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  1. Article ; Online: T cell development made EZ.

    Lavaert, Marieke / Bhandoola, Avinash

    Cell stem cell

    2022  Volume 29, Issue 8, Page(s) 1155–1156

    Abstract: In this issue of Cell Stem Cell, Jing et al. inhibit EZH1 expression in a system that supports mature T cell development from iPSCs in vitro. The authors efficiently generate T cells that are highly functional against tumors. ...

    Abstract In this issue of Cell Stem Cell, Jing et al. inhibit EZH1 expression in a system that supports mature T cell development from iPSCs in vitro. The authors efficiently generate T cells that are highly functional against tumors.
    MeSH term(s) Cell Differentiation ; Induced Pluripotent Stem Cells/metabolism ; T-Lymphocytes
    Language English
    Publishing date 2022-07-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2022.07.003
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  2. Article ; Online: Building early defenses.

    Ding, Yi / Bhandoola, Avinash

    Cell research

    2021  Volume 31, Issue 10, Page(s) 1041–1042

    Language English
    Publishing date 2021-07-15
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-021-00535-4
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  3. Article ; Online: ThymUS in times of stress.

    Shissler, Susannah C / Bhandoola, Avinash

    Nature immunology

    2021  Volume 22, Issue 5, Page(s) 545–549

    MeSH term(s) Allergy and Immunology ; Animals ; Biomedical Research ; COVID-19 ; Cell Differentiation ; Humans ; Phenotype ; Stress, Physiological ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Telecommunications ; Thymocytes/immunology ; Thymocytes/metabolism ; Thymus Gland/immunology ; Thymus Gland/metabolism
    Language English
    Publishing date 2021-03-10
    Publishing country United States
    Document type Congress ; Portrait
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-021-00897-2
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  4. Article ; Online: Early Development of Innate Lymphoid Cells.

    Ding, Yi / Harly, Christelle / Das, Arundhoti / Bhandoola, Avinash

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2580, Page(s) 51–69

    Abstract: Innate lymphoid cells (ILCs) are transcriptionally and functionally similar to T cells but lack adaptive antigen receptors. They play critical roles in early defense against pathogens. In this review, we summarize recent discoveries of ILC progenitors ... ...

    Abstract Innate lymphoid cells (ILCs) are transcriptionally and functionally similar to T cells but lack adaptive antigen receptors. They play critical roles in early defense against pathogens. In this review, we summarize recent discoveries of ILC progenitors and discuss possible mechanisms that separate ILCs from T cells. We consider mechanisms of lineage specification in early ILC development and also examine whether differences exist between adult and fetal ILC development.
    MeSH term(s) Immunity, Innate ; Lymphocytes ; T-Lymphocytes
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2740-2_3
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  5. Article: ILC Differentiation from Progenitors in the Bone Marrow.

    Das, Arundhoti / Harly, Christelle / Ding, Yi / Bhandoola, Avinash

    Advances in experimental medicine and biology

    2022  Volume 1365, Page(s) 7–24

    Abstract: Innate lymphoid cells (ILCs) are a family of immune cells that possess similar functions as T cells. We review steps of central ILC development in the bone marrow of adult mice and discuss recent evidence for peripheral ILC development suggesting ... ...

    Abstract Innate lymphoid cells (ILCs) are a family of immune cells that possess similar functions as T cells. We review steps of central ILC development in the bone marrow of adult mice and discuss recent evidence for peripheral ILC development suggesting extramedullary sites of ILC development. We also assess the contribution of development during different phases of life towards shaping the composition of the adult ILC pool. Finally, we briefly review the local cues that lead to heterogeneity of ILCs between tissues. We propose that tissue-resident ILC progenitors may economically allow tissues to elicit rapid expansion of specific ILC types that are needed based on the nature of antigenic assaults in tissues.
    MeSH term(s) Animals ; Bone Marrow ; Cell Differentiation ; Immunity, Innate ; Lymphocytes ; Mice ; T-Lymphocytes
    Language English
    Publishing date 2022-05-14
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-16-8387-9_2
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  6. Article ; Online: Bone marrow plasma cells require P2RX4 to sense extracellular ATP.

    Ishikawa, Masaki / Hasanali, Zainul S / Zhao, Yongge / Das, Arundhoti / Lavaert, Marieke / Roman, Carly J / Londregan, Jennifer / Allman, David / Bhandoola, Avinash

    Nature

    2024  Volume 626, Issue 8001, Page(s) 1102–1107

    Abstract: Plasma cells produce large quantities of antibodies and so play essential roles in immune ... ...

    Abstract Plasma cells produce large quantities of antibodies and so play essential roles in immune protection
    MeSH term(s) Animals ; Mice ; Adenosine Triphosphate/metabolism ; Autoantibodies/immunology ; Autoimmunity/immunology ; Bone Marrow Cells/cytology ; Bone Marrow Cells/metabolism ; Cell Lineage ; Connexins/genetics ; Connexins/metabolism ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress ; Mutation ; Osteoblasts/metabolism ; Plasma Cells/cytology ; Plasma Cells/immunology ; Plasma Cells/metabolism ; Receptors, Purinergic P2X4/metabolism ; Signal Transduction
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE) ; Atf4 protein, mouse ; Autoantibodies ; Connexins ; Ddit3 protein, mouse ; P2rx4 protein, mouse ; pannexin 3 protein, mouse ; Receptors, Purinergic P2X4
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07047-2
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    Zs.MO 244: Show issues

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  7. Article ; Online: Switch hitter: Bcl11b in T cells and ILC2s.

    Harly, Christelle / Bhandoola, Avinash

    The Journal of experimental medicine

    2019  Volume 217, Issue 1

    Abstract: In this issue of JEM, Hosokawa et al. (https://doi.org/10.1084/jem.20190972) establish that transcription factor Bcl11b regulates almost completely distinct sets of genes in T cell precursors and ILC2s. To understand how this occurs, they identify ... ...

    Abstract In this issue of JEM, Hosokawa et al. (https://doi.org/10.1084/jem.20190972) establish that transcription factor Bcl11b regulates almost completely distinct sets of genes in T cell precursors and ILC2s. To understand how this occurs, they identify multiple levels of functional regulation for Bcl11b that are used differently by T cell precursors and ILC2s.
    MeSH term(s) Immunity, Innate ; Lymphocytes ; Repressor Proteins ; Transcription Factors ; Tumor Suppressor Proteins
    Chemical Substances Repressor Proteins ; Transcription Factors ; Tumor Suppressor Proteins
    Language English
    Publishing date 2019-12-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20191739
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  8. Article ; Online: Revelations in Thymic Epithelial Cell Biology and Heterogeneity from Single-Cell RNA Sequencing and Lineage Tracing Methodologies.

    Morales-Sanchez, Abigail / Shissler, Susannah C / Cowan, Jennifer E / Bhandoola, Avinash

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2580, Page(s) 25–49

    Abstract: Thymic epithelial cells (TECs) make up the thymic microenvironments that support the generation of a functionally competent and self-tolerant T-cell repertoire. Cortical (c)TECs, present in the cortex, are essential for early thymocyte development ... ...

    Abstract Thymic epithelial cells (TECs) make up the thymic microenvironments that support the generation of a functionally competent and self-tolerant T-cell repertoire. Cortical (c)TECs, present in the cortex, are essential for early thymocyte development including selection of thymocytes expressing functional TCRs (positive selection). Medullary (m)TECs, located in the medulla, play a key role in late thymocyte development, including depletion of self-reactive T cells (negative selection) and selection of regulatory T cells. In recent years, transcriptomic analysis by single-cell (sc)RNA sequencing (Seq) has revealed TEC heterogeneity previously masked by population-level RNA-Seq or phenotypic studies. We summarize the discoveries made possible by scRNA-Seq, including the identification of novel mTEC subsets, advances in understanding mTEC promiscuous gene expression, and TEC alterations from embryonic to adult stages. Whereas pseudotime analyses of scRNA-Seq data can suggest relationships between TEC subsets, experimental methods such as lineage tracing and reaggregate thymic organ culture (RTOC) are required to test these hypotheses. Lineage tracing - namely, of β5t or Aire expressing cells - has exposed progenitor and parent-daughter cellular relationships within TEC.
    MeSH term(s) Animals ; Mice ; Cell Differentiation/genetics ; Thymus Gland ; Epithelial Cells ; Sequence Analysis, RNA ; Biology ; Mice, Inbred C57BL ; Cell Lineage/genetics
    Language English
    Publishing date 2022-11-22
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2740-2_2
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  9. Article ; Online: A novel role for p53 in self-tolerance.

    Larsen, Brian M / Bhandoola, Avinash

    Blood

    2017  Volume 130, Issue 4, Page(s) 388–389

    MeSH term(s) Humans ; Immune Tolerance ; Self Tolerance ; Tumor Suppressor Protein p53
    Chemical Substances Tumor Suppressor Protein p53
    Language English
    Publishing date 2017-07-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-06-789115
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  10. Article ; Online: Response to Comment on "Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of

    Larsen, Brian M / Cowan, Jennifer E / Bhandoola, Avinash

    Journal of immunology (Baltimore, Md. : 1950)

    2019  Volume 203, Issue 9, Page(s) 2355–2356

    MeSH term(s) Epithelial Cells ; Introns ; Regulatory Sequences, Nucleic Acid
    Language English
    Publishing date 2019-09-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1901011
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