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  1. Book: Echocardiography in pediatric and adult congenital heart disease

    Eidem, Benjamin W. / Lopez, Leo / Johnson, Jonathan N. / Cetta, Frank

    2021  

    Author's details edited by Benjamin W. Eidem, Jonathan N. Johnson, Leo Lopez, Frank Cetta
    Keywords Heart Defects, Congenital / diagnostic imaging ; Echocardiography / methods ; Multimodal Imaging / methods
    Language English
    Size xv, 796 Seiten, Illustrationen
    Edition Third edition
    Publisher Wolters Kluwer
    Publishing place Philadelphia
    Publishing country United States
    Document type Book
    Note Zugang zur Online-Ausgabe über Code
    HBZ-ID HT020696993
    ISBN 978-1-4963-9401-9 ; 1-4963-9401-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 A 116 available for loan (reading room) Lesesaal EG
    Zugang zur Online-Ausgabe aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Book ; Online: The Role of Plant Hormones in Plant-Microbe Symbioses

    Foo, Eloise / Michael Plett, Jonathan / Antonio Lopez-Raez, Juan / Reid, Dugald

    2020  

    Keywords Science: general issues ; Botany & plant sciences ; Mycorrhizae and Rhizobium ; Plant hormone ; endosymbiont ; ectomyccorhizas ; plant associated bacteria
    Size 1 electronic resource (212 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231414
    ISBN 9782889632756 ; 288963275X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Homeostatic plasticity of axonal excitable sites in Alzheimer's disease.

    Quintela-López, Tania / Lezmy, Jonathan

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1277251

    Language English
    Publishing date 2023-10-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1277251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ecosystems for future generations.

    Jonathan, M P / Torres, Kalina Bermúdez / Marmolejo-Rodríguez, Ana Judith / López, Eugenia López

    Environmental science and pollution research international

    2022  Volume 29, Issue 41, Page(s) 61547–61549

    MeSH term(s) Ecosystem ; Social Responsibility
    Language English
    Publishing date 2022-07-06
    Publishing country Germany
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-21664-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  5. Article: Comparison of the Chemical Composition of Six Canihua (

    Mérida-López, Jenny / Pérez, Sander Jonathan / Morales, Rocío / Purhagen, Jeanette / Bergenståhl, Björn / Rojas, Cinthia Carola

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 8

    Abstract: The canihua ( ...

    Abstract The canihua (
    Language English
    Publishing date 2023-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12081734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Method to Measure Ubiquitination of NLRs.

    Worboys, Jonathan D / Palazón-Riquelme, Pablo / López-Castejón, Gloria

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2696, Page(s) 105–114

    Abstract: Posttranslational modifications are crucial in determining the functions of proteins in the cell. Modification of the NLRP3 inflammasome by the ubiquitin system has recently emerged as a new level of regulation of the inflammasome complex. Here we ... ...

    Abstract Posttranslational modifications are crucial in determining the functions of proteins in the cell. Modification of the NLRP3 inflammasome by the ubiquitin system has recently emerged as a new level of regulation of the inflammasome complex. Here we describe a method to detect poly-ubiquitination of NRLP3 using two different approaches: (i) detection with a ubiquitin antibody or (ii) using TUBEs (Tandem Ubiquitin Binding entities). This approach can be used to detect ubiquitination of other NLRs or other proteins.
    MeSH term(s) Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Ubiquitination ; Ubiquitin/metabolism ; Protein Processing, Post-Translational
    Chemical Substances Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Ubiquitin
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3350-2_7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Cell Surface Nucleocapsid Protein Expression: A Betacoronavirus Immunomodulatory Strategy.

    López-Muñoz, Alberto Domingo / Santos, Jefferson J S / Yewdell, Jonathan W

    bioRxiv : the preprint server for biology

    2023  

    Abstract: We recently reported that SARS-CoV-2 Nucleocapsid (N) protein is abundantly expressed on the surface of both infected and neighboring uninfected cells, where it enables activation of Fc receptor-bearing immune cells with anti-N antibodies (Abs) and ... ...

    Abstract We recently reported that SARS-CoV-2 Nucleocapsid (N) protein is abundantly expressed on the surface of both infected and neighboring uninfected cells, where it enables activation of Fc receptor-bearing immune cells with anti-N antibodies (Abs) and inhibits leukocyte chemotaxis by binding chemokines (CHKs). Here, we extend these findings to N from the seasonal human coronavirus (HCoV)-OC43, which is also robustly expressed on the surface of infected and non-infected cells by binding heparan-sulfate/heparin (HS/H). HCoV-OC43 N binds with high affinity to the same set of 11 human CHKs as SARS-CoV-2 N, but also to a non-overlapping set of 6 cytokines (CKs). As with SARS-CoV-2 N, HCoV-OC43 N inhibits CXCL12β-mediated leukocyte migration in chemotaxis assays, as do all highly pathogenic and endemic HCoV N proteins. Together, our findings indicate that cell surface HCoV N plays important evolutionary conserved roles in manipulating host innate immunity and as a target for adaptive immunity.
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.24.529952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The reproduction number and its probability distribution for stochastic viral dynamics.

    Williams, Bevelynn / Carruthers, Jonathan / Gillard, Joseph J / Lythe, Grant / Perelson, Alan S / Ribeiro, Ruy M / Molina-París, Carmen / López-García, Martín

    Journal of the Royal Society, Interface

    2024  Volume 21, Issue 210, Page(s) 20230400

    Abstract: We consider stochastic models of individual infected cells. The reproduction number, ...

    Abstract We consider stochastic models of individual infected cells. The reproduction number,
    MeSH term(s) Probability ; Reproduction ; Virion
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2156283-0
    ISSN 1742-5662 ; 1742-5689
    ISSN (online) 1742-5662
    ISSN 1742-5689
    DOI 10.1098/rsif.2023.0400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cell surface nucleocapsid protein expression: A betacoronavirus immunomodulatory strategy.

    López-Muñoz, Alberto Domingo / Santos, Jefferson J S / Yewdell, Jonathan W

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 28, Page(s) e2304087120

    Abstract: We recently reported that SARS-CoV-2 nucleocapsid (N) protein is abundantly expressed on the surface of both infected and neighboring uninfected cells, where it enables activation of Fc receptor-bearing immune cells with anti-N antibodies (Abs) and ... ...

    Abstract We recently reported that SARS-CoV-2 nucleocapsid (N) protein is abundantly expressed on the surface of both infected and neighboring uninfected cells, where it enables activation of Fc receptor-bearing immune cells with anti-N antibodies (Abs) and inhibits leukocyte chemotaxis by binding chemokines (CHKs). Here, we extend these findings to N from the common cold human coronavirus (HCoV)-OC43, which is also robustly expressed on the surface of infected and noninfected cells by binding heparan sulfate/heparin (HS/H). HCoV-OC43 N binds with high affinity to the same set of 11 human CHKs as SARS-CoV-2 N, but also to a nonoverlapping set of six cytokines. As with SARS-CoV-2 N, HCoV-OC43 N inhibits CXCL12β-mediated leukocyte migration in chemotaxis assays, as do all highly pathogenic and common cold HCoV N proteins. Together, our findings indicate that cell surface HCoV N plays important evolutionarily conserved roles in manipulating host innate immunity and as a target for adaptive immunity.
    MeSH term(s) Humans ; Coronavirus OC43, Human/genetics ; Membrane Proteins ; Nucleocapsid ; SARS-CoV-2/genetics ; Immunity, Innate
    Chemical Substances Membrane Proteins
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2304087120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Automatic mechanistic inference from large families of Boolean models generated by Monte Carlo tree search.

    Glazer, Bryan J / Lifferth, Jonathan T / Lopez, Carlos F

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1198359

    Abstract: Many important processes in biology, such as signaling and gene regulation, can be described using logic models. These logic models are typically built to behaviorally emulate experimentally observed phenotypes, which are assumed to be steady states of a ...

    Abstract Many important processes in biology, such as signaling and gene regulation, can be described using logic models. These logic models are typically built to behaviorally emulate experimentally observed phenotypes, which are assumed to be steady states of a biological system. Most models are built by hand and therefore researchers are only able to consider one or perhaps a few potential mechanisms. We present a method to automatically synthesize Boolean logic models with a specified set of steady states. Our method, called MC-Boomer, is based on Monte Carlo Tree Search an efficient, parallel search method using reinforcement learning. Our approach enables users to constrain the model search space using prior knowledge or biochemical interaction databases, thus leading to generation of biologically plausible mechanistic hypotheses. Our approach can generate very large numbers of data-consistent models. To help develop mechanistic insight from these models, we developed analytical tools for multi-model inference and model selection. These tools reveal the key sets of interactions that govern the behavior of the models. We demonstrate that MC-Boomer works well at reconstructing randomly generated models. Then, using single time point measurements and reasonable biological constraints, our method generates hundreds of thousands of candidate models that match experimentally validated
    Language English
    Publishing date 2023-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1198359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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