenous (i.v.) to oral antibiotic therapy for orthopaedic bone and joint infections (BJIs) is debated. In this narrative article, we discuss the evidence for and against an early switch in BJIs.: Data ... ...

Abstract	Objectives: The timing of the switch from intravenous (i.v.) to oral antibiotic therapy for orthopaedic bone and joint infections (BJIs) is debated. In this narrative article, we discuss the evidence for and against an early switch in BJIs. Data sources: We performed a PubMed and internet search investigating the association between the duration of i.v. treatment for BJI and remission of infection among adult orthopaedic patients. Content: Among eight randomized controlled trials and multiple retrospective studies, we failed to find any minimal duration of postsurgical i.v. therapy associated with clinical outcomes. We did not find scientific data to support the prolonged use of i.v. therapy or to inform a minimal duration of i.v. Therapy: Growing evidence supports the safety of an early switch to oral medications once the patient is clinically stable. Implications: After surgery for BJI, a switch to oral antibiotics within a few days is reasonable in most cases. We recommend making the decision on the time point based on clinical criteria and in an interdisciplinary team at the bedside.
MeSH term(s)	Adult ; Humans ; Administration, Intravenous ; Administration, Oral ; Anti-Bacterial Agents/administration & dosage ; Retrospective Studies ; Randomized Controlled Trials as Topic
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-05-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2023.05.008
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Article ; Online: Antibiotic Use in Total Knee Arthroplasty Periprosthetic Joint Infection.

Wouthuyzen-Bakker, Marjan / Lora-Tamayo, Jaime / Soriano, Alex

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2020 Volume 70, Issue 6, Page(s) 1259–1260

MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Arthritis, Infectious/drug therapy ; Arthroplasty, Replacement, Knee/adverse effects ; Humans ; Knee Prosthesis/adverse effects ; Prosthesis-Related Infections/drug therapy ; Prosthesis-Related Infections/surgery
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2020-12-22
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciz631
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Article ; Online: What Is the Most Effective Treatment for Periprosthetic Joint Infection After Total Joint Arthroplasty in Patients with Rheumatoid Arthritis?: A Systematic Review.

Desai, Vineet / Farid, Alexander R / Liimakka, Adriana P / Lora-Tamayo, Jaime / Wouthuyzen-Bakker, Marjan / Kuiper, Jesse W P / Sandiford, Nemandra / Chen, Antonia F

JBJS reviews

2024 Volume 12, Issue 2

Abstract: Background: Rheumatoid arthritis (RA) is a risk factor for periprosthetic joint infection (PJI) after total joint arthroplasty (TJA). The purpose of this study was to perform a systematic review comparing the failure rates of debridement, antibiotics, ... ...

Abstract	Background: Rheumatoid arthritis (RA) is a risk factor for periprosthetic joint infection (PJI) after total joint arthroplasty (TJA). The purpose of this study was to perform a systematic review comparing the failure rates of debridement, antibiotics, and implant retention (DAIR), one-stage exchange arthroplasty/revision (OSR), and 2-stage exchange arthroplasty/revision (TSR) for RA patients with PJI and identify risk factors in the RA population associated with increased treatment failure rate. Methods: PubMed, Ovid MEDLINE, and Ovid Embase databases were screened with the terms "rheumatoid arthritis," "total joint arthroplasty," "prosthetic joint infection," and "treatment for PJI" on August 29, 2021. Four hundred ninety-one studies were screened, of which 86 were evaluated. The primary outcome evaluated was failure of surgical treatment for PJI. Results: Ten retrospective cohort studies were included after full-text screening, yielding 401 patients with RA. Additional demographic and PJI management data were obtained for 149 patients. Patients with RA who underwent TSR demonstrated a lower failure rate (26.8%) than both DAIR (60.1%) and OSR (39.2%) (χ2 = 37.463, p < 0.00001). Patients with RA who underwent DAIR had a 2.27 (95% CI, 1.66-3.10) times higher risk of experiencing treatment failure than those who underwent TSR. Among risk factors, there was a significant difference in the C-reactive protein of patients who did vs. did not experience treatment failure (p = 0.02). Conclusion: TSR has a higher rate of success in the management of PJI patients with RA compared with DAIR and OSR. The complete removal of the infected prosthesis and delayed reimplantation may lower the treatment failure rate. Level of evidence: Level III. See Instructions for Authors for a complete description of levels of evidence.
MeSH term(s)	Humans ; Retrospective Studies ; Prosthesis-Related Infections/etiology ; Prosthesis-Related Infections/surgery ; Debridement ; Anti-Bacterial Agents/therapeutic use ; Arthroplasty, Replacement, Knee/adverse effects ; Arthritis, Rheumatoid/surgery ; Arthritis, Rheumatoid/drug therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Systematic Review ; Journal Article
ISSN	2329-9185
ISSN (online)	2329-9185
DOI	e23.00124
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of a Hospitalist Co-Management Program on Medical Complications and Length of Stay in Neurosurgical Patients.

Marchán-López, Álvaro / Lora-Tamayo, Jaime / de la Calle, Cristina / Jiménez Roldán, Luis / Moreno Gómez, Luis Miguel / Sáez de la Fuente, Ignacio / Chico Fernández, Mario / Lagares, Alfonso / Lumbreras, Carlos / García Reyne, Ana

Joint Commission journal on quality and patient safety

2024 Volume 50, Issue 5, Page(s) 318–325

Abstract: Background: The impact of co-management on clinical outcomes in neurosurgical patients is uncertain. This study aims to describe the implementation of a hospitalist co-management program in a neurosurgery department and its impact on the incidence of ... ...

Abstract	Background: The impact of co-management on clinical outcomes in neurosurgical patients is uncertain. This study aims to describe the implementation of a hospitalist co-management program in a neurosurgery department and its impact on the incidence of complications, mortality, and length of stay. Methods: The authors used a quasi-experimental study design that compared a historical control period (July-December 2017) to a prospective intervention arm. During the intervention period, patients admitted to a neurosurgery inpatient unit who were older than 65 years, suffered certain conditions, or were admitted from ICUs were included in the co-management program. Two hospitalists joined the surgical staff and intervened in the diagnostic and therapeutical plan of patients, participating in clinical decisions and coordinating patient navigation with neurosurgeons. The incidence of moderate or severe complications measured by the Accordion Severity Grading System, in-hospital mortality, and length of stay of the two cohorts were compared. Multivariate regression was used to adjust for confounders, and the average treatment effect was estimated using inverse probability of treatment weighting. Results: The adjusted incidence of moderate or severe complications was lower among co-managed patients (odds ratio [OR] 0.60, 95% confidence interval [CI] 0.39-0.91). Mortality was unchanged (OR 0.83, 95% CI 0.15-4.17). Length of stay was lower in co-managed patients, with a 1.3-day reduction observed after inverse probability of treatment weighting analysis. Conclusion: Hospitalist co-management was associated with a reduced incidence of complications and length of stay in neurosurgical patients, but there was no difference in in-hospital mortality.
MeSH term(s)	Humans ; Length of Stay/statistics & numerical data ; Hospitalists ; Female ; Male ; Aged ; Hospital Mortality ; Neurosurgical Procedures ; Postoperative Complications/epidemiology ; Middle Aged ; Prospective Studies ; Incidence
Language	English
Publishing date	2024-01-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1189890-2
ISSN	1938-131X ; 1549-425X ; 1553-7250 ; 1070-3241 ; 1549-3741
ISSN (online)	1938-131X ; 1549-425X
ISSN	1553-7250 ; 1070-3241 ; 1549-3741
DOI	10.1016/j.jcjq.2024.01.003
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Article: Clinical Use of Colistin in Biofilm-Associated Infections.

Lora-Tamayo, Jaime / Murillo, Oscar / Ariza, Javier

Advances in experimental medicine and biology

2019 Volume 1145, Page(s) 181–195

Abstract: Biofilm is an adaptive bacterial strategy whereby microorganisms become encased in a complex glycoproteic matrix. The low concentration of oxygen and nutrients in this environment leads to heterogeneous phenotypic changes in the bacteria, with ... ...

Abstract	Biofilm is an adaptive bacterial strategy whereby microorganisms become encased in a complex glycoproteic matrix. The low concentration of oxygen and nutrients in this environment leads to heterogeneous phenotypic changes in the bacteria, with antimicrobial tolerance being of paramount importance. As with other antibiotics, the activity of colistin is impaired by biofilm-embedded bacteria. Therefore, the recommendation for administering high doses in combination with a second drug, indicated for planktonic infections, remains valid in this setting. Notably, colistin has activity against metabolically inactive biofilm-embedded cells located in the inner layers of the biofilm structure. This is opposite and complementary to the activity of other antimicrobials that are able to kill metabolically active cells in the outer layers of the biofilm. Several experimental models have shown a higher activity of colistin when used in combination with other agents, and have reported that this can avoid the emergence of colistin-resistant subpopulations. Most experience of colistin in biofilm-associated infections comes from patients with cystic fibrosis, where the use of nebulized colistin allows high concentrations to reach the site of the infection. However, limited clinical experience is available in other scenarios, such as osteoarticular infections or device-related central nervous system infections caused by multi-drug resistant microorganisms. In the latter scenario, the use of intraventricular or intrathecal colistin also permits high local concentrations and good clinical results. Overall, the efficacy of intravenous colistin seems to be poor, but its association with a second antimicrobial significantly increases the response rate. Given its activity against inner bioflm-embedded cells, its possible role in combination with other antibiotics, beyond last-line therapy situations, should be further explored.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Biofilms/drug effects ; Bone Diseases, Infectious/drug therapy ; Central Nervous System Infections/drug therapy ; Colistin/therapeutic use ; Cystic Fibrosis/microbiology ; Drug Resistance, Multiple, Bacterial ; Humans ; Microbial Sensitivity Tests
Chemical Substances	Anti-Bacterial Agents ; Colistin (Z67X93HJG1)
Language	English
Publishing date	2019-07-30
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-16373-0_13
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Editorial Commentary: Pyogenic Vertebral Osteomyelitis and Antimicrobial Therapy: It's Not Just the Length, but Also the Choice.

Murillo, Oscar / Lora-Tamayo, Jaime

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2016 Volume 62, Issue 10, Page(s) 1270–1271

MeSH term(s)	Anti-Bacterial Agents ; Anti-Infective Agents ; Drug Therapy, Combination ; Humans ; Microbial Sensitivity Tests ; Osteomyelitis ; Rifampin ; Staphylococcal Infections ; Staphylococcus aureus ; Vancomycin
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Vancomycin (6Q205EH1VU) ; Rifampin (VJT6J7R4TR)
Language	English
Publishing date	2016--15
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciw100
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Article: Dalbavancin for the Treatment of Prosthetic Joint Infections: A Narrative Review.

Buzón-Martín, Luis / Zollner-Schwetz, I / Tobudic, Selma / Cercenado, Emilia / Lora-Tamayo, Jaime

Antibiotics (Basel, Switzerland)

2021 Volume 10, Issue 6

Abstract: Dalbavancin (DAL) is a lipoglycopeptide with bactericidal activity against a very wide range of Gram-positive microorganisms. It also has unique pharmacokinetic properties, namely a prolonged half-life (around 181 h), which allows a convenient weekly ... ...

Abstract	Dalbavancin (DAL) is a lipoglycopeptide with bactericidal activity against a very wide range of Gram-positive microorganisms. It also has unique pharmacokinetic properties, namely a prolonged half-life (around 181 h), which allows a convenient weekly dosing regimen, and good diffusion in bone tissue. These features have led to off-label use of dalbavancin in the setting of bone and joint infection, including prosthetic joint infections (PJI). In this narrative review, we go over the pharmacokinetic and pharmacodynamic characteristics of DAL, along with published in vitro and in vivo experimental models evaluating its activity against biofilm-embedded bacteria. We also examine published experience of osteoarticular infection with special attention to DAL and PJI.
Language	English
Publishing date	2021-05-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics10060656
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