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  1. Article ; Online: Successful treatment of lupus protein-losing enteropathy with belimumab: A case report.

    Kojima, Marenori / Hanaoka, Hironari / Aoki, Kaito / Matsushita, Hiromi / Ito, Hiroshi / Yamada, Hidehiro

    Modern rheumatology case reports

    2024  

    Abstract: Lupus protein-losing enteropathy (LUPLE) is a rare condition in patients with systemic lupus erythematosus (SLE). Since the causes and exact pathological mechanism have not been elucidated, appropriate treatment has not been determined. Here, we report ... ...

    Abstract Lupus protein-losing enteropathy (LUPLE) is a rare condition in patients with systemic lupus erythematosus (SLE). Since the causes and exact pathological mechanism have not been elucidated, appropriate treatment has not been determined. Here, we report the case of a 69-year-old woman with systemic lupus erythematosus who developed LUPLE which was successfully treated with belimumab without an increase in glucocorticoid dose. This case suggests that belimumab monotherapy may be a treatment option for LUPLE.
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ISSN 2472-5625
    ISSN (online) 2472-5625
    DOI 10.1093/mrcr/rxae010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Case of Successful Immunosuppressive Therapy for Interstitial Lung Disease Associated with Sjögren's Syndrome With Double-positive Anti-SS-A and Anti-centromere Antibodies.

    Suzuki, Koji / Akiyama, Mitsuhiro / Kondo, Yasushi / Saito, Shuntaro / Kikuchi, Jun / Hanaoka, Hironari / Kaneko, Yuko

    Internal medicine (Tokyo, Japan)

    2024  

    Abstract: Sjögren's syndrome (SS) can present with extraglandular organs, such as interstitial lung disease (ILD). Anti-SS-A antibody is frequently found in SS cases, whereas anti-centromere antibody (ACA) is detected in some SS cases. Notably, the anti-SS-A and ... ...

    Abstract Sjögren's syndrome (SS) can present with extraglandular organs, such as interstitial lung disease (ILD). Anti-SS-A antibody is frequently found in SS cases, whereas anti-centromere antibody (ACA) is detected in some SS cases. Notably, the anti-SS-A and ACA double-positive cases exhibited distinct features with a higher prevalence of ILD. However, there have so far been no reports on the treatment of ILD in anti-SS-A and ACA double-positive cases. We herein present a case of ILD with anti-SS-A and ACA double-positive SS that was successfully treated with immunosuppressive therapy. Our case suggests the potential efficacy of immunosuppressive therapy for this poorly understood condition.
    Language English
    Publishing date 2024-03-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.3384-23
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  3. Article ; Online: Toxic epidermal necrosis-like acute cutaneous lupus erythematosus.

    Suzuki, Koji / Saito, Shuntaro / Akiyama, Mitsuhiro / Kondo, Yasushi / Kikuchi, Jun / Hanaoka, Hironari / Kaneko, Yuko

    The Lancet. Rheumatology

    2023  Volume 6, Issue 4, Page(s) e252

    MeSH term(s) Humans ; Lupus Erythematosus, Cutaneous/diagnosis ; Acute Disease ; Necrosis
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(23)00154-6
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  4. Article ; Online: Rapidly progressive interstitial lung disease in clinically amyopathic dermatomyositis triggered by a 23-valent pneumococcal polysaccharide vaccine.

    Suzuki, Koji / Akiyama, Mitsuhiro / Kondo, Yasushi / Saito, Shuntaro / Kikuchi, Jun / Hanaoka, Hironari / Kaneko, Yuko

    Autoimmunity reviews

    2023  Volume 22, Issue 5, Page(s) 103307

    MeSH term(s) Humans ; Immunosuppressive Agents ; Dermatomyositis/complications ; Pneumococcal Vaccines/therapeutic use ; Lung Diseases, Interstitial/complications ; Disease Progression
    Chemical Substances Immunosuppressive Agents ; Pneumococcal Vaccines
    Language English
    Publishing date 2023-02-24
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2023.103307
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    Zs.A 5913: Show issues Location:
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  5. Article ; Online: Apremilast is a potentially useful treatment for severe palmoplantar pustulosis with extra-palmoplantar symptoms.

    Fukushima-Nomura, Ayano / Takamiyagi, Saeko / Kakuta, Risa / Ito, Yoshihiro / Hirai, Ikuko / Umemoto, Junichi / Hanaoka, Hironari / Kaneko, Yuko / Tanese, Keiji

    Skin health and disease

    2024  Volume 4, Issue 2, Page(s) e336

    Abstract: Palmoplantar pustulosis (PPP) is a chronic inflammatory skin disorder affecting the palms and soles. In rare cases, severe patients develop acute extra-palmoplantar lesions often accompanied by arthralgia. Such cases with extensive symptoms often ... ...

    Abstract Palmoplantar pustulosis (PPP) is a chronic inflammatory skin disorder affecting the palms and soles. In rare cases, severe patients develop acute extra-palmoplantar lesions often accompanied by arthralgia. Such cases with extensive symptoms often necessitate systemic treatments with variable efficacy and potential side effects. Apremilast, known for its broad immune response modulation, presents promise as a therapeutic option for severe PPP with joint and extra-palmoplantar lesions. This case highlights apremilast as a potential systemic treatment for such cases with minimal side effects.
    Language English
    Publishing date 2024-01-15
    Publishing country England
    Document type Case Reports
    ISSN 2690-442X
    ISSN (online) 2690-442X
    DOI 10.1002/ski2.336
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  6. Article ; Online: Comparison between the BioPlex 2200 ANA Screen™ and a conventional method with respect to the detection of autoantibodies.

    Kaneko, Yuko / Saito, Shuntaro / Kojima, Marenori / Oshige, Tatsuhiro / Ota, Yuichiro / Nishina, Naoshi / Kikuchi, Jun / Hanaoka, Hironari / Tsutomu, Takeuchi

    Modern rheumatology

    2023  

    Language English
    Publishing date 2023-07-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2078157-X
    ISSN 1439-7609 ; 1439-7595
    ISSN (online) 1439-7609
    ISSN 1439-7595
    DOI 10.1093/mr/road075
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    Zs.B 2982: Show issues Location:
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  7. Article ; Online: Sarcopenia in patients with rheumatic musculoskeletal diseases.

    Hanaoka, Hironari / Kikuchi, Jun / Hiramoto, Kazuoto / Akiyama, Mitsuhiro / Saito, Shutaro / Kondo, Yasushi / Kaneko, Yuko

    International journal of rheumatic diseases

    2023  Volume 26, Issue 10, Page(s) 2007–2013

    Abstract: Aim: To investigate the impact of high-dose glucocorticoid therapy on sarcopenia in hospitalized patients with rheumatic musculoskeletal diseases (RMDs).: Methods: We included patients with RMDs who were hospitalized between 2020 and 2022 for ... ...

    Abstract Aim: To investigate the impact of high-dose glucocorticoid therapy on sarcopenia in hospitalized patients with rheumatic musculoskeletal diseases (RMDs).
    Methods: We included patients with RMDs who were hospitalized between 2020 and 2022 for remission induction treatment and collected information on skeletal mass index (SMI) before high-dose glucocorticoid therapy and 1 month later. We divided the patients into 2 groups according to the progression of sarcopenia, defined as a >10% decrease in SMI, and compared their clinical characteristics.
    Results: Forty-nine patients were included in this analysis. The mean age was 53.3 years, 73.5% were female, and the mean SMI was 5.3 kg/m
    Conclusions: One-month hospitalization with high-dose glucocorticoid therapy is associated with sarcopenia progression in patients with RMDs. An early decrease in body weight can be used to predict muscle volume loss.
    Language English
    Publishing date 2023-08-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.14856
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    Zs.A 6098: Show issues Location:
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  8. Article ; Online: Re-emphasising the importance of catheter-based angiography to differentiate polyarteritis nodosa from cutaneous arteritis: Two case reports.

    Suzuki, Koji / Akiyama, Mitsuhiro / Kondo, Yasushi / Saito, Shuntaro / Kikuchi, Jun / Hanaoka, Hironari / Kaneko, Yuko

    Modern rheumatology case reports

    2023  Volume 8, Issue 1, Page(s) 133–136

    Abstract: Polyarteritis nodosa (PAN) is a systemic necrotising vasculitis with a poor prognosis, characterised by inflammation and necrosis of medium-sized arteries. PAN patients can present with a wide range of systemic manifestations, whereas cutaneous arteritis ...

    Abstract Polyarteritis nodosa (PAN) is a systemic necrotising vasculitis with a poor prognosis, characterised by inflammation and necrosis of medium-sized arteries. PAN patients can present with a wide range of systemic manifestations, whereas cutaneous arteritis (CA) is a restricted manifestation to skin of the disease with a more favourable prognosis. Thus, differentiation between PAN and CA is crucial. Here, we present two cases that were initially diagnosed as CA due to the limited presence of systemic symptoms, but were finally diagnosed as PAN through catheter-based angiography. Although contrast-enhanced computed tomography and computed tomographic angiography are increasingly used to diagnose PAN, neither case had any abnormal findings on these examinations. Our cases therefore underscore that catheter-based angiography is critical for differentiation between PAN and CA, even in cases with limited systemic symptoms.
    MeSH term(s) Humans ; Polyarteritis Nodosa/diagnosis ; Arteritis ; Vasculitis ; Skin ; Angiography
    Language English
    Publishing date 2023-11-10
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 2472-5625
    ISSN (online) 2472-5625
    DOI 10.1093/mrcr/rxad064
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  9. Article: Dissociating Autoantibody Responses against Ro52 Antigen in Patients with Anti-Synthetase or Anti-MDA5 Antibodies.

    Yoshida, Akira / Nagata, Shunya / Okazaki, Yuka / Hanaoka, Hironari / Gono, Takahisa / Kuwana, Masataka

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 24

    Abstract: We aimed to dissociate the autoantibody response against the Ro52 protein in patients with anti-synthetase or anti-melanoma differentiation-associated gene 5 (MDA5) antibodies to explore the potential roles of different anti-Ro52 autoantibody responses ... ...

    Abstract We aimed to dissociate the autoantibody response against the Ro52 protein in patients with anti-synthetase or anti-melanoma differentiation-associated gene 5 (MDA5) antibodies to explore the potential roles of different anti-Ro52 autoantibody responses in disease subclassification. This study used a single-center, prospective myositis cohort involving 122 consecutive patients with anti-synthetase antibodies identified by RNA immunoprecipitation (RNA-IP) and 34 patients with anti-MDA5 antibodies detected using enzyme immunoassay (EIA). Anti-Ro52 antibodies were measured using commercial EIA kits, while anti-Ro/SSA antibodies were identified using RNA-IP. Clinical features and outcomes were stratified according to two different patterns of autoantibody responses against Ro52, including "isolated anti-Ro52", defined by positive anti-Ro52 and negative anti-Ro/SSA antibodies, and "anti-SSA-Ro52", defined by positive anti-Ro52 and anti-Ro/SSA antibodies. Isolated anti-Ro52 positivity was the most prevalent autoantibody response in patients with both anti-synthetase (40/122; 32.8%) and anti-MDA5 antibodies (8/34; 23.5%). Isolated anti-Ro52 or anti-SSA-Ro52 positivity was associated with Gottron's sign in patients with anti-synthetase antibodies, while in patients with anti-MDA5 antibodies, isolated anti-Ro52 positivity was associated with respiratory insufficiency at initial presentation and poor overall survival. Isolated anti-Ro52 positivity could be a potential biomarker for patient stratification; however, the clinical significance of dissociating isolated anti-Ro52 positivity from overall anti-Ro52 positivity was not evident.
    Language English
    Publishing date 2023-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13243621
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  10. Article: Deep remission within 12 months prevents renal flare and damage accrual in lupus nephritis.

    Kikuchi, Jun / Hanaoka, Hironari / Saito, Shuntaro / Oshige, Tatsuhiro / Hiramoto, Kazuoto / Takeuchi, Tsutomu / Kaneko, Yuko

    Clinical and experimental rheumatology

    2023  Volume 41, Issue 7, Page(s) 1500–1506

    Abstract: Objectives: To evaluate the significance of achieving deep remission by induction therapy in lupus nephritis (LN) patients.: Methods: We assessed consecutive patients undergoing induction therapy for active LN. Achievement of complete renal response ( ...

    Abstract Objectives: To evaluate the significance of achieving deep remission by induction therapy in lupus nephritis (LN) patients.
    Methods: We assessed consecutive patients undergoing induction therapy for active LN. Achievement of complete renal response (CR) was defined as a urine protein creatinine ratio (UPCR) ≤0.5 g/gCr, and deep remission (DR) was defined as a UPCR ≤0.15 g/gCr with stabilisation of serum creatinine levels assessed every 2-3 months. We compared renal flare and damage accrual rates among patients with CR, CR without DR, and DR at 3, 6, and 12 months and later.
    Results: Fifty-nine Asian patients were enrolled, and the median observation period was 48.6 months. Of these, 55 patients achieved CR, and 33 achieved DR within 12 months of receiving induction therapy. The patients with DR within 12 months experienced a significantly lower rate of subsequent renal flare (p<0.001) and damage accrual (p=0.046) than those without CR, those with DR after 12 months, and those with no DR but CR within 12 months. In addition, younger age, shorter disease duration, lower urine protein at baseline, and earlier renal response were associated with DR within 12 months.
    Conclusions: Achievement of DR within 12 months after induction therapy should be a treatment target for active LN, as it has implications for preventing renal flare and damage accrual.
    MeSH term(s) Humans ; Infant ; Lupus Nephritis/drug therapy ; Treatment Outcome ; Immunosuppressive Agents ; Retrospective Studies ; Kidney ; Remission Induction
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2023-01-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/7yv1dz
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