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  1. Article ; Online: Telemedizin bei chronischer Herzinsuffizienz – von klinischen Studien zur Regelversorgung.

    Spethmann, Sebastian / Köhler, Friedrich

    Der Internist

    2022  Volume 63, Issue 3, Page(s) 266–273

    Abstract: Telemedicine has the potential to solve many current and especially future challenges in medical care. Using the example of heart failure (HF), the transition of telemedicine from clinical studies to standard care is presented. In patients with chronic ... ...

    Title translation Telemedicine in chronic heart failure-From clinical studies to standard care.
    Abstract Telemedicine has the potential to solve many current and especially future challenges in medical care. Using the example of heart failure (HF), the transition of telemedicine from clinical studies to standard care is presented. In patients with chronic HF, randomized controlled trials have shown that telemedicine-based care leads to a reduction in mortality and cardiovascular morbidity. Based on these data, the Federal Joint Committee (G-BA) decided that for the first time a digital method should be introduced into standard care for high-risk patients with reduced left ventricular ejection fraction. In the future, this group of patients will be entitled to telemedical care using active rhythm devices or noninvasive measuring devices. The indications are assessed by the primary treating physician (PBA), who works together with a telemedicine center (TMZ) managed through cardiology that receives daily telemetric data and notifies the PBA of abnormal findings. Alternatively, a cardiologist PBA with an associated TMZ infrastructure can also provide telemedical care. In the future, advanced technologies such as artificial intelligence or mobile communication standard 5G will help to make telemedicine both widely available and usable for alternative sensor technology.
    MeSH term(s) Artificial Intelligence ; Heart Failure/diagnosis ; Heart Failure/therapy ; Humans ; Stroke Volume ; Telemedicine/methods ; Ventricular Function, Left
    Language German
    Publishing date 2022-02-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2913-0
    ISSN 1432-1289 ; 0020-9554
    ISSN (online) 1432-1289
    ISSN 0020-9554
    DOI 10.1007/s00108-022-01268-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Gaze patterns reflect and predict expertise in dynamic echocardiographic imaging.

    Laubrock, Jochen / Krutz, Alexander / Nübel, Jonathan / Spethmann, Sebastian

    Journal of medical imaging (Bellingham, Wash.)

    2023  Volume 10, Issue Suppl 1, Page(s) S11906

    Abstract: Purpose: Echocardiography is the most important modality in cardiac imaging. Rapid valid visual assessment is a critical skill for image interpretation. However, it is unclear how skilled viewers assess echocardiographic images. Therefore, guidance and ... ...

    Abstract Purpose: Echocardiography is the most important modality in cardiac imaging. Rapid valid visual assessment is a critical skill for image interpretation. However, it is unclear how skilled viewers assess echocardiographic images. Therefore, guidance and implicit advice are needed for learners to achieve valid image interpretation.
    Approach: Using a signal detection approach, we compared 15 certified experts with 15 medical students in their diagnostic decision-making and viewing behavior. To quantify attention allocation, we recorded eye movements while viewing dynamic echocardiographic imaging loops of patients with reduced ejection fraction and healthy controls. Participants evaluated left ventricular ejection fraction and image quality (as diagnostic and visual control tasks, respectively).
    Results: Experts were much better at discriminating between patients and healthy controls (
    Conclusions: Judgments and eye tracking revealed significant differences between echocardiography experts and novices that can be used to derive numerical expertise scores. Experts have implicitly learned to ignore the salient motion cue presented by the mitral valve and to focus on the diagnostically more relevant left ventricle. These findings have implications for echocardiography training, objective characterization of echocardiographic expertise, and the design of user-friendly interfaces for echocardiography.
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article
    ISSN 2329-4302
    ISSN 2329-4302
    DOI 10.1117/1.JMI.10.S1.S11906
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  3. Article ; Online: From Videogames to Teaching - Different Camera Perspectives in an Interactive Synchronous Online Tutorial.

    Boten, David Niklas / Daum, Nils / Schutz, Thomas / Spethmann, Sebastian

    Medical science educator

    2023  Volume 33, Issue 5, Page(s) 1029–1031

    Abstract: The global COVID-19 pandemic has required clinical skills training to be transferred to an online format. An interactive synchronous online tutorial with different camera perspectives was developed. In a survey, 79% of the students preferred the first- ... ...

    Abstract The global COVID-19 pandemic has required clinical skills training to be transferred to an online format. An interactive synchronous online tutorial with different camera perspectives was developed. In a survey, 79% of the students preferred the first-person perspective, which allowed students to view the abdominal examination through the examiner's eyes.
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article
    ISSN 2156-8650
    ISSN (online) 2156-8650
    DOI 10.1007/s40670-023-01833-9
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  4. Article ; Online: mRNA vaccines for COVID-19 are safe and clinically effective in patients with cardiac amyloidosis.

    Barzen, Gina / Rieber, Finn / Stangl, Karl / Hahn, Katrin / Spethmann, Sebastian

    Vaccine

    2023  Volume 42, Issue 4, Page(s) 723–726

    Abstract: Introduction: Amyloidosis is a rare disease in which malformed proteins are deposited in tissues occurring mostly commonly in older age. These deposits can lead to severe organ dysfunction e.g. in the myocardium with great impact on prognosis. The Covid- ...

    Abstract Introduction: Amyloidosis is a rare disease in which malformed proteins are deposited in tissues occurring mostly commonly in older age. These deposits can lead to severe organ dysfunction e.g. in the myocardium with great impact on prognosis. The Covid-19 pandemic has caused excess mortality worldwide since 2020. Risk factors for a severe course include pre-existing cardiac diseases like heart failure and advanced age. Therefore, vaccination against Sars-CoV2 viruses is highly recommended for patients with cardiac amyloidosis. However, since there are no specific data on mRNA vaccines in patients with cardiac amyloidosis, some patients have concerns about cardiac adverse events following immunization (AEFI), such as myocarditis.
    Purpose: The purpose of the study is to assess the safety and efficacy of mRNA vaccines in patients with cardiac amyloidosis.
    Methods: Patients of the Amyloidosis Center Charité Berlin (ACCB) were assessed about the vaccination, its tolerability and clinical effectiveness. To date, we included 62 patients (54 men) with a median age of 82,5 years (range 37 to 92). 46 patients had wtATTR amyloidosis, ten patients had hATTR amyloidosis, and six patients had AL amyloidosis. The mean systolic left ventricular function was 51% (range 30 to 62) with a mean global strain of -11,5% (range -18,5 to -3,1). The mean NT-pro-BNP was 1145 ng/l (range 24 to 48297).
    Results: 59 patients were triple vaccinated and three patients so far are double vaccinated. Three of the patients were unvaccinated. 171 of the vaccine doses administered were mRNA vaccines and eight doses were a viral vector-vaccine. None of the patients reported severe side effects. Thirteen patients reported feeling of pressure and pain at the injection site after vaccination and four patients had fever of maximum two days, eight patients reported lower general condition of maximum five days. One patient reported malaise for 14 days after each vaccination, which resolved spontaneously. There was no clinical or laboratory evidence of suspected vaccine-induced myocarditis. Five patients reported of a COVID-19 breakthrough infection, all of which with a mild course of disease. None of the patients had symptoms of worsening heart failure in temporal relation to the vaccination. Most of the vaccinations (103) were performed at an official vaccination center, 59 were performed at a general practitioner.
    Conclusion: In patients with cardiac amyloidosis, mRNA vaccines for COVID-19 are safe with respect to severe cardiac adverse events and show effective protection against clinically relevant SARS-CoV2 infection.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Humans ; Male ; Middle Aged ; Amyloidosis ; Breakthrough Infections ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; Heart Failure ; mRNA Vaccines ; Myocarditis ; Pandemics ; RNA, Viral ; SARS-CoV-2 ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines ; mRNA Vaccines ; RNA, Viral
    Language English
    Publishing date 2023-12-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.12.041
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    Zs.MO 458: Show issues

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  5. Conference proceedings: Inanspruchnahme und Herausforderungen digitaler Präventionsmaßnahmen bei Hypertonie – eine qualitative Studie von Menschen mit Bluthochdruck in Berlin/Brandenburg

    Wengemuth, Eileen / Bruch, Dunja / May, Susann / Muehlensiepen, Felix / Spethmann, Sebastian

    2023  , Page(s) 23dkvf072

    Event/congress 22. Deutscher Kongress für Versorgungsforschung (DKVF); Berlin; Deutsches Netzwerk Versorgungsforschung; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-10-02
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dkvf072
    Database German Medical Science

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  6. Article ; Conference proceedings: Einstellungen und Informationsbedarfe zu digitalen Gesundheitsanwendungen für die Prävention von Bluthochdruck in Deutschland – eine qualitative Interviewstudie mit Ärzt:innen und medizinischem Personal

    May, Susann / Muehlensiepen, Felix / Bruch, Dunja / Wengemuth, Eileen / Spethmann, Sebastian

    Das Gesundheitswesen

    2023  Volume 85, Issue 08/09

    Event/congress Gemeinsame Jahrestagung der Deutschen Gesellschaft für Sozialmedizin und Prävention e.V. (DGSMP)*, des Deutschen Netzwerks Gesundheitskompetenz e. V. (DNGK) und des Nationalen Aktionsplans Gesundheitskompetenz (NAP), Hannover, 2023-08-30
    Language German
    Publishing date 2023-08-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1101426-x
    ISSN 1439-4421 ; 0941-3790 ; 0949-7013
    ISSN (online) 1439-4421
    ISSN 0941-3790 ; 0949-7013
    DOI 10.1055/s-0043-1770421
    Database Thieme publisher's database

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  7. Article ; Online: Anwendung von „large language models“ in der Klinik : Ersetzt ChatGPT die Arztbrieferstellung? Ein Erfahrungsbericht.

    Zernikow, Jasmin / Grassow, Leonhard / Gröschel, Jan / Henrion, Philippe / Wetzel, Paul J / Spethmann, Sebastian

    Innere Medizin (Heidelberg, Germany)

    2023  Volume 64, Issue 11, Page(s) 1058–1064

    Abstract: Artificial intelligence (AI)-based language models, such as ChatGPT offer an enormous potential for research and medical care but also for clinical workflow optimization by making medical documentation easier and more efficient in taking over ... ...

    Title translation Clinical application of large language models : Does ChatGPT replace medical report formulation? An experience report.
    Abstract Artificial intelligence (AI)-based language models, such as ChatGPT offer an enormous potential for research and medical care but also for clinical workflow optimization by making medical documentation easier and more efficient in taking over standardized routine tasks. With their ability to guess a text's content using word statistics and thus outputting contextually relevant results in chat dialogues, large language models (LLM) can provide appropriate summaries of medical documentation for different target groups. For instance, text generation in easy to understand language could potentially contribute to an increase in patients' health literacy and, consequently, to increased adherence to treatment. Subsequent, the function of AI-based chatbot models to improve user experiences and enhance competence in the use of AI-based language models will be adressed. Current limitations and chances in creating epicrises are presented as an experience report. In the future, the implementation of local LLMs in medical management systems (hospital information systems, HIS and practice administration systems, PAS) and in conjunction with the electronic patient records (ePA) can fundamentally change clinical and outpatient care.
    MeSH term(s) Humans ; Artificial Intelligence ; Electronic Health Records ; Ambulatory Care ; Choline O-Acetyltransferase ; Language
    Chemical Substances Choline O-Acetyltransferase (EC 2.3.1.6)
    Language German
    Publishing date 2023-10-16
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7099
    ISSN (online) 2731-7099
    DOI 10.1007/s00108-023-01600-3
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  8. Conference proceedings: Einstellungen und Informationsbedarfe zu digitalen Gesundheitsanwendungen für die Prävention von Bluthochdruck in Deutschland – eine qualitative Studie mit hypertonieversorgenden Ärzt:innen und medizinischem Personal

    May, Susann / Muehlensiepen, Felix / Bruch, Dunja / Wengemuth, Eileen / Spethmann, Sebastian

    2023  , Page(s) 23dkvf334

    Event/congress 22. Deutscher Kongress für Versorgungsforschung (DKVF); Berlin; Deutsches Netzwerk Versorgungsforschung; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-10-02
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dkvf334
    Database German Medical Science

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  9. Book ; Online ; Thesis: Echokardiographie als nicht-invasive kardiologische Bildgebung nach perkutanem Aortenklappenersatz

    Spethmann, Sebastian

    2015  

    Title variant Echocardiography as noninvasive cardiac imaging after percutaneous aortic valve replacement
    Author's details vorgelegt von Sebastian Spethmann
    Language German
    Size Online-Ressource, Ill., graph. Darst.
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ.-Medizin, Habil.--Berlin, 2015
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article ; Online: Distinctive Paravalvular Jets of a Novel Self-Expanding Transcatheter Aortic Valve With a Unique Skirt Design.

    Romero Dorta, Elena / Mattig, Isabel / Kösters, Lorenz / Sündermann, Simon H / Spethmann, Sebastian / Stangl, Karl / Dreger, Henryk

    JACC. Cardiovascular interventions

    2023  Volume 16, Issue 13, Page(s) 1694–1695

    MeSH term(s) Humans ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Treatment Outcome ; Transcatheter Aortic Valve Replacement/adverse effects ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Heart Valve Prosthesis ; Aortic Valve Insufficiency/surgery ; Prosthesis Design
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2023.05.006
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