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  1. Article ; Online: Protocol to detect antigen-specific nasal-resident T cells in humans.

    Lim, Joey Ming Er / Tan, Anthony T / Bertoletti, Antonio

    STAR protocols

    2023  Volume 4, Issue 1, Page(s) 101995

    Abstract: Specialized T cells are located in the nasal cavity and act as the first line of defense against ... specific nasal-resident T cells. We detail steps for localized nasal swabbing to collect the nasal samples ... nasal-resident T cells. For complete details on the use and execution of this protocol, please refer ...

    Abstract Specialized T cells are located in the nasal cavity and act as the first line of defense against respiratory viral infection. Here, we present a protocol for the detection and characterization of antigen-specific nasal-resident T cells. We detail steps for localized nasal swabbing to collect the nasal samples. We then describe IFN-γ ELISpot and an activation-induced marker assay to detect and characterize antigen-specific nasal-resident T cells. For complete details on the use and execution of this protocol, please refer to Lim et al. (2022).
    MeSH term(s) Humans ; T-Lymphocytes ; Biological Assay
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101995
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  2. Article ; Online: Protection from infection or disease? Re-evaluating the broad immunogenicity of inactivated SARS-CoV-2 vaccines.

    Tan, Anthony T / Lim, Joey Ming Er / Bertoletti, Antonio

    Virologica Sinica

    2022  

    Language English
    Publishing date 2022-11-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1011219-4
    ISSN 1995-820X ; 1000-3223 ; 1003-5125
    ISSN (online) 1995-820X
    ISSN 1000-3223 ; 1003-5125
    DOI 10.1016/j.virs.2022.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4175: Show issues Location:
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  3. Article ; Online: HBV-HCC treatment with mRNA electroporated HBV-TCR T cells.

    Tan, Anthony T / Bertoletti, Antonio

    Immunotherapy advances

    2021  Volume 2, Issue 1, Page(s) ltab026

    Abstract: ... the considerable success of adoptive T-cell immunotherapy against B-cell malignancies, it is conceivable ... of T-cell therapy strategies for HBV-HCC and discuss the safety and the efficacy of the strategies ... of the T cells. ...

    Abstract Hepatocellular carcinoma is a significant global health challenge with steadily increasing incidence in the East Asia region. While both Hepatitis C and B virus infections account for the majority of HCC cases, the advent of potent antivirals against HCV infection has biased the aetiology towards chronic HBV infection that at the moment remains without an effective cure. For this reason, HBV-HCC remains a persistent global problem. Treatment options for intermediate to advanced stages of HBV-HCC remain limited, hence novel therapeutic strategies are required to fulfil this medical need. Following the considerable success of adoptive T-cell immunotherapy against B-cell malignancies, it is conceivable to envision whether the same could be achieved against HBV-HCC. In this review, we describe the development of T-cell therapy strategies for HBV-HCC and discuss the safety and the efficacy of the strategies in terms of the direct killing of tumour cells and the other alterations possibly induced by the action of the T cells.
    Language English
    Publishing date 2021-12-24
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2732-4303
    ISSN (online) 2732-4303
    DOI 10.1093/immadv/ltab026
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  4. Article ; Online: Act Early and at the Right Location: SARS-CoV-2 T Cell Kinetics and Tissue Localization.

    Bertoletti, Antonio / Le Bert, Nina / Tan, Anthony T

    International journal of molecular sciences

    2022  Volume 23, Issue 18

    Abstract: ... Therefore, the role played by T cells in the containment of viral replication and spread after infection has taken a more ... central stage. In this brief review, we will discuss the role played by T cells in the protection ... from COVID-19, with a particular emphasis on the kinetics of the T cell response and its localization ...

    Abstract The emergence of new SARS-CoV-2 lineages able to escape antibodies elicited by infection or vaccination based on the Spike protein of the Wuhan isolates has reduced the ability of Spike-specific antibodies to protect previously infected or vaccinated individuals from infection. Therefore, the role played by T cells in the containment of viral replication and spread after infection has taken a more central stage. In this brief review, we will discuss the role played by T cells in the protection from COVID-19, with a particular emphasis on the kinetics of the T cell response and its localization at the site of primary infection.
    MeSH term(s) Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 ; Humans ; Kinetics ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; T-Lymphocytes ; Vaccination
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-09-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms231810679
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  5. Article ; Online: SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic.

    Bertoletti, Antonio / Le Bert, Nina / Tan, Anthony T

    Immunity

    2022  Volume 55, Issue 10, Page(s) 1764–1778

    Abstract: ... CoV-2-specific T cells induced by infection, by vaccination or by their combination (defined as hybrid ... that can modify the magnitude, function, and anatomical localization of SARS-CoV-2-specific T cells and ... their influence in the possible ability of T cells to protect the host from severe COVID-19 development. ...

    Abstract Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increasing ability to evade neutralizing antibodies have emerged. Thus, earlier interest in defining the correlates of protection from infection, mainly mediated by humoral immunity, has shifted to correlates of protection from disease, which require a more comprehensive analysis of both humoral and cellular immunity. In this review, we summarized the evidence that supports the role of SARS-CoV-2-specific T cells induced by infection, by vaccination or by their combination (defined as hybrid immunity) in disease protection. We then analyzed the different epidemiological and virological variables that can modify the magnitude, function, and anatomical localization of SARS-CoV-2-specific T cells and their influence in the possible ability of T cells to protect the host from severe COVID-19 development.
    MeSH term(s) Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 ; Humans ; Immunity, Humoral ; Pandemics ; SARS-CoV-2 ; T-Lymphocytes ; Vaccination
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.08.008
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    Zs.A 4227: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 69: Show issues

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  6. Article ; Online: Difference in sensitivity between SARS-CoV-2-specific T cell assays in patients with underlying conditions. Reply.

    Tan, Anthony T / Le Bert, Nina / Bertoletti, Antonio

    The Journal of clinical investigation

    2021  Volume 131, Issue 24

    MeSH term(s) Antibodies, Viral ; COVID-19 ; Humans ; Immunity, Humoral ; SARS-CoV-2 ; T-Lymphocytes
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2021-09-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI155701
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    Ua VI Zs.184: Show issues Location:
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  7. Article ; Online: Adoptive T-cell therapy for HBV-associated HCC and HBV infection.

    Tan, Anthony T / Schreiber, Sophia

    Antiviral research

    2020  Volume 176, Page(s) 104748

    Abstract: ... applicable only for early stages of the disease. With the general success of chimeric antigen receptor T ... cell immunotherapy against B-cell leukemia, adoptively transferring engineered autologous T cells specific for HBV or ... HCC. This review will describe the novel T cell-related immunotherapies being ...

    Abstract Chronic hepatitis B virus (HBV) infection remains a major global concern due to its high prevalence and the increased probability of progressing toward cirrhosis and hepatocellular carcinoma (HCC). While currently available therapies are effective in controlling HBV replication, they rarely achieve functional cure. Similarly, effective treatment options for HBV-related HCC (HBV-HCC) are limited and primarily applicable only for early stages of the disease. With the general success of chimeric antigen receptor T-cell immunotherapy against B-cell leukemia, adoptively transferring engineered autologous T cells specific for HBV or HCC antigens might represent a promising therapeutic approach for both chronic HBV infection and HBV-HCC. This review will describe the novel T cell-related immunotherapies being developed for both indications and discuss the approach of each strategy, their considerations and limitations when applied for treatment of chronic HBV infection (CHB) and HBV-HCC.
    MeSH term(s) Adoptive Transfer ; Animals ; Carcinoma, Hepatocellular/immunology ; Carcinoma, Hepatocellular/therapy ; Carcinoma, Hepatocellular/virology ; Clinical Trials as Topic ; Hepatitis B virus ; Hepatitis B, Chronic/immunology ; Hepatitis B, Chronic/therapy ; Humans ; Liver Cirrhosis/pathology ; Liver Neoplasms/immunology ; Liver Neoplasms/therapy ; Liver Neoplasms/virology ; Mice ; T-Lymphocytes/immunology
    Language English
    Publishing date 2020-02-19
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2020.104748
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    Zs.A 1627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: The T-cell response to SARS-CoV-2: kinetic and quantitative aspects and the case for their protective role.

    Bertoletti, Antonio / Tan, Anthony T / Le Bert, Nina

    Oxford open immunology

    2021  Volume 2, Issue 1, Page(s) iqab006

    Abstract: ... of virus-specific antibodies and T cells. Although kinetic and quantitative aspects of antibodies have been ... analyzed in large patient cohorts, similar information about SARS-CoV-2-specific T cells are scarce ... We summarize the available knowledge of quantitative and temporal features of the SARS-CoV-2 T-cell response ...

    Abstract Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), the etiological agent of Coronavirus Diseases 2019 (COVID-19), triggers an adaptive immunity in the infected host that results in the production of virus-specific antibodies and T cells. Although kinetic and quantitative aspects of antibodies have been analyzed in large patient cohorts, similar information about SARS-CoV-2-specific T cells are scarce. We summarize the available knowledge of quantitative and temporal features of the SARS-CoV-2 T-cell response in this review. Currently, most of the data are derived only from the analysis of the circulatory compartment. Despite this limitation, early appearance, multi-specificity and functionality of SARS-CoV-2-specific T cells are associated with accelerated viral clearance and with protection from severe COVID-19.
    Language English
    Publishing date 2021-02-23
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2633-6960
    ISSN (online) 2633-6960
    DOI 10.1093/oxfimm/iqab006
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  9. Article ; Online: Optimizing a therapy for opiate use disorders

    Manhong Wu / Zhuanfen Cheng / Anthony T. Le / Yalun Tan / Gary Peltz

    Clinical and Translational Science, Vol 16, Iss 2, Pp 216-

    Characterizing ondansetron pharmacokinetics in blood and brain

    2023  Volume 223

    Abstract: Abstract Administration of a widely used 5‐hydroxytryptamine receptor (5HT3AR) antagonist (ondansetron) potently inhibited the development of experimentally induced opioid dependence and withdrawal responses in mice and humans. However, in several ... ...

    Abstract Abstract Administration of a widely used 5‐hydroxytryptamine receptor (5HT3AR) antagonist (ondansetron) potently inhibited the development of experimentally induced opioid dependence and withdrawal responses in mice and humans. However, in several studies examining withdrawal symptoms in subjects with chronic opioid use disorders (OUDs), ondansetron exhibited reduced or absent efficacy. Because attenuation of opioid withdrawal symptomatology is mediated within the brain, this study examined single‐dose ondansetron pharmacokinetics in the blood and brain of mice. We demonstrate that ondansetron concentrations in the brain (Cbrain ng/mg) are 1000‐fold lower than the blood concentrations (Cblood ng/ml) and decrease rapidly after ondansetron administration; and that a large percentage of brain ondansetron remains in the ventricular fluid. These results indicate that the ondansetron dose, and the time window between ondansetron and opioid administration, and when withdrawal is assessed are critical considerations for clinical studies involving subjects with chronic OUD. The pharmacokinetic results and the dosing considerations discussed here can be used to improve the design of subsequent clinical trials, which will test whether a more prolonged period of ondansetron administration can provide a desperately needed therapy that can prevent the development of neonatal opioid withdrawal syndrome in babies born to mothers with chronic OUD.
    Keywords Therapeutics. Pharmacology ; RM1-950 ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Optimizing a therapy for opiate use disorders: Characterizing ondansetron pharmacokinetics in blood and brain.

    Wu, Manhong / Cheng, Zhuanfen / Le, Anthony T / Tan, Yalun / Peltz, Gary

    Clinical and translational science

    2022  Volume 16, Issue 2, Page(s) 216–223

    Abstract: Administration of a widely used 5-hydroxytryptamine receptor ( ... ...

    Abstract Administration of a widely used 5-hydroxytryptamine receptor (5HT
    MeSH term(s) Humans ; Mice ; Animals ; Ondansetron ; Analgesics, Opioid ; Opiate Alkaloids/therapeutic use ; Brain ; Morphine ; Opioid-Related Disorders/drug therapy ; Substance Withdrawal Syndrome/drug therapy
    Chemical Substances Ondansetron (4AF302ESOS) ; Analgesics, Opioid ; Opiate Alkaloids ; Morphine (76I7G6D29C)
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2433157-0
    ISSN 1752-8062 ; 1752-8054
    ISSN (online) 1752-8062
    ISSN 1752-8054
    DOI 10.1111/cts.13440
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