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Book ; Thesis: Einfluss der Kompressionstherapie auf die strukturelle Veränderung unterschiedlicher Gewebekompartimente von Oberarmen und Oberschenkeln unter isoinertialem Muskeltraining

Ruf, Jasmine / Baeßler, Bettina / Wegmann, Kilian

2020

Institution	Institut und Poliklinik für Radiologische Diagnostik
Author's details	vorgelegt von Jasmine Ruf ; 1. Gutachterin: Privatdozentin Dr. med. habil. B. Baeßler, 2. Gutachter: Privatdozent Dr. med. K. Wegmann ; aus dem Institut und Poliklinik für Radiologische Diagnostik der Universität zu Köln
Subject code	610
Language	German
Size	60 Seiten, Illustrationen, Diagramme
Publishing place	Köln
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Universität zu Köln, 2021
HBZ-ID	HT021001962
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Book ; Thesis: Der TORC2-SGK1 Signalweg hemmt die SKN-1-Nrf vermittelte Embryonalentwicklung in C. elegans

Widmeier, Vanessa

2014

Author's details	von Vanessa Widmeier
Language	German
Size	106 S. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Freiburg (Breisgau), Univ., Diss., 2015
HBZ-ID	HT018757923
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Article ; Online: Cough-induced chylothorax in a two-year-old boy - case report and review of the literature.

Anger, Melanie / Hofmann, Julian / Ruf, Bettina / Steinborn, Marc / Reber, Daniela / Warncke, Katharina / Rieber, Nikolaus

BMC pediatrics

2023 Volume 23, Issue 1, Page(s) 416

Abstract: Background: Chylothorax is a very rare form of pleural effusion in children, especially after the neonatal period, and predominantly occurs secondary to cardiothoracic surgery. It can lead to significant respiratory distress, immunodeficiency, and ... ...

Abstract	Background: Chylothorax is a very rare form of pleural effusion in children, especially after the neonatal period, and predominantly occurs secondary to cardiothoracic surgery. It can lead to significant respiratory distress, immunodeficiency, and malnutrition. Effective treatment strategies are therefore required to reduce morbidity. Case presentation: A previously healthy two-year old boy was admitted with history of heavy coughing followed by progressive dyspnea. The chest X-ray showed an extensive opacification of the right lung. Ultrasound studies revealed a large pleural effusion of the right hemithorax. Pleural fluid analysis delivered the unusual diagnosis of chylothorax, most likely induced by preceded excessive coughing. After an unsuccessful treatment attempt with a fat-free diet and continuous pleural drainage for two weeks, therapy with octreotide was initiated. This led to complete and permanent resolution of his pleural effusion within 15 days, without any side effects. Conclusions: Severe cough may be a rare cause of chylothorax in young children. Octreotide seems to be an effective and safe treatment of spontaneous or traumatic chylothorax in children. There is, however, a lack of comprehensive studies for chylothorax in children and many issues concerning diagnostic strategies and treatment algorithms remain.
MeSH term(s)	Male ; Child ; Infant, Newborn ; Humans ; Child, Preschool ; Chylothorax/etiology ; Chylothorax/therapy ; Cough/etiology ; Octreotide/therapeutic use ; Pleural Effusion/diagnostic imaging ; Pleural Effusion/etiology ; Pleural Effusion/therapy ; Algorithms ; Dyspnea
Chemical Substances	Octreotide (RWM8CCW8GP)
Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Review ; Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-023-04221-9
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Book ; Thesis: Akzidentelle gefährliche Vergiftungen im landwirtschaftlichen Betrieb

Meier-Ruf, Bettina

1986

Size	117 Bl. : graph. Darst.
Publishing country	Switzerland
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Zürich, Univ., Diss., 1986
HBZ-ID	HT003160420
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Article ; Online: Impact of calorie intake and weight gain after Norwood procedure on the outcome of stage II palliation.

Staehler, Helena / Schaeffer, Thibault / Ruf, Bettina / Heinisch, Paul Philipp / Di Padua, Chiara / Burri, Melchior / Piber, Nicole / Hager, Alfred / Ewert, Peter / Hörer, Jürgen / Ono, Masamichi

Cardiology in the young

2023 Volume 34, Issue 4, Page(s) 876–883

Abstract: Background: This study aimed to assess the impact of caloric intake and weight-for-age-Z-score after the Norwood procedure on the outcome of bidirectional cavopulmonary shunt.: Methods: A total of 153 neonates who underwent the Norwood procedure ... ...

Abstract	Background: This study aimed to assess the impact of caloric intake and weight-for-age-Z-score after the Norwood procedure on the outcome of bidirectional cavopulmonary shunt. Methods: A total of 153 neonates who underwent the Norwood procedure between 2012 and 2020 were surveyed. Postoperative daily caloric intake and weight-for-age-Z-score up to five months were calculated, and their impact on outcome after bidirectional cavopulmonary shunt was analysed. Results: Median age and weight at the Norwood procedure were 9 days and 3.2 kg, respectively. Modified Blalock-Taussig shunt was used in 95 patients and right ventricle to pulmonary artery conduit in 58. Postoperatively, total caloric intake gradually increased, whereas weight-for-age-Z-score constantly decreased. Early and inter-stage mortality before stage II correlated with low caloric intake. Older age (p = 0.023) at Norwood, lower weight (p < 0.001) at Norwood, and longer intubation (p = 0.004) were correlated with low weight-for-age-Z-score (< -3.0) at 2 months of age. Patients with weight-for-age-Z-score < -3.0 at 2 months of age had lower survival after stage II compared to those with weight-for-age-Z-score of -3.0 or more (85.3 versus 92.9% at 3 years after stage II, p = 0.017). There was no difference between inter-stage weight gain and survival after bidirectional cavopulmonary shunt between the shunt types. Conclusion: Weight-for-age-Z-score decreased continuously throughout the first 5 months after the Norwood procedure. Age and weight at Norwood and intubation time were associated with weight gain. Inter-stage low weight gain (Z-score < -3) was a risk for survival after stage II.
MeSH term(s)	Infant, Newborn ; Humans ; Infant ; Hypoplastic Left Heart Syndrome/surgery ; Treatment Outcome ; Norwood Procedures ; Fontan Procedure ; Pulmonary Artery/surgery ; Blalock-Taussig Procedure ; Heart Ventricles/surgery ; Weight Gain ; Retrospective Studies
Language	English
Publishing date	2023-11-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951123003736
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Article ; Online: Risk Factors for Thrombus Formation at Stage 2 Palliation and Its Effect on Long-Term Outcome in Patients With Univentricular Heart.

Ono, Masamichi / Kido, Takashi / Burri, Melchior / Anderl, Lisa / Ruf, Bettina / Cleuziou, Julie / Strbad, Martina / Hager, Alfred / Hörer, Jürgen / Lange, Rüdiger

Seminars in thoracic and cardiovascular surgery

2021 Volume 34, Issue 2, Page(s) 669–679

Abstract: Thrombus formation is a feared complication following bidirectional cavopulmonary shunt (BCPS). We aimed to investigate the effect of thrombus formation on outcome. BCPS was performed in 525 patients at our center between 1998 and 2018. The impacts of ... ...

Abstract	Thrombus formation is a feared complication following bidirectional cavopulmonary shunt (BCPS). We aimed to investigate the effect of thrombus formation on outcome. BCPS was performed in 525 patients at our center between 1998 and 2018. The impacts of thrombus formation on survival and probability of Fontan completion were analyzed, and risk factors for thrombus formation were examined. Thrombus formation occurred in 30 patients (5.7%). Compared with the remaining 495 patients, there was no significant difference in the median age at BCPS (4.9 vs 4.7 months; P = 0.587). However, unbalanced atrioventricular septal defects (17 vs 5%; P = 0.008) and preoperative ventricular dysfunction (23.3 vs 8%; P = 0.004) were more frequent in patients who developed a thrombus. Thrombolytic therapy was performed in all patients and surgical thrombus removal was required in 13 patients. In-hospital mortality was higher in patients with thrombus (30.0 vs 2.2%; P < 0.001). Of 505 hospital survivors, an estimated survival at 1 year after hospital discharge following BCPS was 84.4% (95% CI, 76.1-92.7%) in patients with thrombus and 96.8% (95% CI, 96.0-97.6%) in those without (P < 0.001). Cumulative incidence of Fontan completion at 3 years after BCPS was 52.8% (95% CI, 30.3-75.2%) in patients with thrombus and 90.1% (95% CI, 87.2-92.9%) in those without (P = 0.004). Higher left atrial pressure (OR = 1.165; P = 0.029) and longer cardiopulmonary bypass time (OR = 1.013, P = 0.001) at BCPS were independent risk factors for thrombus formation after BCPS. Thrombus formation after BCPS poses a significant risk for survival and Fontan completion. Preoperative higher left atrial pressure and longer cardiopulmonary bypass time are significant risk factors.
MeSH term(s)	Fontan Procedure/adverse effects ; Heart Defects, Congenital/diagnostic imaging ; Heart Defects, Congenital/surgery ; Humans ; Infant ; Retrospective Studies ; Risk Factors ; Thrombosis/diagnostic imaging ; Thrombosis/etiology ; Thrombosis/surgery ; Treatment Outcome ; Univentricular Heart
Language	English
Publishing date	2021-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1038278-1
ISSN	1532-9488 ; 1043-0679
ISSN (online)	1532-9488
ISSN	1043-0679
DOI	10.1053/j.semtcvs.2021.02.024
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Article ; Conference proceedings: Heart and Brain: Homozygous Mutations of GNB5 Gene in Two Siblings with Early Onset Sinus Node Dysfunction and Severe Neurological Symptoms

Leiz, Steffen / Shoukier, Moneef / Wagner, Matias / Ruf, Bettina / Baethmann, Martina

Neuropediatrics

2019 Volume 50, Issue S 02

Event/congress	Abstracts of the 45th Annual Meeting of the Society for Neuropediatrics, München, 2019-09-11
Language	English
Publishing date	2019-09-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	573291-8
ISSN	1439-1899 ; 0174-304X
ISSN (online)	1439-1899
ISSN	0174-304X
DOI	10.1055/s-0039-1698274
Database	Thieme publisher's database

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Zs.A 728: Show issues

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Article ; Online: Cardiovascular magnetic resonance in children with suspected myocarditis: current practice and applicability of adult protocols.

Pitak, Barbara / Opgen-Rhein, Bernd / Schubert, Stephan / Reineker, Katja / Wiegand, Gesa / Boecker, Dorothée / Rentzsch, Axel / Ruf, Bettina / Özcan, Sevinc / Wannenmacher, Bardo / Pickardt, Thomas / Seidel, Franziska / Messroghli, Daniel

Cardiology in the young

2022 , Page(s) 1–9

Abstract: Background: Cardiovascular magnetic resonance serves as a useful tool in diagnosing myocarditis. Current adult protocols are yet to be validated for children; thus, it remains unclear if the methods used can be applied with sufficient image quality in ... ...

Abstract	Background: Cardiovascular magnetic resonance serves as a useful tool in diagnosing myocarditis. Current adult protocols are yet to be validated for children; thus, it remains unclear if the methods used can be applied with sufficient image quality in children. This study assesses the use of cardiovascular magnetic resonance in children with suspected myocarditis. Methods: Image data from clinical cardiovascular magnetic resonance studies performed in children enrolled in Mykke between June 2014 and April 2019 were collected and analysed. The quality of the data sets was evaluated using a four-point quality scale (4: excellent, 3: good, 2: moderate, 1: non-diagnostic). Results: A total of 102 patients from 9 centres were included with a median age (interquartile range) of 15.4(10.7-16.6) years, 137 cardiovascular magnetic resonance studies were analysed. Diagnostic image quality was found in 95%. Examination protocols were consistent with the original Lake Louise criteria in 58% and with the revised criteria in 35%. Older patients presented with better image quality, with the best picture quality in the oldest age group (13-18 years). Sedation showed a negative impact on image quality in late gadolinium enhancement and oedema sequences. No such correlation was seen in cardiac function assessment sequences. In contrast to initial scans, in follow-up examinations, the use of parametric mapping increased while late gadolinium enhancement and oedema sequences decreased. Conclusion: Cardiovascular magnetic resonance protocols for the assessment of adult myocarditis can be applied to children without significant constraints in image quality. Given the lack of specific recommendations for children, cardiovascular magnetic resonance protocols should follow recent recommendations for adult cardiovascular magnetic resonance.
Language	English
Publishing date	2022-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951121005291
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Article: Pleural and mediastinal effusions after the extracardiac total cavopulmonary connection: Risk factors and impact on outcome.

Heinisch, Paul Philipp / Metz, Paul / Staehler, Helena / Mayr, Benedikt / Vodiskar, Janez / Strbad, Martina / Ruf, Bettina / Ewert, Peter / Hager, Alfred / Hörer, Jürgen / Ono, Masamichi

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 1026445

Abstract: Background: This study investigated the volume and duration of pleural and mediastinal effusions following extracardiac total cavopulmonary connection, as well as preoperative risk factors and their impact on outcome.: Materials and methods: A total ... ...

Abstract	Background: This study investigated the volume and duration of pleural and mediastinal effusions following extracardiac total cavopulmonary connection, as well as preoperative risk factors and their impact on outcome. Materials and methods: A total of 210 patients who underwent extracardiac total cavopulmonary connection at our center between 2012 and 2020 were included in this study. Postoperative daily amount of pleural and mediastinal drainage were collected and factors influencing duration and amount of effusions were analyzed. The impact of effusions on adverse events was analyzed. Results: Median age at extracardiac total cavopulmonary connection was 2.2 (interquartile range, 1.8-2.7) years with median weight of 11.6 (10.7-13.0) kg. Overall duration of drainage after extracardiac total cavopulmonary connection was 9 (6-17) days. The total volume of mediastinal, right pleural, and left pleural drainage was 18.8 (11.9-36.7), 64.4 (27.4-125.9), and 13.6 (0.0-53.5) mL/kg, respectively. Hypoplastic left heart syndrome ( Conclusion: Volume and duration of pleural and mediastinal effusions following extracardiac total cavopulmonary connection were related with hypoplastic left heart syndrome, aortopulmonary collaterals, and end-diastolic pressure. The duration of drainage for effusions was a risk factor for adverse events after total cavopulmonary connection.
Language	English
Publishing date	2022-11-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.1026445
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Article ; Online: Management of failing bidirectional cavopulmonary shunt: Influence of additional systemic-to-pulmonary-artery shunt with classic Glenn physiology.

Euringer, Caecilia / Kido, Takashi / Ruf, Bettina / Burri, Melchior / Heinisch, Paul Philipp / Vodiskar, Janez / Strbad, Martina / Cleuziou, Julie / Dilber, Daniel / Hager, Alfred / Ewert, Peter / Hörer, Jürgen / Ono, Masamichi

JTCVS open

2022 Volume 11, Page(s) 373–387

Abstract: Objectives: Severe hypoxemia in the early postoperative period after bidirectional cavopulmonary shunt (BCPS) is a critical complication. We aimed to evaluate patients who underwent additional systemic to pulmonary shunt and septation of central ... ...

Abstract	Objectives: Severe hypoxemia in the early postoperative period after bidirectional cavopulmonary shunt (BCPS) is a critical complication. We aimed to evaluate patients who underwent additional systemic to pulmonary shunt and septation of central pulmonary artery (partial takedown) after BCPS. Methods: The medical records of all patients who underwent BCPS between 2007 and 2020 were reviewed. Patients who underwent partial takedown were extracted and their outcomes were analyzed. Results: Of 441 BCPS patients, 27 patients (6%) required partial takedown. Most frequent diagnosis was hypoplastic left heart syndrome (n = 14; 52%). Additional complicating factors included pulmonary artery hypoplasia (n = 12) and pulmonary venous obstruction (n = 3). Thirteen patients (48%) underwent partial takedown on the same day of BCPS, and all of them survived the procedure. The remaining 14 patients (52%) underwent partial takedown between postoperative 1 to 64 days. The reasons for partial takedown were: postoperative high pulmonary vascular resistance (n = 4), early BCPS (<90 days) with PA hypoplasia (n = 3), mediastinitis/pneumonia (n = 3), pulmonary venous obstruction (n = 2), ventricular dysfunction (n = 1), and recurrent pneumothorax (n = 1). Four patients experienced hospital deaths. Six patients died after discharge, 10 achieved Fontan completion, and 6 were alive and waiting for Fontan. Overall survival after partial takedown was 54% at 3 years. The pulmonary venous obstruction ( Conclusions: The partial takedown resulted in a 3-year survival rate of more than 50%. Of these patients, a significant number underwent successful Fontan completion who would exhibit potential early death with conservative treatment.
Language	English
Publishing date	2022-06-11
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-2736
ISSN (online)	2666-2736
DOI	10.1016/j.xjon.2022.06.007
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