Article ; Online: Vitamin D and cathelicidin levels and susceptibility to Mycobacterium tuberculosis infection acquisition in household contacts.
Enfermedades infecciosas y microbiologia clinica (English ed.)
2023 Volume 41, Issue 8, Page(s) 489–493
Abstract: Introduction: Vitamin D deficiency has been proposed to confer susceptibility to acquiring tuberculosis infection by impairing the innate immune response.: Methods: In an exploratory study, we examined whether the levels of 25-hydroxyvitamin D: ... ...
| Abstract | Introduction: Vitamin D deficiency has been proposed to confer susceptibility to acquiring tuberculosis infection by impairing the innate immune response. Methods: In an exploratory study, we examined whether the levels of 25-hydroxyvitamin D Results: Within a prospective cohort of 231 tuberculosis household contacts tested with repeated interferon-gamma release assays, we serially analyzed all the uninfected contacts acquiring tuberculosis infection at follow-up ("converters", n=18), and an age and sex-matched control group of contacts not acquiring tuberculosis infection ("non-converters", n=36). The median levels of serum 25(OH)D Conclusion: These data argue against a major role for hypovitaminosis D in tuberculosis infection susceptibility. |
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| Language | English |
| Publishing date | 2023-01-25 |
| Publishing country | Spain |
| Document type | Journal Article |
| ISSN | 2529-993X |
| ISSN (online) | 2529-993X |
| DOI | 10.1016/j.eimce.2022.04.013 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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