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  1. Article ; Online: Carl Friedrich Wilhelm Ludwig, a fabled physiologist and mentor of Scandinavian Physiology Announcing the Carl Ludwig Award for young authors in Acta Physiologica (Oxford).

    Persson, Pontus B

    Acta physiologica (Oxford, England)

    2012  Volume 204, Issue 3, Page(s) 289–290

    MeSH term(s) Authorship ; Awards and Prizes ; Biomedical Research/history ; History, 19th Century ; Humans ; Periodicals as Topic/history ; Physiology/history
    Language English
    Publishing date 2012-03
    Publishing country England
    Document type Biography ; Editorial ; Historical Article ; Portraits
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/j.1748-1716.2012.02405.x
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  2. Article ; Online: Plasma proteins defending infected, intact nasal mucosa.

    Persson, Carl

    The Journal of allergy and clinical immunology

    2023  Volume 151, Issue 5, Page(s) 1411–1412

    MeSH term(s) Humans ; Nasal Mucosa/metabolism ; Blood Proteins/metabolism
    Chemical Substances Blood Proteins
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.12.817
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  3. Article ; Online: Epithelial repair in asthma: Defect or exaggerated?

    Persson, Carl

    The Journal of allergy and clinical immunology

    2022  Volume 149, Issue 3, Page(s) 1131–1132

    MeSH term(s) Asthma/genetics ; Epithelial Cells ; Humans
    Language English
    Publishing date 2022-01-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2021.12.764
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  4. Article ; Online: Creola bodies and pathogenesis of childhood asthma.

    Persson, Carl

    The European respiratory journal

    2022  Volume 60, Issue 5

    MeSH term(s) Humans ; Asthma/epidemiology ; Asthma/etiology ; Asthma/pathology ; Eosinophils/pathology ; Phenotype
    Language English
    Publishing date 2022-11-17
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01204-2022
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  5. Article ; Online: Susceptibility of Patients with Asthma to a Poor Outcome of COVID-19.

    Persson, Carl

    American journal of respiratory and critical care medicine

    2022  Volume 206, Issue 7, Page(s) 922–923

    MeSH term(s) Asthma ; COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2022-06-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202205-0978LE
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  6. Article ; Online: Epithelial regeneration in vivo in pathogenesis of severe asthma.

    Persson, Carl

    The Journal of allergy and clinical immunology

    2022  Volume 150, Issue 5, Page(s) 1244–1245

    MeSH term(s) Humans ; Asthma/pathology ; Respiratory Mucosa/pathology ; Regeneration ; Epithelial Cells/pathology
    Language English
    Publishing date 2022-08-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.07.019
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  7. Article ; Online: Early humoral defense under the radar: microvascular-epithelial cooperation at airways infection in asthma and health.

    Persson, Carl

    American journal of physiology. Lung cellular and molecular physiology

    2022  Volume 322, Issue 3, Page(s) L503–L506

    MeSH term(s) Asthma ; COVID-19 ; Humans ; Respiratory System
    Language English
    Publishing date 2022-03-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00470.2021
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  8. Article ; Online: Bronchial Mucosal Microcirculation in SARS-CoV-2 Infection: Role in Innate Humoral Defense?

    Persson, Carl

    American journal of respiratory and critical care medicine

    2022  Volume 206, Issue 2, Page(s) 228–229

    MeSH term(s) Antibodies, Viral ; Bronchi ; COVID-19 ; Humans ; Immunity, Humoral ; Immunity, Innate ; Microcirculation ; SARS-CoV-2
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202202-0412LE
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  9. Article ; Online: 'Bedside' observations challenge aspects of the 'epithelial barrier hypothesis'.

    Persson, Carl

    Nature reviews. Immunology

    2021  Volume 21, Issue 12, Page(s) 829

    Language English
    Publishing date 2021-11-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-021-00650-8
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  10. Article ; Online: Early humoral defence: Contributing to confining COVID-19 to conducting airways?

    Persson, Carl

    Scandinavian journal of immunology

    2021  Volume 93, Issue 6, Page(s) e13024

    Abstract: Early airway responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are of interest since they could decide whether coronavirus disease-19 (COVID-19) will proceed to life-threatening pulmonary disease stages. Here I discuss ... ...

    Abstract Early airway responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are of interest since they could decide whether coronavirus disease-19 (COVID-19) will proceed to life-threatening pulmonary disease stages. Here I discuss endothelial-epithelial co-operative in vivo responses producing first-line, humoral innate defence opportunities in human airways. The pseudostratified epithelium of human nasal and tracheobronchial airways are prime sites of exposure and infection by SARS-CoV-2. Just beneath the epithelium runs a profuse systemic microcirculation. Its post-capillary venules respond conspicuously to mucosal challenges with autacoids, allergens and microbes, and to mere loss of epithelium. By active venular endothelial gap formation, followed by transient yielding of epithelial junctions, non-sieved plasma macromolecules move from the microcirculation to the mucosal surface. Hence, plasma-derived protein cascade systems and antimicrobial peptides would have opportunity to operate jointly on an unperturbed mucosal lining. Similarly, a plasma-derived, dynamic gel protects sites of epithelial sloughing-regeneration. Precision for this indiscriminate humoral molecular response lies in restricted location and well-regulated duration of plasma exudation. Importantly, the endothelial responsiveness of the airway microcirculation differs distinctly from the relatively non-responsive, low-pressure pulmonary microcirculation that non-specifically, almost irreversibly, leaks plasma in life-threatening COVID-19. Observations in humans of infections with rhinovirus, coronavirus 229E, and influenza A and B support a general but individually variable early occurrence of plasma exudation in human infected nasal and tracheobronchial airways. Investigations are warranted to elucidate roles of host- and drug-induced airway plasma exudation in restriction of viral infection and, specifically, whether it contributes to variable disease responses following exposure to SARS-CoV-2.
    MeSH term(s) Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Biomarkers/blood ; Blood Proteins ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19/metabolism ; COVID-19/virology ; Capillary Permeability/immunology ; Complement Activation/immunology ; Complement System Proteins/immunology ; Complement System Proteins/metabolism ; Exudates and Transudates ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Humoral ; Immunity, Innate ; Immunoglobulin M/blood ; Immunoglobulin M/immunology ; Microvessels/immunology ; Microvessels/metabolism ; Respiratory Mucosa/immunology ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/virology ; SARS-CoV-2/immunology
    Chemical Substances Antibodies, Viral ; Biomarkers ; Blood Proteins ; Immunoglobulin M ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2021-02-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 120476-2
    ISSN 1365-3083 ; 0300-9475
    ISSN (online) 1365-3083
    ISSN 0300-9475
    DOI 10.1111/sji.13024
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