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  1. Article: Patient Satisfaction Following Orthognathic Surgery: A Systematic Review.

    Uppada, Uday Kiran / Tauro, David / Senthilnathan, K P

    Journal of maxillofacial and oral surgery

    2023  Volume 22, Issue 4, Page(s) 762–769

    Abstract: Objective: This study is intended to review data pertaining to patient satisfaction following orthognathic surgery through a systematic literature survey.: Methods and materials: An electronic search was done on Medline, EMBASE and CENTRAL databases. ...

    Abstract Objective: This study is intended to review data pertaining to patient satisfaction following orthognathic surgery through a systematic literature survey.
    Methods and materials: An electronic search was done on Medline, EMBASE and CENTRAL databases. The inclusion criteria considered were as follows: (1) assessment of patients' satisfaction, (2) one-stage orthognathic surgery, and (3) follow-up period of 8 weeks or more in English literature. The exclusion criteria considered were as follows: (1) presence of craniofacial syndromes, cleft lip and palate or traumatic injuries, (2) previous facial surgery, and (3) psychological problems before surgery. The data were extracted and analyzed under three categories: function, esthetics and overall satisfaction.
    Results: Eighteen studies met the inclusion criteria. Esthetic and function were improved in majority of patients; however, it was not possible to assess the overall satisfaction levels statistically. Overall satisfaction analysis revealed that 70-87% of patients were satisfied, while nearly 15% of patients were dissatisfied with the treatment outcome.
    Conclusion: Most of the patients were satisfied with the surgical outcome. However, satisfaction seemed to be multifactorial and it was not possible to predict satisfaction prior to the surgery.
    Language English
    Publishing date 2023-11-28
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2502352-4
    ISSN 0974-942X ; 0972-8279
    ISSN (online) 0974-942X
    ISSN 0972-8279
    DOI 10.1007/s12663-023-02066-4
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  2. Article: Is There a Need for Greater Emphasis on Clinical Facial Analysis than Cephalometrics & 3D Software Solutions in the Diagnosis and Treatment Planning of Patients with Dentofacial Deformities?

    Uppada, Uday Kiran / Tauro, David P / Senthilnathan, K P

    Journal of maxillofacial and oral surgery

    2023  Volume 22, Issue 4, Page(s) 820–826

    Abstract: Purpose: This study is designed to evaluate the need for a greater emphasis on clinical facial analysis over cephalometrics in the diagnosis and treatment planning of patients with dentofacial deformities.: Materials and method: A predetermined ... ...

    Abstract Purpose: This study is designed to evaluate the need for a greater emphasis on clinical facial analysis over cephalometrics in the diagnosis and treatment planning of patients with dentofacial deformities.
    Materials and method: A predetermined questionnaire study was designed to get the thought process of surgeons and consultants involved in orthognathic surgery from various parts of southern India. Two hundred and twenty-eight maxillofacial consultants were involved in the survey. Demographic information, type of professional practice, preferred tool in the diagnosis & treatment planning: Cephalometrics or 3D software solutions and flaw in the available tools were evaluated.
    Results: The results of this study revealed that only 36.8% of the consultants felt that cephalometrics is the prime tool and 73.3% of the consultants felt that 3D software solutions were superior to cephalometrics in the diagnosis and treatment planning of patients with dentofacial deformities. However, 46% of the consultants preferred facial analysis as the prime tool with cephalometrics as an adjunct. Pertaining to the clinical outcome of their treated cases of dentofacial deformities, 61.8% of the consultants felt the need to address additional cosmetic issues following an orthognathic procedure. It was observed that 92.1% of the participants felt the need for greater emphasis on clinical facial analysis than cephalometrics.
    Conclusion: Human faces should always be evaluated taking into consideration the various esthetic units of the face. Performing corrective jaw surgery merely based on cephalometric values inevitably fails to address the various other innate imbalances of the face. Hence, cephalometric data should only be considered as an adjunct to clinical judgment in the diagnosis and treatment planning of dentofacial deformities.
    Language English
    Publishing date 2023-11-04
    Publishing country India
    Document type Journal Article
    ZDB-ID 2502352-4
    ISSN 0974-942X ; 0972-8279
    ISSN (online) 0974-942X
    ISSN 0972-8279
    DOI 10.1007/s12663-023-02022-2
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  3. Article ; Online: "Hunting" for the pseudoaneurysm in a vascular maze: Endoscopic ultrasound solving the puzzle.

    Samanta, Jayanta / Dhar, Jahnvi / Mangipudi, Uday Kiran / Siddharda, Bikkina Venkat / Gupta, Pankaj / Gupta, Vikas

    Endoscopy

    2023  Volume 55, Issue S 01, Page(s) E839–E840

    MeSH term(s) Humans ; Aneurysm, False/diagnostic imaging ; Endosonography
    Language English
    Publishing date 2023-06-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2106-0907
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  4. Book ; Online: On an Edge-Preserving Variational Model for Optical Flow Estimation

    Doshi, Hirak / Kiran, N. Uday

    2022  

    Abstract: It is well known that classical formulations resembling the Horn and Schunck model are still largely competitive due to the modern implementation practices. In most cases, these models outperform many modern flow estimation methods. In view of this, we ... ...

    Abstract It is well known that classical formulations resembling the Horn and Schunck model are still largely competitive due to the modern implementation practices. In most cases, these models outperform many modern flow estimation methods. In view of this, we propose an effective implementation design for an edge-preserving $L^1$ regularization approach to optical flow. The mathematical well-posedness of our proposed model is studied in the space of functions of bounded variations $BV(\Omega,\mathbb{R}^2)$. The implementation scheme is designed in multiple steps. The flow field is computed using the robust Chambolle-Pock primal-dual algorithm. Motivated by the recent studies of Castro and Donoho we extend the heuristic of iterated median filtering to our flow estimation. Further, to refine the flow edges we use the weighted median filter established by Li and Osher as a post-processing step. Our experiments on the Middlebury dataset show that the proposed method achieves the best average angular and end-point errors compared to some of the state-of-the-art Horn and Schunck based variational methods.
    Keywords Computer Science - Computer Vision and Pattern Recognition ; 35A15 ; 35J47 ; 35Q68
    Subject code 004
    Publishing date 2022-07-21
    Publishing country us
    Document type Book ; Online
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  5. Article ; Online: Mediastinal Histoplasmosis Diagnosed by Endoscopic Ultrasound-Guided Fine Needle Biopsy.

    Mangipudi, Uday Kiran / Kundu, Reetu / Ramachandran, Raja / Gupta, Rajesh / Rana, Surinder Singh

    Digestive diseases and sciences

    2023  Volume 68, Issue 6, Page(s) 2204–2206

    MeSH term(s) Humans ; Biopsy, Fine-Needle ; Histoplasmosis/diagnostic imaging ; Histoplasmosis/pathology ; Mediastinum/diagnostic imaging ; Lung Neoplasms ; Ultrasonography, Interventional ; Endosonography
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-023-07940-2
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  6. Article ; Online: Pancreatic cystic lesion: Appearances can be deceptive (with video)!

    Mangipudi, Uday Kiran / Mahajan, Gaurav / Kundu, Reetu / Gupta, Rajesh / Rana, Surinder Singh

    Gastrointestinal endoscopy

    2023  Volume 99, Issue 1, Page(s) 125–126

    MeSH term(s) Humans ; Pancreas/diagnostic imaging ; Endosonography ; Pancreatic Cyst/diagnostic imaging ; Pancreatic Cyst/surgery ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/surgery
    Language English
    Publishing date 2023-07-08
    Publishing country United States
    Document type Video-Audio Media ; Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2023.07.013
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  7. Article: Iatrogenic Mandibular Ramus Fracture Following Surgical Removal of Impacted Third Molar.

    Uppada, Uday Kiran / Sinha, Ramen

    Journal of maxillofacial and oral surgery

    2020  Volume 22, Issue 1, Page(s) 46–48

    Abstract: Surgical removal of an impacted tooth is considered to be one of the most frequently performed minor oral surgical procedures due to the plethora of indications associated with it. Like any other surgical intervention, the surgical removal of impacted ... ...

    Abstract Surgical removal of an impacted tooth is considered to be one of the most frequently performed minor oral surgical procedures due to the plethora of indications associated with it. Like any other surgical intervention, the surgical removal of impacted third molars is also associated with numerous complications. Lot of emphasis has been laid to prevent the complications associated with the surgical removal of impacted third molars. However, at times in spite of delivering the utmost caution, complications occur as a consequence of surgical removal of impacted third molars. We report a rare case in which iatrogenic mandibular ramus fracture occurred in an attempt to surgically removal of an impacted third molar.
    Language English
    Publishing date 2020-05-14
    Publishing country India
    Document type Case Reports
    ZDB-ID 2502352-4
    ISSN 0974-942X ; 0972-8279
    ISSN (online) 0974-942X
    ISSN 0972-8279
    DOI 10.1007/s12663-020-01382-3
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  8. Article ; Online: Novel classification system for walled-off pancreatic necrosis: a step in the right direction.

    Telaprolu, Harshavardhan / Srinu, Deshidi / Mangipudi, Uday Kiran / Yadav, Abhishek / Jearth, Vaneet / Shah, Jimil / Rana, Surinder S

    Gastrointestinal endoscopy

    2023  Volume 98, Issue 5, Page(s) 873

    MeSH term(s) Humans ; Pancreatitis, Acute Necrotizing/diagnostic imaging ; Drainage ; Treatment Outcome ; Necrosis
    Language English
    Publishing date 2023-06-11
    Publishing country United States
    Document type Letter
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2023.05.060
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  9. Article ; Online: Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks.

    Velagapudi, Uday Kiran / Rouleau-Turcotte, Élise / Billur, Ramya / Shao, Xuwei / Patil, Manisha / Black, Ben E / Pascal, John M / Talele, Tanaji T

    The Biochemical journal

    2024  Volume 481, Issue 6, Page(s) 437–460

    Abstract: Catalytic poly(ADP-ribose) production by PARP1 is allosterically activated through interaction with DNA breaks, and PARP inhibitor compounds have the potential to influence PARP1 allostery in addition to preventing catalytic activity. Using the ... ...

    Abstract Catalytic poly(ADP-ribose) production by PARP1 is allosterically activated through interaction with DNA breaks, and PARP inhibitor compounds have the potential to influence PARP1 allostery in addition to preventing catalytic activity. Using the benzimidazole-4-carboxamide pharmacophore present in the first generation PARP1 inhibitor veliparib, a series of 11 derivatives was designed, synthesized, and evaluated as allosteric PARP1 inhibitors, with the premise that bulky substituents would engage the regulatory helical domain (HD) and thereby promote PARP1 retention on DNA breaks. We found that core scaffold modifications could indeed increase PARP1 affinity for DNA; however, the bulk of the modification alone was insufficient to trigger PARP1 allosteric retention on DNA breaks. Rather, compounds eliciting PARP1 retention on DNA breaks were found to be rigidly held in a position that interferes with a specific region of the HD domain, a region that is not targeted by current clinical PARP inhibitors. Collectively, these compounds highlight a unique way to trigger PARP1 retention on DNA breaks and open a path to unveil the pharmacological benefits of such inhibitors with novel properties.
    MeSH term(s) Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerases/metabolism ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Antineoplastic Agents ; Benzimidazoles/pharmacology ; DNA Repair ; DNA Breaks ; DNA Damage
    Chemical Substances Poly(ADP-ribose) Polymerase Inhibitors ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30) ; veliparib (01O4K0631N) ; Poly (ADP-Ribose) Polymerase-1 (EC 2.4.2.30) ; Antineoplastic Agents ; Benzimidazoles
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2969-5
    ISSN 1470-8728 ; 0006-2936 ; 0306-3275 ; 0264-6021
    ISSN (online) 1470-8728
    ISSN 0006-2936 ; 0306-3275 ; 0264-6021
    DOI 10.1042/BCJ20230406
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    Uc I Zs.110: Show issues Location:
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  10. Book ; Online: Nonlinear Evolutionary PDE-Based Refinement of Optical Flow

    Doshi, Hirak / Kiran, N. Uday

    2021  

    Abstract: The goal of this paper is to propose two nonlinear variational models for obtaining a refined motion estimation from an image sequence. Both the proposed models can be considered as a part of a generalized framework for an accurate estimation of physics- ... ...

    Abstract The goal of this paper is to propose two nonlinear variational models for obtaining a refined motion estimation from an image sequence. Both the proposed models can be considered as a part of a generalized framework for an accurate estimation of physics-based flow fields such as rotational and fluid flow. The first model is novel in the sense that it is divided into two phases: the first phase obtains a crude estimate of the optical flow and then the second phase refines this estimate using additional constraints. The correctness of this model is proved using an evolutionary PDE approach. The second model achieves the same refinement as the first model, but in a standard manner, using a single functional. A special feature of our models is that they permit us to provide efficient numerical implementations through the first-order primal-dual Chambolle-Pock scheme. Both the models are compared in the context of accurate estimation of angle by performing an anisotropic regularization of the divergence and curl of the flow respectively. We observe that, although both the models obtain the same level of accuracy, the two-phase model is more efficient. In fact, we empirically demonstrate that the single-phase and the two-phase models have convergence rates of order $O(1/N^2)$ and $O(1/N)$ respectively.
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Mathematics - Analysis of PDEs ; 35A15 ; 35J47 ; 35Q68
    Subject code 621
    Publishing date 2021-01-31
    Publishing country us
    Document type Book ; Online
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