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  1. Article ; Online: SKA3 targeted therapies in cancer precision surgery: a commentary.

    Wu, Changjiang / Yao, Yi / Lu, Wenqiang / Ji, Ze / Mao, Yiming

    International journal of surgery (London, England)

    2024  

    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000001463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6502: Show issues Location:
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  2. Article ; Online: Fluorine in anti-HIV drugs approved by FDA from 1981 to 2023.

    Han, Sheng / Lu, Yiming

    European journal of medicinal chemistry

    2023  Volume 258, Page(s) 115586

    Abstract: Human immunodeficiency virus (HIV) is the etiological agent of acquired immunodeficiency syndrome (AIDS). Nowadays, FDA has approved over thirty antiretroviral drugs grouped in six categories. Interestingly, one-third of these drugs contain different ... ...

    Abstract Human immunodeficiency virus (HIV) is the etiological agent of acquired immunodeficiency syndrome (AIDS). Nowadays, FDA has approved over thirty antiretroviral drugs grouped in six categories. Interestingly, one-third of these drugs contain different number of fluorine atoms. The introduction of fluorine to obtain drug-like compounds is a well-accepted strategy in medicinal chemistry. In this review, we summarized 11 fluorine-containing anti-HIV drugs, focusing on their efficacy, resistance, safety, and specific roles of fluorine in the development of each drug. These examples may be of help for the discovery of new drug candidates bearing fluorine in their structures.
    MeSH term(s) Humans ; Fluorine/chemistry ; Acquired Immunodeficiency Syndrome/drug therapy ; Anti-HIV Agents/chemistry ; HIV-1 ; HIV Infections/drug therapy
    Chemical Substances Fluorine (284SYP0193) ; Anti-HIV Agents
    Language English
    Publishing date 2023-06-27
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2023.115586
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    Zs.B 784: Show issues Location:
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  3. Article ; Online: Influence of boundary layer jets on the vertical distribution of ozone in Guangdong, China.

    He, Yuanping / Fan, Shaojia / Wang, Yiming / Liu, Yiming / Lu, Xiao / Wang, Haolin / He, Cheng / Mai, Chuying / Du, Yu

    The Science of the total environment

    2024  Volume 927, Page(s) 171874

    Abstract: The planetary boundary layer (PBL) characteristics during ozone ( ... ...

    Abstract The planetary boundary layer (PBL) characteristics during ozone (O
    Language English
    Publishing date 2024-03-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171874
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    Zs.A 949: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Discovery and properties of novel analogues of the aphid pheromones nepetalactone and nepetalactol.

    Lu, Yiming / Li, Zhong / Shao, Xusheng / Maienfisch, Peter

    Pest management science

    2024  

    Abstract: Background: Pheromones have unique advantages for pest control. Current aphid pheromone research focuses on alarm and sex pheromones. However, practical applications are limited so far, as (E)-β-farnesene has only been investigated to a small extent as ... ...

    Abstract Background: Pheromones have unique advantages for pest control. Current aphid pheromone research focuses on alarm and sex pheromones. However, practical applications are limited so far, as (E)-β-farnesene has only been investigated to a small extent as an alarm pheromone and only male aphids are targeted by sex pheromones. Previous literature reports electrophysiological responses and repellent behavior of asexual aphids to nepetalactone (1B), therefore our objective was to modify nepetalactone's structure to identify key fragments responsible for repellent effects, as guidance for subsequent modifications and further investigation.
    Results: In this study, seven derivatives were designed and synthesized based on nepetalactol (1A) and nepetalactone (1B) as lead compounds. Free-choice tests, conducted using cowpea aphids (Aphis craccivora), revealed that the lactone moiety was crucial for the repellent activity, and the removal of the carbonyl group eliminated the repelling effect. Compound (±)1I, an analogue of nepetalactone (1B), demonstrated a significantly higher repellent value than nepetalactone (1B) at three different concentrations, and even at 0.1 mg/mL it maintained a considerable repellent effect (26.5%). Electrostatic potential and density functional theory calculations supported the importance of the carbonyl group for the repellent effects.
    Conclusion: The newly discovered para-pheromone (±)1I shows improved repellent effects and potential for development as a novel biological control agent. Based on our innovative findings, analogues with improved efficacy and properties can be designed and prepared. Our research contributes to understanding the effects of structural modifications on pheromone activity and properties, which is crucial for exploring novel pheromone-based products for crop protection. © 2024 Society of Chemical Industry.
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001705-4
    ISSN 1526-4998 ; 1526-498X
    ISSN (online) 1526-4998
    ISSN 1526-498X
    DOI 10.1002/ps.7984
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    In stock of ZB MED Bonn / Germany

    Z 2731: Show issues

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  5. Article ; Online: Letter to the editor for the article "Comparative efficacy and safety of different minimal invasive pyeloplasty in treating patients with ureteropelvic junction obstruction: a network meta-analysis".

    Yan, Jiulong / Chen, Mengqing / Lu, Wenqiang / Mao, Yiming

    World journal of urology

    2023  Volume 41, Issue 11, Page(s) 3389–3390

    MeSH term(s) Humans ; Network Meta-Analysis ; Ureter/surgery ; Ureteral Obstruction/surgery ; Kidney
    Language English
    Publishing date 2023-09-26
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-023-04621-7
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    Zs.A 1832: Show issues Location:
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  6. Article ; Online: Author Correction: Studying the impact of marital status on diagnosis and survival prediction in pancreatic ductal carcinoma using machine learning methods.

    Chen, Qingquan / Hu, Yiming / Lin, Wen / Huang, Zhimin / Li, Jiaxin / Lu, Haibin / Dai, Rongrong / You, Liuxia

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6911

    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-57179-8
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  7. Article ; Online: Boosted elimination of florfenicol by BiOCl

    Tan, Lu / Yuan, Zhenxi / Chen, Weirui / Lin, Ziyi / Tang, Yiming / Li, Laisheng / Wang, Jing

    Journal of colloid and interface science

    2023  Volume 658, Page(s) 487–496

    Abstract: In this work, a series of ... ...

    Abstract In this work, a series of BiOCl
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2023.12.086
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    Z 71/707: Show issues

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  8. Article: CfCpmd1

    Kong, Yuanyuan / Yuan, Yilong / Menghan, Yang / Yiming, Lu / Liang, Xiaofei / Gleason, Mark L / Rong, Zhang / Sun, Guangyu

    Phytopathology

    2023  Volume 113, Issue 10, Page(s) 1985–1993

    Abstract: Colletotrichum ... ...

    Abstract Colletotrichum fructicola
    MeSH term(s) Phyllachorales ; Malus/microbiology ; Virulence ; Plant Diseases/microbiology ; Sexual Development
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208889-7
    ISSN 1943-7684 ; 0031-949X
    ISSN (online) 1943-7684
    ISSN 0031-949X
    DOI 10.1094/PHYTO-02-23-0071-R
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    Zs.B 698: Show issues Location:
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  9. Article: The learning curve and experience of a novel multi-modal image fusion targeted transperineal prostate biopsy technique using electromagnetic needle tracking under local anesthesia.

    Yang, Yongjun / He, Xianya / Zeng, Yiming / Lu, Qiang / Li, Yuanwei

    Frontiers in oncology

    2024  Volume 14, Page(s) 1361093

    Abstract: Background: Prostate cancer is the most common malignant tumor of male genitourinary system, and the gold standard for its diagnosis is prostate biopsy. Focusing on the methods and skills of prostate biopsy, we explored the learning curve and experience ...

    Abstract Background: Prostate cancer is the most common malignant tumor of male genitourinary system, and the gold standard for its diagnosis is prostate biopsy. Focusing on the methods and skills of prostate biopsy, we explored the learning curve and experience of a novel magnetic resonance imaging and transrectal ultrasound (mpMRI-TRUS) image fusion transperineal biopsy (TPB) technique using electromagnetic needle tracking under local anesthesia.
    Methods: The clinical and pathological data of 92 patients who underwent targeted TPB from January 2023 to July 2023 in our center were prospectively collected. The cumulative sum (CUSUM) analysis method and the best fitting curve were used to analyze the learning curve of this novel technique, and the clinical characteristics, perioperative data and tumor positive rate of prostate biopsy of patients at different stages of the learning curve were compared.
    Results: With the increase of the number of surgical cases, the overall operative time showed a downward trend. The best fitting curve of CUSUM reached its peak at the twelfth case, which is the minimum cumulative number of surgical cases needed to cross the learning curve of the operation. Taking this as the boundary, the learning curve is divided into two stages: learning improvement stage (group A, 12 cases) and proficiency stage (group B, 80 cases). The surgical time and visual analog scale score during prostate biopsy in group A were significantly higher than those in group B. The visual numerical scale score during prostate biopsy in group A was significantly lower than that in group B. There was no statistically significant difference between group A and group B in the detection rate of csPCa and the incidence of perioperative complications.
    Conclusion: The novel targeted TPB technique is divided into learning improvement stage and proficiency stage, and 12 cases may be the least cumulative number.
    Language English
    Publishing date 2024-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1361093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Dimethylcyclosiloxanes in Mobile Smart Terminal Devices: Concentrations, Distributions, Profiles, and Environmental Emissions.

    Xing, Yuanna / Ge, Yiming / Lu, Shaoyou / Yang, Tao / Peng, Xianzhi

    Toxics

    2024  Volume 12, Issue 4

    Abstract: Dimethylcyclosiloxanes (DMCs) are utilized as vital monomers in the synthesis of organosilicon compounds, integral to the manufacture of mobile smart terminal devices. Toxicological studies have revealed potential endocrine-disrupting activity, ... ...

    Abstract Dimethylcyclosiloxanes (DMCs) are utilized as vital monomers in the synthesis of organosilicon compounds, integral to the manufacture of mobile smart terminal devices. Toxicological studies have revealed potential endocrine-disrupting activity, reproductive toxicity, neurotoxicity, and other toxicities of the DMCs. This study investigated the concentrations and composition profiles of seven DMCs, including hexamethylcyclotrisiloxane (D3), octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), dodecamethylcyclohexasiloxane (D6), and tetradecamethylcycloheptasiloxane (D7), hexadecamethylcyclooctasiloxane (D8), and octadecamethylcyclononasiloxane (D9) in three types of mobile smart terminal device components (silicone rubber, adhesive, and plastics). Environmental emissions of DMCs from silicone rubber materials were also estimated to improve the recognition of their potential fate within the environment. D5-D9 were widely present in silicone rubber and adhesives with detection rates ranging from 91-95.5% and 50-100%, respectively, while D3 and D4 were more frequently detected in plastics, both showing a detection rate of 61.1%. Silicone rubber had the highest total DMCs (∑7DMCs) and a concentration of 802.2 mg/kg, which were dominated by D7, D8, and D9. DMCs detected in adhesives were dominated by D4, D5, and D6. The estimated emission of ∑DMCs released into the environment in China from silicone rubber used in mobile smart terminal devices exceeds 5000 tons per year. Further studies are needed on the presence of DMCs in various commodities and environmental media to assess their ecological and human health impacts, as well as the toxicological effects of D7-D9 for the appropriate regulation of these chemicals.
    Language English
    Publishing date 2024-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics12040287
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