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  1. Article ; Online: Author Correction: ATM inhibitor KU60019 synergistically sensitizes lung cancer cells to topoisomerase II poisons by multiple mechanisms.

    Shu, Jianfeng / Wang, Xiaofang / Yang, Xuejie / Zhao, Guofang

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8785

    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59332-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Author Correction: ATM inhibitor KU60019 synergistically sensitizes lung cancer cells to topoisomerase II poisons by multiple mechanisms.

    Shu, Jianfeng / Wang, Xiaofang / Yang, Xuejie / Zhao, Guofang

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 13850

    Language English
    Publishing date 2023-08-24
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-40952-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: End-to-end aperture layout optimization and image restoration for optical sparse aperture systems.

    Zhao, Wenxiu / Zhang, Xiaofang

    Optics letters

    2023  Volume 48, Issue 10, Page(s) 2504–2507

    Abstract: The optical sparse aperture (OSA) imaging technique is capable of improving the spatial resolution of a telescope while maintaining lower size, weight, and cost. The majority of OSA system researches separately focus on the design optimization of ... ...

    Abstract The optical sparse aperture (OSA) imaging technique is capable of improving the spatial resolution of a telescope while maintaining lower size, weight, and cost. The majority of OSA system researches separately focus on the design optimization of aperture layout and the method for image restoration, which have great design redundancy. In this Letter, an end-to-end design framework that simultaneously optimizes the aperture layout parameters of the OSA system and neural network parameters of image restoration is proposed, which achieves excellent imaging quality. The results show that adequate image mid-frequency information captured by the OSA system benefits network processing more than incomplete high-frequency information in a few directions. Based on this framework, we design a simplified OSA system on geostationary orbit. The simulation results show that our simplified OSA system with six sub-apertures measuring 1.2m each has a comparable imaging performance to a single-aperture system measuring 12 m.
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.485418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Single-photon ranging lidar based on multi-repetition-rate pulse train correlation and accumulation.

    Kang, Yan / Wang, Xiaofang / Zhang, Tongyi / Zhao, Wei

    Optics letters

    2024  Volume 49, Issue 6, Page(s) 1628–1631

    Abstract: A single-photon lidar based on multi-repetition-rate pulse train correlation and accumulation is proposed, and a ranging experiment is conducted on a 32 m target. By accumulating the correlation ranging results of pulse trains with internal spacings of ... ...

    Abstract A single-photon lidar based on multi-repetition-rate pulse train correlation and accumulation is proposed, and a ranging experiment is conducted on a 32 m target. By accumulating the correlation ranging results of pulse trains with internal spacings of 80, 100, and 125 ns, the signal-to-noise ratio of the cross correlation function is improved by about three-fold, which enables our method to improve the ranging precisions by more than 20% compared with the single repetition-rate method, and the shorter the acquisition time, the more obvious the advantage will be. Experimental results show that at an acquisition time of 0.01 s, our method can still achieve a ranging precision of 2.59 cm, while the single repetition-rate method can no longer obtain effective ranging results at this time. This method will be of great significance for realizing high-speed, large-scale unambiguous single-photon lidar ranging.
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.511411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Circ_0030042 inhibits trophoblast cell growth, invasion and epithelial-mesenchymal transition process in preeclampsia via miR-942-5p/LITAF.

    Tian, Xiaolong / Zhang, Yajun / Zhao, Meng / Yin, Xiaofang

    Journal of reproductive immunology

    2024  Volume 162, Page(s) 104205

    Abstract: Background: There is increasing evidence that circular RNAs (circRNAs) are involved in the processes of preeclampsia (PE). Circ_0030042 was found to be abnormally expressed in PE patients. However, the role and molecular mechanism of circ_0030042 in PE ... ...

    Abstract Background: There is increasing evidence that circular RNAs (circRNAs) are involved in the processes of preeclampsia (PE). Circ_0030042 was found to be abnormally expressed in PE patients. However, the role and molecular mechanism of circ_0030042 in PE progression remains unclear.
    Methods: Quantitative real-time PCR was used for determining the expression of circ_0030042, microRNA (miR)- 942-5p and lipopolysaccharide induced TNF-α factor (LITAF). Trophoblast cell functions were determined using cell counting kit 8 assay, EdU assay, flow cytometry and transwell assay. The protein levels of epithelial-mesenchymal transition (EMT)-related markers and LITAF were examined using western blot analysis. Dual-luciferase reporter assay and RNA pull-down assay were used to verify RNA interaction.
    Results: Circ_0030042 had an elevated expression in PE patients, and its overexpression inhibited trophoblast cell growth, invasion, and EMT process. Circ_0030042 served as miR-942-5p sponge, and miR-942-5p inhibitor also reversed the regulation of circ_0030042 on trophoblast cell growth, invasion and EMT process. LITAF was targeted by miR-942-5p, and its knockdown abolished the inhibition effect of miR-942-5p on trophoblast cell growth, invasion, and EMT process. Also, circ_0030042 regulated LITAF expression via sponging miR-942-5p.
    Conclusion: Circ_0030042 regulated trophoblast cell growth, invasion, and EMT process via the miR-942-5p/LITAF axis, providing a novel insight for PE treatment.
    MeSH term(s) Female ; Humans ; Pregnancy ; Cell Movement ; Cell Proliferation ; Epithelial-Mesenchymal Transition/genetics ; Lipopolysaccharides ; MicroRNAs/genetics ; Nuclear Proteins ; Pre-Eclampsia/genetics ; Transcription Factors ; Trophoblasts ; Tumor Necrosis Factor-alpha ; RNA, Circular
    Chemical Substances Lipopolysaccharides ; LITAF protein, human ; MicroRNAs ; MIRN942 microRNA, human ; Nuclear Proteins ; Transcription Factors ; Tumor Necrosis Factor-alpha ; RNA, Circular
    Language English
    Publishing date 2024-01-17
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 424421-7
    ISSN 1872-7603 ; 0165-0378
    ISSN (online) 1872-7603
    ISSN 0165-0378
    DOI 10.1016/j.jri.2024.104205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1483: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: A Ship Detection Model Based on Dynamic Convolution and an Adaptive Fusion Network for Complex Maritime Conditions.

    Li, Zhisheng / Deng, Zhihui / Hao, Kun / Zhao, Xiaofang / Jin, Zhigang

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 3

    Abstract: Ship detection is vital for maritime safety and vessel monitoring, but challenges like false and missed detections persist, particularly in complex backgrounds, multiple scales, and adverse weather conditions. This paper presents YOLO-Vessel, a ship ... ...

    Abstract Ship detection is vital for maritime safety and vessel monitoring, but challenges like false and missed detections persist, particularly in complex backgrounds, multiple scales, and adverse weather conditions. This paper presents YOLO-Vessel, a ship detection model built upon YOLOv7, which incorporates several innovations to improve its performance. First, we devised a novel backbone network structure called Efficient Layer Aggregation Networks and Omni-Dimensional Dynamic Convolution (ELAN-ODConv). This architecture effectively addresses the complex background interference commonly encountered in maritime ship images, thereby improving the model's feature extraction capabilities. Additionally, we introduce the space-to-depth structure in the head network, which can solve the problem of small ship targets in images that are difficult to detect. Furthermore, we introduced ASFFPredict, a predictive network structure addressing scale variation among ship types, bolstering multiscale ship target detection. Experimental results demonstrate YOLO-Vessel's effectiveness, achieving a 78.3% mean average precision (mAP), surpassing YOLOv7 by 2.3% and Faster R-CNN by 11.6%. It maintains real-time detection at 8.0 ms/frame, meeting real-time ship detection needs. Evaluation in adverse weather conditions confirms YOLO-Vessel's superiority in ship detection, offering a robust solution to maritime challenges and enhancing marine safety and vessel monitoring.
    Language English
    Publishing date 2024-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24030859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Research Landscape of Physiologically Based Pharmacokinetic Model Utilization in Different Fields: A Bibliometric Analysis (1999-2023).

    Wang, Xin / Wu, Jiangfan / Ye, Hongjiang / Zhao, Xiaofang / Zhu, Shenyin

    Pharmaceutical research

    2024  Volume 41, Issue 4, Page(s) 609–622

    Abstract: Purpose: The physiologically based pharmacokinetic (PBPK) modeling has received increasing attention owing to its excellent predictive abilities. However, there has been no bibliometric analysis about PBPK modeling. This research aimed to summarize the ... ...

    Abstract Purpose: The physiologically based pharmacokinetic (PBPK) modeling has received increasing attention owing to its excellent predictive abilities. However, there has been no bibliometric analysis about PBPK modeling. This research aimed to summarize the research development and hot points in PBPK model utilization overall through bibliometric analysis.
    Methods: We searched for publications related to the PBPK modeling from 1999 to 2023 in the Web of Science Core Collection (WoSCC) database. The Microsoft Office Excel, CiteSpace and VOSviewers were used to perform the analyses.
    Results: A total of 4,649 records from 1999 to 2023 were identified, and the largest number of publications focused in the period 2018-2023. The United States was the leading country, and the Environmental Protection Agency (EPA) was the leading institution. The journal Drug Metabolism and Disposition published and co-cited the most articles. Drug-drug interactions, special populations, and new drug development are the main topics in this research field.
    Conclusion: We first visualize the research landscape and hotspots of the PBPK modeling through bibliometric methods. Our study provides a better understanding for researchers, especially beginners about the dynamization of PBPK modeling and presents the relevant trend in the future.
    MeSH term(s) Bibliometrics ; Databases, Factual ; Drug Development
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 843063-9
    ISSN 1573-904X ; 0724-8741 ; 0739-0742
    ISSN (online) 1573-904X
    ISSN 0724-8741 ; 0739-0742
    DOI 10.1007/s11095-024-03676-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1937: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Deciphering the core seed endo-bacteriome of the highland barley in Tibet plateau.

    Hao, Zhao / Wang, Yanhong / Guo, Xiaofang / De, Ji

    Frontiers in plant science

    2022  Volume 13, Page(s) 1041504

    Abstract: Highland barley ( ...

    Abstract Highland barley (
    Language English
    Publishing date 2022-10-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.1041504
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Recent Advances in Stimuli-Responsive Metallogels

    Zhixiong Liu / Xiaofang Zhao / Qingkai Chu / Yu Feng

    Molecules, Vol 28, Iss 2274, p

    2023  Volume 2274

    Abstract: Recently, stimuli-responsive supramolecular gels have received significant attention because their properties can be modulated through external stimuli such as heat, light, electricity, magnetic fields, mechanical stress, pH, ions, chemicals and enzymes. ...

    Abstract Recently, stimuli-responsive supramolecular gels have received significant attention because their properties can be modulated through external stimuli such as heat, light, electricity, magnetic fields, mechanical stress, pH, ions, chemicals and enzymes. Among these gels, stimuli-responsive supramolecular metallogels have shown promising applications in material science because of their fascinating redox, optical, electronic and magnetic properties. In this review, research progress on stimuli-responsive supramolecular metallogels in recent years is systematically summarized. According to external stimulus sources, stimuli-responsive supramolecular metallogels, including chemical, physical and multiple stimuli-responsive metallogels, are discussed separately. Moreover, challenges, suggestions and opportunities regarding the development of novel stimuli-responsive metallogels are presented. We believe the knowledge and inspiration gained from this review will deepen the current understanding of stimuli-responsive smart metallogels and encourage more scientists to provide valuable contributions to this topic in the coming decades.
    Keywords metallogel ; stimuli-responsive ; supramolecular chemistry ; self-assembly ; Organic chemistry ; QD241-441
    Subject code 150
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Recent Advances in Stimuli-Responsive Metallogels.

    Liu, Zhixiong / Zhao, Xiaofang / Chu, Qingkai / Feng, Yu

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 5

    Abstract: Recently, stimuli-responsive supramolecular gels have received significant attention because their properties can be modulated through external stimuli such as heat, light, electricity, magnetic fields, mechanical stress, pH, ions, chemicals and enzymes. ...

    Abstract Recently, stimuli-responsive supramolecular gels have received significant attention because their properties can be modulated through external stimuli such as heat, light, electricity, magnetic fields, mechanical stress, pH, ions, chemicals and enzymes. Among these gels, stimuli-responsive supramolecular metallogels have shown promising applications in material science because of their fascinating redox, optical, electronic and magnetic properties. In this review, research progress on stimuli-responsive supramolecular metallogels in recent years is systematically summarized. According to external stimulus sources, stimuli-responsive supramolecular metallogels, including chemical, physical and multiple stimuli-responsive metallogels, are discussed separately. Moreover, challenges, suggestions and opportunities regarding the development of novel stimuli-responsive metallogels are presented. We believe the knowledge and inspiration gained from this review will deepen the current understanding of stimuli-responsive smart metallogels and encourage more scientists to provide valuable contributions to this topic in the coming decades.
    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28052274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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