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  1. Article: Case report:

    Wang, Zhulin / Huang, Chunyao / Fan, Wenbo / Sun, Shaowu / Li, Kaiyuan / Liu, Xu / Pu, Jiangtao / Zhang, Guoqing / Li, Xiangnan

    Frontiers in oncology

    2024  Volume 14, Page(s) 1347282

    Abstract: Given their good antitumor effects, epidermal growth factor receptor ( ...

    Abstract Given their good antitumor effects, epidermal growth factor receptor (
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1347282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The role and underlying mechanism of miR-1299 in cancer.

    Kaiyuan, Deng / Lijuan, Huang / Xueyuan, Sun / Yunhui, Zang

    Future science OA

    2021  Volume 7, Issue 6, Page(s) FSO693

    Abstract: A type of evolutionarily conserved, noncoding, small, endogenous, single-stranded RNA, miRNAs are widely distributed in eukaryotes, where they participate in various biological processes as critical regulatory molecules. miR-1299 has mainly been ... ...

    Abstract A type of evolutionarily conserved, noncoding, small, endogenous, single-stranded RNA, miRNAs are widely distributed in eukaryotes, where they participate in various biological processes as critical regulatory molecules. miR-1299 has mainly been investigated in cancers. miR-1299 is a tumor suppressor that regulates the expression of its target genes, activating or inhibiting the transcription of genes regulating biological activities including cell proliferation, migration, survival and programmed cell death. miR-1299 has become a hotspot in research of disease mechanisms and biomarkers; elucidation of the regulatory roles of miR-1299 in tumorigenesis, proliferation, apoptosis, invasion, migration and angiogenesis may provide a new perspective for understanding its biological functions as a tumor suppressor.
    Language English
    Publishing date 2021-03-02
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2056-5623
    ISSN 2056-5623
    DOI 10.2144/fsoa-2021-0014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: UAV-Aided Dual-User Wireless Power Transfer: 3D Trajectory Design and Energy Optimization.

    Gou, Xiaogang / Sun, Zhaojie / Huang, Kaiyuan

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 6

    Abstract: Unmanned aerial vehicles (UAVs) have been widely considered to enhance the communication coverage, as well as the wireless power transfer (WPT) of energy-constrained communication networks to prolong their lifetime. However, the trajectory design of a ... ...

    Abstract Unmanned aerial vehicles (UAVs) have been widely considered to enhance the communication coverage, as well as the wireless power transfer (WPT) of energy-constrained communication networks to prolong their lifetime. However, the trajectory design of a UAV in such a system remains a key problem, especially considering the three-dimensional (3D) feature of the UAV. To address this issue, a UAV-assisted dual-user WPT system was investigated in this paper, where a UAV-mounted energy transmitter (ET) flies in the air to broadcast wireless energy to charge the energy receivers (ERs) on the ground. By optimizing the UAV's 3D trajectory toward a balanced tradeoff between energy consumption and WPT performance, the energy harvested by all ERs during a given mission period was maximized. The above goal was achieved through the following detailed designs. On the one hand, on the basis of previous research results, there is a one-to-one correspondence between the UAV's abscissa and height, so only the relationship between the height and time was focused on in this work to obtain the UAV's optimal 3D trajectory. On the other hand, the idea of calculus was employed to calculate the total harvested energy, leading to the proposed high-efficiency trajectory design. Finally, the simulation results demonstrated that this contribution is capable of enhancing the energy supply by carefully designing the 3D trajectory of the UAV, compared to its conventional counterpart. In general, the above-mentioned contribution could be a promising way for UAV-aided WPT in the future Internet of Things (IoT) and wireless sensor networks (WSNs).
    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23062994
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  4. Article: Circulating Tumour Cells in the Prediction of Bone Metastasis.

    Choi, Siu-Wai / Sun, Aria Kaiyuan / Cheung, Jason Pui-Yin / Ho, Jemmi Ching-Ying

    Cancers

    2024  Volume 16, Issue 2

    Abstract: Bone is the most common organ for the development of metastases in many primary tumours, including those of the breast, prostate and lung. In most cases, bone metastasis is incurable, and treatment is predominantly palliative. Much research has focused ... ...

    Abstract Bone is the most common organ for the development of metastases in many primary tumours, including those of the breast, prostate and lung. In most cases, bone metastasis is incurable, and treatment is predominantly palliative. Much research has focused on the role of Circulating Tumour Cells (CTCs) in the mechanism of metastasis to the bone, and methods have been developed to isolate and count CTCs from peripheral blood. Several methods are currently being used in the study of CTCs, but only one, the CellSearchTM system has been approved by the United States Food and Drug Administration for clinical use. This review summarises the advantages and disadvantages, and outlines which clinical studies have used these methods. Studies have found that CTC numbers are predictive of bone metastasis in breast, prostate and lung cancer. Further work is required to incorporate information on CTCs into current staging systems to guide treatment in the prevention of tumour progression into bone.
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16020252
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  5. Article: Long noncoding RNA lnc-SNAPC5-3:4 inhibits malignancy by directly upregulating miR-224-3p in non-small cell lung cancer.

    Hu, Chenxi / Wu, Shuo / Sun, Wen / Li, Jiawen / Hui, Kaiyuan / Jiang, Xiaodong

    Heliyon

    2024  Volume 10, Issue 2, Page(s) e24668

    Abstract: The mounting body of evidence demonstrates the growing importance of long noncoding RNAs in the advancement of tumors. This study aimed to investigate the molecular mechanism of lnc-SNAPC5-3:4 in non-small cell lung cancer (NSCLC). We investigated the ... ...

    Abstract The mounting body of evidence demonstrates the growing importance of long noncoding RNAs in the advancement of tumors. This study aimed to investigate the molecular mechanism of lnc-SNAPC5-3:4 in non-small cell lung cancer (NSCLC). We investigated the expression of miR-224-3p and lnc-SNAPC5-3:4 in clinical NSCLC samples and NSCLC cell lines using reverse transcription polymerase chain reaction (RT-PCR).
    Language English
    Publishing date 2024-01-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24668
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  6. Article ; Online: Impact of contact tracing on SARS-CoV-2 transmission.

    Sun, Kaiyuan / Viboud, Cécile

    The Lancet. Infectious diseases

    2020  Volume 20, Issue 8, Page(s) 876–877

    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Contact Tracing ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral ; Retrospective Studies ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(20)30357-1
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: The risk of mpox importation and subsequent outbreak potential in Chinese mainland: a retrospective statistical modelling study.

    Deng, Xiaowei / Tian, Yuyang / Zou, Junyi / Yang, Juan / Sun, Kaiyuan / Yu, Hongjie

    Infectious diseases of poverty

    2024  Volume 13, Issue 1, Page(s) 21

    Abstract: Background: The 2022-2023 mpox (monkeypox) outbreak has spread rapidly across multiple countries in the non-endemic region, mainly among men who have sex with men (MSM). In this study, we aimed to evaluate mpox's importation risk, border screening ... ...

    Abstract Background: The 2022-2023 mpox (monkeypox) outbreak has spread rapidly across multiple countries in the non-endemic region, mainly among men who have sex with men (MSM). In this study, we aimed to evaluate mpox's importation risk, border screening effectiveness and the risk of local outbreak in Chinese mainland.
    Methods: We estimated the risk of mpox importation in Chinese mainland from April 14 to September 11, 2022 using the number of reported mpox cases during this multi-country outbreak from Global.health and the international air-travel data from Official Aviation Guide. We constructed a probabilistic model to simulate the effectiveness of a border screening scenario during the mpox outbreak and a hypothetical scenario with less stringent quarantine requirement. And we further evaluated the mpox outbreak potential given that undetected mpox infections were introduced into men who have sex with men, considering different transmissibility, population immunity and population activity.
    Results: We found that the reduced international air-travel volume and stringent border entry policy decreased about 94% and 69% mpox importations respectively. Under the quarantine policy, 15-19% of imported infections would remain undetected. Once a case of mpox is introduced into active MSM population with almost no population immunity, the risk of triggering local transmission is estimated at 42%, and would rise to > 95% with over six cases.
    Conclusions: Our study demonstrates that the reduced international air-travel volume and stringent border entry policy during the COVID-19 pandemic reduced mpox importations prominently. However, the risk could be substantially higher with the recovery of air-travel volume to pre-pandemic level. Mpox could emerge as a public health threat for Chinese mainland given its large MSM community.
    MeSH term(s) Humans ; Male ; China/epidemiology ; Disease Outbreaks ; Homosexuality, Male ; Models, Statistical ; Mpox (monkeypox) ; Pandemics/prevention & control ; Retrospective Studies ; Sexual and Gender Minorities
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2689396-4
    ISSN 2049-9957 ; 2049-9957
    ISSN (online) 2049-9957
    ISSN 2049-9957
    DOI 10.1186/s40249-024-01189-1
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  8. Article: Complex Modification Orders Alleviate the Gelling Weakening Behavior of High Microbial Transglutaminase (MTGase)-Catalyzed Fish Gelatin: Gelling and Structural Analysis.

    Su, Kaiyuan / Sun, Wanyi / Li, Zhang / Huang, Tao / Lou, Qiaoming / Zhan, Shengnan

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 16

    Abstract: In this paper, the effects of different modification orders of microbial transglutaminase (MTGase) and contents of pectin (0.1-0.5%, ...

    Abstract In this paper, the effects of different modification orders of microbial transglutaminase (MTGase) and contents of pectin (0.1-0.5%,
    Language English
    Publishing date 2023-08-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12163027
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  9. Article ; Online: Paleo Distribution and Habitat Risks under Climate Change of Helleborus thibetanus

    Xiaohua Shi / Lihui Mao / Miao Sun / Guangying Ma / Kaiyuan Zhu

    Forests, Vol 14, Iss 630, p

    2023  Volume 630

    Abstract: As an endemic species and the only Helleborus species in China, Helleborus thibetanus is highly valued in medicinal and ornamental applications, and basic research is needed for its further resource conservation and utilization. Considering the ... ...

    Abstract As an endemic species and the only Helleborus species in China, Helleborus thibetanus is highly valued in medicinal and ornamental applications, and basic research is needed for its further resource conservation and utilization. Considering the interesting disjunct distribution of the genus Helleborus , we focus on the distribution pattern of H. thibetanus in this research. Based on species distribution models using three different algorithms (MaxEnt, RF, and FDA), we constructed a robust ensemble model and predicted potential distributions under different scenarios: current situation, paleo periods since the Last Glacial Maximum, and simulations of climate change in the 2070s. The habitat suitability of H. thibetanus across geography and scenarios was further analyzed by calculating regional areas and centroids. The results showed that H. thibetanus is currently distributed in southern Shaanxi and northern Sichuan, while central and southern Sichuan used to be suitable 14 thousand years ago but gradually became unsuitable, which may reflect the population decrease in Sichuan and the population expansion in Shaanxi over the last 14 thousand years. Our results showed that current populations are under limited extinction pressure in the soft climate change scenario (ssp126), but most populations in Shaanxi are under extinction pressure in the hardy situation scenario (ssp585). Fortunately, northern Sichuan is predicted to be relatively stable under climate change (both ssp126 and ssp585), and regions in western Sichuan and eastern Qinghai are predicted to become newly suitable for H. thibetanus . These findings should be helpful for the further conservation and utilization of H. thibetanus and also help us understand the history of the conjunct distribution pattern of the Helleborus genus.
    Keywords Helleborus thibetanus ; species distribution ; climate change ; bioclimatic variables ; Plant ecology ; QK900-989
    Subject code 333
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Sustainable bacterial cellulose derived composites for high-efficiency hydrogen evolution reaction.

    Wang, Tao / Sun, Bianjing / Tang, Kaiyuan / Shen, Wei / Chen, Chuntao / Sun, Dongping

    International journal of biological macromolecules

    2023  Volume 242, Issue Pt 3, Page(s) 125173

    Abstract: Incorporating heteroatoms into carbon structure has been demonstrated to be efficient for hydrogen evolution reaction (HER). However, the preparation complexity and poor durability are insufficient for the future hydrogen economy. In this work, the ... ...

    Abstract Incorporating heteroatoms into carbon structure has been demonstrated to be efficient for hydrogen evolution reaction (HER). However, the preparation complexity and poor durability are insufficient for the future hydrogen economy. In this work, the preparation of ZIF-67/BC precursor with BC as the template was done for the in-situ growth of MOFs (ZIF-67) crystals, followed by the carbonization and phosphating of ZIF-67/BC to prepare the CoP-NC/CBC N-doped composite carbon material with CoP as the primary active material. The results show that as an HER catalyst, CoP-NC/CBC can provide a current density of 10 mA cm
    MeSH term(s) Carbon ; Cellulose ; Hydrogen
    Chemical Substances Carbon (7440-44-0) ; Cellulose (9004-34-6) ; Hydrogen (7YNJ3PO35Z)
    Language English
    Publishing date 2023-06-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.125173
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