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  1. Article ; Online: Beth Levine receives the 2014 ASCI/Stanley J. Korsmeyer Award.

    Levine, Beth / Jackson, Sarah

    The Journal of clinical investigation

    2014  Volume 124, Issue 4, Page(s) 1423–1424

    MeSH term(s) Animals ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/physiology ; Autophagy/genetics ; Autophagy/physiology ; Awards and Prizes ; Beclin-1 ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/physiology ; Proto-Oncogene Proteins c-bcl-2/physiology ; Societies, Medical ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/physiology ; United States
    Chemical Substances Apoptosis Regulatory Proteins ; BECN1 protein, human ; Beclin-1 ; Membrane Proteins ; Proto-Oncogene Proteins c-bcl-2 ; Tumor Suppressor Proteins
    Language English
    Publishing date 2014-04-01
    Publishing country United States
    Document type Interview ; Portrait
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI75543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Autophagy in infection and immunity

    Levine, Beth

    (Current topics in microbiology and immunology ; 335)

    2009  

    Author's details Beth Levine ..., ed
    Series title Current topics in microbiology and immunology ; 335
    Collection
    Keywords Autophagie ; Cytologie ; Immunologie ; Infektiologie
    Subject Infektionslehre ; Autophagozytose ; Autophagocytose ; Klinische Immunologie ; Zellbiologie ; Zellenlehre ; Zellforschung ; Zellkunde ; Zelluologie ; Zytologie ; Zelle
    Language English
    Size XIII, 339 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016123940
    ISBN 978-3-642-00301-1 ; 9783642003028 ; 3-642-00301-X ; 3642003028
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Ud II Zs 24 -335- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Closing the loop.

    Levine, Beth

    Science (New York, N.Y.)

    2016  Volume 354, Issue 6315, Page(s) 968–969

    MeSH term(s) Autophagy ; Cell Membrane/physiology ; Humans
    Language English
    Publishing date 2016--25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aal3145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 77: Show issues

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  4. Article ; Online: Autophagy in Human Diseases.

    Mizushima, Noboru / Levine, Beth

    The New England journal of medicine

    2020  Volume 383, Issue 16, Page(s) 1564–1576

    MeSH term(s) Aging/physiology ; Autoimmune Diseases/physiopathology ; Autophagy/genetics ; Autophagy/physiology ; Disease ; Humans ; Inflammation/physiopathology ; Mutation ; Neoplasms/physiopathology ; Neurodegenerative Diseases/physiopathology
    Language English
    Publishing date 2020-10-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra2022774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: An International Society for Cell & Gene Therapy working group short report on the future of expanded access to unapproved cell and gene therapies.

    Zettler, Patricia J / Ikonomou, Laertis / Levine, Aaron D / Turner, Leigh / Grilley, Bambi / Roxland, Beth E

    Cytotherapy

    2023  Volume 25, Issue 7, Page(s) 712–717

    Abstract: Patient interest in non-trial access pathways to investigational cell-and gene-based interventions, such as expanded access in the USA, is increasing, while the regulatory and business environments for non-trial access in the cell and gene therapy field ... ...

    Abstract Patient interest in non-trial access pathways to investigational cell-and gene-based interventions, such as expanded access in the USA, is increasing, while the regulatory and business environments for non-trial access in the cell and gene therapy field are shifting. Against this background, in 2022 the International Society for Cell & Gene Therapy (ISCT) established a Working Group on Expanded Access to identify practical, ethical, and regulatory issues emerging from the use (and possible misuse) of the expanded access pathway in the cell and gene therapy field. In this Short Report, the Working Group sets the stage for its future activities by analyzing the history of expanded access and identifying three examples of questions that we anticipate arising as uses of expanded access for investigational cell and gene-based interventions increase and evolve.
    MeSH term(s) Humans ; Compassionate Use Trials ; Drugs, Investigational ; Genetic Therapy ; Genetic Engineering
    Chemical Substances Drugs, Investigational
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2039821-9
    ISSN 1477-2566 ; 1465-3249
    ISSN (online) 1477-2566
    ISSN 1465-3249
    DOI 10.1016/j.jcyt.2023.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Aggressive human MenG C meningiomas have a molecular counterpart in canines.

    Harmanci, Akdes S / Boudreau, Beth / Lau, Sean / Hosseingholi Nouri, Shervin / Mandel, Jacob J / Lu, Hsiang-Chih / Harmanci, Arif O / Klisch, Tiemo J / Levine, Jonathan M / Patel, Akash J

    Acta neuropathologica

    2024  Volume 147, Issue 1, Page(s) 42

    MeSH term(s) Humans ; Animals ; Dogs ; Meningioma/genetics ; Meningeal Neoplasms/genetics
    Language English
    Publishing date 2024-02-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1079-0
    ISSN 1432-0533 ; 0001-6322
    ISSN (online) 1432-0533
    ISSN 0001-6322
    DOI 10.1007/s00401-024-02692-3
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  7. Article ; Online: Biological Functions of Autophagy Genes: A Disease Perspective.

    Levine, Beth / Kroemer, Guido

    Cell

    2019  Volume 176, Issue 1-2, Page(s) 11–42

    Abstract: The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy-related (ATG) genes. Definitive etiological links exist between mutations in ... ...

    Abstract The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy-related (ATG) genes. Definitive etiological links exist between mutations in genes that control autophagy and human disease, especially neurodegenerative, inflammatory disorders and cancer. Autophagy selectively targets dysfunctional organelles, intracellular microbes, and pathogenic proteins, and deficiencies in these processes may lead to disease. Moreover, ATG genes have diverse physiologically important roles in other membrane-trafficking and signaling pathways. This Review discusses the biological functions of autophagy genes from the perspective of understanding-and potentially reversing-the pathophysiology of human disease and aging.
    MeSH term(s) Animals ; Autophagy/genetics ; Autophagy/physiology ; Autophagy-Related Proteins/genetics ; Autophagy-Related Proteins/metabolism ; Homeostasis ; Humans ; Lysosomes/metabolism ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/pathology ; Proteins/metabolism ; Signal Transduction
    Chemical Substances Autophagy-Related Proteins ; Proteins
    Language English
    Publishing date 2019-01-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2018.09.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Biological Functions of Autophagy Genes: A Disease Perspective

    Levine, Beth / Kroemer, Guido

    Cell. 2019 Jan. 10, v. 176, no. 1-2

    2019  

    Abstract: The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy-related (ATG) genes. Definitive etiological links exist between mutations in ... ...

    Abstract The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy-related (ATG) genes. Definitive etiological links exist between mutations in genes that control autophagy and human disease, especially neurodegenerative, inflammatory disorders and cancer. Autophagy selectively targets dysfunctional organelles, intracellular microbes, and pathogenic proteins, and deficiencies in these processes may lead to disease. Moreover, ATG genes have diverse physiologically important roles in other membrane-trafficking and signaling pathways. This Review discusses the biological functions of autophagy genes from the perspective of understanding—and potentially reversing—the pathophysiology of human disease and aging.
    Keywords autophagy ; cell membranes ; etiology ; genes ; homeostasis ; human diseases ; microorganisms ; mutation ; neoplasms ; organelles ; pathophysiology ; physiological transport ; proteins ; signal transduction
    Language English
    Dates of publication 2019-0110
    Size p. 11-42.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2018.09.048
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  9. Article ; Online: Autophagy balances inflammation in innate immunity.

    Deretic, Vojo / Levine, Beth

    Autophagy

    2018  Volume 14, Issue 2, Page(s) 243–251

    Abstract: Macroautophagy/autophagy is a homeostatic process with multiple effects on immunity. One of the pivotal contributions of autophagy in immunity is the cell autonomous control of inflammation. This property leads to systemic consequences and thereby ... ...

    Abstract Macroautophagy/autophagy is a homeostatic process with multiple effects on immunity. One of the pivotal contributions of autophagy in immunity is the cell autonomous control of inflammation. This property leads to systemic consequences and thereby influences the development of innate and adaptive immunity, which promotes or suppresses pathology in various disease contexts. In this review we focus on the intersections between autophagy and inflammasome activation, autophagy and interferons, and autophagy and inflammation in association with infection.
    MeSH term(s) Adaptive Immunity ; Animals ; Autophagy/immunology ; Galectins/immunology ; Homeostasis ; Humans ; Immunity, Innate ; Infections/immunology ; Inflammasomes/immunology ; Inflammation/immunology ; Interferons/immunology ; Interferons/metabolism
    Chemical Substances Galectins ; Inflammasomes ; Interferons (9008-11-1)
    Language English
    Publishing date 2018-01-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2017.1402992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: GRB2 is a BECN1 interacting protein that regulates autophagy.

    Montero-Vergara, Jetsy / Plachetta, Kira / Kinch, Lisa / Bernhardt, Stephan / Kashyap, Kriti / Levine, Beth / Thukral, Lipi / Vetter, Martina / Thomssen, Christoph / Wiemann, Stefan / Peña-Llopis, Samuel / Jendrossek, Verena / Vega-Rubin-de-Celis, Silvia

    Cell death & disease

    2024  Volume 15, Issue 1, Page(s) 14

    Abstract: GRB2 is an adaptor protein of HER2 (and several other tyrosine kinases), which we identified as a novel BECN1 (Beclin 1) interacting partner. GRB2 co-immunoprecipitated with BECN1 in several breast cancer cell lines and regulates autophagy through a ... ...

    Abstract GRB2 is an adaptor protein of HER2 (and several other tyrosine kinases), which we identified as a novel BECN1 (Beclin 1) interacting partner. GRB2 co-immunoprecipitated with BECN1 in several breast cancer cell lines and regulates autophagy through a mechanism involving the modulation of the class III PI3Kinase VPS34 activity. In ovo studies in a CAM (Chicken Chorioallantoic Membrane) model indicated that GRB2 knockdown, as well as overexpression of GRB2 loss-of-function mutants (Y52A and S86A-R88A) compromised tumor growth. These differences in tumor growth correlated with differential autophagy activity, indicating that autophagy effects might be related to the effects on tumorigenesis. Our data highlight a novel function of GRB2 as a BECN1 binding protein and a regulator of autophagy.
    MeSH term(s) Animals ; Adaptor Proteins, Signal Transducing ; Autophagy ; Beclin-1/metabolism ; Carcinogenesis ; Cell Transformation, Neoplastic ; Humans ; GRB2 Adaptor Protein/metabolism
    Chemical Substances Adaptor Proteins, Signal Transducing ; Beclin-1 ; GRB2 protein, human ; BECN1 protein, human ; GRB2 Adaptor Protein
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-023-06387-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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