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  1. Article: GnRH test for the diagnosis of central precocious puberty: is it time to revisit the protocol ?

    Sodero, Giorgio / Pane, Lucia Celeste / Di Sarno, Lorenzo / Rigante, Donato / Cipolla, Clelia

    Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology

    2023  Volume 32, Issue 3, Page(s) 192–194

    Language English
    Publishing date 2023-04-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2079760-6
    ISSN 0918-5739
    ISSN 0918-5739
    DOI 10.1297/cpe.2023-0011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5710: Show issues Location:
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  2. Article ; Online: Preterm ovarian hyperstimulation syndrome in a female neonate.

    Cipolla, Clelia / Sinatti, Dario / Villa, Paola

    Minerva endocrinology

    2021  Volume 48, Issue 1, Page(s) 124–126

    MeSH term(s) Female ; Humans ; Infant, Newborn ; Ovarian Hyperstimulation Syndrome/diagnosis
    Language English
    Publishing date 2021-06-11
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 3062786-2
    ISSN 2724-6116
    ISSN (online) 2724-6116
    DOI 10.23736/S2724-6507.21.03486-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2105: Show issues Location:
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  3. Article ; Online: GH Therapy in children and adolescents with Growth Hormone Deficiency during the first phase of COVID-19 lockdown: a survey in an Italian center.

    Sodero, Giorgio / Talloa, Dario / Cipolla, Clelia

    Minerva pediatrics

    2022  

    Abstract: Background: Coronavirus Disease - 19 (COVID-19) had a profound impact on mental health of people and can influence the quality of life of children who need chronic therapies, affecting daily adherence to drug therapy and altering long-term outcomes. In ... ...

    Abstract Background: Coronavirus Disease - 19 (COVID-19) had a profound impact on mental health of people and can influence the quality of life of children who need chronic therapies, affecting daily adherence to drug therapy and altering long-term outcomes. In Growth Hormone Deficiency (GHD) regular drug intake guarantees height improvement and, consequently, self-esteem of children. We conducted a survey to evaluate adherence to daily therapy and changes of height standard deviations in children with GHD during a pandemic-associated lockdown.
    Methods: 30 children (17 boys and 13 girls) with aged between 7 and 18 years were examined during the observational period. Adherence to therapy (self-reported and also confirmed with a standardized questionnaire), height and growth velocity during treatment were analyzed.
    Results: All of our patients reported a moderate to high level of adherence during the period of sanitary emergency (N=2 Morisky 7; N=28 Morisky 8). Adherence assessed by the Morisky Scale was in agreement in all cases with the self-reported one. Analysis of our data confirmed an improvement of the patients' height standard deviations, which could be related to the good adherence to growth hormone therapy during lockdown.
    Conclusions: We can hypothesize that limitations during the lockdown period have positively influenced adherence to therapy and, consequently, height standard deviations of children with GHD in substitution therapy. The evaluation of adherence carried out by our interview showed an increased regularity in hormonal administration due to various factors, such as the greatest amount of time spent indoors. The increased adherence is coherent with the results of our auxological evaluations, which showed an increase in percentiles and standard deviations of height, compared to chronological age.
    Language English
    Publishing date 2022-01-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062664-X
    ISSN 2724-5780
    ISSN (online) 2724-5780
    DOI 10.23736/S2724-5276.21.06645-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Fever of unknown origin and systemic inflammation revealing a pheochromocytoma.

    Soldato, Manuel / Cipolla, Clelia / Rigante, Donato / Manna, Raffaele

    Minerva endocrinology

    2021  Volume 46, Issue 4, Page(s) 482–484

    MeSH term(s) Adrenal Gland Neoplasms/complications ; Fever of Unknown Origin/etiology ; Humans ; Immunotherapy ; Inflammation ; Pheochromocytoma
    Language English
    Publishing date 2021-04-21
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062786-2
    ISSN 2724-6116
    ISSN (online) 2724-6116
    DOI 10.23736/S2724-6507.21.03434-5
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  5. Article ; Online: Diabetic ketoacidosis during treatment with sodiumglucose cotransporter 2 inhibitors reveals a latent autoimmune diabetes in adult.

    Nardella, Elisabetta / D'Addio, Stefano / Cipolla, Clelia / Manna, Raffaele

    Minerva endocrinology

    2021  

    Language English
    Publishing date 2021-04-15
    Document type Journal Article
    ISSN 2724-6116
    ISSN (online) 2724-6116
    DOI 10.23736/S2724-6507.21.03432-5
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  6. Article ; Online: Bone mineral density and body mass composition measurements in premenopausal anorexic patients: the impact of lean body mass.

    Villa, Paola / Cipolla, Clelia / Amar, Inbal / Sodero, Giorgio / Pane, Lucia Celeste / Ingravalle, Fabio / Pontecorvi, Alfredo / Scambia, Giovanni

    Journal of bone and mineral metabolism

    2024  Volume 42, Issue 1, Page(s) 134–141

    Abstract: Introduction: Evaluating bone density and body composition by dual-energy x-ray absorptiometry (DXA) and analyzing their relationships among young anorexic women in comparison with normal-lean matched controls.: Materials and methods: In this ... ...

    Abstract Introduction: Evaluating bone density and body composition by dual-energy x-ray absorptiometry (DXA) and analyzing their relationships among young anorexic women in comparison with normal-lean matched controls.
    Materials and methods: In this observational cohort study, 98 normal-underweight young females were enrolled (aged more than 16 and less than 24 years). The study group included 68 anorexic patients and 30 healthy age-matched controls. The patients underwent a DXA examination to evaluate bone mineral density and body composition. Several indexes of body composition were used: the FMI (Fat Mass Index), the TLMI (Total Lean Mass Index) and the SMI (Skeletal Muscle mass Index) the last one as a marker of sarcopenia.
    Results: According to the ISCD (International Society for Clinical Densitometry) criteria, a significantly higher percentage of anorexic patients were found to be below the expected range for age as compared to controls (P < 0.01). According to WHO criteria, 20% of the anorexic patients presented an osteoporotic T-score index at the lumbar level and 18% presented an osteoporotic T-score at the femoral level. As regards the lean body characteristics, the SMI and TLMI were significantly lower in the anorexic population (P < 0.01 and P < 0.001, respectively) and 24% of the anorexic patients presented SMI values that are indicative of pre-sarcopenia. In addition, only the SMI significantly correlated with both the lumbar and the femoral BMD values.
    Conclusion: Anorexic patients have a very high risk of osteoporosis and fractures. Bone density is influenced by fat body mass and also significantly by lean body mass. Special consideration should be given to the sarcopenic condition since it is a worsening factor of bone health.
    MeSH term(s) Humans ; Female ; Bone Density/physiology ; Sarcopenia/diagnostic imaging ; Osteoporosis/epidemiology ; Absorptiometry, Photon ; Body Composition/physiology
    Language English
    Publishing date 2024-01-09
    Publishing country Japan
    Document type Observational Study ; Journal Article
    ZDB-ID 1295123-7
    ISSN 1435-5604 ; 0914-8779
    ISSN (online) 1435-5604
    ISSN 0914-8779
    DOI 10.1007/s00774-023-01487-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4894: Show issues Location:
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  7. Article: Plasma Levels of Neudesin and Glucose Metabolism in Obese and Overweight Children.

    Vergani, Edoardo / Bruno, Carmine / Cipolla, Clelia / Currò, Diego / Mancini, Antonio

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 881524

    Abstract: Childhood overweight and obesity are among the major health problems of modern times, especially in Western countries, due to their association with increased cardiovascular and cancer risk in adulthood. Neudesin, a recently discovered peptide secreted ... ...

    Abstract Childhood overweight and obesity are among the major health problems of modern times, especially in Western countries, due to their association with increased cardiovascular and cancer risk in adulthood. Neudesin, a recently discovered peptide secreted mainly in the brain and adipose tissue, is being investigated for its possible activity as a negative regulator of energy expenditure. We conducted a cross-sectional observational preliminary study with the aim of testing the hypothesis that plasma levels of neudesin can be modified in obese and overweight children and to evaluate any possible relationship between plasma neudesin levels and metabolic and anthropometric parameters. 34 Children (Tanner's stage 1) were included and divided in two groups according to Cole's criteria. Group A included obese and overweight children (23 patients, 17 females and 6 males, aged 4-10 years); Group B included healthy normal-weight children (11 subjects, 7 females and 4 males, aged 3-10 years). Metabolic (glucose and insulin, total, LDL- and HDL-cholesterol, triglycerides, uric acid) and hormonal (fT3, fT4, TSH, IGF-1, leptin) parameters were evaluated. HOMA-IR and QUICKI index and the area under the curve (AUC) of glucose and insulin after oral glucose load were calculated in obese and overweight children. Neudesin was measured by ELISA. Neudesin levels were significantly higher in obese/overweight children than in controls. In obese and overweight children, plasma neudesin levels were significantly directly correlated with blood glucose and glucose AUC. Taken together, these results, although preliminary, may suggest a possible age-related role of neudesin in glucose homeostasis in obese/overweight children.
    MeSH term(s) Adult ; Blood Glucose/analysis ; Body Mass Index ; Child ; Cross-Sectional Studies ; Female ; Humans ; Insulin ; Insulin Resistance ; Male ; Metabolic Syndrome ; Overweight ; Pediatric Obesity
    Chemical Substances Blood Glucose ; Insulin
    Language English
    Publishing date 2022-07-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.881524
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  8. Article: Characteristics of Children and Adolescents with Hyperinsulinemia Undergoing Oral Glucose Tolerance Test: A Single-Center Retrospective Observational Study.

    Cipolla, Clelia / Lazzareschi, Ilaria / Curatola, Antonietta / Lasorella, Claudia / Pane, Lucia Celeste / Sessa, Linda / Rotunno, Giulia / Rigante, Donato / Sodero, Giorgio

    Diseases (Basel, Switzerland)

    2023  Volume 11, Issue 3

    Abstract: The aim of this study was to evaluate a potential correlation between results of the oral glucose tolerance test (OGTT) and the auxological/metabolic parameters in a cohort of overweight patients assessed for suspicion of hyperinsulinism. We analyzed 206 ...

    Abstract The aim of this study was to evaluate a potential correlation between results of the oral glucose tolerance test (OGTT) and the auxological/metabolic parameters in a cohort of overweight patients assessed for suspicion of hyperinsulinism. We analyzed 206 patients, comparing those with insulin peak below (nonhyperinsulinemic) and over 100 uIU/mL (hyperinsulinemic) at the OGTT. We found a significant difference in weight (
    Language English
    Publishing date 2023-08-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720869-2
    ISSN 2079-9721
    ISSN 2079-9721
    DOI 10.3390/diseases11030110
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  9. Article ; Online: Neuropsychiatric symptoms, oral pigmentation and fever as revealing hints of autoimmune Addison's disease.

    Manna, Raffaele / Bianchi, Antonio / Gerardino, Laura / Cipolla, Clelia / Rigante, Donato / Landolfi, Raffaele

    Minerva endocrinology

    2021  Volume 48, Issue 2, Page(s) 251–252

    MeSH term(s) Humans ; Addison Disease/complications ; Addison Disease/diagnosis ; Mental Disorders ; Pigmentation
    Language English
    Publishing date 2021-07-21
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062786-2
    ISSN 2724-6116
    ISSN (online) 2724-6116
    DOI 10.23736/S2724-6507.21.03521-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2105: Show issues Location:
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  10. Article ; Online: Central precocious puberty in children after COVID-19 outbreak: a single-center retrospective study.

    Turriziani Colonna, Arianna / Curatola, Antonietta / Sodero, Giorgio / Lazzareschi, Ilaria / Cammisa, Ignazio / Cipolla, Clelia

    Minerva pediatrics

    2022  

    Abstract: Background: Central precocious puberty (CPP) was an unexplored issue during COVID-19 pandemic and an important disease in the adolescence life. Our aim was to evaluate the incidence of the new cases of central precocious puberty (CPP) during COVID-19 ... ...

    Abstract Background: Central precocious puberty (CPP) was an unexplored issue during COVID-19 pandemic and an important disease in the adolescence life. Our aim was to evaluate the incidence of the new cases of central precocious puberty (CPP) during COVID-19 pandemic, comparing these results with the data for the same period over the previous three years. The secondary objective was to analyze the rate of pubertal progression in children during COVID-19 outbreak.
    Methods: We performed a retrospective study of all children presented at our hospital for suspected CPP during COVID-19 outbreak, comparing their clinical and endocrinological data to the same over the previous three years. Secondary, endocrinological data of some patients in follow-up, with at least two visits 6 months apart during the COVID-19 period, are compared to evaluate the rate of pubertal progression.
    Results: We enrolled 90 suspected enrolled CPP cases, 26 (28.9%) referred to our hospital during the COVID-19 outbreak and 64 (71.1%) in the previous 3 years. During COVID-19 outbreak 12 girls (42.9%) were at stage T3 compared to 14 (23%) of the 3 previous years (p=0.01). New CPP diagnosis were found in 11 (39.3%) children during pandemic, while 15 (24.2%) in the previous 3 years. A accelerated pubertal progression rate was observed in 22/45 (48.9%) patients, with a greater number of children at stages T3 and T4-5.
    Conclusions: Our data showed a progressive increase of newly diagnosed CPP and a significantly accelerated rate of pubertal progression in children during COVID-19 outbreak. We hypothesize that the increase in the weight and BMI during the lockdown and the psychological effects of the COVID-19 outbreak were involved in triggering and progression of puberty.
    Language English
    Publishing date 2022-05-18
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062664-X
    ISSN 2724-5780
    ISSN (online) 2724-5780
    DOI 10.23736/S2724-5276.22.06827-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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