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Article: Acanthomatous Ameloblastoma: An Early Stage Case Report with Difficult Management.

Pippi, Roberto / Santoro, Marcello / Pietrantoni, Alessandra / Pernazza, Angelina

2021 Volume 2021, Page(s) 9941779

Abstract: A case of a mandibular acanthomatous ameloblastoma, with an admixed little component of follicular type, is reported. The epidemiological features of the present case agree with those reported in the international literature. Clinico-radiographic ... ...

Abstract	A case of a mandibular acanthomatous ameloblastoma, with an admixed little component of follicular type, is reported. The epidemiological features of the present case agree with those reported in the international literature. Clinico-radiographic differential diagnostic difficulties existed with several other noncystic osteolytic lesions of the mandible. Recurrence was diagnosed early 1 year after the initial excisional biopsy, and a definitive rim resection was therefore performed. No further recurrence occurred in the following 4-year follow-up.
Language	English
Publishing date	2021-06-18
Publishing country	Egypt
Document type	Case Reports
ZDB-ID	2627632-X
ISSN	2090-6455 ; 2090-6447
ISSN (online)	2090-6455
ISSN	2090-6447
DOI	10.1155/2021/9941779
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Article: High-grade serous carcinoma of unknown primary origin associated with STIC clinically presented as isolated inguinal lymphadenopathy: a case report.

Giancontieri, Paola / Turetta, Camilla / Barchiesi, Giacomo / Pernazza, Angelina / Pignataro, Gemma / D'Onghia, Giuliano / Santini, Daniele / Tomao, Federica

Frontiers in oncology

2024 Volume 13, Page(s) 1307573

Abstract: Serous tubal intraepithelial carcinoma (STIC) is a precancerous lesion of high-grade serous ovarian carcinoma (HGSOC). Usually, it arises from the fimbrial end of the tube, and it is associated with metastatic potential. On average, the time to progress ... ...

Abstract	Serous tubal intraepithelial carcinoma (STIC) is a precancerous lesion of high-grade serous ovarian carcinoma (HGSOC). Usually, it arises from the fimbrial end of the tube, and it is associated with metastatic potential. On average, the time to progress from STIC to HGSOC is 6.5 years. Therefore, whenever a STIC lesion is found, surgical staging and prophylactic salpingectomy are recommended in order to prevent ovarian cancer. We report a rare case of a 45-year-old female patient who clinically presented an isolated right inguinal lymphadenopathy. The remaining clinical examination was normal. Therefore, an excisional biopsy of the lymph node was performed. Pathological analysis revealed a high-grade serous carcinoma, most likely of gynecological origin. Due to histological evidence, a computed tomography (CT) scan was carried out. There was no CT evidence of ovarian disease, pelvic involvement, intra-abdominal lymphadenopathies, metastatic disease, or ascites. All tumor markers were negative. The patient underwent laparoscopic hysterectomy and bilateral salpingo-oophorectomy followed by surgical staging. Surprisingly, pathological examination showed a STIC lesion in the fimbria of the left fallopian tube. We aim to report the potential capability of STIC to spread particularly through lymphatic pathways rather than peritoneal dissemination.
Language	English
Publishing date	2024-02-02
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1307573
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Article ; Online: Extremely late-onset pulmonary metastasis from uterine PEComa.

Ascione, Andrea / Martignoni, Guido / d'Amati, Giulia / Della Rocca, Carlo / Graziano, Paolo / Pernazza, Angelina

Pathologica

2022 Volume 114, Issue 4, Page(s) 312–315

Abstract: A 79-year-old woman underwent surgical resection of a peripheral, solitary, pulmonary lesion that was diagnosed as malignant PEComa. Her clinical history was positive for uterine leiomyosarcoma, excised 20 years before. Re-evaluation of the primary ... ...

Abstract	A 79-year-old woman underwent surgical resection of a peripheral, solitary, pulmonary lesion that was diagnosed as malignant PEComa. Her clinical history was positive for uterine leiomyosarcoma, excised 20 years before. Re-evaluation of the primary uterine lesion led to the final diagnosis of lung metastasis from uterine PEComa. While long latency between primary tumour and metastasis is a known and characteristic feature of PEComas, a 20-year interval is unprecedented in the literature.
MeSH term(s)	Aged ; Female ; Humans ; Lung Neoplasms/secondary ; Perivascular Epithelioid Cell Neoplasms/diagnosis ; Perivascular Epithelioid Cell Neoplasms/pathology ; Perivascular Epithelioid Cell Neoplasms/surgery ; Uterine Neoplasms/diagnosis ; Uterine Neoplasms/pathology
Language	English
Publishing date	2022-09-08
Publishing country	Italy
Document type	Case Reports
ZDB-ID	418229-7
ISSN	1591-951X ; 0031-2983
ISSN (online)	1591-951X
ISSN	0031-2983
DOI	10.32074/1591-951X-762
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Article ; Online: Ciliated Cells in Renal Calyx mucosa: Metaplastic Change or Developmental Abnormality? Immunohistochemical Study of one Case and Review of the Literature.

Rullo, Emma / Pecorella, Irene / Pernazza, Angelina / Carletti, Raffaella / Tornese, Andrea / Larghi Laureiro, Zoe

International journal of surgical pathology

2022 Volume 31, Issue 5, Page(s) 662–666

Abstract: Ciliated epithelial cells have been rarely observed in urothelium lined mucosa. Only extremely rare reports in the literature have described this phenomenon and no cases have been described in other sites than the male urethra. Herein, we illustrate the ... ...

Abstract	Ciliated epithelial cells have been rarely observed in urothelium lined mucosa. Only extremely rare reports in the literature have described this phenomenon and no cases have been described in other sites than the male urethra. Herein, we illustrate the finding of ciliated pseudostratified columnar cells in the renal calyx mucosa adjacent to an area of urothelial invasive carcinoma in an 82 year-old man with previous history of nephrolithiasis. The ciliated cells covered a linear extension of 0.5 cm: they were positive for keratin 7 and keratin 8/18 and negative for keratin 20. Alcian blue staining was positive in some vacuoles in the apical cytoplasm of the same cells whereas PAS (Periodic Acid-Schiff) staining was negative. GATA3 resulted negative in ciliated cells except for a layer in the basal portion of the epithelium, just above the basal membrane. The actual prevalence of ciliated epithelia in the urinary tract is not well documented and the current knowledge on the subject is limited to electron scanning microscopy studies. The significance of this phenomenon remains unknown: it could be either a developmental abnormality or more probably a metaplastic change. Associated urolithiasis, which has been described in both a previous report and in the present one, could hypothetically represent a possible trigger for this unusual cell change. However, this hypothesis needs to be confirmed through further investigation.
MeSH term(s)	Humans ; Male ; Aged, 80 and over ; Cilia/pathology ; Microscopy, Electron ; Mucous Membrane ; Epithelium ; Epithelial Cells ; Metaplasia/pathology ; Carcinoma, Transitional Cell/pathology
Language	English
Publishing date	2022-08-09
Publishing country	United States
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	1336393-1
ISSN	1940-2465 ; 1066-8969
ISSN (online)	1940-2465
ISSN	1066-8969
DOI	10.1177/10668969221117988
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Article ; Online: PD-L1 testing in metastatic triple-negative breast cancer: Interobserver and interplatform reproducibility of CE-IVD assays for CPS and IC scores.

Ivanova, Mariia / Frascarelli, Chiara / Cerbelli, Bruna / Pignataro, Maria Gemma / Pernazza, Angelina / Venetis, Konstantinos / Sajjadi, Elham / Criscitiello, Carmen / Curigliano, Giuseppe / Guerini-Rocco, Elena / Graziano, Paolo / Martini, Maurizio / d'Amati, Giulia / Fusco, Nicola

Human pathology

2024 Volume 144, Page(s) 22–27

Abstract: PD-L1 test is recommended in different types of tumors to select patients eligible for immune checkpoint inhibitors (ICI) therapy. Several factors make this test challenging in metastatic triple-negative breast cancer (mTNBC). Different assays and ... ...

Abstract	PD-L1 test is recommended in different types of tumors to select patients eligible for immune checkpoint inhibitors (ICI) therapy. Several factors make this test challenging in metastatic triple-negative breast cancer (mTNBC). Different assays and platforms are available, each associated with distinct scoring systems and threshold values specific to the ICI compound used, i.e. CPS≥10 for pembrolizumab and IC ≥ 1 % for atezolizumab. Our objective was to assess the consistency of PD-L1 testing in mTNBC by examining interobserver and interassay reproducibility. We assessed n = 60 mTNBC samples for PD-L1 testing using 22C3 pharmDx assay on a Dako Autostainer Link 48 and VENTANA PD-L1 (SP263) on a Ventana BenchMark Ultra. Additionally, a subset of n = 19 samples was tested using the SP142 assay, also on the Ventana BenchMark Ultra. CPS with both 22C3 and SP263 was independently evaluated by five pathologists, all certified PD-L1 trainers. The IC with SP142 was assessed by three of these pathologists, who have particular expertise in breast pathology. Following the computation of the intraclass correlation coefficient (ICC) for each assay and their respective thresholds, we assessed the agreement between different raters and assays using Fleiss's κ, with a 95 % confidence interval (CI). Overall, we observed a significant (p < 0.001) ICC with both CPS assays [22C3 = 0.939 (CI:0.913-0.96); SP263 = 0.972 (CI:0.96-0.982); combined 22C3-SP263 = 0.909 (CI:0.874-0.938)]. Fleiss's κ confirmed an almost perfect agreement among pathologists and assays: 22C3 = 0.938 (CI:0.857-1.018); SP263 = 0.972 (CI:0.890-1.052); combined 22C3-SP263 = 0.907 (CI:0.869-0.945). Perfect inter-rater agreement was reached considering IC. This study establishes the reliability of assessing CPS in mTNBC using either the 22C3 pharmDx, as employed in the KEYNOTE studies, or the VENTANA SP263 assay. Each assay must be used on its designated platform, namely the Dako for 22C3 pharmDx and the Ventana for VENTANA SP263. It is important to remark that CPS and IC identify different patient cohorts and, therefore, are not interchangeable.
MeSH term(s)	Humans ; Reproducibility of Results ; Immunohistochemistry ; Triple Negative Breast Neoplasms/diagnosis ; B7-H1 Antigen ; Lung Neoplasms/pathology ; Biomarkers, Tumor
Chemical Substances	B7-H1 Antigen ; Biomarkers, Tumor
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	207657-3
ISSN	1532-8392 ; 0046-8177
ISSN (online)	1532-8392
ISSN	0046-8177
DOI	10.1016/j.humpath.2024.01.008
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Article ; Online: Circulating CD137

Cirillo, Alessio / Zizzari, Ilaria Grazia / Botticelli, Andrea / Strigari, Lidia / Rahimi, Hassan / Scagnoli, Simone / Scirocchi, Fabio / Pernazza, Angelina / Pace, Angelica / Cerbelli, Bruna / d'Amati, Giulia / Marchetti, Paolo / Nuti, Marianna / Rughetti, Aurelia / Napoletano, Chiara

International journal of molecular sciences

2023 Volume 24, Issue 8

Abstract: Pembrolizumab, an anti-PD-1 antibody, has been approved as first-line treatment for recurrent or metastatic head and neck squamous cell carcinoma ((R/M) HNSCC). However, only a minority of patients benefit from immunotherapy, which highlights the need to ...

Abstract	Pembrolizumab, an anti-PD-1 antibody, has been approved as first-line treatment for recurrent or metastatic head and neck squamous cell carcinoma ((R/M) HNSCC). However, only a minority of patients benefit from immunotherapy, which highlights the need to identify novel biomarkers to optimize treatment strategies. CD137
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; T-Lymphocytes ; Head and Neck Neoplasms/drug therapy ; Biomarkers
Chemical Substances	pembrolizumab (DPT0O3T46P) ; Biomarkers
Language	English
Publishing date	2023-04-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24087114
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Article ; Online: The contribution of the

Dolciami, Miriam / Canese, Rossella / Testa, Claudia / Pernazza, Angelina / Santangelo, Giusi / Palaia, Innocenza / Rocca, Carlo Della / Catalano, Carlo / Manganaro, Lucia

European radiology experimental

2022 Volume 6, Issue 1, Page(s) 47

Abstract: Background: The aim of this study was to investigate the role of the lipid peak derived from : Methods: We enrolled 17 patients with histologically proven cervical cancer who underwent 3-T MR imaging at baseline. In addition to conventional imaging ... ...

Abstract	Background: The aim of this study was to investigate the role of the lipid peak derived from Methods: We enrolled 17 patients with histologically proven cervical cancer who underwent 3-T MR imaging at baseline. In addition to conventional imaging sequences for pelvic assessment, the protocol included a single-voxel point-resolved spectroscopy (PRESS) sequence, with repetition time of 1,500 ms and echo times of 28 and 144 ms. Spectra were analysed using the LCModel fitting routine, thus extracting multiple metabolites, including lipids (Lip) and total choline (tCho). Patients with LACC were treated with NACT and reassessed by MRI at term. Based on tumour volume reduction, patients were classified as good responder (GR; tumour volume reduction > 50%) and poor responder or nonresponder (PR-or-NR; tumour volume reduction ≤ 50%). Results: Of 17 patients, 11 were LACC. Of these 11, only 6 had both completed NACT and had good-quality Conclusions: Assessment of lipid peak at
MeSH term(s)	Choline/metabolism ; Choline/therapeutic use ; Female ; Humans ; Lipids/therapeutic use ; Magnetic Resonance Imaging/methods ; Proton Magnetic Resonance Spectroscopy ; Uterine Cervical Neoplasms/diagnostic imaging ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/pathology
Chemical Substances	Lipids ; Choline (N91BDP6H0X)
Language	English
Publishing date	2022-10-03
Publishing country	England
Document type	Journal Article
ISSN	2509-9280
ISSN (online)	2509-9280
DOI	10.1186/s41747-022-00300-1
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Article ; Online: Xanthoma of rib: a case report and review of the literature.

Mottola, Emilia / Adotti, Flavia / Pernazza, Angelina / Della Rocca, Carlo / D'Amati, Giulia / Nardis, Piergiorgio / Vannucci, Jacopo / Bassi, Massimiliano / Venuta, Federico / Anile, Marco

Journal of cardiothoracic surgery

2023 Volume 18, Issue 1, Page(s) 205

Abstract: Background: Xanthomas are well-circumscribed benign proliferative lesions seen mainly in soft tissues. Usually, they are found in hyperlipidemia and familial hyperlipoproteinemia. Histologically, are characterized by macrophage-like mononuclear cells, ... ...

Abstract	Background: Xanthomas are well-circumscribed benign proliferative lesions seen mainly in soft tissues. Usually, they are found in hyperlipidemia and familial hyperlipoproteinemia. Histologically, are characterized by macrophage-like mononuclear cells, multinucleated giant cells and abundant foam cells. The bone involvement, however, is notoriously rare and rib localization is extremely rare. Case presentation: A 55-year-old man performed a chest X-ray and a subsequent chest Computed Tomography scan showing a rib lesion that was surgically removed and a diagnosis of rib xanthoma was made. The patient presented an unknown condition of hyperlipidemia. Conclusion: Rib xanthoma can be discovered accidentally and can be helpful in identifying an unrecognized condition of hyperlipidemia.
MeSH term(s)	Humans ; Male ; Middle Aged ; Xanthomatosis/diagnostic imaging ; Xanthomatosis/surgery ; Tomography, X-Ray ; Ribs/diagnostic imaging ; Ribs/surgery ; Hyperlipidemias/complications ; Hyperlipidemias/diagnosis
Language	English
Publishing date	2023-07-03
Publishing country	England
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-023-02315-0
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Article: Laterocervical lymph node metastases from suspected thyroidal primary site that turned out to be metastases of lung cancer: A case report.

Scorziello, Chiara / Borcea, Maria Carola / Biffoni, Marco / Pernazza, Angelina / Arienzo, Francesca / Melcarne, Rossella / Ventrone, Luca / Laca, Angelo / Grani, Giorgio / Durante, Cosimo / Consorti, Fabrizio / Giacomelli, Laura

Clinical case reports

2023 Volume 11, Issue 7, Page(s) e7417

Abstract: Incidental sonographic discovery of thyroid nodules is an increasingly common event in clinical practice. Less frequently, patients with cytological benign thyroid nodules have suspicious cervical lymph nodes detected by ultrasound examination or by ... ...

Abstract	Incidental sonographic discovery of thyroid nodules is an increasingly common event in clinical practice. Less frequently, patients with cytological benign thyroid nodules have suspicious cervical lymph nodes detected by ultrasound examination or by cytological exam. Here, we discuss an intriguing case of cervical lymph node metastasis with a probable thyroid origin in a 65-year-old asymptomatic male smoker. He underwent thyroidectomy and unilateral cervical lymphadenectomy. Despite a negative chest X-ray, the postoperative histological examination revealed that the lymph node metastasis was actually from a lung carcinoma. Metastatic lesions in cervical lymph nodes from non-thyroidal origins must be excluded when evaluating lesions in the region, especially when thyroid nodules subjected to fine needle aspiration biopsy yield negative results, or lymph node cytological evaluations are inconsistent with thyroid cytological findings and sonographic features. Thyroid and lung adenocarcinomas share some epithelial and mesenchymal markers. Thyroglobulin helps differentiate primary thyroid tumors from lung ones, but in cases of poor differentiation, distinguishing metastatic lesions in the thyroid gland can be challenging. Lung cancer (LC) is the leading cause of cancer mortality worldwide, and survival rates have only marginally improved over the last several decades. The ongoing clinical challenge is detecting LC at earlier stages of the disease.
Language	English
Publishing date	2023-07-21
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.7417
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Article ; Online: Atypical cellular neurothekeoma (ACN) of the elderly: case report and brief review of the literature.

D'Alessandris, Nicoletta / Picchetto, Andrea / Pignataro, Maria Gemma / Cerbelli, Bruna / Manzo, Domenico / Rocca, Carlo Della / d'Amati, Giulia / Pernazza, Angelina

Pathologica

2021 Volume 112, Issue 4, Page(s) 210–213

Abstract: Atypical cellular neurothekeoma (ACN) is an aggressive and rare variant of cellular neurothekeoma. Only few cases have been reported in the literature and the biological behavior seems to be uncertain. We describe the case of an ACN presenting on the ... ...

Abstract	Atypical cellular neurothekeoma (ACN) is an aggressive and rare variant of cellular neurothekeoma. Only few cases have been reported in the literature and the biological behavior seems to be uncertain. We describe the case of an ACN presenting on the scalp of an elderly man, emphasizing the cytologic features of malignancy. In addition, we provide a brief overview of the literature and discuss the differential diagnosis with other entities, and the possible diagnostic pitfalls.
MeSH term(s)	Aged ; Biomarkers, Tumor/analysis ; Diagnosis, Differential ; Humans ; Immunohistochemistry ; Male ; Neurothekeoma/diagnosis ; Neurothekeoma/pathology ; Scalp/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology ; Soft Tissue Neoplasms/diagnosis ; Soft Tissue Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2021-01-04
Publishing country	Italy
Document type	Case Reports
ZDB-ID	418229-7
ISSN	1591-951X ; 0031-2983
ISSN (online)	1591-951X
ISSN	0031-2983
DOI	10.32074/1591-951X-104
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