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  1. Article ; Online: Letter to the Editor: Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy, Allowing Liver Regeneration and Survival by Induction of H2-Bl/HLA-G.

    Lin, Aifen / Yan, Wei-Hua

    Hepatology (Baltimore, Md.)

    2021  Volume 73, Issue 3, Page(s) 1238

    MeSH term(s) Growth Hormone ; HLA-G Antigens ; Hepatectomy ; Humans ; Inflammation ; Liver ; Liver Regeneration
    Chemical Substances HLA-G Antigens ; Growth Hormone (9002-72-6)
    Language English
    Publishing date 2021-02-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.31532
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  2. Article ; Online: High genetic diversity and different type VI secretion systems in Enterobacter species revealed by comparative genomics analysis.

    Peng, Mu / Lin, Weiyuan / Zhou, Aifen / Jiang, Zhihui / Zhou, Fangzhen / Wang, Zhiyong

    BMC microbiology

    2024  Volume 24, Issue 1, Page(s) 26

    Abstract: The human-pathogenic Enterobacter species are widely distributed in diverse environmental conditions, however, the understanding of the virulence factors and genetic variations within the genus is very limited. In this study, we performed comparative ... ...

    Abstract The human-pathogenic Enterobacter species are widely distributed in diverse environmental conditions, however, the understanding of the virulence factors and genetic variations within the genus is very limited. In this study, we performed comparative genomics analysis of 49 strains originated from diverse niches and belonged to eight Enterobacter species, in order to further understand the mechanism of adaption to the environment in Enterobacter. The results showed that they had an open pan-genome and high genomic diversity which allowed adaptation to distinctive ecological niches. We found the number of secretion systems was the highest among various virulence factors in these Enterobacter strains. Three types of T6SS gene clusters including T6SS-A, T6SS-B and T6SS-C were detected in most Enterobacter strains. T6SS-A and T6SS-B shared 13 specific core genes, but they had different gene structures, suggesting they probably have different biological functions. Notably, T6SS-C was restricted to E. cancerogenus. We detected a T6SS gene cluster, highly similar to T6SS-C (91.2%), in the remote related Citrobacter rodenitum, suggesting that this unique gene cluster was probably acquired by horizontal gene transfer. The genomes of Enterobacter strains possess high genetic diversity, limited number of conserved core genes, and multiple copies of T6SS gene clusters with differentiated structures, suggesting that the origins of T6SS were not by duplication instead by independent acquisition. These findings provide valuable information for better understanding of the functional features of Enterobacter species and their evolutionary relationships.
    MeSH term(s) Humans ; Type VI Secretion Systems/genetics ; Enterobacter/genetics ; Bacterial Proteins/genetics ; Genomics ; Virulence Factors/genetics ; Genetic Variation
    Chemical Substances Type VI Secretion Systems ; Bacterial Proteins ; Virulence Factors
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041505-9
    ISSN 1471-2180 ; 1471-2180
    ISSN (online) 1471-2180
    ISSN 1471-2180
    DOI 10.1186/s12866-023-03164-6
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  3. Article ; Online: Perspective of HLA-G Induced Immunosuppression in SARS-CoV-2 Infection.

    Lin, Aifen / Yan, Wei-Hua

    Frontiers in immunology

    2021  Volume 12, Page(s) 788769

    Abstract: COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has threatened public health worldwide. Host antiviral immune responses are essential for viral clearance and disease control, however, remarkably decreased ... ...

    Abstract COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has threatened public health worldwide. Host antiviral immune responses are essential for viral clearance and disease control, however, remarkably decreased immune cell numbers and exhaustion of host cellular immune responses are commonly observed in patients with COVID-19. This is of concern as it is closely associated with disease severity and poor outcomes. Human leukocyte antigen-G (HLA-G) is a ligand for multiple immune inhibitory receptors, whose expression can be upregulated by viral infections. HLA-G/receptor signalling, such as engagement with immunoglobulin-like transcript 2 (ILT-2) or ILT-4, not only inhibit T and natural killer (NK) cell immune responses, dendritic cell (DC) maturation, and B cell antibody production. It also induces regulatory cells such as myeloid-derived suppressive cells (MDSCs), or M2 type macrophages. Moreover, HLA-G interaction with CD8 and killer inhibitory receptor (KIR) 2DL4 can provoke T cell apoptosis and NK cell senescence. In this context, HLA-G can induce profound immune suppression, which favours the escape of SARS-CoV-2 from immune attack. Although detailed knowledge on the clinical relevance of HLA-G in SARS-CoV-2 infection is limited, we herein review the immunopathological aspects of HLA-G/receptor signalling in SARS-CoV-2 infection, which could provide a better understanding of COVID-19 disease progression and identify potential immunointerventions to counteract SARS-CoV-2 infection.
    MeSH term(s) COVID-19/immunology ; HLA-G Antigens/immunology ; Humans ; Immune Tolerance/immunology ; SARS-CoV-2/immunology
    Chemical Substances HLA-G Antigens
    Language English
    Publishing date 2021-12-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.788769
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  4. Article ; Online: HLA-G/ILTs Targeted Solid Cancer Immunotherapy: Opportunities and Challenges.

    Lin, Aifen / Yan, Wei-Hua

    Frontiers in immunology

    2021  Volume 12, Page(s) 698677

    Abstract: Immune checkpoint inhibitors (ICIs) have become a promising immunotherapy for cancers. Human leukocyte antigen-G (HLA-G), a neoantigen, its biological functions and clinical relevance have been extensively investigated in malignancies, and early clinical ...

    Abstract Immune checkpoint inhibitors (ICIs) have become a promising immunotherapy for cancers. Human leukocyte antigen-G (HLA-G), a neoantigen, its biological functions and clinical relevance have been extensively investigated in malignancies, and early clinical trials with "anti-HLA-G strategy" are being launched for advance solid cancer immunotherapy. The mechanism of HLA-G as a new ICI is that HLA-G can bind immune cell bearing inhibitory receptors, the immunoglobulin-like transcript (ILT)-2 and ILT-4. HLA-G/ILT-2/-4 (HLA-G/ILTs) signaling can drive comprehensive immune suppression, promote tumor growth and disease progression. Though clinical benefits could be expected with application of HLA-G antibodies to blockade the HLA-G/ILTs signaling in solid cancer immunotherapy, major challenges with the diversity of HLA-G isoforms, HLA-G/ILTs binding specificity, intra- and inter-tumor heterogeneity of HLA-G, lack of isoform-specific antibodies and validated assay protocols, which could dramatically affect the clinical efficacy. Clinical benefits of HLA-G-targeted solid cancer immunotherapy may be fluctuated or even premature unless major challenges are addressed.
    MeSH term(s) Animals ; HLA-G Antigens/drug effects ; HLA-G Antigens/immunology ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immunotherapy/methods ; Neoplasms/drug therapy ; Neoplasms/immunology
    Chemical Substances HLA-G Antigens ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2021-06-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.698677
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  5. Article ; Online: Impact of Sample Processing and Storage Conditions on RNA Quality of Fresh-Frozen Cancer Tissues.

    Chen, Yuan-Yuan / Han, Qiu-Yue / Chen, Qiong-Yuan / Zhou, Wen-Jun / Zhang, Jian-Gang / Zhang, Xia / Lin, Aifen

    Biopreservation and biobanking

    2023  Volume 21, Issue 5, Page(s) 510–517

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2593993-2
    ISSN 1947-5543 ; 1947-5535
    ISSN (online) 1947-5543
    ISSN 1947-5535
    DOI 10.1089/bio.2022.0069
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  6. Article: Intercellular transfer of HLA-G: its potential in cancer immunology.

    Lin, Aifen / Yan, Wei-Hua

    Clinical & translational immunology

    2019  Volume 8, Issue 9, Page(s) e1077

    Abstract: Intercellular protein transfer between cancer cells and immune cells is a very common phenomenon that can affect different stages of host antitumor immune responses. HLA-G, a non-classical HLA class I antigen, has been observed to be widely expressed in ... ...

    Abstract Intercellular protein transfer between cancer cells and immune cells is a very common phenomenon that can affect different stages of host antitumor immune responses. HLA-G, a non-classical HLA class I antigen, has been observed to be widely expressed in various malignancies, and its immune-suppressive functions have been well recognised. HLA-G expression in cancer cells can directly mediate immune tolerance by interacting with inhibitory receptors such as ILT2 and ILT4 expressed on immune cells. Moreover, a network of multiple directional intercellular transfers of HLA-G among cancer cells and immune cells through trogocytosis, exosomes and tunnelling nanotubes provides malignant cells with an alternative ploy for antigen sharing and induces more complex heterogeneity, to modulate immune responses, ultimately leading to immune evasion, therapy resistance, disease progression and poor clinical outcome. Herein, we discuss the relative aspects of the intercellular transfer of HLA-G between tumor cells and immune cells and its potential use in tumor immunology research and translational cancer therapy.
    Language English
    Publishing date 2019-08-30
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2694482-0
    ISSN 2050-0068
    ISSN 2050-0068
    DOI 10.1002/cti2.1077
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  7. Article ; Online: The Emerging Roles of Human Leukocyte Antigen-F in Immune Modulation and Viral Infection.

    Lin, Aifen / Yan, Wei-Hua

    Frontiers in immunology

    2019  Volume 10, Page(s) 964

    Abstract: Human leukocyte antigens (HLAs) play various critical roles in both innate and adaptive immunity through processes such as presenting antigens to T cells and serving as ligands for receptors expressed on natural killer (NK) cells. Among the HLA class I ... ...

    Abstract Human leukocyte antigens (HLAs) play various critical roles in both innate and adaptive immunity through processes such as presenting antigens to T cells and serving as ligands for receptors expressed on natural killer (NK) cells. Among the HLA class I family, the clinical significance and biological function of HLA-F have been the least investigated and have remained elusive for a long period of time. Previous studies have revealed that HLA-F expression might be involved in various physiological and pathological processes, such as pregnancy, viral infection, cancer, transplantation, and autoimmune diseases. However, recent data have shown that, akin to other HLA family members, HLA-F molecules can interact with both activating and inhibitory receptors on immune cells, such as NK cells, and can present a diverse panel of peptides. These important findings pave new avenues for investigations regarding the functions of HLA-F as an important immune regulatory molecule. In the present review, we summarize the studies on the role of HLA-F in immune modulation, with a special emphasis placed on the roles of HLA-F and KIR3DS1 interactions in viral infection.
    MeSH term(s) Adaptive Immunity/immunology ; Histocompatibility Antigens Class I/immunology ; Humans ; Immunity, Innate/immunology ; Killer Cells, Natural/immunology ; Receptors, KIR3DS1/immunology ; T-Lymphocytes/immunology ; Virus Diseases/immunology
    Chemical Substances HLA-F antigens ; Histocompatibility Antigens Class I ; KIR3DS1 protein, human ; Receptors, KIR3DS1
    Language English
    Publishing date 2019-05-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.00964
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  8. Article ; Online: The reference genome of seed hemp (Cannabis sativa) provides new insights into fatty acid and vitamin E synthesis.

    Wei, Huawei / Yang, Zuqing / Niyitanga, Sylvain / Tao, Aifen / Xu, Jiantang / Fang, Pingping / Lin, Lihui / Zhang, Liemei / Qi, Jianmin / Ming, Ray / Zhang, Liwu

    Plant communications

    2023  Volume 5, Issue 1, Page(s) 100718

    MeSH term(s) Fatty Acids/genetics ; Cannabis/genetics ; Plant Oils ; Vitamin E ; Seeds/genetics
    Chemical Substances Fatty Acids ; Plant Oils ; Vitamin E (1406-18-4)
    Language English
    Publishing date 2023-09-16
    Publishing country China
    Document type Journal Article
    ISSN 2590-3462
    ISSN (online) 2590-3462
    DOI 10.1016/j.xplc.2023.100718
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  9. Article ; Online: Novel Insights into Anthocyanin Synthesis in the Calyx of Roselle Using Integrated Transcriptomic and Metabolomic Analyses.

    Li, Jing / Li, Yunqing / Li, Mei / Lin, Lihui / Qi, Jianmin / Xu, Jiantang / Zhang, Liwu / Fang, Pingping / Tao, Aifen

    International journal of molecular sciences

    2022  Volume 23, Issue 22

    Abstract: Roselle ( ...

    Abstract Roselle (
    MeSH term(s) Animals ; Humans ; Hibiscus ; Anthocyanins ; Transcriptome ; Plant Breeding ; Flavonoids ; Porifera
    Chemical Substances Anthocyanins ; Flavonoids
    Language English
    Publishing date 2022-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232213908
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  10. Article ; Online: Effects of Biocontrol Agents Application on Soil Bacterial Community and the Quality of Tobacco.

    Li, Zhongkui / Chen, Yulan / Ling, Aifen / Li, Hongli / Lin, Zhengquan / Wang, Yan

    Current microbiology

    2022  Volume 79, Issue 11, Page(s) 320

    Abstract: In this study, to evaluate the effect of different biocontrol agents (BCAs) on the soil bacterial community, we investigated the effects of Bacillus amyloliquefaciens, synthetic bacterial community (Aspergillus niger:Bacillus subtilis:Bacillus ... ...

    Abstract In this study, to evaluate the effect of different biocontrol agents (BCAs) on the soil bacterial community, we investigated the effects of Bacillus amyloliquefaciens, synthetic bacterial community (Aspergillus niger:Bacillus subtilis:Bacillus licheniformis:Streptomyces microflavus = 3:3:3:1, SynCom), and BCAs combined with lime-nitrogen on soil bacterial community by utilizing 16S rRNA sequencing technology. The sequencing shows that BCAs application can improve the value of Shannon and Sobs index of bacterial community during tobacco rosette and vigorous growing period. With the growth of tobacco, the effect of BCAs on the composition and difference of soil bacterial community structure becomes more and more obvious. In terms of average relative richness, the top six phyla of soil bacterial community are Proteobacteria, Actinobacteria, Chloroflexi, Acidobacteria, Gemmatimonadetes, and Bacteroidetes. Bacillus amyloliquefaciens application can increase the relative richness of Proteobacteria and Bacteroidetes. And the combination between BCAs and lime-nitrogen can increase the relative richness of Gemmatimonadetes and Bacteroidetes. The SynCom also can increase the relative richness of Bacteroidetes, whereas it decreases the relative richness of Acidobacteria. Proteobacteria, Acidobacteria, Gemmatimonadetes, and Bacteroidetes showing an extremely significant correlation with pH and exchangeable magnesium (EMg). BCAs application can improve the tobacco yield, effective leaves, and reducing sugar content that also has extremely significant positive correlation with pH and EMg. In conclusion, the results of our field experiments clearly show that BCAs application can significantly affect the soil pH and EMg by changing most of the dominant soil bacterial species. The richness of Bacteroidetes can serve as an indicator of the changes in soil pH and EMg caused by BCAs application.
    MeSH term(s) Acidobacteria ; Bacteria/genetics ; Bacteroidetes/genetics ; Calcium Compounds ; Magnesium ; Nitrogen/analysis ; Oxides ; Proteobacteria/genetics ; RNA, Ribosomal, 16S/genetics ; Soil/chemistry ; Soil Microbiology ; Sugars ; Nicotiana/microbiology
    Chemical Substances Calcium Compounds ; Oxides ; RNA, Ribosomal, 16S ; Soil ; Sugars ; lime (C7X2M0VVNH) ; Magnesium (I38ZP9992A) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2022-09-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-022-02937-y
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    In stock of ZB MED Cologne/Königswinter

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