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  1. Article ; Online: Clinical relevance of spectral tissue Doppler-derived E/e' in the diagnosis of heart failure with preserved ejection fraction: reply.

    Donal, Erwan / Galli, Elena

    European journal of heart failure

    2018  Volume 20, Issue 5, Page(s) 941–942

    MeSH term(s) Echocardiography, Doppler ; Heart Failure ; Humans ; Stroke Volume ; Ventricular Function, Left
    Language English
    Publishing date 2018-01-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.1090
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    Zs.A 5299: Show issues Location:
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  2. Article ; Online: Non-invasive estimation of left heart filling pressures: another nail in the coffin for E/e'?

    Donal, Erwan / Galli, Elena / Fraser, Alan G

    European journal of heart failure

    2017  Volume 19, Issue 12, Page(s) 1661–1663

    MeSH term(s) Echocardiography, Doppler ; Heart Failure ; Humans ; Ventricular Dysfunction, Left ; Ventricular Function, Left ; Ventricular Pressure
    Language English
    Publishing date 2017-10-06
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.944
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  3. Article ; Online: Potential for release of pulmonary toxic ketene from vaping pyrolysis of vitamin E acetate.

    Wu, Dan / O'Shea, Donal F

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 12, Page(s) 6349–6355

    Abstract: A combined analytical, theoretical, and experimental study has shown that the vaping of vitamin E ... to the upsurge in pulmonary injuries associated with using e-cigarette/vaping products. Additionally ... the pyrolysis of vitamin E acetate also produces carcinogen alkenes and benzene for which the negative long-term ...

    Abstract A combined analytical, theoretical, and experimental study has shown that the vaping of vitamin E acetate has the potential to produce exceptionally toxic ketene gas, which may be a contributing factor to the upsurge in pulmonary injuries associated with using e-cigarette/vaping products. Additionally, the pyrolysis of vitamin E acetate also produces carcinogen alkenes and benzene for which the negative long-term medical effects are well recognized. As temperatures reached in vaping devices can be equivalent to a laboratory pyrolysis apparatus, the potential for unexpected chemistries to take place on individual components within a vape mixture is high. Educational programs to inform of the danger are now required, as public perception has grown that vaping is not harmful.
    MeSH term(s) Acetates/analysis ; Acetates/chemistry ; Electronic Nicotine Delivery Systems ; Ethylenes/analysis ; Ethylenes/toxicity ; Ketones/analysis ; Ketones/toxicity ; Lung Injury/chemically induced ; Molecular Structure ; Phenols/analysis ; Phenols/chemistry ; Pyrolysis ; Vaping/adverse effects ; Vitamin E/analysis ; Vitamin E/chemistry
    Chemical Substances Acetates ; Ethylenes ; Ketones ; Phenols ; Vitamin E (1406-18-4) ; phenyl acetate (355G9R500Y) ; ketene (LEP3SM032A)
    Language English
    Publishing date 2020-03-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1920925117
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    Zs.A 1148: Show issues Location:
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  4. Article ; Online: Yeast Mannan-Rich Fraction Modulates Endogenous Reactive Oxygen Species Generation and Antibiotic Sensitivity in Resistant E. coli

    Helen Smith / Sharon Grant / Paula Meleady / Michael Henry / Donal O’Gorman / Martin Clynes / Richard Murphy

    International Journal of Molecular Sciences, Vol 24, Iss 1, p

    2022  Volume 218

    Abstract: ... production in resistant E. coli by 59.29 ± 4.03% compared to the control ( p ≤ 0.05). We further examined ... the effect of MRF alone and in combination with antibiotic treatment on E. coli growth and explored how MRF ... we demonstrated that MRF supplementation in the growth media of ampicillin-resistant E. coli had a significant ...

    Abstract Mannan-rich fraction (MRF) isolated from Saccharomyces cerevisiae has been studied for its beneficial impact on animal intestinal health. Herein, we examined how MRF affected the formation of reactive oxygen species (ROS), impacting antibiotic susceptibility in resistant Escherichia coli through the modulation of bacterial metabolism. The role of MRF in effecting proteomic change was examined using a proteomics-based approach. The results showed that MRF, when combined with bactericidal antibiotic treatment, increased ROS production in resistant E. coli by 59.29 ± 4.03% compared to the control ( p ≤ 0.05). We further examined the effect of MRF alone and in combination with antibiotic treatment on E. coli growth and explored how MRF potentiates bacterial susceptibility to antibiotics via proteomic changes in key metabolic pathways. Herein we demonstrated that MRF supplementation in the growth media of ampicillin-resistant E. coli had a significant impact on the normal translational control of the central metabolic pathways, including those involved in the glycolysis–TCA cycle ( p ≤ 0.05).
    Keywords antimicrobial resistance ; yeast mannan fraction ; bacterial metabolism ; antibiotic susceptibility ; reactive oxygen species ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: European multicentre validation study of the accuracy of E/e' ratio in estimating invasive left ventricular filling pressure: EURO-FILLING study.

    Galderisi, Maurizio / Lancellotti, Patrizio / Donal, Erwan / Cardim, Nuno / Edvardsen, Thor / Habib, Gilbert / Magne, Julien / Maurer, Gerald / Popescu, Bogdan A

    European heart journal cardiovascular Imaging

    2014  Volume 15, Issue 7, Page(s) 810–816

    Abstract: ... for calculating the ratio between the preload-dependent transmitral E velocity and the average of septal and ... lateral early diastolic velocities (e') of the mitral annulus. Despite its wide use, real utility of the E ... invasive estimation of LVFP simultaneously. The EURO-FILLING Study will validate the E/e' ratio (and ...

    Abstract Aims: The non-invasive estimation of left ventricular filling pressures (LVFPs) represents a main goal in the clinical setting. Current recommendations encourage the use of pulsed-wave Tissue Doppler for calculating the ratio between the preload-dependent transmitral E velocity and the average of septal and lateral early diastolic velocities (e') of the mitral annulus. Despite its wide use, real utility of the E/e' ratio has been recently challenged in patients with either very advanced heart failure or preserved left ventricular (LV) ejection fraction. However, only few studies performed the invasive and non-invasive estimation of LVFP simultaneously. The EURO-FILLING Study will validate the E/e' ratio (and additional non-invasive estimates) against simultaneously measured LVFP obtained by left heart catheterization in a multicentre study involving reference European echo laboratories collecting a wide population sample size of cardiac patients with and without heart failure.
    Methods and results: The EURO-FILLING study is a large, prospective observational study in which simultaneous assessment of invasive and non-invasive measurements of LVFP will be acquired in eight reference European centres. Centralized reading of the collected parameters will be performed in a core laboratory. Not only standardized echo Doppler measurements but also novel echo parameters such as LV global longitudinal strain and global atrial strain (obtainable by two-dimensional speckle tracking echocardiography) will be tested for predicting invasive measurements of LVFP.
    Conclusions: The EURO-FILLING study is expected to provide important information on non-invasive assessment of LVFP and to contribute to the standardization of this assessment in clinical practice.
    MeSH term(s) Aged ; Echocardiography, Doppler, Pulsed/methods ; Europe ; Female ; Heart Failure/diagnostic imaging ; Heart Failure/physiopathology ; Humans ; Image Processing, Computer-Assisted ; Logistic Models ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Sensitivity and Specificity ; Severity of Illness Index ; Ventricular Function, Left ; Ventricular Pressure/physiology
    Language English
    Publishing date 2014-07
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't ; Validation Studies
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeu022
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    Zs.A 5614: Show issues Location:
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  6. Article: Seroprevalence of Hepatitis E virus infection in the Irish pig population.

    O'Connor, Michael / Roche, Sarah-Jayne / Sammin, Dónal

    Irish veterinary journal

    2015  Volume 68, Issue 1, Page(s) 8

    Abstract: Background: Hepatitis E is an acute viral disease of humans, occurring in explosive outbreaks ... if hepatitis E virus is present in Irish pigs, sera from 330 animals were examined for antibodies using ... Conclusions: Hepatitis E virus is present in most Irish pig herds and in many animals within these herds. ...

    Abstract Background: Hepatitis E is an acute viral disease of humans, occurring in explosive outbreaks in the developing world and as sporadic cases in returning travellers. Increasing recognition of indigenous transmission in Western countries suggests a zoonotic source of infection, most likely pigs. To determine if hepatitis E virus is present in Irish pigs, sera from 330 animals were examined for antibodies using a commercially available ELISA.
    Findings: Antibodies were detected in 89 pigs (27%) in 13 herds (81%).
    Conclusions: Hepatitis E virus is present in most Irish pig herds and in many animals within these herds.
    Language English
    Publishing date 2015
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2571182-9
    ISSN 2046-0481 ; 0368-0762
    ISSN (online) 2046-0481
    ISSN 0368-0762
    DOI 10.1186/s13620-015-0036-3
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  7. Article: Barriers to open e-learning in public administrations

    Stoffregen, Julia Dorothée / Fitzpatrick, Dónal / Friedrich, Horst / Mehigan, Tracey / Moebs, Sabine / Pawlowski, Jan Martin / Przygoda, Christiane / Ras, Eric / Schilling, Peter / Steffens, Petra / Šćepanović, Snezana / Tobias, Eric

    Technological forecasting & social change : an international journal Vol. 111 , p. 198-208

    a comparative case study of the European countries Luxembourg, Germany, Montenegro and Ireland

    2016  Volume 111, Page(s) 198–208

    Author's details Julia Dorothée Stoffregen, Jan M. Pawlowski, Eric Ras, Eric Tobias, Snezana Šćepanović, Dónal Fitzpatrick, Tracey Mehigan, Petra Steffens, Christiane Przygoda, Peter Schilling, Horst Friedrich, Sabine Moebs
    Keywords Comparative study ; Public administrations ; OER ; e-Learning
    Language English
    Publisher Elsevier
    Publishing place Amsterdam
    Document type Article
    ZDB-ID 280700-2
    ISSN 0040-1625
    Database ECONomics Information System

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  8. Article: Seroprevalence of Hepatitis E virus infection in the Irish pig population

    O’Connor, Michael / Roche, Sarah-Jayne / Sammin, Dónal

    Irish veterinary journal. 2015 Dec., v. 68, no. 1

    2015  

    Abstract: BACKGROUND: Hepatitis E is an acute viral disease of humans, occurring in explosive outbreaks ... if hepatitis E virus is present in Irish pigs, sera from 330 animals were examined for antibodies using ... CONCLUSIONS: Hepatitis E virus is present in most Irish pig herds and in many animals within these herds. ...

    Abstract BACKGROUND: Hepatitis E is an acute viral disease of humans, occurring in explosive outbreaks in the developing world and as sporadic cases in returning travellers. Increasing recognition of indigenous transmission in Western countries suggests a zoonotic source of infection, most likely pigs. To determine if hepatitis E virus is present in Irish pigs, sera from 330 animals were examined for antibodies using a commercially available ELISA. FINDINGS: Antibodies were detected in 89 pigs (27%) in 13 herds (81%). CONCLUSIONS: Hepatitis E virus is present in most Irish pig herds and in many animals within these herds.
    Keywords Hepatitis E virus ; antibodies ; enzyme-linked immunosorbent assay ; hepatitis E ; herds ; humans ; seroprevalence ; swine
    Language English
    Dates of publication 2015-12
    Size p. 36.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 2571182-9
    ISSN 2046-0481 ; 0368-0762
    ISSN (online) 2046-0481
    ISSN 0368-0762
    DOI 10.1186/s13620-015-0036-3
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: The computer is fantastic for our daily echocardiography practice.

    Marut, Benjamin / Donal, Erwan

    International journal of cardiology

    2024  , Page(s) 132013

    Language English
    Publishing date 2024-04-04
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2024.132013
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    Zs.A 1673: Show issues Location:
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  10. Book ; Online: Electronic Payment Systems For E-commerce

    O'Mahony, Donal

    2006  

    Abstract: Generally society has been moving towards electronic payment systems since the 1970s, but it is only the arrival of the Internet and its vertiginous growth, that has made possible the recent advances in this ... ...

    Abstract Generally society has been moving towards electronic payment systems since the 1970s, but it is only the arrival of the Internet and its vertiginous growth, that has made possible the recent advances in this area
    Language English
    Size Online-Ressource (359 p.)
    Edition 2nd ed
    Publisher Artech House
    Publishing place Norwood
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9781580532686 ; 1580532683
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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