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  1. Book ; Thesis: Stammbaumuntersuchung bei einem Fall von familiärer Alzheimerscher Krankheit

    Kohlmeier, Johannes

    1989  

    Author's details Johannes Kohlmeier
    Size 42 S.: graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Techn. Univ., Diss., 1990
    HBZ-ID HT003676747
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Early improvement of symptoms using LCZ696 in a patient with systolic heart failure and a reduced ejection fraction: a case report.

    Kohlmeier, Johannes / Bramlage, Peter

    Perfusion

    2016  Volume 31, Issue 8, Page(s) 699–702

    Abstract: Introduction:: Heart failure is a progressive disease with high mortality and morbidity. LCZ696 is a drug that has recently shown its improved efficacy and safety in patients with systolic heart failure and a reduced ejection fraction. Reports on its ... ...

    Abstract Introduction:: Heart failure is a progressive disease with high mortality and morbidity. LCZ696 is a drug that has recently shown its improved efficacy and safety in patients with systolic heart failure and a reduced ejection fraction. Reports on its impact on the improvement of clinical symptoms are, however, scarce. These are important because they improve a patient's compliance with treatment and their quality of life.
    Case presentation:: We report on the case of a 71-year-old patient who had deteriorating symptoms and signs of heart failure (ejection fraction [EF] 34%) in whom we initiated LCZ696 treatment. After two months of LCZ696 treatment (including titration), the New York Heart Association (NYHA) classification had improved (III→II/I) with no residual signs of acrocyanosis and orthopnea. While creatinine values remained stable, potassium increased to 5.0 mmol/l and brain natriuretic peptide (BNP) dropped from 1260 ng/l to 680 ng/ml. The final EF was 47%. The patient reported substantial improvement of his quality of life.
    Conclusion:: We show, based on a case report, that symptoms associated with heart failure deterioration are improved early after the initiation of LCZ696. This should foster specific research into symptoms and quality of life improvements with LCZ696.
    Language English
    Publishing date 2016-07-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 645038-6
    ISSN 1477-111X ; 0267-6591
    ISSN (online) 1477-111X
    ISSN 0267-6591
    DOI 10.1177/0267659116660608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2424: Show issues Location:
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  3. Article ; Online: Sensitivity and specificity of sentinel lymph node biopsy in patients with oral squamous cell carcinomas using indocyanine green fluorescence imaging.

    Al-Dam, Ahmed / Precht, Clarissa / Barbe, Armelle / Kohlmeier, Carsten / Hanken, Henning / Wikner, Johannes / Schön, Gerhard / Heiland, Max / Assaf, Alexandre T

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

    2018  Volume 46, Issue 8, Page(s) 1379–1384

    Abstract: Purpose: The purpose of this clinical study was to evaluate the sensitivity and specificity of cervical sentinel lymph node biopsy after mapping with indocyanine green fluorescence (ICG) for imaging early-stage oral cancer.: Patients and methods: A ... ...

    Abstract Purpose: The purpose of this clinical study was to evaluate the sensitivity and specificity of cervical sentinel lymph node biopsy after mapping with indocyanine green fluorescence (ICG) for imaging early-stage oral cancer.
    Patients and methods: A sentinel lymph node biopsy (SLNB) was performed during a selective neck dissection (SND) in 20 patients with oral squamous cell carcinoma (OSCC, cT1 or cT2, N0 status). The sentinel lymph nodes (SLN) were identified using an infrared video camera after ICG injection. Lymph nodes were examined histologically. The endpoint of this study was to investigate the rate of false-negative results in SLNB.
    Results: Sentinel lymph nodes could be detected after 8.1 min (range 1-22 min). In eight out of 20 cases, lymph node metastases were found during histopathological evaluation of the neck dissection specimen. In four cases a metastasis could be found in the detected SLN (sensitivity 50%). In the other four cases metastases were found in different lymph nodes. Specificity was 100%, positive predictive value 100%, and negative predictive value 75%.
    Conclusion: In this study, reliability of sentinel lymph node biopsy after ICG imaging could not be verified, as there were false-negative results in 50% of the cases. Therefore, SND can still be recommended as for patients with cT1 or cT2 OSCC, and a N0 neck status.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/pathology ; Female ; Fluorescence ; Fluorescent Dyes/therapeutic use ; Humans ; Indocyanine Green/therapeutic use ; Male ; Middle Aged ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/pathology ; Neck Dissection ; Sensitivity and Specificity ; Sentinel Lymph Node Biopsy/methods
    Chemical Substances Fluorescent Dyes ; Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2018-05-23
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 91267-0
    ISSN 1878-4119 ; 1010-5182 ; 0301-0503
    ISSN (online) 1878-4119
    ISSN 1010-5182 ; 0301-0503
    DOI 10.1016/j.jcms.2018.05.039
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    Zs.A 882: Show issues Location:
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  4. Article ; Online: Diagnostic value of CT-localizer and axial low-dose computed tomography for the detection of drug body packing.

    Aissa, Joel / Kohlmeier, Antonia / Rubbert, Christian / Hohn, Ulrich / Blondin, Dirk / Schleich, Christoph / Kröpil, Patric / Boos, Johannes / Antoch, Gerald / Miese, Falk

    Journal of forensic and legal medicine

    2016  Volume 37, Page(s) 55–60

    Abstract: Objectives: The purpose of this study was to assess the diagnostic performance of CT-localizers in the detection of intracorporal containers.: Methods: This study was approved by the research ethics committee of our clinic. From March 2012 to March ... ...

    Abstract Objectives: The purpose of this study was to assess the diagnostic performance of CT-localizers in the detection of intracorporal containers.
    Methods: This study was approved by the research ethics committee of our clinic. From March 2012 to March 2013, 108 subjects were referred to our institute with suspected body packing. The CT-localizer and the axial CT-images were compared by two blinded observers retrospectively. Presence of body packs was assessed in consensus. Sensitivity and specificity, PPV and NPV of the CT-localizer were calculated.
    Results: Packets were detected in the CT-localizer of 19 suspects. In 28 of 108 cases packs were detected in axial CT-images. Sensitivity of CT-localizer for detection of packs was 0.68, and specificity was 1.00. There were no cases rated as false positive. The PPV was 1.0 and the NPV was 0.89. The omission of the axial CT-images would have led to a mean radiation dose reduction of 1.94 ± 0.5 mSv.
    Conclusions: The value of CT-localizers lies in their high PPV. Localizers are limited by low sensitivity, compared to axial CT-images in screening of potential body packers. However, in positive cases their high PPV may possibly allow to omit the complete axial abdominal CT to achieve even lower radiation exposure.
    MeSH term(s) Adolescent ; Adult ; Drug Trafficking ; Female ; Foreign Bodies/diagnostic imaging ; Humans ; Male ; Middle Aged ; Radiation Dosage ; Retrospective Studies ; Sensitivity and Specificity ; Tomography, X-Ray Computed ; Young Adult
    Language English
    Publishing date 2016-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2268721-X
    ISSN 1878-7487 ; 1752-928X
    ISSN (online) 1878-7487
    ISSN 1752-928X
    DOI 10.1016/j.jflm.2015.10.009
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    Zs.A 4217: Show issues Location:
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  5. Article ; Online: Prospective biomechanical evaluation of donor site morbidity after radial forearm free flap.

    Riecke, Björn / Kohlmeier, Carsten / Assaf, Alexandre T / Wikner, Johannes / Drabik, Anna / Catalá-Lehnen, Philip / Heiland, Max / Rendenbach, Carsten

    The British journal of oral & maxillofacial surgery

    2016  Volume 54, Issue 2, Page(s) 181–186

    Abstract: Although the radial forearm free flap (RFF) is a commonly-used microvascular flap for orofacial reconstruction, we are aware of few prospective biomechanical studies of the donor site. We have therefore evaluated the donor site morbidity biomechanically ... ...

    Abstract Although the radial forearm free flap (RFF) is a commonly-used microvascular flap for orofacial reconstruction, we are aware of few prospective biomechanical studies of the donor site. We have therefore evaluated the donor site morbidity biomechanically of 30 consecutive RFF for orofacial reconstruction preoperatively and three months postoperatively. This included the Mayo wrist score, the Disabilities of the Arm, Shoulder and Hand (DASH) score, grip strength, followed by tip pinch, key pinch, palmar pinch, and range of movement of the wrist. Primary defects were all closed with local full-thickness skin grafts from the donor site forearm, thereby circumventing the need for a second defect. Postoperative functional results showed that there was a reduction in hand strength measured by (grip strength: -24.1%, in tip pinch: -23.3%, in key pinch: -16.5, and in palmar pinch: -19.3%); and wrist movement measured by extension (active=14.3% / passive= -11.5%) and flexion = -14.8% / -8.9%), and radial (-9.8% / -9.8%) and ulnar (-11.0% / -9.3%) abduction. The Mayo wrist score was reduced by 9.4 points (-12.9%) and the DASH score increased by 16.1 points (+35.5%) compared with the same forearm preoperatively. The local skin graft resulted in a robust wound cover with a good functional result. Our results show that the reduction in hand strength and wrist movement after harvest of a RFF is objectively evaluable, and did not reflect the subjectively noticed extent and restrictions in activities of daily living. Use of a local skin graft avoids a second donor site and the disadvantages of a split-thickness skin graft.
    MeSH term(s) Activities of Daily Living ; Biomechanical Phenomena ; Forearm ; Free Tissue Flaps ; Humans ; Prospective Studies ; Reconstructive Surgical Procedures ; Skin Transplantation
    Language English
    Publishing date 2016-02
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 605685-4
    ISSN 1532-1940 ; 0266-4356
    ISSN (online) 1532-1940
    ISSN 0266-4356
    DOI 10.1016/j.bjoms.2015.11.021
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    Uk I Zs.238: Show issues Location:
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  6. Article ; Online: Functional donor site morbidity longer than one year after fibula free flap: A prospective biomechanical analysis.

    Rendenbach, Carsten / Rashad, Ashkan / Hansen, Lara / Kohlmeier, Carsten / Dyck, Moritz L / Suling, Anna / Assaf, Alexandre T / Amling, Michael / Heiland, Max / Wikner, Johannes / Riecke, Bjoern / Kreutzer, Kilian

    Microsurgery

    2017  Volume 38, Issue 4, Page(s) 395–401

    Abstract: Objectives: The fibula free flap is the workhorse procedure for osseous reconstruction. The objective of this study was to investigate long-term functional outcomes of the harvesting site.: Patients and methods: About 19 patients (10 male, 9 female, ... ...

    Abstract Objectives: The fibula free flap is the workhorse procedure for osseous reconstruction. The objective of this study was to investigate long-term functional outcomes of the harvesting site.
    Patients and methods: About 19 patients (10 male, 9 female, mean age 58.1 years) were available for the long-term analysis 13-51 months after surgery. Jumping mechanography and balance testing on a ground force reaction plate (Leonardo Mechanograph GFRP) were performed before and surgery. The Esslinger Fitness Index (EFI, maximum peak power in W/kg normalized for age and gender) was considered as primary endpoint. Secondary outcomes were maximum force, range of motion in the ankle joint, sensory limitations, the American Orthopedic Foot and Ankle Society Score (AOFAS-Score), and subjective perceptions.
    Results: We found no significant difference between pre- and postoperative EFI (70.4% versus 66.0%, P = 0.07) and body sway (1.72 cm
    Conclusions: Reduced peak power and balance ability seem to be reversible short-term effects after fibula harvesting. We recommend preoperative patient education and standardized protocols for physiotherapy.
    MeSH term(s) Adult ; Aged ; Ankle Joint/physiology ; Bone Transplantation ; Female ; Fibula/transplantation ; Free Tissue Flaps ; Humans ; Male ; Middle Aged ; Motor Activity/physiology ; Postural Balance ; Prospective Studies ; Range of Motion, Articular/physiology ; Recovery of Function/physiology ; Time Factors ; Tissue and Organ Harvesting/adverse effects ; Transplant Donor Site/pathology ; Transplant Donor Site/physiopathology ; Weight-Bearing/physiology
    Language English
    Publishing date 2017-07-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605524-2
    ISSN 1098-2752 ; 0738-1085
    ISSN (online) 1098-2752
    ISSN 0738-1085
    DOI 10.1002/micr.30205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1570: Show issues Location:
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  7. Book ; Thesis: Stammbaumuntersuchung bei einem Fall von familiärer Alzheimerscher Krankheit

    Kohlmeier, Johannes

    1990  

    Author's details Johannes Kohlmeier
    Language Undetermined
    Size 42 Bl, graph. Darst, 21 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @München, Techn. Univ., Diss. : 1990
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article ; Online: Long-term biomechanical analysis of donor site morbidity after radial forearm free flap.

    Riecke, Björn / Kohlmeier, Carsten / Kreiker, Henri / Suling, Anna / Assaf, Alexandre Thomas / Wikner, Johannes / Hanken, Henning / Heiland, Max / Gröbe, Alexander / Rendenbach, Carsten

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

    2015  Volume 43, Issue 9, Page(s) 1776–1780

    Abstract: Background: Although the radial forearm free flap (RFF) is a commonly used microvascular graft for head and neck reconstruction, long-term biomechanical results regarding donor site morbidity are rare.: Patients and methods: In a prospective panel ... ...

    Abstract Background: Although the radial forearm free flap (RFF) is a commonly used microvascular graft for head and neck reconstruction, long-term biomechanical results regarding donor site morbidity are rare.
    Patients and methods: In a prospective panel study, 32 patients were included. Biomechanical assessment was performed preoperatively, three months postoperatively and two years postoperatively. The primary endpoint of the study was grip strength. In addition, the Mayo wrist score, DASH score (disabilities of the arm, shoulder and hand score), fine motor skill strengths (tip pinch, key pinch, palmar pinch) and the range of motion were analysed. Primary defects were closed with local full-thickness skin grafts (FTSG) from the donor site forearm avoiding a secondary defect site.
    Results: In the long-term analysis, grip strength was reduced in both arms. A significant improvement over time was found only for the donor arm. A persistent deficit of tip pinch strength and dorsal extension was recorded. Persistent sensory limitations occurred in four cases. Patient contentment after two years of follow-up was high and daily life routine was not restricted.
    Conclusion: Gross and fine motor skill limitations are reversible short-term effects after RFF harvesting and do not restrict daily routine in the long term. These findings substantiate the value of the RFF as a workhorse in reconstructive surgery.
    Language English
    Publishing date 2015-11
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 91267-0
    ISSN 1878-4119 ; 1010-5182 ; 0301-0503
    ISSN (online) 1878-4119
    ISSN 1010-5182 ; 0301-0503
    DOI 10.1016/j.jcms.2015.07.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 882: Show issues Location:
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