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  1. Article ; Online: Chronic sacroiliac joint dysfunction and CT-guided percutaneous fixation: a 6-year experience.

    Jedi, F / Krysiak, R / Hirsch, J A / Ventura, F / De Vivo, E / Manfrè, L

    Neuroradiology

    2023  Volume 65, Issue 10, Page(s) 1527–1534

    Abstract: Purpose: Reporting the clinical outcomes, patient satisfaction, and complications following an imaging-guided percutaneous screw fixation in the treatment of sacroiliac joint dysfunction and evaluating the safety and effectiveness of this method.: ... ...

    Abstract Purpose: Reporting the clinical outcomes, patient satisfaction, and complications following an imaging-guided percutaneous screw fixation in the treatment of sacroiliac joint dysfunction and evaluating the safety and effectiveness of this method.
    Methods: We performed a retrospective study on a prospectively gathered cohort of patients with physiotherapy-resistant pain due to sacroiliac joint incompetence that underwent percutaneous screw fixation, between 2016 and 2022 in our center. A minimum of two screws were used in all patients to obtain fixation of the sacroiliac joint, using percutaneous screw insertion under CT guidance, coupled with a C-arm fluoroscopy unit.
    Results: The mean visual analog scale significantly improved at 6 months of follow-up (p < 0.05). One hundred percent of the patients reported significant improvement in pain scores at the final follow-up. None of our patients experienced intraoperative or postoperative complications.
    Conclusion: The use of percutaneous sacroiliac screws provides a safe and effective technique for the treatment of sacroiliac joint dysfunction in patients with chronic resistant pain.
    MeSH term(s) Humans ; Fracture Fixation, Internal/adverse effects ; Fracture Fixation, Internal/methods ; Retrospective Studies ; Sacroiliac Joint/diagnostic imaging ; Sacroiliac Joint/surgery ; Treatment Outcome ; Tomography, X-Ray Computed ; Pain
    Language English
    Publishing date 2023-06-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 123305-1
    ISSN 1432-1920 ; 0028-3940
    ISSN (online) 1432-1920
    ISSN 0028-3940
    DOI 10.1007/s00234-023-03171-4
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    Zs.A 658: Show issues Location:
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  2. Article: Intolerance of uncertainty heightens negative emotional states and dampens positive emotional states.

    Morriss, Jayne / Goh, Kimberly / Hirsch, Colette R / Dodd, Helen F

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1147970

    Abstract: Individuals high in self-reported Intolerance of Uncertainty (IU) tend to view uncertainty as unbearable and stressful. Notably, IU is transdiagnostic, and high levels of IU are observed across many different emotional disorders (e.g., anxiety, ... ...

    Abstract Individuals high in self-reported Intolerance of Uncertainty (IU) tend to view uncertainty as unbearable and stressful. Notably, IU is transdiagnostic, and high levels of IU are observed across many different emotional disorders (e.g., anxiety, depression). Research has primarily focused on how IU evokes and modulates emotional states such as fear and anxiety. However, recent research suggests that IU may have relevance for a broader range of emotional states. Here, an online survey was conducted to examine whether IU evokes and modulates a range of negative (e.g., fear/anxiety, sadness/upset, anger/frustration, disgust) and positive (e.g., happiness/joy, excitement/enthusiasm, surprise/interest) emotional states. Findings within a community sample (
    Language English
    Publishing date 2023-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1147970
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  3. Article ; Online: The role of anti-EGFR therapies in EGFR-TKI-resistant advanced non-small cell lung cancer.

    Ciardiello, Fortunato / Hirsch, Fred R / Pirker, Robert / Felip, Enriqueta / Valencia, Christian / Smit, Egbert F

    Cancer treatment reviews

    2023  Volume 122, Page(s) 102664

    Abstract: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are the current recommended option for the first-line treatment of patients with EGFR-mutant non-small cell lung cancer (NSCLC). Resistance to first-generation TKIs led to the ... ...

    Abstract Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are the current recommended option for the first-line treatment of patients with EGFR-mutant non-small cell lung cancer (NSCLC). Resistance to first-generation TKIs led to the development of second- and third-generation TKIs with improved clinical outcomes. However, sequential administration of TKIs has led to the emergence of new EGFR resistance mutations and persistent tumor cell survival. This evidence highlights the potential role of EGFR in transducing growth signals in NSCLC tumor cells. Therefore, dual inhibition of EGFR using combinations of anti-EGFR monoclonal antibodies (mAbs) and EGFR-TKIs may offer a unique treatment strategy to suppress tumor cell growth. Several clinical studies have demonstrated the benefits of dual blockade of EGFR using anti-EGFR mAbs coupled with EGFR-TKIs in overcoming treatment resistance in patients with EGFR-mutated NSCLC. However, a single treatment option may not result in the same clinical benefits in all patients with acquired resistance. Biomarkers, including EGFR overexpression, EGFR gene copy number, EGFR and KRAS mutations, and circulating tumor DNA, have been associated with improved clinical efficacy with anti-EGFR mAbs in patients with NSCLC and acquired resistance. Further investigation of biomarkers may allow patient selection for those who could benefit from anti-EGFR mAbs in combination with EGFR-TKIs. This review summarizes findings of recent studies of anti-EGFR mAbs in combination with EGFR-TKIs for the treatment of patients with EGFR-mutated NSCLC, as well as clinical evidence for potential biomarkers towards personalized targeted medicine.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; ErbB Receptors ; Protein Kinase Inhibitors/adverse effects ; Antineoplastic Agents/adverse effects ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal/pharmacology ; Mutation ; Biomarkers ; Drug Resistance, Neoplasm
    Chemical Substances ErbB Receptors (EC 2.7.10.1) ; Protein Kinase Inhibitors ; Antineoplastic Agents ; Antibodies, Monoclonal ; Biomarkers ; EGFR protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2023-11-25
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 125102-8
    ISSN 1532-1967 ; 0305-7372
    ISSN (online) 1532-1967
    ISSN 0305-7372
    DOI 10.1016/j.ctrv.2023.102664
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    Zs.MO 611: Show issues

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  4. Article: Uncertainty Makes Me Emotional: Uncertainty as an Elicitor and Modulator of Emotional States.

    Morriss, Jayne / Tupitsa, Emma / Dodd, Helen F / Hirsch, Colette R

    Frontiers in psychology

    2022  Volume 13, Page(s) 777025

    Abstract: Uncertainty and emotion are an inevitable part of everyday life and play a vital role in mental health. Yet, our understanding of how uncertainty and emotion interact is limited. Here, an online survey was conducted ( ...

    Abstract Uncertainty and emotion are an inevitable part of everyday life and play a vital role in mental health. Yet, our understanding of how uncertainty and emotion interact is limited. Here, an online survey was conducted (
    Language English
    Publishing date 2022-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.777025
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  5. Article ; Online: Cognitive mechanisms and resilience in UK-based general practitioners: cross-sectional findings.

    Kaleta, F O / Kristensen, C B / Duncan, M / Crutchley, P / Kerr, P / Hirsch, C R

    Occupational medicine (Oxford, England)

    2023  Volume 73, Issue 2, Page(s) 91–96

    Abstract: ... with positive interpretation bias (r = 0.60, ρ = 0.60, P < 0.01) and cognitive reappraisal (r = 0.39, ρ = 0.40 ...

    Abstract Background: Being a general practitioner (GP) is a stressful occupation, and the strain GPs are under can have negative effects on their psychological well-being, as well as on the patients' experience of healthcare. Resilience can help buffer against this and is a dynamic process by which one can cope with adversity and stress.
    Aims: This study aimed to identify modifiable cognitive mechanisms related to resilience in GPs, specifically interpretation bias and cognitive reappraisal.
    Methods: One hundred and fourteen GPs completed an online cross-sectional correlational study. This comprised questionnaires assessing resilience, emotional distress, work environment and cognitive mechanisms (emotion regulation), as well as a task assessing interpretation bias.
    Results: Resilience of GPs was negatively correlated with measures of emotional distress. Furthermore, resilience was positively correlated with positive interpretation bias (r = 0.60, ρ = 0.60, P < 0.01) and cognitive reappraisal (r = 0.39, ρ = 0.40, P < 0.01). In a hierarchical regression, positive interpretation bias (B = 0.25, SE B = 0.06, β = 0.39, P < 0.01) was a significant independent predictor of resilience when controlling for depression, anxiety and stress.
    Conclusions: This is the first study to establish an association between resilience and positive interpretation bias and cognitive reappraisal in GPs. Future research should use longitudinal designs to determine if they have a causal role in promoting resilience, and importantly whether interventions focusing on these processes may foster resilience in less resilient GPs.
    MeSH term(s) Humans ; Resilience, Psychological ; General Practitioners ; Cross-Sectional Studies ; Cognition ; United Kingdom
    Language English
    Publishing date 2023-02-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1103950-4
    ISSN 1471-8405 ; 0962-7480
    ISSN (online) 1471-8405
    ISSN 0962-7480
    DOI 10.1093/occmed/kqad016
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    Zs.B 426: Show issues Location:
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  6. Article ; Online: Correction: Fries et al. Impact of Drug Administration Routes on the

    Fries, Franziska / Kany, Andreas M / Rasheed, Sari / Hirsch, Anna K H / Müller, Rolf / Herrmann, Jennifer

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: The authors would like to make the following corrections to the original publication [ ... ]. ...

    Abstract The authors would like to make the following corrections to the original publication [...].
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042011
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  7. Article ; Online: A systematic review of the literature on interpretation bias and its physiological correlates.

    Collins, A / Scott, R B / Hirsch, C R / Ottaviani, C / Krahé, C / Meeten, F

    Biological psychology

    2022  Volume 173, Page(s) 108398

    Abstract: An important, yet under-explored area of interpretation bias research concerns the examination of potential physiological correlates and sequalae of this bias. Developing a better understanding of the physiological processes that underpin interpretation ... ...

    Abstract An important, yet under-explored area of interpretation bias research concerns the examination of potential physiological correlates and sequalae of this bias. Developing a better understanding of the physiological processes that underpin interpretation biases will extend current theoretical frameworks underlying interpretation bias, as well as optimise the efficacy of cognitive bias modification for interpretation (CBM-I) interventions aimed at improving symptoms of emotional disorders. To this end, systematic searches were conducted across the Web of Science, PsycInfo and Pubmed databases to identify physiological markers of interpretation bias. In addition, grey literature database searches were conducted to compliment peer-reviewed research and to counter publication bias. From a combined initial total of 898 records, 15 studies were included in qualitative synthesis (one of which was obtained from the grey literature). Eligible studies were assessed using a quality assessment tool adapted from the Quality Checklist for Healthcare Intervention Studies. The searches revealed seven psychophysiological correlates of interpretation bias, namely event-related potentials, heart rate and heart rate variability, respiratory sinus arrythmia, skin conductance response, pupillometry, and electromyography. The respective theoretical and practical implications of the research are discussed, followed by recommendations for future research.
    MeSH term(s) Bias ; Humans
    Language English
    Publishing date 2022-07-27
    Publishing country Netherlands
    Document type Journal Article ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 185105-6
    ISSN 1873-6246 ; 0301-0511
    ISSN (online) 1873-6246
    ISSN 0301-0511
    DOI 10.1016/j.biopsycho.2022.108398
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    Zs.A 1544: Show issues Location:
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  8. Article ; Online: Development and psychometric evaluation of a scrambled sentences test specifically for worry in individuals with generalised anxiety disorder.

    Krahé, Charlotte / Meeten, Frances / Hirsch, Colette R

    Journal of anxiety disorders

    2022  Volume 91, Page(s) 102610

    Abstract: The tendency to draw negative conclusions from ambiguous information (interpretation bias) is prevalent across emotional disorders and plays a key role in the development and maintenance of pathological worry and anxious mood. Assessing interpretation ... ...

    Abstract The tendency to draw negative conclusions from ambiguous information (interpretation bias) is prevalent across emotional disorders and plays a key role in the development and maintenance of pathological worry and anxious mood. Assessing interpretation bias using valid and reliable measures is central to empirical research. A commonly used measure of interpretation bias is the scrambled sentences test (SST), originally relating to depression. Given the association between interpretation bias and worry, we aimed to develop and psychometrically evaluate a new version of the SST with items pertaining to common worry domains for use in worry and anxiety research. In Studies 1-3 (analogue samples, combined N = 288), the new worry SST showed excellent construct validity (moderate-to-strong associations with worry and anxiety-related measures), and reliability (split-half and test-retest reliability). We confirmed construct validity in Study 4 (N = 215 individuals with generalised anxiety disorder). Furthermore, we demonstrated version specificity in analogue and clinical samples: the worry SST was associated with trait worry but not trait rumination, while the original depression SST largely showed the opposite pattern. Overall, the new worry SST is a psychometrically robust measure that may be especially useful for research into cognitive processes underpinning worry and anxiety.
    MeSH term(s) Anxiety/diagnosis ; Anxiety/psychology ; Anxiety Disorders/diagnosis ; Anxiety Disorders/psychology ; Bias ; Humans ; Psychometrics ; Reproducibility of Results ; Surveys and Questionnaires
    Language English
    Publishing date 2022-08-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 619417-5
    ISSN 1873-7897 ; 0887-6185
    ISSN (online) 1873-7897
    ISSN 0887-6185
    DOI 10.1016/j.janxdis.2022.102610
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  9. Article ; Conference proceedings: Association of perfusion deficit in early phase beta-amyloid-PET and neuropsychological performance in Alzheimer’s disease patients

    Völter, F. / Eckenweber, S. / Scheifele, M. / Eckenweber, F. / Hirsch, F. / Franzmeier, N. / Janowitz, D. / Levin, J. / Palleis, C. / Rauchmann, B. / Schöberl, F. / Wlasich, E. / Bürger, K. / Wagemann, O. / Perneczky, R. / Weidinger, E. / Höglinger, G. / Bartenstein, P. / Brendel, M. /
    Schönecker, S.

    Nuklearmedizin - NuclearMedicine

    2024  Volume 63, Issue 02

    Event/congress 62. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin, Leipzig, 2024-04-10
    Language German
    Publishing date 2024-03-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2030804-8
    ISSN 2567-6407 ; 0029-5566
    ISSN (online) 2567-6407
    ISSN 0029-5566
    DOI 10.1055/s-0044-1782450
    Database Thieme publisher's database

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  10. Article ; Conference proceedings: Real time-MRT in der Lungendiagnostik bei Kindern: ein vollkommen neuer Ansatz in der MRT-Diagnostik der Lunge

    Hirsch, F W / Sorge, I / Gräfe, D / Roth, C / Anders, R / Prenzel, F / Voit, D / Frahm, J

    RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

    2023  Volume 195, Issue S 02

    Event/congress 60. GPR Jahrestagung, Wien, 2023-09-14
    Language German
    Publishing date 2023-09-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    ISSN (online) 1438-9010
    ISSN 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    DOI 10.1055/s-0043-1771422
    Database Thieme publisher's database

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