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  1. Article ; Online: Validation and Invalidation of SARS-CoV-2 Papain-like Protease Inhibitors.

    Ma, Chunlong / Wang, Jun

    ACS pharmacology & translational science

    2022  Volume 5, Issue 2, Page(s) 102–109

    Abstract: SARS-CoV-2 encodes two viral cysteine proteases, the main protease ( ... ...

    Abstract SARS-CoV-2 encodes two viral cysteine proteases, the main protease (M
    Language English
    Publishing date 2022-01-24
    Publishing country United States
    Document type Journal Article
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.1c00240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors.

    Ma, Chunlong / Wang, Jun

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 8

    MeSH term(s) Acetates ; Atazanavir Sulfate ; Benzimidazoles ; COVID-19/drug therapy ; Chloroquine ; Cyclopropanes ; Dipyridamole ; Humans ; Oxytetracycline ; Pharmaceutical Preparations ; Protease Inhibitors ; Quinolines ; SARS-CoV-2 ; Sulfides ; Tetrazoles
    Chemical Substances Acetates ; Benzimidazoles ; Cyclopropanes ; Pharmaceutical Preparations ; Protease Inhibitors ; Quinolines ; Sulfides ; Tetrazoles ; Atazanavir Sulfate (4MT4VIE29P) ; Dipyridamole (64ALC7F90C) ; Chloroquine (886U3H6UFF) ; montelukast (MHM278SD3E) ; candesartan (S8Q36MD2XX) ; Oxytetracycline (X20I9EN955)
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2024420118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article: Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor.

    Tan, Haozhou / Ma, Chunlong / Wang, Jun

    Research square

    2022  

    Abstract: The COVID-19 pandemic spurred a broad interest in antiviral drug discovery. The SARS-CoV-2 main protease ( ... ...

    Abstract The COVID-19 pandemic spurred a broad interest in antiviral drug discovery. The SARS-CoV-2 main protease (M
    Language English
    Publishing date 2022-03-30
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-1490282/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor.

    Tan, Haozhou / Ma, Chunlong / Wang, Jun

    Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents

    2022  Volume 31, Issue 7, Page(s) 1147–1153

    Abstract: The COVID-19 pandemic spurred a broad interest in antiviral drug discovery. The SARS-CoV-2 main protease ( ... ...

    Abstract The COVID-19 pandemic spurred a broad interest in antiviral drug discovery. The SARS-CoV-2 main protease (M
    Language English
    Publishing date 2022-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1116702-6
    ISSN 1054-2523
    ISSN 1054-2523
    DOI 10.1007/s00044-022-02903-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3444: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Scoparone from

    Zheng, Bowen / Song, Weichen / Liu, Chunlong / Kou, Xiaohong / Yu, Yue / Wang, Yumeng / Ma, Juan / Liu, Yazhou / Jiang, Jingyu / Xue, Zhaohui

    Natural product research

    2023  , Page(s) 1–7

    Abstract: Six separated compounds were identified ... ...

    Abstract Six separated compounds were identified from
    Language English
    Publishing date 2023-12-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2023.2298383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cytopathic Effect Assay and Plaque Assay to Evaluate

    Hu, Yanmei / Ma, Chunlong / Wang, Jun

    Bio-protocol

    2022  Volume 12, Issue 3, Page(s) e4314

    Abstract: Coronaviruses are important human pathogens, among which the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for the COVID-19 pandemic. To combat the SARS-CoV-2 pandemic, there is a pressing need for antivirals, ... ...

    Abstract Coronaviruses are important human pathogens, among which the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for the COVID-19 pandemic. To combat the SARS-CoV-2 pandemic, there is a pressing need for antivirals, especially broad-spectrum antivirals that are active against all seven human coronaviruses (HCoVs). For this reason, we are interested in developing antiviral assays to expedite the drug discovery process. Here, we provide the detailed protocol for the cytopathic effect (CPE) assay and the plaque assay for human coronaviruses 229E (HCoV-229E), HCoV-OC43, and HCoV-NL63, to identify novel antivirals against HCoVs. Neutral red was used in the CPE assay, as it is relatively inexpensive and more sensitive than other reagents. Multiple parameters including multiplicity of infection, incubation time and temperature, and staining conditions have been optimized for CPE and plaque assays for HCoV-229E in MRC-5, Huh-7, and RD cell lines; HCoV-OC43 in RD, MRC-5, and BSC-1 cell lines, and HCoV-NL63 in Vero E6, Huh-7, MRC-5, and RD cell lines. Both CPE and plaque assays have been calibrated with the positive control compounds remdesivir and GC-376. Both CPE and plaque assays have high sensitivity, excellent reproducibility, and are cost-effective. The protocols described herein can be used as surrogate assays in the biosafety level 2 facility to identify entry inhibitors and protease inhibitors for SARS-CoV-2, as HCoV-NL63 also uses ACE2 as the receptor for cell entry, and the main proteases of HCoV-OC43 and SARS-CoV-2 are highly conserved. In addition, these assays can also be used as secondary assays to profile the broad-spectrum antiviral activity of existing SARS-CoV-2 drug candidates.
    Language English
    Publishing date 2022-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays.

    Ma, Chunlong / Tan, Haozhou / Choza, Juliana / Wang, Yuyin / Wang, Jun

    Acta pharmaceutica Sinica. B

    2021  Volume 12, Issue 4, Page(s) 1636–1651

    Abstract: SARS-CoV-2 main protease ( ... ...

    Abstract SARS-CoV-2 main protease (M
    Language English
    Publishing date 2021-11-01
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2211-3835
    ISSN 2211-3835
    DOI 10.1016/j.apsb.2021.10.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Drug-Repurposing Screening Identified Tropifexor as a SARS-CoV-2 Papain-like Protease Inhibitor.

    Ma, Chunlong / Hu, Yanmei / Wang, Yuyin / Choza, Juliana / Wang, Jun

    ACS infectious diseases

    2022  Volume 8, Issue 5, Page(s) 1022–1030

    Abstract: The global COVID-19 pandemic underscores the dire need for effective antivirals. Encouraging progress has been made in developing small-molecule inhibitors targeting the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) and main protease ( ... ...

    Abstract The global COVID-19 pandemic underscores the dire need for effective antivirals. Encouraging progress has been made in developing small-molecule inhibitors targeting the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) and main protease (M
    MeSH term(s) Antiviral Agents/chemistry ; Benzothiazoles/pharmacology ; Coronavirus Papain-Like Proteases/antagonists & inhibitors ; Drug Repositioning ; Humans ; Isoxazoles/pharmacology ; Pandemics ; SARS-CoV-2/drug effects ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; Benzothiazoles ; Isoxazoles ; Coronavirus Papain-Like Proteases (EC 3.4.22.2) ; papain-like protease, SARS-CoV-2 (EC 3.4.22.2) ; tropifexor (NMZ08KM76Z)
    Language English
    Publishing date 2022-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.1c00629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Evaluation of cardiac index and right ventricular hypertrophy index in rats under a chronic hypoxic environment at high altitude.

    Sun, Yanqiu / Ma, Jinfeng / Yan, Tingjun / Tian, Dengfeng / Zhang, Chenhong / Zhang, Fengjuan / Zhao, Yuchun / Fu, Shihan / Yan, Chunlong

    Heliyon

    2024  Volume 10, Issue 3, Page(s) e25229

    Abstract: High-altitude areas are characterized by low pressure and hypoxia, which have a significant impact on various body systems. This study aimed to investigate the alterations in cardiac index and right ventricular hypertrophy index(RVHI) in rats at ... ...

    Abstract High-altitude areas are characterized by low pressure and hypoxia, which have a significant impact on various body systems. This study aimed to investigate the alterations in cardiac index and right ventricular hypertrophy index(RVHI) in rats at different altitudes.Twenty-one male Sprague-Dawley (SD) rats aged 4 weeks were randomly divided into three groups based on altitude. The rats were raised for 28 weeks and then transferred to Qinghai University Plateau Medicine Laboratory. Body weight was measured, heart organs were isolated and weighed, and cardiac index and right ventricular hypertrophy index were determined. Statistical analysis was performed on the data from the three groups. Compared with the plain group, the body weight of the middle-altitude group was significantly decreased (P < 0.05), and cardiac index, RVHI-1, RVHI-2 increased significantly ((P < 0.05). The body weight, whole heart mass, right ventricular mass were significantly decreased in high-altitude group (P < 0.05), RVHI-1 and RVHI-2 were significantly increased (P < 0.05). Compared with the middle-altitude group, the body weight, whole heart mass and right ventricular mass of the high-altitude group were significantly decreased (P < 0.05), and RVHI-1 and RVHI-2 were significantly increased (P < 0.05). Increasing altitude led to a decrease in body weight, whole heart mass, and right ventricular mass in rats, indicating structural changes in the right heart. Additionally, the proportion of right heart to body weight and whole heart increased with altitude.
    Language English
    Publishing date 2024-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e25229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Development and characterization of 40 InDel markers from the major histocompatibility complex genes of largemouth bass (Micropterus salmoides).

    Zhang, Meng / Wang, Zerui / Cui, Jiao / Ma, Xiao / Qiao, Zhigang / Kong, Xianghui / Xu, Ruwei / Li, Shengjie / Du, Jinxing / Zhao, Chunlong

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 470

    Abstract: Background: The genetic improvement in growth and food habit domestication of largemouth bass (Micropterus salmoides) have made breakthroughs in past decades, while the relevant work on disease resistance were rarely carried out. Major ... ...

    Abstract Background: The genetic improvement in growth and food habit domestication of largemouth bass (Micropterus salmoides) have made breakthroughs in past decades, while the relevant work on disease resistance were rarely carried out. Major histocompatibility complex (MHC) genes, which are well known as their numbers and high polymorphisms, have been used as candidate genes to mine disease-resistant-related molecular markers in many species.
    Methods and results: In present study, we developed and characterized 40 polymorphic and biallelic InDel markers from the major histocompatibility complex genes of largemouth bass. The minor allele frequency, observed heterozygosity, expected heterozygosity and polymorphic information content of these markers ranged from 0.0556 to 0.5000, 0.1111 to 0.6389, 0.1064 to 0.5070, and 0.0994 to 0.3750, respectively. Three loci deviated significantly from Hardy-Weinberg equilibrium, while linkage disequilibrium existed at none of these loci.
    Conclusion: These InDel markers might provide references for the further correlation analysis and molecular assisted selection of disease resistance in largemouth bass.
    MeSH term(s) Animals ; Bass/genetics ; Disease Resistance/genetics ; Polymorphism, Genetic/genetics ; Gene Frequency/genetics ; Major Histocompatibility Complex/genetics
    Language English
    Publishing date 2024-03-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-024-09429-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
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