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  1. Article ; Online: Finding Hope in a Sleeping City.

    Caputo, Nicholas D / Shenvi, Christina

    Annals of emergency medicine

    2020  Volume 76, Issue 4, Page(s) 544–545

    Language English
    Publishing date 2020-09-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2020.05.030
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    Zs.A 1344: Show issues Location:
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  2. Article ; Online: Early Self-Proning in Awake, Non-intubated Patients in the Emergency Department: A Single ED's Experience During the COVID-19 Pandemic.

    Caputo, Nicholas D / Strayer, Reuben J / Levitan, Richard

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    2020  Volume 27, Issue 5, Page(s) 375–378

    Abstract: Objective: Prolonged and unaddressed hypoxia can lead to poor patient outcomes. Proning has become a standard treatment in the management of patients with ARDS who have difficulty achieving adequate oxygen saturation. The purpose of this study was to ... ...

    Abstract Objective: Prolonged and unaddressed hypoxia can lead to poor patient outcomes. Proning has become a standard treatment in the management of patients with ARDS who have difficulty achieving adequate oxygen saturation. The purpose of this study was to describe the use of early proning of awake, non-intubated patients in the emergency department (ED) during the COVID-19 pandemic.
    Methods: This pilot study was carried out in a single urban ED in New York City. We included patients suspected of having COVID-19 with hypoxia on arrival. A standard pulse oximeter was used to measure SpO
    Results: Fifty patients were included. Overall, the median SpO
    Conclusion: Awake early self-proning in the emergency department demonstrated improved oxygen saturation in our COVID-19 positive patients. Further studies are needed to support causality and determine the effect of proning on disease severity and mortality.
    MeSH term(s) Adult ; Betacoronavirus ; COVID-19 ; Cannula ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Emergency Service, Hospital ; Female ; Humans ; Hypoxia/etiology ; Intubation, Intratracheal ; Male ; Middle Aged ; New York City ; Oximetry ; Oxygen ; Pandemics ; Pilot Projects ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Prone Position ; Respiration, Artificial ; SARS-CoV-2 ; Wakefulness
    Chemical Substances Oxygen (S88TT14065)
    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1329813-6
    ISSN 1553-2712 ; 1069-6563
    ISSN (online) 1553-2712
    ISSN 1069-6563
    DOI 10.1111/acem.13994
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  3. Article ; Online: Effects of Ionic Liquids on Metalloproteins.

    Patel, Aashka Y / Jonnalagadda, Keertana S / Paradis, Nicholas / Vaden, Timothy D / Wu, Chun / Caputo, Gregory A

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 2

    Abstract: In the past decade, innovative protein therapies and bio-similar industries have grown rapidly. Additionally, ionic liquids (ILs) have been an area of great interest and rapid development in industrial processes over a similar timeline. Therefore, there ... ...

    Abstract In the past decade, innovative protein therapies and bio-similar industries have grown rapidly. Additionally, ionic liquids (ILs) have been an area of great interest and rapid development in industrial processes over a similar timeline. Therefore, there is a pressing need to understand the structure and function of proteins in novel environments with ILs. Understanding the short-term and long-term stability of protein molecules in IL formulations will be key to using ILs for protein technologies. Similarly, ILs have been investigated as part of therapeutic delivery systems and implicated in numerous studies in which ILs impact the activity and/or stability of protein molecules. Notably, many of the proteins used in industrial applications are involved in redox chemistry, and thus often contain metal ions or metal-associated cofactors. In this review article, we focus on the current understanding of protein structure-function relationship in the presence of ILs, specifically focusing on the effect of ILs on metal containing proteins.
    MeSH term(s) Ionic Liquids/pharmacology ; Metalloproteins/chemistry ; Metalloproteins/metabolism ; Structure-Activity Relationship
    Chemical Substances Ionic Liquids ; Metalloproteins
    Language English
    Publishing date 2021-01-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26020514
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  4. Article ; Online: Behind the Scenes of Successful Research in Emergency Medicine: Nine Tips for Junior Investigators.

    Probst, Marc A / Caputo, Nicholas D / Chang, Bernard P

    AEM education and training

    2019  Volume 4, Issue Suppl 1, Page(s) S75–S81

    Abstract: Education related to clinical research often focuses on methodology, statistics, ethics, and study design. While knowledge of these conventional skills is essential to the operationalization of research, many "soft" skills related to leadership, ... ...

    Abstract Education related to clinical research often focuses on methodology, statistics, ethics, and study design. While knowledge of these conventional skills is essential to the operationalization of research, many "soft" skills related to leadership, communication, and team management are critical to the successful conduct research in the real world. Conducting clinical research in the emergency department is generally a challenging endeavor. Based on our prior experience as clinical researchers and a narrative review of the published literature, we offer nine practical strategies to help junior investigators conduct research. To successfully execute a research study, investigators must know how to motivate their team, create a brand around their study, communicate effectively, maximize clinician and patient engagement, and celebrate victory, among other skills. These skills and strategies are often missing from the formal research education and in peer-reviewed manuscripts but are, in fact, invaluable to the successful development of junior investigators. Thus, we offer the "story behind the study" in an effort to contribute to research education with material that is not typically covered in formal curricula.
    Language English
    Publishing date 2019-09-12
    Publishing country United States
    Document type Journal Article
    ISSN 2472-5390
    ISSN (online) 2472-5390
    DOI 10.1002/aet2.10383
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  5. Article: Novel Use of a Gas Analyzer Can Reliably Predict the Arterial Oxygen among Emergency Department Patients Undergoing Rapid Sequence Intubation.

    Murphy, Sara / Reilly, James / Caputo, Nicholas D / West, Jason R

    The Journal of emergency medicine

    2020  Volume 58, Issue 3, Page(s) 407–412

    Abstract: Background: To our knowledge, no study has assessed the correlation of fraction of inspired oxygen (FiO: Objective: The purpose of this study was to determine whether a simple equation using EtO: Methods: We conducted an observational pilot study ... ...

    Abstract Background: To our knowledge, no study has assessed the correlation of fraction of inspired oxygen (FiO
    Objective: The purpose of this study was to determine whether a simple equation using EtO
    Methods: We conducted an observational pilot study performed in an adult ED utilizing a gas analyzer to obtain EtO
    Results: Seventy-five patients were enrolled. The equation's mean predicted minimal PaO
    Conclusions: Among ED patients undergoing RSI, the use of a gas analyzer to measure EtO
    MeSH term(s) Adult ; Blood Gas Analysis ; Emergency Service, Hospital ; Humans ; Intubation ; Oxygen/blood ; Pilot Projects ; Rapid Sequence Induction and Intubation
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2020-01-22
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2019.12.025
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    Zs.A 1895: Show issues Location:
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  6. Article ; Online: Respiratory adjusted shock index for identifying occult shock and level of Care in Sepsis Patients.

    Jiang, Lynn / Caputo, Nicholas D / Chang, Bernard P

    The American journal of emergency medicine

    2019  Volume 37, Issue 3, Page(s) 506–509

    Abstract: Objective: Early identification of shock allows for timely resuscitation. Previous studies note the utility of bedside calculations such as the shock index (SI) and quick sepsis-related organ failure assessment (qSOFA) to detect occult shock. ... ...

    Abstract Objective: Early identification of shock allows for timely resuscitation. Previous studies note the utility of bedside calculations such as the shock index (SI) and quick sepsis-related organ failure assessment (qSOFA) to detect occult shock. Respiratory rate may also be an important marker of occult shock. The goal of our study was to evaluate whether using a modified SI with respiratory rate would improve identification of emergency department sepsis patients admitted to an ICU or stepdown unit.
    Methods: A prospective, observational cohort study of the respiratory adjusted shock index (RASI), defined as HR/SBP × RR/10, was conducted. RASI was calculated from triage vital signs and compared to serum lactate. Primary outcome was admission to a higher level of care defined as ICU or stepdown unit. A multivariable logistic regression model including RASI, SI, lactate, age and sex was performed with disposition as the outcome variable. Areas under the curve (AUC) were calculated to detect occult shock and level of care for RASI, SI, and qSOFA.
    Results: 408 patients were enrolled, 360 were included in the analysis. Regression analysis revealed that lactate (OR 1.55, z = 4.38, p < 0.0001) and RASI (OR 2.27, z = 3.03, p < 0.002) were predictive of need for higher level of care. The AUC for RASI, SI, and qSOFA to detect occult shock were 0.71, 0.6, and 0.61 respectively. RASI also had a significant AUC in predicting level of care at 0.75 compared to SI (0.64) and qSOFA (0.62).
    Conclusions: RASI may have utility as a rapid bedside tool for predicting critical illness in sepsis patients.
    MeSH term(s) Adult ; Aged ; Biomarkers/blood ; Early Diagnosis ; Emergency Service, Hospital ; Female ; Humans ; Lactic Acid/blood ; Male ; Middle Aged ; New York City ; Point-of-Care Testing ; Prospective Studies ; Respiratory Rate ; Severity of Illness Index ; Shock, Septic/diagnosis
    Chemical Substances Biomarkers ; Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2019-01-15
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, N.I.H., Extramural
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2019.01.026
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    Zs.A 2005: Show issues Location:
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  7. Article ; Online: The application of gap analysis to develop a call out/call back airway checklist: An ED quality improvement study.

    Caputo, Nicholas D / Kanter, Marc P / Scott, Sandra

    The American journal of emergency medicine

    2018  Volume 36, Issue 9, Page(s) 1704–1706

    MeSH term(s) Checklist ; Emergency Service, Hospital ; Humans ; Intubation, Intratracheal/methods ; Intubation, Intratracheal/standards ; Quality Improvement
    Language English
    Publishing date 2018-05-07
    Publishing country United States
    Document type Letter
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2018.01.063
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  8. Article ; Online: Early Self‐Proning in Awake, Non‐intubated Patients in the Emergency Department

    Caputo, Nicholas D. / Strayer, Reuben J. / Levitan, Richard

    Academic Emergency Medicine

    A Single ED’s Experience During the COVID‐19 Pandemic

    2020  Volume 27, Issue 5, Page(s) 375–378

    Keywords Emergency Medicine ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1329813-6
    ISSN 1553-2712 ; 1069-6563
    ISSN (online) 1553-2712
    ISSN 1069-6563
    DOI 10.1111/acem.13994
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  9. Article ; Online: Time to Renitrogenation After Maximal Denitrogenation in Healthy Volunteers in the Supine and Sitting Positions.

    West, Jason R / Levine, Rykiel / Raggi, Jason / Nguyen, Du-Thuyen / Oliver, Matthew / Caputo, Nicholas D / Sakles, John C

    The western journal of emergency medicine

    2022  Volume 23, Issue 6, Page(s) 926–930

    Abstract: Introduction: Prior to intubation, preoxygenation is performed to denitrogenate the lungs and create an oxygen reservoir. After oxygen is removed, it is unclear whether renitrogenation after preoxygenation occurs faster in the supine vs the sitting ... ...

    Abstract Introduction: Prior to intubation, preoxygenation is performed to denitrogenate the lungs and create an oxygen reservoir. After oxygen is removed, it is unclear whether renitrogenation after preoxygenation occurs faster in the supine vs the sitting position.
    Methods: We enrolled 80 healthy volunteers who underwent two preoxygenation and loss of preoxygenation procedures (one while supine and one while sitting) via bag-valve-mask ventilation with spontaneous breathing. End-tidal oxygen (ETO
    Results: The mean ETO
    Conclusion: Preoxygenation loss, or renitrogenation, occurred rapidly after oxygen removal and was not different in the supine and sitting positions. After maximal denitrogenation in healthy volunteers, renitrogenation occurred rapidly after oxygen removal and was not different in the supine and sitting positions.
    MeSH term(s) Humans ; Sitting Position ; Healthy Volunteers ; Respiration, Artificial/methods ; Oxygen ; Lung
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2375700-0
    ISSN 1936-9018 ; 1936-9018
    ISSN (online) 1936-9018
    ISSN 1936-9018
    DOI 10.5811/westjem.2022.5.55378
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  10. Article ; Online: Noninvasive ventilation during procedural sedation in the ED: a case series.

    Strayer, Reuben J / Caputo, Nicholas D

    The American journal of emergency medicine

    2015  Volume 33, Issue 1, Page(s) 116–120

    MeSH term(s) Adult ; Aged ; Conscious Sedation ; Emergency Service, Hospital ; Female ; Humans ; Male ; Middle Aged ; Noninvasive Ventilation/methods ; Prospective Studies
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Letter
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2014.10.023
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