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  1. Book ; Thesis: MAP-Kinasemodule in der Pankreasazinuszelle und die Beziehung zum Transkriptionsfaktor NF-KappaB

    Hann von Weyhern, Claus

    2010  

    Author's details Claus Hann von Weyhern
    Subject code 610
    Language German
    Size II, 68 Bl., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Techn. Univ., Diss., 2010
    HBZ-ID HT017197659
    Database Catalogue ZB MED Medicine, Health

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    2012 E 701 order for loan Magazin

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  2. Article ; Online: Neuropathology associated with SARS-CoV-2 infection - Authors' reply.

    von Weyhern, Claus Hann / Kaufmann, Ines / Neff, Frauke / Kremer, Marcus

    Lancet (London, England)

    2021  Volume 397, Issue 10271, Page(s) 277–278

    MeSH term(s) COVID-19 ; Humans ; Nervous System Diseases ; SARS-CoV-2
    Language English
    Publishing date 2021-01-23
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)00097-0
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  3. Article ; Online: Early evidence of pronounced brain involvement in fatal COVID-19 outcomes.

    von Weyhern, Claus Hann / Kaufmann, Ines / Neff, Frauke / Kremer, Marcus

    Lancet (London, England)

    2020  Volume 395, Issue 10241, Page(s) e109

    MeSH term(s) Anticoagulants ; Betacoronavirus ; Brain ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Anticoagulants
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)31282-4
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  5. Article ; Online: Early evidence of pronounced brain involvement in fatal COVID-19 outcomes

    von Weyhern, Claus Hann / Kaufmann, Ines / Neff, Frauke / Kremer, Marcus

    The Lancet

    2020  Volume 395, Issue 10241, Page(s) e109

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/s0140-6736(20)31282-4
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Diagnosis of bilateral giant adrenal myelolipoma.

    Ketelsen, Dominik / von Weyhern, Claus Hann / Horger, Marius

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2010  Volume 28, Issue 33, Page(s) e678–9

    MeSH term(s) Adrenal Gland Neoplasms/diagnosis ; Adrenal Gland Neoplasms/pathology ; Adult ; Female ; Humans ; Myelolipoma/diagnosis ; Myelolipoma/pathology
    Language English
    Publishing date 2010-11-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2010.30.2588
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  7. Article ; Online: Application of laser microdissection and quantitative PCR to assess the response of esophageal cancer to neoadjuvant chemo-radiotherapy.

    von Weyhern, Claus Hann / Brücher, Björn L D M

    Methods in molecular biology (Clifton, N.J.)

    2011  Volume 755, Page(s) 197–202

    Abstract: Tissues are complicated three-dimensional structures, composed of different types of interacting cells. Since the cell population of interest might constitute only a minor fraction of the total tissue volume, the problem of tissue heterogeneity has been ... ...

    Abstract Tissues are complicated three-dimensional structures, composed of different types of interacting cells. Since the cell population of interest might constitute only a minor fraction of the total tissue volume, the problem of tissue heterogeneity has been a major barrier to the molecular analysis of normal versus diseased tissue. Thus, tissue microdissection represents one of the most promising techniques in molecular pathology offering the link between morphology and genetic analysis since it was established in the early 1970s. These first applications and further developments in the techniques enable preparation of morphologically well described and circumscribed cell populations of either tumor cells or surrounding tissue or even cytology specimens without contamination of unwanted cells. Laser capture microdissection is suitable for the dissection of both paraffin embedded and fresh frozen material. Further applications of the dissected genomic material are isolation of DNA and RNA as described later on followed by PCR or RT-PCR and sequencing.
    MeSH term(s) Esophageal Neoplasms/genetics ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/therapy ; Gene Expression Profiling ; Humans ; Lasers ; Microdissection/methods ; Neoadjuvant Therapy ; Paraffin Embedding ; RNA/genetics ; RNA/isolation & purification ; Reverse Transcriptase Polymerase Chain Reaction/methods ; Staining and Labeling/methods ; Tissue Fixation ; Treatment Outcome
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2011
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-61779-163-5_16
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  8. Article ; Online: Longitudinal Clinical Performance of the RNA-Based Aptima Human Papillomavirus (AHPV) Assay in Comparison to the DNA-Based Hybrid Capture 2 HPV Test in Two Consecutive Screening Rounds with a 6-Year Interval in Germany.

    Iftner, Thomas / Neis, Klaus-Joachim / Castanon, Alejandra / Landy, Rebecca / Holz, Barbara / Woll-Herrmann, Astrid / Iftner, Angelika / Staebler, Annette / Wallwiener, Diethelm / Hann von Weyhern, Claus / Neis, Felix / Haedicke-Jarboui, Juliane / Martus, Peter / Brucker, Sara / Henes, Melanie / Sasieni, Peter

    Journal of clinical microbiology

    2019  Volume 57, Issue 1

    Abstract: Longitudinal data on the E6/E7 mRNA-based Aptima human papillomavirus (AHPV) assay exceeding three years in comparison to the gold standard Digene Hybrid Capture 2 (HC2) test are not available. We previously reported the cross-sectional data of the ... ...

    Abstract Longitudinal data on the E6/E7 mRNA-based Aptima human papillomavirus (AHPV) assay exceeding three years in comparison to the gold standard Digene Hybrid Capture 2 (HC2) test are not available. We previously reported the cross-sectional data of the German AHPV Screening Trial (GAST) in which 10,040 women were recruited and tested by liquid-based cytology, the HC2 assay, and the AHPV assay. Four hundred eleven test-positive women were followed for up to six years. In addition, 3,295 triple-negative women were screened after a median time of six years. Overall, 28 high-grade cervical intraepithelial neoplasia (CIN3) cases were detected. The absolute risk of developing high-risk HPV-positive CIN3+ over six years among those women that tested negative at baseline was 2.2 (95% confidence interval [95% CI], 1.0 to 4.9) and 3.1 (95% CI, 1.7 to 5.7) per 1,000 women screened by the HC2 and the AHPV tests; the additional risk for those with AHPV-negative compared with HC2-negative results was 0.9 (95% CI, -0.2 to 2.1) per 1,000. In comparison, the absolute risk following a negative LBC test was 9.3 (95% CI, 2.9 to 30.2). The relative sensitivity of AHPV compared to HC2 was 91.5% for CIN3+, and the negative predictive values were 99.8% (95% CI, 99.5 to 99.9%) for HC2 and 99.7% (95% CI, 99.4 to 99.8%) for AHPV. Our data show that the longitudinal performance of the AHPV test over six years is comparable to the performance of the HC2 test and that the absolute risk of CIN3+ over six years following a negative AHPV result in a screening population is low. (This study is registered at ClinicalTrials.gov under registration number NCT02634190.).
    MeSH term(s) Adult ; DNA, Viral/analysis ; Early Detection of Cancer/methods ; Female ; Germany ; Humans ; Longitudinal Studies ; Middle Aged ; Molecular Diagnostic Techniques/methods ; Molecular Diagnostic Techniques/standards ; Oncogene Proteins, Viral/genetics ; Papillomaviridae/classification ; Papillomaviridae/genetics ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/diagnosis ; RNA, Messenger/analysis ; RNA, Viral/analysis ; Sensitivity and Specificity ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Dysplasia/diagnosis
    Chemical Substances DNA, Viral ; Oncogene Proteins, Viral ; RNA, Messenger ; RNA, Viral
    Language English
    Publishing date 2019-01-02
    Publishing country United States
    Document type Comparative Study ; Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.01177-18
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  9. Article ; Online: EMMPRIN expression is involved in the development of interstitial fibrosis and tubular atrophy in human kidney allografts.

    Kemmner, Stephan / Schulte, Christian / von Weyhern, Claus Hann / Schmidt, Roland / Baumann, Marcus / Heemann, Uwe / Renders, Lutz / Schmaderer, Christoph

    Clinical transplantation

    2016  Volume 30, Issue 3, Page(s) 218–225

    Abstract: Background: Matrix metalloproteinases (MMP) are involved in the development of interstitial fibrosis and tubular atrophy (IF/TA) in renal disease. The synthesis of MMP is activated by the extracellular matrix metalloproteinases inducer protein (EMMPRIN). ...

    Abstract Background: Matrix metalloproteinases (MMP) are involved in the development of interstitial fibrosis and tubular atrophy (IF/TA) in renal disease. The synthesis of MMP is activated by the extracellular matrix metalloproteinases inducer protein (EMMPRIN). To analyze the role of EMMPRIN in IF/TA, we retrospectively detected EMMPRIN expression in specimens of human renal allografts with various levels of IF/TA.
    Methods: Immunohistochemistry was performed to detect EMMPRIN expression. In a retrospective analysis, a total cohort of 50 specimens were divided according to BANFF-classification into four subgroups (0-3): no, mild (≤ 25%), moderate (26-50%), or severe (>50%) IF/TA. Among other parameters, renal function was analyzed and compared to EMMPRIN expression.
    Results: In 24 of 38 biopsies, we detected positive EMMPRIN staining. All nephrectomy (n = 12) samples were negative for EMMPRIN. Positive staining in the biopsy samples was detectable on the basolateral side of tubular epithelial cells. EMMPRIN staining was negatively correlated with IF/TA (p < 0.001). We found significant differences between the mean EMMPRIN expression in IF/TA groups 0 and 3 (p = 0.021) and groups 1 and 3 (p = 0.004). Furthermore, we found significant correlations between EMMPRIN staining and renal function.
    Conclusion: Our data suggest that EMMPRIN is involved in the pathophysiology of IF/TA.
    MeSH term(s) Allografts ; Atrophy/etiology ; Atrophy/metabolism ; Atrophy/pathology ; Basigin/metabolism ; Female ; Fibrosis/etiology ; Fibrosis/metabolism ; Fibrosis/pathology ; Follow-Up Studies ; Graft Rejection/diagnosis ; Graft Rejection/metabolism ; Humans ; Kidney Function Tests ; Kidney Transplantation/adverse effects ; Kidney Tubules/metabolism ; Kidney Tubules/pathology ; Male ; Middle Aged ; Nephrectomy/adverse effects ; Postoperative Complications ; Prognosis ; Retrospective Studies ; Risk Factors
    Chemical Substances BSG protein, human ; Basigin (136894-56-9)
    Language English
    Publishing date 2016-03
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.12677
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  10. Article ; Online: Randomised phase II trial of trofosfamide vs. doxorubicin in elderly patients with untreated metastatic soft-tissue sarcoma.

    Hartmann, Joerg T / Kopp, Hans-G / Gruenwald, Viktor / Piperno-Neumann, Sophie / Kunitz, Annegret / Hofheinz, Ralf / Mueller, Lothar / Geissler, Michael / Horger, Marius / Fix, Peter / Chemnitz, Jens M / Neise, Michael / Wehler, Thomas / Zander, Ingo / Eckert, Robert / Hann von Weyhern, Claus / Bauer, Sebastian / Mayer, Frank

    European journal of cancer (Oxford, England : 1990)

    2019  Volume 124, Page(s) 152–160

    Abstract: Doxorubicin represents the standard first-line treatment for metastatic soft-tissue sarcoma. We assessed the efficacy and safety of trofosfamide in elderly patients. In this controlled phase II trial, we randomly (1:2) assigned 120 previously untreated ... ...

    Abstract Doxorubicin represents the standard first-line treatment for metastatic soft-tissue sarcoma. We assessed the efficacy and safety of trofosfamide in elderly patients. In this controlled phase II trial, we randomly (1:2) assigned 120 previously untreated patients with soft-tissue sarcoma, older than 60 years, with an Eastern Cooperative Oncology Group score of 0-2, to receive either doxorubicin for 6 cycles (arm A) or oral trofosfamide (arm B). The primary end-point was a 6-month progression-free rate (PFR) in the experimental arm (clinical trial information: NCT00204568). Between August 2004 and October 2012, forty and 80 patients were randomly assigned to arm A and arm B, respectively, in 16 centres. The median age was 70 years (range, 60-89). The primary study end-point (6-month PFR) was exceeded, with 27.6% in arm B (95% confidence interval [CI], 18.0-39.1) and 35.9% in arm A: (95% CI, 21.2-52.8). Survival data in terms of progression-free survival were 4.3 months (95% CI, 2.2-6.3) and 2.8 months (95% CI, 1.7-3.6) and in terms of overall survival were 9.8 months (95% CI, 6.7-11.6) and 12.3 months (95% CI, 9.6-16.2), respectively. The number of serious adverse event (SAE) was 59% in arm A and 30.3% in arm B (p = 0.005). Trofosfamide caused more often dyspnoea and low-grade fatigue, whereas with doxorubicin, more often leukocytopenia, neutropenia and mucositis were seen. Discontinuation rates for reasons other than disease progression were 15.4% (arm A) vs. 7.9% (arm B). In an elderly population of patients, oral trofosfamide achieved the estimated primary end-point 6-month PFR and was associated with a favourable toxicity profile compared with doxorubicin.
    MeSH term(s) Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cyclophosphamide/analogs & derivatives ; Cyclophosphamide/pharmacology ; Cyclophosphamide/therapeutic use ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Sarcoma/drug therapy
    Chemical Substances Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; trofosfamide (H64JRU6GJ0)
    Language English
    Publishing date 2019-11-28
    Publishing country England
    Document type Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2019.10.016
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