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Article ; Online: S

Elphinstone, Robyn E / Besla, Rickvinder / Shikatani, Eric A / Lu, Ziyue / Hausladen, Alfred / Davies, Matthew / Robbins, Clinton S / Husain, Mansoor / Stamler, Jonathan S / Kain, Kevin C

Infection and immunity

2017 Volume 85, Issue 9

Abstract: Artesunate remains the mainstay of treatment for cerebral malaria, but it is less effective in later stages of disease when the host inflammatory response and blood-brain barrier integrity dictate clinical outcomes. Nitric oxide (NO) is an important ... ...

Abstract	Artesunate remains the mainstay of treatment for cerebral malaria, but it is less effective in later stages of disease when the host inflammatory response and blood-brain barrier integrity dictate clinical outcomes. Nitric oxide (NO) is an important regulator of inflammation and microvascular integrity, and impaired NO bioactivity is associated with fatal outcomes in malaria. Endogenous NO bioactivity in mammals is largely mediated by
MeSH term(s)	Alcohol Dehydrogenase/deficiency ; Animals ; Antimalarials/administration & dosage ; Artemisinins/administration & dosage ; Disease Models, Animal ; Female ; Malaria, Cerebral/drug therapy ; Malaria, Cerebral/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Nitric Oxide/metabolism ; Plasmodium berghei/pathogenicity ; Survival Analysis ; T-Lymphocytes/immunology ; Treatment Outcome
Chemical Substances	Antimalarials ; Artemisinins ; Nitric Oxide (31C4KY9ESH) ; artesunate (60W3249T9M) ; Adh5 protein, mouse (EC 1.1.1.1) ; Alcohol Dehydrogenase (EC 1.1.1.1)
Language	English
Publishing date	2017-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
DOI	10.1128/IAI.00371-17
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Article ; Online: Development of Synergy-Based Combination of Methanolic Extract of Andrographis paniculata and Berberis aristata Against E. coli and S. aureus.

Abass, Sageer / Zahiruddin, Sultan / Ali, Asghar / Irfan, Mohammad / Jan, Bisma / Haq, Qazi Mohd Rizwanul / Husain, Syed Akhtar / Ahmad, Sayeed

Current microbiology

2022 Volume 79, Issue 8, Page(s) 223

Abstract: This study evaluates the antibacterial activity and phytochemical characterizations of Andrographis paniculata extract (APE) and Berberis aristata extract (BAE). The stem of Andrographis paniculata (AP) and root of Berberis aristata (BA) were extracted ... ...

Abstract	This study evaluates the antibacterial activity and phytochemical characterizations of Andrographis paniculata extract (APE) and Berberis aristata extract (BAE). The stem of Andrographis paniculata (AP) and root of Berberis aristata (BA) were extracted with methanol. The results confirmed that APE and BAE possess high phenolic and flavonoid content. The antioxidant activity of the APE and BAE showed an elevated potential to scavenge DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals with IC
MeSH term(s)	Andrographis paniculata ; Anti-Bacterial Agents/pharmacology ; Berberis/chemistry ; Escherichia coli ; Methanol ; Methicillin-Resistant Staphylococcus aureus ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Staphylococcus aureus
Chemical Substances	Anti-Bacterial Agents ; Plant Extracts ; Methanol (Y4S76JWI15)
Language	English
Publishing date	2022-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-022-02911-8
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Article ; Online: Variations in deceased donor kidney procurement biopsy practice patterns: A survey of U.S. organ procurement organizations.

Emmons, Brendan R / Husain, S Ali / King, Kristen L / Adler, Joel T / Mohan, Sumit

Clinical transplantation

2021 Volume 35, Issue 9, Page(s) e14411

Abstract: Background: Procurement biopsies have become a common practice in the evaluation and allocation of deceased donor kidneys in the United States despite questions about their value and reproducibility. We sought to determine the extent of OPO-level ... ...

Abstract	Background: Procurement biopsies have become a common practice in the evaluation and allocation of deceased donor kidneys in the United States despite questions about their value and reproducibility. We sought to determine the extent of OPO-level differences in criteria used to decide which deceased donor kidneys undergo a procurement biopsy and to assess the degree of variability in procurement biopsy technique and interpretation across OPOs. Methods: Each of the country's 58 OPOs were invited to participate in the survey. OPOs were divided into two groups based on organ availability ratio and deceased donor kidney discard rate. Results and conclusions: Fifty-out-of-fifty-eight invited OPOs (86% response rate) responded to the survey between November 2020 and December 2020. Thirty (60%) OPOs reported that they have formal criteria for performing kidney procurement biopsy, but for 29 of these OPOs, transplant centers can request biopsy on kidneys that do not meet criteria. OPOs used a total of seven different variables and 12 different numerical thresholds to define impaired kidney function that would prompt a procurement biopsy. Additionally, wide variability was seen in biopsy technique and procedures for biopsy interpretation and reporting of findings to transplant programs. These findings identify a clear opportunity for standardization of procurement biopsies to best practices.
MeSH term(s)	Biopsy ; Humans ; Kidney ; Reproducibility of Results ; Tissue Donors ; Tissue and Organ Procurement ; United States
Language	English
Publishing date	2021-07-14
Publishing country	Denmark
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.14411
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Article ; Online: Ewing’s sarcoma of the right kidney with multiple metastasis on PET/CT

Man Mohan Singh / Shashwat Verma / Lavish Kakkar / Satyawati Deswal / Nuzhat Husain

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 54, Iss 1, Pp 1-

2023 Volume 5

Abstract: Abstract Background Ewing’s sarcoma is categorized as small round cell aggressive tumor ... which commonly occurs in bone and soft tissue. Primary renal Ewing’s sarcoma is an extremely rare entity and ... few reported cases in the literature. Primary renal Ewing’s sarcoma is indistinguishable ...

Abstract	Abstract Background Ewing’s sarcoma is categorized as small round cell aggressive tumor which commonly occurs in bone and soft tissue. Primary renal Ewing’s sarcoma is an extremely rare entity and accounts for less than 1% of renal masses. It is characterized by a very aggressive course, with very few reported cases in the literature. Primary renal Ewing’s sarcoma is indistinguishable from renal cell carcinoma on anatomical imaging and therefore need histopathological correlation for confirmation. The positron emission tomography (PET) fused with computed tomography (CT) helps in the evaluation of disease, for staging and metastatic workup. Case presentation We present a case of 48-year-old lady who presented to urology department with difficulty in passing urine for 5 months associated with pain in the right flank region. She had an episode of haematuria 5 months back. Contrast enhanced CT showed a large lobulated heterogeneously enhancing right retroperitoneal mass in renal fossa. Histopathological examination and immunohistochemistry were suggestive of Ewing’s sarcoma. The PET/CT revealed FDG avid right renal mass with lymph nodal and skeletal metastasis. Conclusions Ewing’s sarcoma being aggressive tumour usually present with bone, liver and lung metastasis along with lymph nodal metastasis at time of diagnosis. The 18 F FDG PET/CT helps in diagnosis, staging, appropriate treatment planning, restaging, response evaluation and prognostication of Ewing’s sarcoma.
Keywords	Ewing’s sarcoma ; 18F FDG PET CT ; Renal mass ; Retroperitoneal mass ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	616
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article ; Online: China’s long march to malaria elimination

Duo-quan Wang / Xiao-hui Liang / Shen-ning Lu / Wei Ding / Jing Huang / Xin Wen / Shan Lv / Ning Xiao / Lewis Husain / Xiao-Nong Zhou

Malaria Journal, Vol 21, Iss 1, Pp 1-

a case of adaptive management

2022 Volume 4

Abstract: ... approach to understanding China’s malaria elimination journey. A number of articles and commentaries have ...

Abstract	Abstract Since the 1950s, China has transitioned from a malaria pandemic country with tens of millions of annual cases, through phases of local control and elimination, to sustained national malaria elimination efforts. This marks the first time a country in the World Health Organization (WHO) Western Pacific region has been certified malaria-free in more than 3 decades. This article provides an innovative approach to understanding China’s malaria elimination journey. A number of articles and commentaries have analysed the effectiveness of specific technical approaches implemented in China. Our argument is that we need to look beyond these, and consider the ways in which policy development and implementation capacities have been fostered to support the dynamic change management. The article makes a number of arguments. First is the pragmatic adaptiveness of policies and strategies—and implementation capacities. Second, China has invested in building systems as well as capacities to support the elimination of parasitic diseases, including malaria. Third, the country has both benefited from, and contributed to, global health collaboration on malaria elimination. The ongoing work by the authors is identifying a number of key factors.
Keywords	China ; Malaria elimination ; Adaptive ; Global health ; Arctic medicine. Tropical medicine ; RC955-962 ; Infectious and parasitic diseases ; RC109-216
Subject code	950
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Structural interactions of phytoconstituent(s) from cinnamon, bay leaf, oregano, and parsley with SARS-CoV-2 nucleocapsid protein: A comparative assessment for development of potential antiviral nutraceuticals.

Husain, Ishrat / Ahmad, Rumana / Siddiqui, Sahabjada / Chandra, Anu / Misra, Aparna / Srivastava, Aditi / Ahamad, Tanveer / Khan, Mohd Faheem / Siddiqi, Zeba / Trivedi, Anchal / Upadhyay, Shivbrat / Gupta, Anamika / Srivastava, Anand N / Ahmad, Bilal / Mehrotra, Sudhir / Kant, Surya / Mahdi, Abbas Ali / Mahdi, Farzana

Journal of food biochemistry

2022 Volume 46, Issue 10, Page(s) e14262

Abstract: ... safety. Ten major bioactive compounds were identified in ethanolic extract (s) of Cinnamomum zeylanicum ... APPLICATIONS: Ten major bioactive compounds were identified in the extract(s) of four medicinally important ... Interestingly, while all extract(s) wielded significant cytotoxicity against cancer cells, no significant ...

Abstract	SARS-CoV-2 has been responsible for causing 6,218,308 deaths globally till date and has garnered worldwide attention. The lack of effective preventive and therapeutic drugs against SARS-CoV-2 has further worsened the scenario and has bolstered research in the area. The N-terminal and C-terminal RNA binding domains (NTD and CTD) of SARS-CoV-2 nucleocapsid protein represent attractive therapeutic drug targets. Naturally occurring compounds are an excellent source of novel drug candidates due to their structural diversity and safety. Ten major bioactive compounds were identified in ethanolic extract (s) of Cinnamomum zeylanicum, Cinnamomum tamala, Origanum vulgare, and Petroselinum crispum using HPLC and their cytotoxic potential was determined against cancer and normal cell lines by MTT assay to ascertain their biological activity in vitro. To evaluate their antiviral potential, the binding efficacy to NTD and CTD of SARS-CoV-2 nucleocapsid protein was determined using in silico biology tools. In silico assessment of the phytocomponents revealed that most of the phytoconstituents displayed a druglike character with no predicted toxicity. Binding affinities were in the order apigenin > catechin > apiin toward SARS-CoV-2 nucleocapsid NTD. Toward nucleocapsid CTD, the affinity decreased as apigenin > cinnamic acid > catechin. Remdesivir displayed lesser affinity with NTD and CTD of SARS-CoV-2 nucleocapsid proteins than any of the studied phytoconstituents. Molecular dynamics (MD) simulation results revealed that throughout the 100 ns simulation, SARS-CoV-2 nucleocapsid protein NTD-apigenin complex displayed greater stability than SARS-CoV-2 nucleocapsid protein NTD-cinnamic acid complex. Hence, apigenin, catechin, apiin and cinnamic acid might prove as effective prophylactic and therapeutic candidates against SARS-CoV-2, if examined further in vitro and in vivo. PRACTICAL APPLICATIONS: Ten major bioactive compounds were identified in the extract(s) of four medicinally important plants viz. Cinnamomum zeylanicum, Cinnamomum tamala, Origanum vulgare and Petroselinum crispum using HPLC and their biological activity was also evaluated against cancer and normal cell lines. Interestingly, while all extract(s) wielded significant cytotoxicity against cancer cells, no significant toxicity was found against normal cells. The outcome of the results prompted evaluation of the antiviral potential of the ten bioactive compounds using in silico biology tools. The present study emphasizes on the application of computational approaches to understand the binding interaction and efficacy of the ten bioactive compounds from the above plants with SARS-CoV-2 nucleocapsid protein N-terminal and C-terminal RNA binding domains in preventing and/or treating COVID-19 using in silico tools. Druglikeness and toxicity profiles of the compounds were carried out to check the therapeutic application of the components. Additionally, molecular dynamics (MD) simulation was performed to check the stability of ligand-protein complexes. The results provided useful insights into the structural binding interaction(s) that can be exploited for the further development of potential antiviral agents targeting SARS-CoV-2 especially since no specific therapy is still available to combat the rapidly evolving virus and the existing treatment is more or less symptomatic which makes search for novel antiviral agents all the more necessary and crucial.
MeSH term(s)	Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Apigenin ; COVID-19/drug therapy ; Catechin ; Cinnamates ; Cinnamomum zeylanicum/metabolism ; Dietary Supplements ; Laurus/metabolism ; Ligands ; Origanum ; Petroselinum/metabolism ; SARS-CoV-2
Chemical Substances	Antiviral Agents ; Cinnamates ; Ligands ; cinnamic acid (140-10-3) ; Apigenin (7V515PI7F6) ; Catechin (8R1V1STN48)
Language	English
Publishing date	2022-07-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.14262
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Article ; Online: Predicting the success of the government’s program of lomaya (Regional PKH) in reducing poverty

Ruhmi Sulaehani / Marniyati Husain Botutihe

Ilkom Jurnal Ilmiah, Vol 14, Iss 3, Pp 323-

2022 Volume 328

Abstract: Poverty reduction is one indicator of the success of development. The form of support from the Pohuwato Regency Government through the Social Service is to organize PKH-D, which is known as LOMAYA. It is one of the implementations of the Community ... ...

Abstract	Poverty reduction is one indicator of the success of development. The form of support from the Pohuwato Regency Government through the Social Service is to organize PKH-D, which is known as LOMAYA. It is one of the implementations of the Community Movement Towards Independent Prosperity (Gerakan Masyarakat Menuju Sejahtera Mandiri). This research was conducted to assist the government in predicting the level of development success indicated by the satisfaction of beneficiaries of lomaya. The method employed was the Naïve Bayes method and forward feature selection. The research data was obtained from a survey of lomaya beneficiaries in the last two years. The accuracy result obtained using the Naïve Bayes algorithm was 94.19%, while Naïve Bayes with the Forward Selection feature was only 94.03%. Therefore, the Naïve Bayes algorithm method is better than the Forward Selection based Naïve Bayes algorithm. Forward selection does not improve accuracy because the selection process causes many attributes to be discarded because they are considered irrelevant. This happened because of the inaccuracy of the data after being selected for its attributes using the Forward Selection feature resulting 1 attribute only as a determinant.
Keywords	Electronic computers. Computer science ; QA75.5-76.95
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Fakultas Ilmu Komputer UMI
Document type	Article ; Online
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Article ; Online: COVID-19 Incidence and Mortality Among Unvaccinated and Vaccinated Persons Aged ≥12 Years by Receipt of Bivalent Booster Doses and Time Since Vaccination - 24 U.S. Jurisdictions, October 3, 2021-December 24, 2022.

Johnson, Amelia G / Linde, Lauren / Ali, Akilah R / DeSantis, Allison / Shi, Minchan / Adam, Carolyn / Armstrong, Brandy / Armstrong, Brett / Asbell, Madison / Auche, Steven / Bayoumi, Nagla S / Bingay, Boudu / Chasse, Melisse / Christofferson, Scott / Cima, Michael / Cueto, Kevin / Cunningham, Spencer / Delgadillo, Janelle / Dorabawila, Vajeera /

Drenzek, Cherie / Dupervil, Brandi / Durant, Tonji / Fleischauer, Aaron / Hamilton, Ross / Harrington, Pauline / Hicks, Liam / Hodis, Jeffrey D / Hoefer, Dina / Horrocks, Sam / Hoskins, Mikhail / Husain, Sofia / Ingram, L Amanda / Jara, Amanda / Jones, Amanda / Kanishka, F N U / Kaur, Ramandeep / Khan, Saadiah I / Kirkendall, Samantha / Lauro, Priscilla / Lyons, Shelby / Mansfield, Joshua / Markelz, Amanda / Masarik, John / McCormick, Donald / Mendoza, Erica / Morris, Keeley J / Omoike, Enaholo / Patel, Komal / Pike, Melissa A / Pilishvili, Tamara / Praetorius, Kevin / Reed, Isaiah G / Severson, Rachel L / Sigalo, Nekabari / Stanislawski, Emma / Stich, Sarah / Tilakaratne, Buddhi P / Turner, Kathryn A / Wiedeman, Caleb / Zaldivar, Allison / Silk, Benjamin J / Scobie, Heather M

MMWR. Morbidity and mortality weekly report

2023 Volume 72, Issue 6, Page(s) 145–152

Abstract: On September 1, 2022, CDC recommended an updated (bivalent) COVID-19 vaccine booster to help restore waning protection conferred by previous vaccination and broaden protection against emerging variants for persons aged ≥12 years (subsequently extended to ...

Abstract	On September 1, 2022, CDC recommended an updated (bivalent) COVID-19 vaccine booster to help restore waning protection conferred by previous vaccination and broaden protection against emerging variants for persons aged ≥12 years (subsequently extended to persons aged ≥6 months).* To assess the impact of original (monovalent) COVID-19 vaccines and bivalent boosters, case and mortality rate ratios (RRs) were estimated comparing unvaccinated and vaccinated persons aged ≥12 years by overall receipt of and by time since booster vaccination (monovalent or bivalent) during Delta variant and Omicron sublineage (BA.1, BA.2, early BA.4/BA.5, and late BA.4/BA.5) predominance.
MeSH term(s)	Humans ; Aged ; COVID-19 Vaccines ; COVID-19/epidemiology ; COVID-19/prevention & control ; Incidence ; SARS-CoV-2 ; Vaccination
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	412775-4
ISSN	1545-861X ; 0149-2195
ISSN (online)	1545-861X
ISSN	0149-2195
DOI	10.15585/mmwr.mm7206a3
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Article: Development of Synergy-Based Combination of Methanolic Extract of Andrographis paniculata and Berberis aristata Against E. coli and S. aureus

Abass, Sageer / Zahiruddin, Sultan / Ali, Asghar / Irfan, Mohammad / Jan, Bisma / Haq, Qazi Mohd Rizwanul / Husain, Syed Akhtar / Ahmad, Sayeed

Current microbiology. 2022 Aug., v. 79, no. 8

2022

Abstract: ... the findings showed that APE and BAE had antibacterial activities against E. coli and S. aureus. The growth ... of antibacterial compounds and can be used for treating infectious diseases caused by E. coli and S. aureus. ...

Abstract	This study evaluates the antibacterial activity and phytochemical characterizations of Andrographis paniculata extract (APE) and Berberis aristata extract (BAE). The stem of Andrographis paniculata (AP) and root of Berberis aristata (BA) were extracted with methanol. The results confirmed that APE and BAE possess high phenolic and flavonoid content. The antioxidant activity of the APE and BAE showed an elevated potential to scavenge DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals with IC₅₀ of 95.03 μg/mL and 256.26 μg/mL, respectively. A total of 35 and 32 metabolites in APE and BAE, respectively, were identified through mass spectrometry analysis, whereas 17 and 12 metabolites in APE and BAE, respectively, were detected through high-performance thin-layer chromatography (HPTLC) fingerprinting profiling. Antibacterial activity of the extracts was performed by the well diffusion and microdilution method, and the findings showed that APE and BAE had antibacterial activities against E. coli and S. aureus. The growth curve and time-kill study showed that the extracts had a bacteriostatic effect. A combination study with the standard drug was carried out using the microdilution checkerboard method in which most of the combinations showed synergistic interactions. The findings of this study have shown that APE and BAE are good sources of antibacterial compounds and can be used for treating infectious diseases caused by E. coli and S. aureus.
Keywords	2,2-diphenyl-1-picrylhydrazyl ; Andrographis paniculata ; Berberis aristata ; Escherichia coli ; antibacterial properties ; antioxidant activity ; drugs ; flavonoids ; growth curves ; mass spectrometry ; metabolites ; methanol ; microbiology ; thin layer chromatography
Language	English
Dates of publication	2022-08
Size	p. 223.
Publishing place	Springer US
Document type	Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-022-02911-8
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Article ; Online: An Investigation of Levetiracetam in Alzheimer’s Disease (ILiAD)

Arjune Sen / Mary Akinola / Xin You Tai / Mkael Symmonds / Gabriel Davis Jones / Sergio Mura / Joanne Galloway / Angela Hallam / Jane Y. C. Chan / Ivan Koychev / Chris Butler / John Geddes / Rohan Van Der Putt / Sian Thompson / Sanjay G. Manohar / Eleni Frangou / Sharon Love / Rupert McShane / Masud Husain

Trials, Vol 22, Iss 1, Pp 1-

a double-blind, placebo-controlled, randomised crossover proof of concept study

2021 Volume 17

Abstract: Abstract Background Although Alzheimer’s disease affects around 800,000 people in the UK and costs ... which are more common in patients with Alzheimer’s disease than age matched controls, may contribute ... of Alzheimer’s disease. Levetiracetam has also been shown to improve memory difficulties in patients ...

Abstract	Abstract Background Although Alzheimer’s disease affects around 800,000 people in the UK and costs almost £23 billion per year, currently licenced treatments only offer modest benefit at best. Seizures, which are more common in patients with Alzheimer’s disease than age matched controls, may contribute to the loss of nerve cells and abnormal brain discharges can disrupt cognition. This aberrant electrical activity may therefore present potentially important drug targets. The anti-seizure medication levetiracetam can reduce abnormal cortical discharges and reverse memory deficits in a mouse model of Alzheimer’s disease. Levetiracetam has also been shown to improve memory difficulties in patients with mild cognitive impairment, a precursor to Alzheimer’s disease. Clinical use of levetiracetam is well-established in treatment of epilepsy and extensive safety data are available. Levetiracetam thus has the potential to provide safe and efficacious treatment to help with memory difficulties in Alzheimer’s disease. Methods The proposed project is a proof of concept study to test whether levetiracetam can help cognitive function in people with dementia. We plan to recruit thirty patients with mild to moderate Alzheimer’s disease with no history of previous seizures or other significant co-morbidity. Participants will be allocated to a double-blind placebo-controlled crossover trial that tests levetiracetam against placebo. Standardised scales to assess cognition and a computer-based touchscreen test that we have developed to better detect subtle improvements in hippocampal function will be used to measure changes in memory. All participants will have an electroencephalogram (EEG) at baseline. The primary outcome measure is a change in the computer-based touchscreen cognitive task while secondary outcomes include the effect of levetiracetam on mood, quality of life and modelling of the EEG, including time series measures and feature-based analysis to see whether the effect of levetiracetam can be predicted. The effect of ...
Keywords	Anti-seizure medication ; Cognition ; Dementia ; Epilepsy ; Levetiracetam ; Randomised controlled trial ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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