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  1. Article ; Online: EMT in breast cancer stem cell generation.

    Ansieau, Stéphane

    Cancer letters

    2013  Volume 338, Issue 1, Page(s) 63–68

    Abstract: The concept of cancer stem cells (CSCs) has been proposed to explain the ability of single disseminated cancer cells to reconstitute tumours with heterogeneity similar to that of the primary tumour they arise from. Although this concept is now commonly ... ...

    Abstract The concept of cancer stem cells (CSCs) has been proposed to explain the ability of single disseminated cancer cells to reconstitute tumours with heterogeneity similar to that of the primary tumour they arise from. Although this concept is now commonly accepted, the origin of these CSCs remains a source of debate. First proposed to arise through stem/progenitor cell transformation, CSCs might also or alternatively arise from differentiated cancer cells through epithelial to mesenchymal transition (EMT), an embryonic transdifferentiation process. Using breast carcinomas as a study model, I propose revisiting the role of EMT in generating CSCs and the debate on potential underlying mechanisms and biological significance.
    MeSH term(s) Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Dedifferentiation/genetics ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Epithelial-Mesenchymal Transition ; Gene Expression Regulation, Neoplastic ; Humans ; Models, Genetic ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Tumor Microenvironment/genetics
    Language English
    Publishing date 2013-09-10
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2012.05.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1177: Show issues Location:
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  2. Article: The Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It Complicated.

    Gouasmi, Roumaïssa / Ferraro-Peyret, Carole / Nancey, Stéphane / Coste, Isabelle / Renno, Toufic / Chaveroux, Cédric / Aznar, Nicolas / Ansieau, Stéphane

    Cancers

    2022  Volume 14, Issue 11

    Abstract: The kynurenine pathway has been highlighted as a gatekeeper of immune-privileged sites through its ability to generate from tryptophan a set of immunosuppressive metabolic intermediates. It additionally constitutes an important source of cellular ... ...

    Abstract The kynurenine pathway has been highlighted as a gatekeeper of immune-privileged sites through its ability to generate from tryptophan a set of immunosuppressive metabolic intermediates. It additionally constitutes an important source of cellular NAD
    Language English
    Publishing date 2022-06-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14112793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Intestinal Epithelial Cells Adapt to Chronic Inflammation through Partial Genetic Reprogramming.

    Collin, Guillaume / Foy, Jean-Philippe / Aznar, Nicolas / Rama, Nicolas / Wierinckx, Anne / Saintigny, Pierre / Puisieux, Alain / Ansieau, Stéphane

    Cancers

    2023  Volume 15, Issue 3

    Abstract: Reactive oxygen species (ROS) are considered to be the main drivers of inflammatory bowel disease. We investigated whether this permanent insult compels intestinal stem cells to develop strategies to dampen the deleterious effects of ROS. As an adverse ... ...

    Abstract Reactive oxygen species (ROS) are considered to be the main drivers of inflammatory bowel disease. We investigated whether this permanent insult compels intestinal stem cells to develop strategies to dampen the deleterious effects of ROS. As an adverse effect, this adaptation process may increase their tolerance to oncogenic insults and facilitate their neoplastic transformation. We submitted immortalized human colonic epithelial cells to either a mimic of chronic inflammation or to a chemical peroxide, analyzed how they adapted to stress, and addressed the biological relevance of these observations in databases. We demonstrated that cells adapt to chronic-inflammation-associated oxidative stress in vitro through a partial genetic reprogramming. Through a gene set enrichment analysis, we showed that this program is recurrently active in the intestinal mucosae of Crohn's and ulcerative colitis disease patients and evolves alongside disease progression. Based on a previously reported characterization of intestinal stem and precursor cells using tracing experiments, we lastly confirmed the activation of the program in intestinal precursor cells during murine colorectal cancer development. This adaptive process is thus likely to play a role in the progression of Crohn's and ulcerative disease, and potentially in the initiation of colorectal cancer.
    Language English
    Publishing date 2023-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15030973
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  4. Article: EMT in breast cancer stem cell generation

    Ansieau, Stéphane

    Cancer letters. 2013 Sept. 10, v. 338, no. 1

    2013  

    Abstract: The concept of cancer stem cells (CSCs) has been proposed to explain the ability of single disseminated cancer cells to reconstitute tumours with heterogeneity similar to that of the primary tumour they arise from. Although this concept is now commonly ... ...

    Abstract The concept of cancer stem cells (CSCs) has been proposed to explain the ability of single disseminated cancer cells to reconstitute tumours with heterogeneity similar to that of the primary tumour they arise from. Although this concept is now commonly accepted, the origin of these CSCs remains a source of debate. First proposed to arise through stem/progenitor cell transformation, CSCs might also or alternatively arise from differentiated cancer cells through epithelial to mesenchymal transition (EMT), an embryonic transdifferentiation process. Using breast carcinomas as a study model, I propose revisiting the role of EMT in generating CSCs and the debate on potential underlying mechanisms and biological significance.
    Keywords breast neoplasms ; models ; stem cells
    Language English
    Dates of publication 2013-0910
    Size p. 63-68.
    Publishing place Elsevier Ireland Ltd
    Document type Article
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2012.05.014
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Senescence versus apoptosis in chemotherapy.

    Ansieau, Stéphane / Collin, Guillaume

    Oncotarget

    2015  Volume 6, Issue 7, Page(s) 4551–4552

    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Camptothecin/analogs & derivatives ; Cell Aging/drug effects ; Colorectal Neoplasms/pathology ; Drug Resistance, Neoplasm/physiology ; Humans ; Male ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism
    Chemical Substances Antineoplastic Agents ; Myeloid Cell Leukemia Sequence 1 Protein ; Camptothecin (XT3Z54Z28A)
    Language English
    Publishing date 2015-03-10
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Un modèle alternatif de progression tumorale.

    Ansieau, Stéphane / Puisieux, Alain

    Biologie aujourd'hui

    2011  Volume 205, Issue 1, Page(s) 47–52

    Abstract: Tumor development is usually described as the result of successive waves of genetic and epigenetic changes and of Darwinian selections that allow the progressive emergence of cells with proliferation and survival advantages. According to this model of ... ...

    Title translation An alternate model of tumoral progression.
    Abstract Tumor development is usually described as the result of successive waves of genetic and epigenetic changes and of Darwinian selections that allow the progressive emergence of cells with proliferation and survival advantages. According to this model of tumoral progression, the acquisition of metastatic properties is perceived as a late stage-induced response to environmentally damaging conditions in the tumor, in particular oxygen and nutriment lack. Analyzing the consequences linked to the reactivation of embryonic programmes leads, for some cancer types, to question the linearity of this model, by showing that the dissemination of cancerous or precancerous cells may begin as early as the lesions convert from a premalignant to a malignant state. We propose to review the main findings that brought about these conclusions and to discuss what consequences they might have.
    MeSH term(s) Animals ; Apoptosis ; Cell Transformation, Neoplastic/pathology ; Cellular Senescence ; Environment ; Humans ; Models, Biological ; Neoplasm Metastasis/pathology ; Twist-Related Protein 1
    Chemical Substances Twist-Related Protein 1
    Language French
    Publishing date 2011
    Publishing country France
    Document type Journal Article ; Review
    ISSN 2105-0678
    ISSN 2105-0678
    DOI 10.1051/jbio/2011001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: EMT or EMT-Promoting Transcription Factors, Where to Focus the Light?

    Ansieau, Stéphane / Collin, Guillaume / Hill, Louise

    Frontiers in oncology

    2014  Volume 4, Page(s) 353

    Language English
    Publishing date 2014-12-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2014.00353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The stress sensor GCN2 differentially controls ribosome biogenesis in colon cancer according to the nutritional context.

    Piecyk, Marie / Triki, Mouna / Laval, Pierre-Alexandre / Duret, Cedric / Fauvre, Joelle / Cussonneau, Laura / Machon, Christelle / Guitton, Jerôme / Rama, Nicolas / Gibert, Benjamin / Ichim, Gabriel / Catez, Frederic / Bourdelais, Fleur / Durand, Sebastien / Diaz, Jean-Jacques / Coste, Isabelle / Renno, Toufic / Manié, Serge N / Aznar, Nicolas /
    Ansieau, Stephane / Ferraro-Peyret, Carole / Chaveroux, Cedric

    Molecular oncology

    2023  

    Abstract: Nutrient availability is a key determinant of tumor cell behavior. While nutrient-rich conditions favor proliferation and tumor growth, scarcity, and particularly glutamine starvation, promotes cell dedifferentiation and chemoresistance. Here, linking ... ...

    Abstract Nutrient availability is a key determinant of tumor cell behavior. While nutrient-rich conditions favor proliferation and tumor growth, scarcity, and particularly glutamine starvation, promotes cell dedifferentiation and chemoresistance. Here, linking ribosome biogenesis plasticity with tumor cell fate, we uncover that the amino acid sensor general control non-derepressible 2 (GCN2; also known as eIF-2-alpha kinase 4) represses the expression of the precursor of ribosomal RNA (rRNA), 47S, under metabolic stress. We show that blockade of GCN2 triggers cell death by an irremediable nucleolar stress and subsequent TP53-mediated apoptosis in patient-derived models of colon adenocarcinoma (COAD). In nutrient-rich conditions, a cell-autonomous GCN2 activity supports cell proliferation by stimulating 47S rRNA transcription, independently of the canonical integrated stress response (ISR) axis. Impairment of GCN2 activity prevents nuclear translocation of methionyl-tRNA synthetase (MetRS), resulting in nucleolar stress, mTORC1 inhibition and, ultimately, autophagy induction. Inhibition of the GCN2-MetRS axis drastically improves the cytotoxicity of RNA polymerase I (RNA pol I) inhibitors, including the first-line chemotherapy oxaliplatin, on patient-derived COAD tumoroids. Our data thus reveal that GCN2 differentially controls ribosome biogenesis according to the nutritional context. Furthermore, pharmacological co-inhibition of the two GCN2 branches and RNA pol I activity may represent a valuable strategy for elimination of proliferative and metabolically stressed COAD cells.
    Language English
    Publishing date 2023-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2415106-3
    ISSN 1878-0261 ; 1574-7891
    ISSN (online) 1878-0261
    ISSN 1574-7891
    DOI 10.1002/1878-0261.13491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6637: Show issues Location:
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  9. Article: La dissémination précoce de cellules métastatiques: une nouvelle donnée aux conséquences majeures!

    Puisieux, Alain / Ansieau, Stéphane

    Medecine sciences : M/S

    2009  Volume 25, Issue 1, Page(s) 28–29

    Title translation The key implication of early migration of metastatic cells.
    MeSH term(s) Cell Movement/physiology ; Humans ; Neoplasm Metastasis/genetics ; Neoplasm Metastasis/pathology ; Neoplasm Metastasis/physiopathology ; Nuclear Proteins/genetics ; Nuclear Proteins/physiology ; Twist-Related Protein 1/genetics ; Twist-Related Protein 1/physiology
    Chemical Substances Nuclear Proteins ; TWIST1 protein, human ; Twist-Related Protein 1
    Language French
    Publishing date 2009-01
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/200925128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: La sénescence prématurée: chimère, ange salvateur ou Dr Jekyll et Mr Hyde?

    Puisieux, Alain / Ansieau, Stéphane

    Medecine sciences : M/S

    2009  Volume 25, Issue 2, Page(s) 115–116

    Title translation The premature senescence: chimera, saving angel or Dr Jekyll and Mr Hyde?.
    MeSH term(s) Aging, Premature/genetics ; Aging, Premature/physiopathology ; Aging, Premature/psychology ; Animals ; Disease Models, Animal ; Humans ; Personality
    Language French
    Publishing date 2009-02
    Publishing country France
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2009252115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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