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Article ; Online: On the association between the ABO blood group and COVID-19 susceptibility.

Golinelli, Davide

Blood transfusion = Trasfusione del sangue

2020 Volume 19, Issue 1, Page(s) 89–90

MeSH term(s)	ABO Blood-Group System/analysis ; COVID-19/etiology ; COVID-19/transmission ; Humans ; Risk Factors ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/physiology ; Virus Internalization
Chemical Substances	ABO Blood-Group System
Language	English
Publishing date	2020-11-12
Publishing country	Italy
Document type	Letter
ZDB-ID	2135732-8
ISSN	2385-2070 ; 0041-1787 ; 1723-2007
ISSN (online)	2385-2070
ISSN	0041-1787 ; 1723-2007
DOI	10.2450/2020.0356-20
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Article ; Online: Analyzing the 20-year declining trend of hospital length-of-stay in European countries with different healthcare systems and reimbursement models.

Golinelli, Davide / Sanmarchi, Francesco / Toscano, Fabrizio / Bucci, Andrea / Nante, Nicola

International journal of health economics and management

2024

Abstract: The study aims to investigate the last 20-year (2000-2019) of hospital length of stay (LOS) trends and their association with different healthcare systems (HS) among 25 European countries. A panel dataset was created using secondary data from Eurostat ... ...

Abstract	The study aims to investigate the last 20-year (2000-2019) of hospital length of stay (LOS) trends and their association with different healthcare systems (HS) among 25 European countries. A panel dataset was created using secondary data from Eurostat and Global Burden of Disease study databases, with dependent and control variables aggregated at the national level over a period of 20 years. A time trend analysis was conducted using a weighted least squares model for panel data to investigate the association between LOS, HS models [National Health Service (NHS), National Health Insurance, Social Health Insurance (SHI), and Etatist Social Health Insurance], healthcare reimbursement schemes [Prospective Global Budget (PGB), Diagnosis Related Groups (DRG), and Procedure Service Payment (PSP)], and control variables. The study showed a reduction of average LOS from 9.20 days in 2000 to 7.24 in 2019. SHI was associated with a lower LOS compared to NHS (b = - 0.6327, p < 0.05). Both DRG (b = 1.2399, p < 0.05) and PSP (b = 1.1677, p < 0.05) reimbursement models were positively associated with LOS compared to PGB. Our results confirmed the downward trend of LOS in the last 20 years, its multifactorial nature, and the influence of the SHI model of HS. This could be due to the financial incentives present in fee-for-service payment models and the role of competition in creating a market for healthcare services. These results offer insight into the factors influencing healthcare utilization and can inform the design of more effective, efficient, and sustainable HS.
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2817492-6
ISSN	2199-9031 ; 2199-9023
ISSN (online)	2199-9031
ISSN	2199-9023
DOI	10.1007/s10754-024-09369-0
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Article: Automated scoring of nematode nictation on a textured background.

McClanahan, Patrick D / Golinelli, Luca / Le, Tuan Anh / Temmerman, Liesbet

bioRxiv : the preprint server for biology

2023

Abstract: Entomopathogenic nematodes ... ...

Abstract	Entomopathogenic nematodes including
Language	English
Publishing date	2023-07-15
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.03.16.533066
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Article ; Online: Automated scoring of nematode nictation on a textured background.

McClanahan, Patrick D / Golinelli, Luca / Le, Tuan Anh / Temmerman, Liesbet

PloS one

2023 Volume 18, Issue 8, Page(s) e0289326

Abstract: Entomopathogenic nematodes, including Steinernema spp., play an increasingly important role as biological alternatives to chemical pesticides. The infective juveniles of these worms use nictation-a behavior in which animals stand on their tails-as a host- ...

Abstract	Entomopathogenic nematodes, including Steinernema spp., play an increasingly important role as biological alternatives to chemical pesticides. The infective juveniles of these worms use nictation-a behavior in which animals stand on their tails-as a host-seeking strategy. The developmentally-equivalent dauer larvae of the free-living nematode Caenorhabditis elegans also nictate, but as a means of phoresy or "hitching a ride" to a new food source. Advanced genetic and experimental tools have been developed for C. elegans, but time-consuming manual scoring of nictation slows efforts to understand this behavior, and the textured substrates required for nictation can frustrate traditional machine vision segmentation algorithms. Here we present a Mask R-CNN-based tracker capable of segmenting C. elegans dauers and S. carpocapsae infective juveniles on a textured background suitable for nictation, and a machine learning pipeline that scores nictation behavior. We use our system to show that the nictation propensity of C. elegans from high-density liquid cultures largely mirrors their development into dauers, and to quantify nictation in S. carpocapsae infective juveniles in the presence of a potential host. This system is an improvement upon existing intensity-based tracking algorithms and human scoring which can facilitate large-scale studies of nictation and potentially other nematode behaviors.
MeSH term(s)	Animals ; Humans ; Caenorhabditis elegans/genetics ; Larva/genetics ; Rhabditida
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0289326
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Article: Injury Patterns and Gender in Italy.

Maietti, Elisa / Capodici, Angelo / Sanmarchi, Francesco / Fantini, Maria Pia / Nante, Nicola / Golinelli, Davide

Annali di igiene : medicina preventiva e di comunita

2024 Volume 36, Issue 3, Page(s) 302–312

Abstract: Introduction: Globally, injuries pose significant public health challenges, with road traffic accidents in particular being responsible for considerable morbidity, mortality, and economic distress. Italy has been significantly impacted due to its high ... ...

Abstract	Introduction: Globally, injuries pose significant public health challenges, with road traffic accidents in particular being responsible for considerable morbidity, mortality, and economic distress. Italy has been significantly impacted due to its high population density and frequency of road traffic and domestic incidents. Method: This study set out to investigate the incidence of self-reported road traffic and home and leisure accidents in the Italian general population. A particular emphasis was placed on exploring possible gender differences across varying age groups. The data was obtained from the European Health Interview Survey and a representative sample of the Italian population was analyzed. Results: The analysis revealed that regardless of age, women experienced a reduced risk of road traffic accidents compared to men. However, gender disparities in home-leisure accidents were observed to be age-dependent. Women under the age of 25 exhibited a lower likelihood of home-leisure accidents and serious accidents necessitating hospital admission in comparison to their male counterparts. In contrast, women aged 65 and above had an increased likelihood of home-leisure accidents as opposed to men in the same age category. Conclusions: The findings of this study highlight the importance of considering age and gender as significant factors in the occurrence of different types of accidents, offering insight into how injury rates vary between these demographic groups within Italy.
MeSH term(s)	Humans ; Male ; Female ; Accidents, Traffic ; Hospitalization ; Incidence ; Italy/epidemiology ; Self Report ; Wounds and Injuries/epidemiology
Language	English
Publishing date	2024-04-18
Publishing country	Italy
Document type	Evaluation Study
ZDB-ID	1018045-x
ISSN	1120-9135 ; 0029-6287
ISSN	1120-9135 ; 0029-6287
DOI	10.7416/ai.2024.2620
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Article: Structural basis for D-amino acid transamination by the pyridoxal 5'-phosphate-dependent catalytic antibody 15A9.

Golinelli-Pimpaneau, Béatrice / Lüthi, Christine / Christen, Philipp

The Journal of biological chemistry

2006 Volume 281, Issue 33, Page(s) 23969–23977

Abstract: ... catalyzes the reversible transamination of hydrophobic D-amino acids with pyridoxal 5'-phosphate (PLP ... The crystal structures of the complexes of Fab 15A9 with PPL-L-alanine, PPL-D-alanine, and the hapten were ... D-alanine aldimine. The space vacated by the absent L-lysine side chain of the hapten can be filled ...

Abstract	Antibody 15A9, raised with 5'-phosphopyridoxyl (PPL)-N(epsilon)-acetyl-L-lysine as hapten, catalyzes the reversible transamination of hydrophobic D-amino acids with pyridoxal 5'-phosphate (PLP). The crystal structures of the complexes of Fab 15A9 with PPL-L-alanine, PPL-D-alanine, and the hapten were determined at 2.3, 2.3, and 2.5A resolution, respectively, and served for modeling the complexes with the corresponding planar imine adducts. The conformation of the PLP-amino acid adduct and its interactions with 15A9 are similar to those occurring in PLP-dependent enzymes, except that the amino acid substrate is only weakly bound, and, due to the immunization and selection strategy, the lysine residue that covalently binds PLP in these enzymes is missing. However, the N-acetyl-L-lysine moiety of the hapten appears to have selected for aromatic residues in hypervariable loop H3 (Trp-H100e and Tyr-H100b), which, together with Lys-H96, create an anion-binding environment in the active site. The structural situation and mutagenesis experiments indicate that two catalytic residues facilitate the transamination reaction of the PLP-D-alanine aldimine. The space vacated by the absent L-lysine side chain of the hapten can be filled, in both PLP-alanine aldimine complexes, by mobile Tyr-H100b. This group can stabilize a hydroxide ion, which, however, abstracts the C alpha proton only from D-alanine. Together with the absence of any residue capable of deprotonating C alpha of L-alanine, Tyr-H100b thus underlies the enantiomeric selectivity of 15A9. The reprotonation of C4' of PLP, the rate-limiting step of 15A9-catalyzed transamination, is most likely performed by a water molecule that, assisted by Lys-H96, produces a hydroxide ion stabilized by the anion-binding environment.
MeSH term(s)	Alanine Transaminase/chemistry ; Alanine Transaminase/metabolism ; Antibodies, Catalytic/chemistry ; Antibodies, Catalytic/metabolism ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/metabolism ; Binding Sites, Antibody ; Catalysis ; Imines/metabolism ; Pyridoxal Phosphate/chemistry ; Pyridoxal Phosphate/metabolism ; Stereoisomerism ; Structure-Activity Relationship
Chemical Substances	15A9 catalytic antibody ; Antibodies, Catalytic ; Antibodies, Monoclonal ; Imines ; Pyridoxal Phosphate (5V5IOJ8338) ; Alanine Transaminase (EC 2.6.1.2)
Language	English
Publishing date	2006-06-21
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M602184200
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Article ; Online: Effects of Meditation for Surgeons: A Systematic Review of the Scientific Literature.

Capodici, Angelo / Sanmarchi, Francesco / Golinelli, Davide

Annals of surgery

2022 Volume 275, Issue 6, Page(s) 1074–1077

Abstract: Objective: The aim of this study was to systematically review the available evidence about meditation's effects on surgeons.: Summary background data: Meditation and Mindfulness are positively associated with better mental health and performance in ... ...

Abstract	Objective: The aim of this study was to systematically review the available evidence about meditation's effects on surgeons. Summary background data: Meditation and Mindfulness are positively associated with better mental health and performance in different types of workers and professionals needing high levels of concentration. Surgery is one of the activities with the greatest need for high concentration. Even though these findings are supported by a number of studies, evidence is lacking on the effect of meditation on surgeons. Methods: We searched PubMed for meditation-related studies that focused on surgeons. A total of 243 articles were retrieved and after screening 8 were selected for data extraction. Four of these studies were pilot studies; 3 of them were randomized controlled trials. Results: Meditation was found to be beneficial for surgeons. Benefits span from motor skills to mental and physiological improvements. Conclusion: More awareness and attention on this subject could improve surgeons' well-being as well as patients' outcomes.
MeSH term(s)	Attention ; Humans ; Meditation/psychology ; Mental Health ; Mindfulness ; Surgeons
Language	English
Publishing date	2022-01-25
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000005398
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Article ; Online: What services should be guaranteed in universal health-care systems?

Adja, Kadjo Yves Cedric / Golinelli, Davide

Journal of primary health care

2020 Volume 12, Issue 3, Page(s) 193–194

Abstract: COVID-19 pandemic highlighted the importance of public, universal and equal access health-care, and reminded us that challenges are always incumbent for health-care systems. Because accessible and universal health-care systems will be critical into the ... ...

Abstract	COVID-19 pandemic highlighted the importance of public, universal and equal access health-care, and reminded us that challenges are always incumbent for health-care systems. Because accessible and universal health-care systems will be critical into the future, it will be crucial to earmark adequate resources, fostering the financing of sectors that for many years have been neglected such as primary care and public health, and investments in new models of care and in health-related workforce.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Climate Change ; Coronavirus Infections/epidemiology ; Health Services Accessibility/organization & administration ; Humans ; Italy/epidemiology ; Models, Organizational ; Pandemics ; Pneumonia, Viral/epidemiology ; Primary Health Care/organization & administration ; SARS-CoV-2 ; Universal Health Insurance/organization & administration
Keywords	covid19
Language	English
Publishing date	2020-09-29
Publishing country	Australia
Document type	Journal Article
ISSN	1172-6156
ISSN (online)	1172-6156
DOI	10.1071/HC20084
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Article: Biased, wrong and counterfeited evidences published during the COVID-19 pandemic, a systematic review of retracted COVID-19 papers.

Capodici, Angelo / Salussolia, Aurelia / Sanmarchi, Francesco / Gori, Davide / Golinelli, Davide

Quality & quantity

2022 , Page(s) 1–33

Abstract: In 2020 COVID-19 led to an unprecedented stream of papers being submitted to journals. Scientists and physicians all around the globe were in need for information about this new disease. In this climate, many articles were accepted after extremely fast ... ...

Abstract	In 2020 COVID-19 led to an unprecedented stream of papers being submitted to journals. Scientists and physicians all around the globe were in need for information about this new disease. In this climate, many articles were accepted after extremely fast peer-reviews to provide the scientific community with the latest discoveries and knowledge. Unfortunately, this also led to articles retraction due to authors' misconduct or errors in methodology and/or conclusions. The aim of this study is to investigate the number and characteristics of retracted papers, and to explore the main causes that led to retraction. We conducted a systematic review on retracted articles, using PubMed as data source. Our inclusion criteria were the following: English-language retracted articles that reported original data, results, opinions or hypotheses on COVID-19 and Sars-CoV-2. Twenty-seven retracted articles were identified, mainly reporting observational studies and opinion pieces. Many articles published during the first year of the pandemic have been retracted, mainly due to the authors' scientific misconduct. Duplications, plagiarism, frauds and absence of consent, were the main reasons for retractions. In modern medicine, researchers are required to publish frequently, and, especially during situations like the COVID-19 pandemic, when articles were rapidly published, gaps in peer-reviews system and in the path to scientific publication arose.
Language	English
Publishing date	2022-11-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2003280-8
ISSN	1573-7845 ; 0033-5177
ISSN (online)	1573-7845
ISSN	0033-5177
DOI	10.1007/s11135-022-01587-3
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Article ; Online: Predict, diagnose, and treat chronic kidney disease with machine learning: a systematic literature review.

Sanmarchi, Francesco / Fanconi, Claudio / Golinelli, Davide / Gori, Davide / Hernandez-Boussard, Tina / Capodici, Angelo

Journal of nephrology

2023 Volume 36, Issue 4, Page(s) 1101–1117

Abstract: Objectives: In this systematic review we aimed at assessing how artificial intelligence (AI), including machine learning (ML) techniques have been deployed to predict, diagnose, and treat chronic kidney disease (CKD). We systematically reviewed the ... ...

Abstract	Objectives: In this systematic review we aimed at assessing how artificial intelligence (AI), including machine learning (ML) techniques have been deployed to predict, diagnose, and treat chronic kidney disease (CKD). We systematically reviewed the available evidence on these innovative techniques to improve CKD diagnosis and patient management. Methods: We included English language studies retrieved from PubMed. The review is therefore to be classified as a "rapid review", since it includes one database only, and has language restrictions; the novelty and importance of the issue make missing relevant papers unlikely. We extracted 16 variables, including: main aim, studied population, data source, sample size, problem type (regression, classification), predictors used, and performance metrics. We followed the Preferred Reporting Items for Systematic Reviews (PRISMA) approach; all main steps were done in duplicate. Results: From a total of 648 studies initially retrieved, 68 articles met the inclusion criteria. Models, as reported by authors, performed well, but the reported metrics were not homogeneous across articles and therefore direct comparison was not feasible. The most common aim was prediction of prognosis, followed by diagnosis of CKD. Algorithm generalizability, and testing on diverse populations was rarely taken into account. Furthermore, the clinical evaluation and validation of the models/algorithms was perused; only a fraction of the included studies, 6 out of 68, were performed in a clinical context. Conclusions: Machine learning is a promising tool for the prediction of risk, diagnosis, and therapy management for CKD patients. Nonetheless, future work is needed to address the interpretability, generalizability, and fairness of the models to ensure the safe application of such technologies in routine clinical practice.
MeSH term(s)	Humans ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/therapy ; Artificial Intelligence ; Machine Learning
Language	English
Publishing date	2023-02-14
Publishing country	Italy
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-023-01573-4
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