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  1. Article ; Online: Auto Sizing of CANDU Nuclear Reactor Fuel Channel Flaws from UT Scans.

    Hammad, Issam / Poloni, Matthew / Isherwood, Andrew / Simpson, Ryan

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 8

    Abstract: The inspection of nuclear power plants is an essential process that occurs during plant outages. During this process, various systems are inspected, including the reactor's fuel channels to ensure that they are safe and reliable for the plant's operation. ...

    Abstract The inspection of nuclear power plants is an essential process that occurs during plant outages. During this process, various systems are inspected, including the reactor's fuel channels to ensure that they are safe and reliable for the plant's operation. The inspection of Canada Deuterium Uranium (CANDU
    Language English
    Publishing date 2023-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23083907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Human induced pluripotent stem cell-derived liver-on-a-chip for studying drug metabolism: the challenge of the cytochrome P450 family.

    Tamargo-Rubio, Isabel / Simpson, Anna Bella / Hoogerland, Joanne A / Fu, Jingyuan

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1223108

    Abstract: The liver is the primary organ responsible for the detoxification and metabolism of drugs. To date, a lack of preclinical models that accurately emulate drug metabolism by the human liver presents a significant challenge in the drug development pipeline, ...

    Abstract The liver is the primary organ responsible for the detoxification and metabolism of drugs. To date, a lack of preclinical models that accurately emulate drug metabolism by the human liver presents a significant challenge in the drug development pipeline, particularly for predicting drug efficacy and toxicity. In recent years, emerging microfluidic-based organ-on-a-chip (OoC) technologies, combined with human induced pluripotent stem cell (hiPSC) technology, present a promising avenue for the complete recapitulation of human organ biology in a patient-specific manner. However, hiPSC-derived organoids and liver-on-a-chip models have so far failed to sufficiently express cytochrome P450 monooxygenase (CYP450) enzymes, the key enzymes involved in first-pass metabolism, which limits the effectiveness and translatability of these models in drug metabolism studies. This review explores the potential of innovative organoid and OoC technologies for studying drug metabolism and discusses their existing drawbacks, such as low expression of CYP450 genes. Finally, we postulate potential approaches for enhancing CYP450 expression in the hope of paving the way toward developing novel, fully representative liver drug-metabolism models.
    Language English
    Publishing date 2023-06-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1223108
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  3. Article ; Online: Examining the Prevalence and Forms of Leveraged Treatment Pressure and Its Relationship to Personal Recovery: A Canadian Cross-Sectional Study.

    Sirotich, Frank / Law, Samuel F / Simpson, Alexander I F / Nakhost, Arash

    Community mental health journal

    2023  Volume 59, Issue 7, Page(s) 1352–1363

    Abstract: Across jurisdictions, the use of 'leverage' to promote adherence to mental health treatment is widespread. However, little research exists on the possible association between the application of leverage and personal recovery. We examined the prevalence ... ...

    Abstract Across jurisdictions, the use of 'leverage' to promote adherence to mental health treatment is widespread. However, little research exists on the possible association between the application of leverage and personal recovery. We examined the prevalence of various forms of leverage in a Canadian context and compared these rates with those in other jurisdictions. Additionally, we examined the relationship between two prominent forms of leverage (financial and housing) and the experience of personal recovery. Structured interviews were conducted with people receiving community-based mental health care in Toronto, Canada. Rates of overall leverage in our sample were similar to rates reported in other jurisdictions. Personal recovery was negatively associated with financial leverage but was not associated with housing leverage. Our results highlight the importance of separately examining the relationship of specific forms of leverage and personal recovery and raise questions for future research about the possible effect of financial leverage on recovery.
    MeSH term(s) Humans ; Mental Disorders/epidemiology ; Mental Disorders/therapy ; Cross-Sectional Studies ; Community Mental Health Services/methods ; Prevalence ; Canada/epidemiology
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 215855-3
    ISSN 1573-2789 ; 0010-3853
    ISSN (online) 1573-2789
    ISSN 0010-3853
    DOI 10.1007/s10597-023-01122-0
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    Zs.B 557: Show issues Location:
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  4. Article ; Online: The experiences of nurses following seclusion or restraint use and immediate staff debriefing in inpatient mental health settings.

    Mangaoil, Remar A / Cleverley, Kristin / Peter, Elizabeth / Simpson, Alexander I F

    Journal of advanced nursing

    2023  Volume 79, Issue 9, Page(s) 3397–3411

    Abstract: Aim: The aim of this study is to explore nurses' experiences of seclusion or restraint use and their participation in immediate staff debriefing in inpatient mental health settings.: Design: This research was conducted using a descriptive exploratory ...

    Abstract Aim: The aim of this study is to explore nurses' experiences of seclusion or restraint use and their participation in immediate staff debriefing in inpatient mental health settings.
    Design: This research was conducted using a descriptive exploratory design and data were gathered through in-depth individual interviews.
    Methods: The experiences of nurses following seclusion or restraint use and their participation in immediate staff debriefing were explored via teleconference, using a semi-structured interview guide. Reflexive thematic analysis was used to identify prevalent themes from the data.
    Results: Interviews (n=10) were conducted with nurses from inpatient mental health wards in July 2020. Five themes emerged through the data analysis: (i) ensuring personal safety; (ii) grappling between the use of least-restrictive interventions and seclusion or restraint use; (iii) navigating ethical issues and personal reactions; (iv) seeking validation from colleagues and (v) attending staff debriefing based on previous experience. The themes were also analysed using Lazarus and Folkman's Transactional Model of Stress and Coping.
    Conclusion: Staff debriefing is a vital resource for nurses to provide and/or receive emotion- and problem-focused coping strategies. Mental health institutions should strive to establish supportive working environments and develop interventions based on the unique needs of nurses and the stressors they experience following seclusion or restraint use.
    Patient or public contribution: Nurses in both frontline and leadership roles were involved in the development and pilot test of the interview guide. The nurses who participated in the study were asked if they can be recontacted if clarification is needed during interview transcription or data analysis.
    MeSH term(s) Humans ; Mental Health ; Inpatients ; Mental Disorders/therapy ; Mental Disorders/psychology ; Patient Isolation/psychology ; Restraint, Physical/psychology ; Nurses
    Language English
    Publishing date 2023-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 197634-5
    ISSN 1365-2648 ; 0309-2402
    ISSN (online) 1365-2648
    ISSN 0309-2402
    DOI 10.1111/jan.15667
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  5. Article ; Online: Benralizumab: A novel treatment for the cutaneous features of paediatric eosinophilic granulomatosis with polyangiitis (pEGPA).

    Bandla, M / Howard, M / McNally, A / Armstrong, D / Simpson, I / Mar, A

    The Australasian journal of dermatology

    2023  Volume 64, Issue 3, Page(s) 404–407

    Abstract: Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis presenting primarily with pulmonary and cutaneous features. The disease is typically seen in the fifth or sixth decade of life (1, 2). We report a case of EGPA in an adolescent ...

    Abstract Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis presenting primarily with pulmonary and cutaneous features. The disease is typically seen in the fifth or sixth decade of life (1, 2). We report a case of EGPA in an adolescent who was successfully treated with the interleukin-5 (IL-5) receptor inhibitor, benralizumab.
    MeSH term(s) Adolescent ; Humans ; Child ; Granulomatosis with Polyangiitis/drug therapy ; Churg-Strauss Syndrome/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use
    Chemical Substances benralizumab (71492GE1FX) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-05-17
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.14081
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    Zs.A 236: Show issues Location:
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  6. Article ; Online: Serious Mental Illness and Sexual Offending in Forensic Psychiatric Patients.

    Lam, Austin A / Penney, Stephanie R / Simpson, Alexander I F

    Sexual abuse : a journal of research and treatment

    2022  Volume 35, Issue 1, Page(s) 103–126

    Abstract: The role of serious mental illness among those who sexually offend is not well understood. We investigated clinical and risk-related areas of difference between male forensic psychiatric patients with ( ...

    Abstract The role of serious mental illness among those who sexually offend is not well understood. We investigated clinical and risk-related areas of difference between male forensic psychiatric patients with (
    MeSH term(s) Humans ; Male ; Criminals/psychology ; Criminals/statistics & numerical data ; Mental Disorders/epidemiology ; Mental Disorders/psychology ; Psychotic Disorders/epidemiology ; Psychotic Disorders/psychology ; Sex Offenses/psychology ; Sex Offenses/statistics & numerical data ; Sexual Behavior/psychology ; Sexual Behavior/statistics & numerical data ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/psychology ; Ontario/epidemiology ; Motivation ; Violence/psychology ; Violence/statistics & numerical data
    Language English
    Publishing date 2022-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1283507-9
    ISSN 1573-286X ; 1079-0632
    ISSN (online) 1573-286X
    ISSN 1079-0632
    DOI 10.1177/10790632221088012
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    Zs.A 3271: Show issues Location:
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  7. Article ; Online: The interplay between maternal-infant anemia and iron deficiency.

    Davidson, Eliza M / Simpson, Julie A / Fowkes, Freya J I

    Nutrition reviews

    2022  Volume 81, Issue 4, Page(s) 480–491

    Abstract: Iron deficiency anemia in pregnancy is a major public health problem known to cause maternal morbidity and adverse birth outcomes, and it may also have lasting consequences on infant development. However, the impact of the maternal hematological ... ...

    Abstract Iron deficiency anemia in pregnancy is a major public health problem known to cause maternal morbidity and adverse birth outcomes, and it may also have lasting consequences on infant development. However, the impact of the maternal hematological environment on fetal and infant hemoglobin and iron stores in the first year of life remains unclear. This review of the epidemiological evidence found that severe maternal iron deficiency anemia in pregnancy is associated with lower ferritin, and to a lesser degree hemoglobin levels, in infants at birth. Emerging data also suggests that severe anemia in pregnancy increases the risk of iron deficiency and anemia in infants 6-12 months of age, although longitudinal studies are limited. Effective anemia prevention in pregnancy, such as iron supplementation, could reduce the risk of infant anemia and iron deficiency during the first year of life; however, more evidence is needed to determine the functional impact of iron supplementation in pregnancy on infant hematological indices.
    MeSH term(s) Pregnancy ; Infant, Newborn ; Female ; Child ; Infant ; Humans ; Anemia, Iron-Deficiency/complications ; Anemia, Iron-Deficiency/epidemiology ; Anemia, Iron-Deficiency/prevention & control ; Iron Deficiencies ; Iron ; Anemia/etiology ; Anemia/complications ; Hemoglobins
    Chemical Substances Iron (E1UOL152H7) ; Hemoglobins
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 82067-2
    ISSN 1753-4887 ; 0029-6643
    ISSN (online) 1753-4887
    ISSN 0029-6643
    DOI 10.1093/nutrit/nuac066
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    Zs.A 3388: Show issues Location:
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  8. Article ; Online: Eruptive cherry angiomas-a novel cutaneous manifestation of immunoglobulin type gamma 4-related disease.

    Bandla, Maanasa / Lee, Senhong / Simpson, Ian / Boyapati, Ann

    The Australasian journal of dermatology

    2022  Volume 63, Issue 3, Page(s) 376–379

    Abstract: Immunoglobulin type gamma 4-related disease (IgG4-RD) is a fibroinflammatory condition that can have systemic and/or cutaneous manifestations. The most common cutaneous features are erythematous papules, nodules and/or plaques, typically involving the ... ...

    Abstract Immunoglobulin type gamma 4-related disease (IgG4-RD) is a fibroinflammatory condition that can have systemic and/or cutaneous manifestations. The most common cutaneous features are erythematous papules, nodules and/or plaques, typically involving the head and neck (J Am Acad Dermatol. 2016;75:197). We report a case of IgG4-RD presenting with eruptive cherry angiomas, a novel cutaneous presentation.
    MeSH term(s) Exanthema ; Hemangioma/complications ; Humans ; Immunoglobulin G ; Immunoglobulin G4-Related Disease ; Skin ; Skin Diseases
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2022-05-03
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.13857
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  9. Article: High pressure study of sodium trihydride.

    Marqueño, Tomas / Kuzovnikov, Mikhail A / Osmond, Israel / Dalladay-Simpson, Phillip / Hermann, Andreas / Howie, Ross T / Peña-Alvarez, Miriam

    Frontiers in chemistry

    2024  Volume 11, Page(s) 1306495

    Abstract: The reactivity between NaH and ... ...

    Abstract The reactivity between NaH and H
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2023.1306495
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  10. Article ; Online: VAEs with structured image covariance applied to compressed sensing MRI.

    Duff, M A G / Simpson, I J A / Ehrhardt, M J / Campbell, N D F

    Physics in medicine and biology

    2023  Volume 68, Issue 16

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Image Processing, Computer-Assisted/methods ; Retrospective Studies ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2023-08-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ace49a
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