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  1. Article ; Online: Reflecting on Excellence: The Wisconsin Medical Journal's Year in Review.

    Aziz, Fahad

    WMJ : official publication of the State Medical Society of Wisconsin

    2024  Volume 123, Issue 1, Page(s) 5–6

    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 441051-8
    ISSN 2379-3961 ; 0043-6542 ; 1098-1861
    ISSN (online) 2379-3961
    ISSN 0043-6542 ; 1098-1861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Four Essential Laws of Connecting With Patients.

    Aziz, Fahad

    WMJ : official publication of the State Medical Society of Wisconsin

    2023  Volume 122, Issue 2, Page(s) 86–87

    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 441051-8
    ISSN 2379-3961 ; 0043-6542 ; 1098-1861
    ISSN (online) 2379-3961
    ISSN 0043-6542 ; 1098-1861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Wisconsin Medical Journal

    Aziz, Fahad

    WMJ : official publication of the State Medical Society of Wisconsin

    2023  Volume 121, Issue 4, Page(s) 252–253

    MeSH term(s) Humans ; Wisconsin ; Forecasting
    Language English
    Publishing date 2023-02-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 441051-8
    ISSN 2379-3961 ; 0043-6542 ; 1098-1861
    ISSN (online) 2379-3961
    ISSN 0043-6542 ; 1098-1861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Power of Shared Decision-Making in Medical Settings.

    Aziz, Fahad

    WMJ : official publication of the State Medical Society of Wisconsin

    2023  Volume 122, Issue 1, Page(s) 5–6

    MeSH term(s) Humans ; Physician-Patient Relations ; Decision Making, Shared
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 441051-8
    ISSN 2379-3961 ; 0043-6542 ; 1098-1861
    ISSN (online) 2379-3961
    ISSN 0043-6542 ; 1098-1861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Compassionate Care Essential for Better Clinical Outcomes, Burnout Prevention.

    Aziz, Fahad

    WMJ : official publication of the State Medical Society of Wisconsin

    2023  Volume 122, Issue 3, Page(s) 160–161

    MeSH term(s) Humans ; Burnout, Professional/prevention & control ; Burnout, Psychological ; Empathy
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 441051-8
    ISSN 2379-3961 ; 0043-6542 ; 1098-1861
    ISSN (online) 2379-3961
    ISSN 0043-6542 ; 1098-1861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: All Clinicians Communicate With Patients, But Too Few Connect.

    Aziz, Fahad

    WMJ : official publication of the State Medical Society of Wisconsin

    2022  Volume 121, Issue 3, Page(s) 172–173

    MeSH term(s) Humans ; Communication
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Editorial
    ZDB-ID 441051-8
    ISSN 2379-3961 ; 0043-6542 ; 1098-1861
    ISSN (online) 2379-3961
    ISSN 0043-6542 ; 1098-1861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Advanced Practice Providers' Wellness Essential for Health Care Organizations.

    Choudoir, Ashley / Aziz, Fahad

    WMJ : official publication of the State Medical Society of Wisconsin

    2024  Volume 123, Issue 1, Page(s) 9–10

    MeSH term(s) Humans ; Delivery of Health Care
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 441051-8
    ISSN 2379-3961 ; 0043-6542 ; 1098-1861
    ISSN (online) 2379-3961
    ISSN 0043-6542 ; 1098-1861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: New Onset Diabetes Mellitus after Transplant: The Challenge Continues.

    Aziz, Fahad

    Kidney360

    2021  Volume 2, Issue 8, Page(s) 1212–1214

    MeSH term(s) Diabetes Mellitus/diagnosis ; Humans ; Kidney Transplantation
    Language English
    Publishing date 2021-08-26
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0004042021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Providing Feedback Is Essential for Professional Growth.

    Aziz, Fahad / Djamali, Kian S

    WMJ : official publication of the State Medical Society of Wisconsin

    2023  Volume 122, Issue 4, Page(s) 238–239

    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 441051-8
    ISSN 2379-3961 ; 0043-6542 ; 1098-1861
    ISSN (online) 2379-3961
    ISSN 0043-6542 ; 1098-1861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Biophysical library screening using a Thermo-FMN assay to identify and characterize Clostridioides difficile FabK inhibitors.

    Pavel, Fahad Bin Aziz / Palmer, Glen E / Hevener, Kirk E

    Biochemical and biophysical research communications

    2024  Volume 705, Page(s) 149740

    Abstract: Clostridioides difficile, a gram-positive anaerobic bacterium, is one of the most frequent causes of nosocomial infections. C. difficile infection (CDI) results in almost a half a million infections and approximately 30,000 deaths in the U.S. each year. ... ...

    Abstract Clostridioides difficile, a gram-positive anaerobic bacterium, is one of the most frequent causes of nosocomial infections. C. difficile infection (CDI) results in almost a half a million infections and approximately 30,000 deaths in the U.S. each year. Broad-spectrum antibacterial use is a strong risk factor for development of recurring CDI. There is a critical need for narrow-spectrum antibacterials with activity limited to C. difficile. The C. difficile enoyl-acyl carrier protein (ACP) reductase II enzyme (CdFabK), an essential and rate-limiting enzyme in the organism's fatty acid biosynthesis pathway (FAS-2), is an attractive target for narrow-spectrum CDI therapeutics as it is not present in many of the non-pathogenic gut organisms. We have previously characterized inhibitors of the CdFabK enzyme with narrow-spectrum anti-difficile activity and favorable in vivo efficacy, ADME, and low dysbiosis. To expand our knowledge of the structural requirements for CdFabK inhibition, we seek to identify new inhibitors with novel chemical scaffolds. Herein we present the optimization of a thermo-FMN biophysical assay based on the principles of differential scanning fluorimetry, or thermal shift, which leverages the fluorescence signal of the FabK enzyme's FMN prosthetic group. The optimized assay was validated by pilot testing a 10K diversity-based chemical library and novel scaffold hit compounds were identified and biochemically characterized. Additionally, we show that the thermo-FMN assay can be used to determine the thermodynamic dissociation constant, Kd, of CdFabK inhibitors.
    MeSH term(s) Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)/genetics ; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)/metabolism ; Clostridioides difficile/metabolism ; Base Composition ; Phylogeny ; RNA, Ribosomal, 16S ; Sequence Analysis, DNA ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry
    Chemical Substances Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) (EC 1.3.1.9) ; RNA, Ribosomal, 16S ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2024.149740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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