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  1. Article ; Online: Discovery of anthraquinones as DPP-IV inhibitors: Structure-activity relationships and inhibitory mechanism.

    Ma, Hong-Hong / Zhang, Jing / Li, Ci-Qin / Zou, Li-Wei

    Fitoterapia

    2023  Volume 168, Page(s) 105549

    Abstract: Dipeptidyl peptidase IV (DPP-IV) is an integrated type II transmembrane protein that reduces endogenous insulin contents and increases plasma glucose levels by hydrolyzing glucagon-like peptide-1 (GLP-1). Inhibition of DPP-IV regulates and maintains ... ...

    Abstract Dipeptidyl peptidase IV (DPP-IV) is an integrated type II transmembrane protein that reduces endogenous insulin contents and increases plasma glucose levels by hydrolyzing glucagon-like peptide-1 (GLP-1). Inhibition of DPP-IV regulates and maintains glucose homeostasis, making it an attractive drug target for the treatment of diabetes II. Natural compounds have tremendous potential to regulate glucose metabolism. In this study, we examined the DPP-IV inhibitory activity of a series of natural anthraquinones and synthetic structural analogues on DPP-IV using fluorescence-based biochemical assays. The inhibitory efficiency differed among anthraquinone compounds with different structures. Alizarin (7), aloe emodin (11), emodin (13) emerged the outstanding inhibitory potential for DPP-IV with IC
    MeSH term(s) Humans ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Dipeptidyl-Peptidase IV Inhibitors/chemistry ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Molecular Docking Simulation ; Emodin/pharmacology ; Emodin/therapeutic use ; Molecular Structure ; Hypoglycemic Agents/pharmacology ; Structure-Activity Relationship ; Dipeptidyl Peptidase 4/chemistry ; Dipeptidyl Peptidase 4/metabolism
    Chemical Substances Dipeptidyl-Peptidase IV Inhibitors ; Emodin (KA46RNI6HN) ; Hypoglycemic Agents ; Dipeptidyl Peptidase 4 (EC 3.4.14.5)
    Language English
    Publishing date 2023-05-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 412385-2
    ISSN 1873-6971 ; 0367-326X
    ISSN (online) 1873-6971
    ISSN 0367-326X
    DOI 10.1016/j.fitote.2023.105549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1873: Show issues Location:
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  2. Article ; Online: Correction to: Early versus late initiation of renal replacement therapy impacts mortality in patients with acute kidney injury post cardiac surgery: a meta-analysis.

    Zou, Honghong / Hong, Qianwen / Xu, Gaosi

    Critical care (London, England)

    2019  Volume 23, Issue 1, Page(s) 142

    Abstract: After publication of this article [1], it was noticed that the affiliations of Honghong Zhou were ...

    Abstract After publication of this article [1], it was noticed that the affiliations of Honghong Zhou were incorrect. The sole affiliation should be, "Department of Nephrology, the Second Affiliated Hospital of Nanchang University, China" and can be seen in the author details of this correction.
    Language English
    Publishing date 2019-04-25
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-018-2065-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A pedigree with

    Zou, Honghong / Zhu, Li / Xu, Rong / Shi, Sufang / Wang, Suxia / Zhou, Fude / Zhang, Hong / Zhao, Minghui

    American journal of translational research

    2022  Volume 14, Issue 8, Page(s) 5746–5753

    Abstract: Alport syndrome (AS) is a heterogeneous hereditary nephropathy which can be caused by ... ...

    Abstract Alport syndrome (AS) is a heterogeneous hereditary nephropathy which can be caused by the
    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Simultaneous Detection and Distribution of Five Juvenile Hormones in 58 Insect Species and the Absolute Configuration in 32 Insect Species.

    Yi, Guoqiang / Ba, Rikang / Luo, Jie / Zou, Lixia / Huang, Mingfeng / Li, Yuxuan / Li, Honghong / Li, Xuesheng

    Journal of agricultural and food chemistry

    2023  Volume 71, Issue 20, Page(s) 7878–7890

    Abstract: Juvenile hormone (JH) plays an important role in regulating various insect physiological processes. Herein, a novel method (chiral and achiral) for the simultaneous detection of five JHs was established by processing a whole insect without complicated ... ...

    Abstract Juvenile hormone (JH) plays an important role in regulating various insect physiological processes. Herein, a novel method (chiral and achiral) for the simultaneous detection of five JHs was established by processing a whole insect without complicated hemolymph extraction. The proposed method was used to determine the distribution of JHs in 58 insect species and the absolute configuration of JHs in 32 species. The results showed that JHSB
    MeSH term(s) Animals ; Insecta/chemistry ; Juvenile Hormones/chemistry ; Diptera ; Lepidoptera ; Stereoisomerism
    Chemical Substances Juvenile Hormones
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c01168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
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  5. Article: Luteolin is an Effective Component of

    Wang, Liang / Hu, Longjiao / Peng, Zhilian / Cao, Honghong / Cao, Danfeng / Long, Yiqin / Zou, Zhengyu

    Clinical, cosmetic and investigational dermatology

    2022  Volume 15, Page(s) 1715–1727

    Abstract: Background: Platycodon grandiflorus: Methods: The protein expression levels of TNF-α and IL-6 were detected by ELISA. QRT-PCR was adopted to detect the expression of TGF-β1 and VEGF. Histopathological changes of scald wounds were analyzed by ... ...

    Abstract Background: Platycodon grandiflorus
    Methods: The protein expression levels of TNF-α and IL-6 were detected by ELISA. QRT-PCR was adopted to detect the expression of TGF-β1 and VEGF. Histopathological changes of scald wounds were analyzed by hematoxylin-eosin staining. Cell viability and migration ability were detected by CCK-8 assay and scratch assay.
    Results: Both in vivo and in vitro experiments showed that luteolin promoted wound healing of cutaneous scald injury. Gene Oncology (GO) functional analysis and rescue experiments showed that endothelial nitric oxide synthase 3 (NOS3) was the critical target of luteolin in treating cutaneous scald.
    Conclusion: This study demonstrated that luteolin is an effective component of
    Language English
    Publishing date 2022-08-20
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494852-4
    ISSN 1178-7015
    ISSN 1178-7015
    DOI 10.2147/CCID.S372229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Wogonin alleviates BaP-induced DNA damage and oxidative stress in human airway epithelial cells by dual inhibiting CYP1A1 activity and expression.

    Ni, Zhenhua / Ma, Honghong / Li, Xiaodong / Zou, Liwei / Liu, Zongjun / Wang, Xiongbiao / Ma, Hong / Yang, Ling

    Environmental toxicology

    2023  Volume 38, Issue 11, Page(s) 2717–2729

    Abstract: Benzo[a]pyrene (BaP) is a common air pollutant that has been reported to cause oxidative stress and carcinogenesis. Wogonin, a flavonoid compound extracted from the roots of Scutellaria baicalensis, has been found to possess a variety of pharmacological ... ...

    Abstract Benzo[a]pyrene (BaP) is a common air pollutant that has been reported to cause oxidative stress and carcinogenesis. Wogonin, a flavonoid compound extracted from the roots of Scutellaria baicalensis, has been found to possess a variety of pharmacological activities, including anti-inflammatory and anti-cancer effects. The purpose of this study was to examine the ability of wogonin to alleviate the cytotoxicity induced by BaP in human airway epithelial cells and explore the corresponding mechanism. Our study found that wogonin treatment inhibited DNA damage and reactive oxygen species overproduction induced by BaP in human airway epithelial cells. In vitro enzyme assays showed that wogonin significantly inhibited the enzymatic activity of CYP1A1. In addition, wogonin decreased the basal level of CYP1A1 and inhibited the CYP1A1 overexpression induced by BaP, whereas overexpression of CYP1A1 partially reversed the effect of wogonin on BaP-induced DNA damage. Meanwhile, a CYP1A1 inhibitor and CYP1A1 knockdown also showed these same effects. Further studies showed that wogonin regulates CYP1A1 expression by inhibiting CDK7 and CDK9 activity. The use of CDK7 or CDK9 inhibitors decreased BaP-induced cytotoxicity and CYP1A1 expression. Finally, we found that the methoxy group of wogonin was crucial for its inhibitory activity. In conclusion, our data indicated that wogonin could effectively relieve BaP induced cytotoxicity, and its mechanism was related to the dual inhibition of CYP1A1 activity and expression.
    Language English
    Publishing date 2023-07-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.23907
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    Zs.A 2676: Show issues Location:
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  7. Book ; Online: Preserving Community Interests in Ocean Governance towards Sustainability

    Zou, Keyuan / Chang, Yen-Chiang

    2022  

    Keywords The arts ; transfer of mining technology ; commercial condition ; protection of intellectual property ; direct technology purchasing ; investment cooperation ; universal jurisdiction ; maritime piracy ; piracy trials ; Somali piracy ; maritime crime ; sustainability ; community interests ; marine genetic resources ; common heritage of mankind ; BBNJ ; integrated coastal management ; land and sea coordination ; ecological environment ; ocean law ; sustainable development ; fishery resources ; community interest ; international cooperation ; climate change ; fishery management ; legal principles ; LOSC ; precautionary approach ; ecosystem ; seasonal closure ; CCAMLR ; MPAs ; RFMOs ; conservation measures ; China ; ocean governance ; sustainable development goals (SDGs) ; SDG 14 ; marine environment ; international environmental law ; Law of the Sea ; ocean acidification ; rising-sea-levels ; meta-governance ; ocean action ; global environment ; regulatory governance ; IMO ; China's role ; submissions' adoption ; law of the sea ; deep seabed mining ; national legislation ; sponsoring state ; marine ecological environment ; multiple subjects ; co-management ; ocean community with a shared future ; cruise ships ; public health emergency of international concern (PHEIC) ; international obligations ; rule of law ; COVID-19 ; China's white paper for Arctic policy ; fisheries resources ; Arctic Ocean ; Chinese legal rights ; Guangdong-Hong Kong-Macao Greater Bay Area (GBA) ; regional integration and cooperation ; SDGs ; Sanchi ship ; oil spill accident ; marine ecology ; ecological damage compensation ; the precautionary principle ; nuclear safety regulation ; UNCLOS ; international law
    Size 1 electronic resource (294 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021290320
    ISBN 9783036528311 ; 3036528318
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Effects of topical insulin on wound healing: a meta-analysis of animal and clinical studies.

    Liu, Honghong / Wang, Jiao / Deng, Yuanyuan / Zou, Guilin / Xu, Jixiong

    Endocrine journal

    2021  Volume 68, Issue 8, Page(s) 969–979

    Abstract: Various researches have reported that the application of topical insulin improves wound healing. Considering the lack of a quantitative comprehensive research on this matter, we conducted a meta-analysis of clinical research and experimental animal ... ...

    Abstract Various researches have reported that the application of topical insulin improves wound healing. Considering the lack of a quantitative comprehensive research on this matter, we conducted a meta-analysis of clinical research and experimental animal studies. Prospective and randomized controlled trials of PubMed, Embase, and Cochrane Library were conducted using appropriate search strategies to compare the effectiveness of topical application of saline and insulin on wounds. The standardized mean difference was calculated as follows: wound healing time, wound healing rate, wound area, and the percentage of wound contraction. Each study used the Cochrane risk-of-bias tool and RevMan 5.3 software to create aggregated assessments and forest plots. The quality of evidence was evaluated in accordance with the methods of the Grading of Recommendations, Assessment, Development and Evaluation working group. Four clinical and nine animal studies eligible for inclusion were included in the meta-analysis. The assessments for clinical studies were as follows: wound healing time, -2.48 [-3.44, -1.51] and wound healing rate, 22.23 [18.17, 26.28]. Meanwhile, for animal studies, the following assessments were noted: wound healing time, -1.27 [-1.75, -0.79]; wound contraction rate, 15.91 [13.88, 17.95]; and wound area, -19.3 [-21.16, -17.44]. For the measurement of the following results, only one animal study was performed, pericyte recruitment of microvessels. Based on the analysis, it can be preliminarily judged that application of topical insulin can aid wound healing.
    MeSH term(s) Administration, Topical ; Animals ; Humans ; Insulin/administration & dosage ; Wound Healing/drug effects
    Chemical Substances Insulin
    Language English
    Publishing date 2021-04-16
    Publishing country Japan
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 1151918-6
    ISSN 1348-4540 ; 0918-8959
    ISSN (online) 1348-4540
    ISSN 0918-8959
    DOI 10.1507/endocrj.EJ20-0575
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    Uh III Zs.207: Show issues Location:
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  9. Article: Identification and functional analysis of

    Wang, Yiting / Zou, Jie / Li, Jiali / Kong, Fanna / Xu, Lina / Xu, Dafeng / Li, Jiaxin / Yang, Huaying / Zhang, Lin / Li, Tingchun / Fan, Honghong

    Frontiers in plant science

    2023  Volume 14, Page(s) 1162826

    Abstract: Terpenes are the main class of secondary metabolites produced in response to pest and germ attacks. In maize ( ...

    Abstract Terpenes are the main class of secondary metabolites produced in response to pest and germ attacks. In maize (
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1162826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Effect and mechanism of ferulic acid inclusion complexes on tyramine production by Enterobacter hormaechei MW386398 in smoked horsemeat sausages

    Huang, Yali / Yu, Honghong / Lu, Shiling / Zou, Liangjun / Tang, Zonggui / Zeng, Tao / Tang, Juan

    Food bioscience. 2022 Apr., v. 46

    2022  

    Abstract: Ferulic acid inclusion complexes (FA-HP-β-CD) effects on tyramine accumulation and gene expression of Enterobacter hormaechei MW386398 in traditional smoked horsemeat sausages were studied. Reverse transcription-quantitative polymerase chain reaction (RT- ...

    Abstract Ferulic acid inclusion complexes (FA-HP-β-CD) effects on tyramine accumulation and gene expression of Enterobacter hormaechei MW386398 in traditional smoked horsemeat sausages were studied. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to identify the expression of tyrosine decarboxylase (TDC) clusters in the tyramine producing pathway. In addition, relevant parameters such as microbial growth, moisture content, pH, and tyramine accumulation in pure cultures and during fermentation of smoked horsemeat sausages were evaluated. Ferulic acid (FA) and FA-HP-β-CD inclusion complexes both significantly decreased tyramine accumulation, as well as significantly inhibited tyrosine decarboxylase (tdcA) and tyrosine/tyramine antiporter (tyrP) genes expression (p < 0.05). Furthermore, FA and FA-HP-β-CD inclusion complexes both reduced the number of Enterobacteriaceae in smoked horsemeat sausages, but did not alter the main microbiota. However, FA-HP-β-CD inclusion complexes exhibited stronger ability in hindering TDC related gene expression, reducing tyramine accumulation and antibacterial properties. These results indicate that FA-HP-β-CD inclusion complexes are able to reduce tyramine accumulation in smoked horsemeat sausages by inhibiting Enterobacteriaceae growth and gene expression.
    Keywords Enterobacter hormaechei ; antiporters ; fermentation ; ferulic acid ; gene expression ; horse meat ; microbial growth ; microorganisms ; pH ; tyramine ; tyrosine ; tyrosine decarboxylase ; water content
    Language English
    Dates of publication 2022-04
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 2212-4292
    DOI 10.1016/j.fbio.2021.101520
    Database NAL-Catalogue (AGRICOLA)

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