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Article ; Online: Utilizing a Combination of Network Pharmacology and Experimental Validation to Unravel the Mechanism by Which Kuanxiongzhuyu Decoction Ameliorates Myocardial Infarction Damage.

Wu, Yihao / Li, Miaofu / Chen, Liuying / Xu, Linhao / Xu, Yizhou / Zhong, Yigang

2023 Volume 59, Issue 10

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Humans ; Animals ; Mice ; Network Pharmacology ; Molecular Docking Simulation ; Proto-Oncogene Proteins c-akt ; Myocardial Infarction/complications ; Myocardial Infarction/drug therapy ; Cardiac Rehabilitation
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2023-09-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59101740
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Article ; Online: Adaptive fixed-time output synchronization for complex dynamical networks with multi-weights.

Cao, Yuting / Zhao, Linhao / Zhong, Qishui / Wen, Shiping / Shi, Kaibo / Xiao, Jianying / Huang, Tingwen

Neural networks : the official journal of the International Neural Network Society

2023 Volume 163, Page(s) 28–39

Abstract: This paper addresses fixed-time output synchronization problems for two types of complex dynamical networks with multi-weights (CDNMWs) by using two types of adaptive control methods. Firstly, complex dynamical networks with multiple state and output ... ...

Abstract	This paper addresses fixed-time output synchronization problems for two types of complex dynamical networks with multi-weights (CDNMWs) by using two types of adaptive control methods. Firstly, complex dynamical networks with multiple state and output couplings are respectively presented. Secondly, several fixed-time output synchronization criteria for these two networks are formulated based on Lyapunov functional and inequality techniques. Thirdly, by employing two types of adaptive control methods, fixed-time output synchronization issues of these two networks are dealt with. At last, the analytical results are verified by two numerical simulations.
MeSH term(s)	Neural Networks, Computer ; Algorithms ; Time Factors
Language	English
Publishing date	2023-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	740542-x
ISSN	1879-2782 ; 0893-6080
ISSN (online)	1879-2782
ISSN	0893-6080
DOI	10.1016/j.neunet.2023.03.032
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Article: Future changes in drought over Central Asia under CMIP6 forcing scenarios

Hua, Lijuan / Zhao, Tianbao / Zhong, Linhao

Journal of hydrology. 2022 Oct., v. 43

2022

Abstract: Study region: Central Asia. Study focus: The possible future changes in meteorological, hydrological and agricultural drought in Central Asia are analyzed based on the multi-model projections from phase 6 of the Coupled Model Intercomparison Project ( ... ...

Abstract	Study region: Central Asia. Study focus: The possible future changes in meteorological, hydrological and agricultural drought in Central Asia are analyzed based on the multi-model projections from phase 6 of the Coupled Model Intercomparison Project (CMIP6). The changes in hydroclimate variables and drought events are examined to reveal the responses to different emissions pathway by comparing the historical period (1995–2014) and future period (2081–2100). New hydrological insights for the region: Corresponding to the spatially consistent warming in Central Asia, an asymmetrical west–east-orientated dipole precipitation pattern, i.e., a decrease in the west but an increase in the east, is found in the warm-season (April to September) precipitation of future projections. A similar but even stronger west–east or northwest–southeast contrast is found in the changes in total runoff and surface soil moisture in response to future warming. Most of Central Asia shows an increase in drought frequency and duration by the end of the current century, mainly caused by the consistently enhanced evaporation that roughly balances the precipitation growth after 2030. When the effect of temperature is considered, the drought area of Central Asia displays a significant upward trend under both the moderate and high emissions pathway. However, in the east of the region, including Northwest China and western Mongolia, warming and wetting tendencies under the future warming climate are apparent, regardless of the drought definition.
Keywords	climate ; drought ; evaporation ; models ; runoff ; soil water ; temperature ; warm season ; Central Asia ; China ; Mongolia
Language	English
Dates of publication	2022-10
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2814784-4
ISSN	2214-5818
ISSN	2214-5818
DOI	10.1016/j.ejrh.2022.101191
Database	NAL-Catalogue (AGRICOLA)

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Article: Beneficial Effects of

Du, Liyu / Chen, Weizhe / Wang, Jie / Huang, Lingzhu / Zheng, Qikai / Chen, Junjie / Wang, Linhao / Cai, Changyu / Zhang, Xiangbin / Wang, Li / Zhong, Qingping / Zhong, Wujie / Fang, Xiang / Liao, Zhenlin

Microorganisms

2023 Volume 11, Issue 7

Abstract: This study investigated the effects of dietary supplementation ... ...

Abstract	This study investigated the effects of dietary supplementation with
Language	English
Publishing date	2023-06-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11071660
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Article ; Online: Brain Iron Metabolism, Redox Balance and Neurological Diseases

Gao, Guofen / You, Linhao / Zhang, Jianhua / Chang, Yan-Zhong / Yu, Peng

Antioxidants. 2023 June 16, v. 12, no. 6

2023

Abstract: The incidence of neurological diseases, such as Parkinson’s disease, Alzheimer’s disease and stroke, is increasing. An increasing number of studies have correlated these diseases with brain iron overload and the resulting oxidative damage. Brain iron ... ...

Abstract	The incidence of neurological diseases, such as Parkinson’s disease, Alzheimer’s disease and stroke, is increasing. An increasing number of studies have correlated these diseases with brain iron overload and the resulting oxidative damage. Brain iron deficiency has also been closely linked to neurodevelopment. These neurological disorders seriously affect the physical and mental health of patients and bring heavy economic burdens to families and society. Therefore, it is important to maintain brain iron homeostasis and to understand the mechanism of brain iron disorders affecting reactive oxygen species (ROS) balance, resulting in neural damage, cell death and, ultimately, leading to the development of disease. Evidence has shown that many therapies targeting brain iron and ROS imbalances have good preventive and therapeutic effects on neurological diseases. This review highlights the molecular mechanisms, pathogenesis and treatment strategies of brain iron metabolism disorders in neurological diseases.
Keywords	brain ; cell death ; homeostasis ; iron ; iron absorption ; iron overload ; mental health ; neurodevelopment ; pathogenesis ; reactive oxygen species ; society ; stroke ; therapeutics
Language	English
Dates of publication	2023-0616
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12061289
Database	NAL-Catalogue (AGRICOLA)

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Article: Interdecadal aridity variations in Central Asia during 1950–2016 regulated by oceanic conditions under the background of global warming

Zhong, Linhao / Hua, Lijuan / Yao, Yao / Feng, Jinming

Climate dynamics. 2021 June, v. 56, no. 11-12

2021

Abstract: As a typical inland arid and semiarid region, Central Asia (CA) is vulnerable to the forced global warming (FGW) due to anthropogenic activity. Aiming at the interdecadal variation of the FGW-forced aridity pattern (FAP) in CA, we try to extract the ... ...

Abstract	As a typical inland arid and semiarid region, Central Asia (CA) is vulnerable to the forced global warming (FGW) due to anthropogenic activity. Aiming at the interdecadal variation of the FGW-forced aridity pattern (FAP) in CA, we try to extract the associated oceanic and atmospheric modes by analyzing observations, reanalysis data and multi-model simulations during 1950–2016. The FAP in CA features a tripolar pattern with wetting–drying-wetting responses arranging from southeast to northwest and shows strong interdecadal-to-interannual amplitude variations. It is found that the sea surface temperature (SST) in the tropical South Atlantic (TSA) well correlates with the amplitude variation of FAP on interdecadal time scale, possibly through modulating the interannual SST modes characterized by the North Atlantic horseshoe-like dipole (NAHD) and the El Ninõ and South Oscillation (ENSO). Corresponding to the enhancing FAP from the middle 1970s to early 2000s, the TSA-modulated NAHD and ENSO, together with the Pacific Decadal Oscillation-modulated Indian Ocean Dipole-like mode, show connections with an Eurasian middle-latitude wave train coupled with the North Arctic Oscillation and equatorial low, which favors the moisture transport to strengthen the tripolar FAP by forming a local circulation dipole with positive/negative anomaly over the northwest/southeast CA. But after the early 2000s, the increasing FAP amplitude is decelerated due to the interdecadal decline of TSA accompanied by the weakened/reversed relationship between FAP and the NAHD/ENSO. Because of the corresponding breakdown of the wave train, the favorable local circulation is unavailable to support the sustained enhancement of FAP. Therefore, the multiscale coupling between the above oceanic and atmospheric modes is significantly related to the characteristic of stage of the forced aridity change in CA under the background of global warming.
Keywords	anthropogenic activities ; dry environmental conditions ; dynamics ; moisture diffusivity ; semiarid zones ; surface water temperature ; Arctic region ; Central Asia ; Indian Ocean
Language	English
Dates of publication	2021-06
Size	p. 3665-3686.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1471747-5
ISSN	1432-0894 ; 0930-7575
ISSN (online)	1432-0894
ISSN	0930-7575
DOI	10.1007/s00382-021-05659-2
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Article ; Online: Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice.

Bai, Xue / Wang, Bing / Cui, Yiduo / Tian, Siqi / Zhang, Yi / You, Linhao / Chang, Yan-Zhong / Gao, Guofen

Journal of neuroinflammation

2024 Volume 21, Issue 1, Page(s) 15

Abstract: Background: Hepcidin is the master regulator of iron homeostasis. Hepcidin downregulation has been demonstrated in the brains of Alzheimer's disease (AD) patients. However, the mechanism underlying the role of hepcidin downregulation in cognitive ... ...

Abstract	Background: Hepcidin is the master regulator of iron homeostasis. Hepcidin downregulation has been demonstrated in the brains of Alzheimer's disease (AD) patients. However, the mechanism underlying the role of hepcidin downregulation in cognitive impairment has not been elucidated. Methods: In the present study, we generated GFAP-Cre-mediated hepcidin conditional knockout mice (Hamp Results: We found that the Hamp Conclusions: The present findings demonstrated a critical role for hepcidin in hippocampal neurogenesis and validated the importance of iron and associated inflammatory cytokines as key modulators of neurodevelopment, providing insights into the potential pathogenesis of cognitive dysfunction and related treatments.
MeSH term(s)	Animals ; Humans ; Mice ; Alzheimer Disease ; Atrophy ; Brain ; Central Nervous System Diseases ; Hepcidins/genetics ; Hippocampus ; Iron ; Memory Disorders/genetics ; Mice, Knockout
Chemical Substances	Hepcidins ; Iron (E1UOL152H7) ; Hamp protein, mouse
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2156455-3
ISSN	1742-2094 ; 1742-2094
ISSN (online)	1742-2094
ISSN	1742-2094
DOI	10.1186/s12974-023-03008-0
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Article: Brain Iron Metabolism, Redox Balance and Neurological Diseases.

Gao, Guofen / You, Linhao / Zhang, Jianhua / Chang, Yan-Zhong / Yu, Peng

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 6

Abstract: The incidence of neurological diseases, such as Parkinson's disease, Alzheimer's disease and stroke, is increasing. An increasing number of studies have correlated these diseases with brain iron overload and the resulting oxidative damage. Brain iron ... ...

Abstract	The incidence of neurological diseases, such as Parkinson's disease, Alzheimer's disease and stroke, is increasing. An increasing number of studies have correlated these diseases with brain iron overload and the resulting oxidative damage. Brain iron deficiency has also been closely linked to neurodevelopment. These neurological disorders seriously affect the physical and mental health of patients and bring heavy economic burdens to families and society. Therefore, it is important to maintain brain iron homeostasis and to understand the mechanism of brain iron disorders affecting reactive oxygen species (ROS) balance, resulting in neural damage, cell death and, ultimately, leading to the development of disease. Evidence has shown that many therapies targeting brain iron and ROS imbalances have good preventive and therapeutic effects on neurological diseases. This review highlights the molecular mechanisms, pathogenesis and treatment strategies of brain iron metabolism disorders in neurological diseases.
Language	English
Publishing date	2023-06-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12061289
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: North Atlantic multidecadal footprint of the recent winter warm Arctic–cold Siberia pattern

Chen, Yanan / Luo, Dehai / Zhong, Linhao

Climate dynamics. 2021 July, v. 57, no. 1-2

2021

Abstract: The multidecadal regulation of wintertime extreme cold temperatures over Eurasia by the change of the North Atlantic sea surface temperature (SST) from 1950–1983 (P1) to 1984–2017 (P2) is examined in this paper. The warm Arctic–cold Siberia (WACS) trend ... ...

Abstract	The multidecadal regulation of wintertime extreme cold temperatures over Eurasia by the change of the North Atlantic sea surface temperature (SST) from 1950–1983 (P1) to 1984–2017 (P2) is examined in this paper. The warm Arctic–cold Siberia (WACS) trend pattern shows a distinct interdecadal transition from P1 to P2, which has a footprint of the Atlantic Multidecadal Oscillation (AMO). The positive trend of the WACS pattern during P2 coincides with the transition of AMO from its negative phase (AMO⁻) to positive phase (AMO⁺). The sea-ice reduction in Barents–Kara Seas (BKS) owing to AMO⁺ contributes to the BKS warming in the WACS pattern trend, while it also reduces the meridional potential vorticity gradient (PVy) over Eurasia and increases the persistence of Ural blocking (UB), thus favoring a positive WACS trend, especially a Siberian cooling trend during P2. During P1, when the AMO changes from AMO⁺ to AMO⁻, a reversed WACS pattern trend is seen because UB shows a shortened duration due to intensified PVy over Eurasia caused by increased BKS sea ice. In addition, the North Atlantic SST forcing on the WACS also shows a multiple time-scale feature. Embedded in the multidecadal timescale (≥ 50 years) of AMO, the North Atlantic SST tripole (NAT) pattern can also significantly influence the Siberian cold anomaly on decadal (10–30 years) time scales not by the BKS sea-ice decline. Even during the suppressed WACS trend period (P1) from AMO⁺ to AMO⁻, a positive WACS pattern is still seen during 1960–1970, which is mainly dominated by the NAT pattern through generating a negative-phase North Atlantic Oscillation with UB.
Keywords	North Atlantic Oscillation ; Siberia ; climate ; cold ; dynamics ; sea ice ; surface water temperature ; winter ; Eurasia
Language	English
Dates of publication	2021-07
Size	p. 121-139.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1471747-5
ISSN	1432-0894 ; 0930-7575
ISSN (online)	1432-0894
ISSN	0930-7575
DOI	10.1007/s00382-021-05698-9
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Datasets of meteorological drought events and risks for the developing countries in Eurasia

Linhao Zhong / Lijuan Hua / Zhongwei Yan

Big Earth Data, Vol 4, Iss 2, Pp 191-

2020 Volume 223

Abstract: For the area of Eurasia concentrated with developing countries (referred to here by the abbreviation DPEA), mainly located in Asia and Eastern Europe, this work presents datasets of gridded meteorological drought events and country-based drought risk by ... ...

Abstract	For the area of Eurasia concentrated with developing countries (referred to here by the abbreviation DPEA), mainly located in Asia and Eastern Europe, this work presents datasets of gridded meteorological drought events and country-based drought risk by combining multiple drought indices and socio-economic data. A basic gridded dataset of the drought events during 1950–2015 is extracted from three drought indices: the self-calibrating Palmer Drought Severity Index, the Standardized Precipitation Index, and the Standardized Precipitation Evapotranspiration Index. The three drought indices generally show consistent characteristics of drought events in DPEA. A second-level dataset (a drought risk dataset) is then produced as the product of drought hazard, exposure and vulnerability during 2000–2015. For drought exposure, the indicators of population and livestock density, agricultural land and water stress are chosen, while drought vulnerability composites multiple social, economic and infrastructural factors. Drought hazard tends to concentrate at the southern rim of Eurasia. Relatively large differences in drought exposure exist between different countries, but for drought vulnerability the differences are small. After considering the socio-economic components in risk assessment, most countries in West, South-Central and South Asia have the highest drought risk in DPEA. The datasets of drought events and risks are available at http://www.dx.doi.org/10.11922/sciencedb.898.
Keywords	drought events ; drought risks ; the developing countries in eurasia ; drought exposure ; drought vulnerability ; Geography. Anthropology. Recreation ; G ; Geology ; QE1-996.5
Subject code	910
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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