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  1. Book: Cardiac Electrosonography

    Herzog, Eyal / Elitzur, Yair / Leibowitz, David

    2023  

    Author's details Dr. Eyal Herzog is a professor of Medicine at Icahn School of Medicine at Mount Sinai in New York where he was the director of the Critical Care Cardiology and Echocardiogrphy for over two decades at Mount Sinai- St. Luke's Hospital. He is currently the Director of the Department of Cardiology at Hadassah Medical Center, The Hebrew University of Jerusalem, in Jerusalem, Israel. §Over the past three decades, Dr. Herzog has developed highly respected methods for improving cardiovascular healthcare through the application of novel algorithmic pathways that simplify the diagnosis, treatment, and management of cardiovascular disease. § Dr. Herzog is internationally recognized for his leadership in Critical Care Cardiology and Echocardiography. He had authored many textbooks, including the "The Cardiac Care Survival Guide" and "Herzog's CCU book," that became bestsellers in the United States and around the globe. § Dr. Herzog is an outstanding teacher. He has been awarded as the "Teac
    Keywords ECG ; cardiacimaging ; Echocardiography ; AcuteCardiacCare ; Cardiac imaging ; Electrosonography ; Acute cardiac care
    Language English
    Size 404 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_24
    Format 183 x 260 x 22
    ISBN 9783031384684 ; 3031384687
    Database PDA

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  2. Article: [Rezension von: The economics of child care, ed. by David M. Blau]

    Leibowitz, Arleen A

    Journal of economic literature 31 ,2, S. 909-910

    1993  

    Author's details Arleen Leibowitz
    Keywords 40;49
    Language English
    Publisher Assoc
    Publishing place Nashville, Tenn
    Document type Article
    ZDB-ID 3076-4 ; 2010159-4
    ISSN 0022-0515
    ISSN 0022-0515
    Database ECONomics Information System

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  3. Article ; Online: The association between myocardial contraction fraction assessed by echocardiography and mortality.

    Leibowitz, David / Zwas, Donna / Amir, Offer / Gotsman, Israel

    Echocardiography (Mount Kisco, N.Y.)

    2023  Volume 40, Issue 7, Page(s) 608–614

    Abstract: Background: Left ventricular ejection fraction (EF) is the most commonly used echocardiographic measurement of LV systolic function. Myocardial contraction fraction (MCF) may be a more accurate assessment of LV systolic function than EF. Limited data ... ...

    Abstract Background: Left ventricular ejection fraction (EF) is the most commonly used echocardiographic measurement of LV systolic function. Myocardial contraction fraction (MCF) may be a more accurate assessment of LV systolic function than EF. Limited data are available regarding the prognostic value of MCF compared to EF in a population referred for echocardiography.
    Objectives: To assess whether MCF was predictive of all-cause mortality in a population referred for echocardiography.
    Methods: All consecutive subjects undergoing echocardiography in a university-affiliated laboratory during a 5-year period were retrieved for analysis. MCF was calculated by dividing LV stroke volume (LV end diastolic volume-LV end systolic volume) by LV myocardial volume and multiplied by 100. All cause mortality was the primary endpoint. Multivariate Cox proportional hazards regression analysis was used to evaluate independent variables associated with survival.
    Results: 18,149 continuous subjects (median age 60 years, 53% male) were included. Median MCF in the cohort was 52% (interquartile range 40-64) while median EF was 64% (56-69). Any reduction in MCF from a value of 60 was significantly associated with survival on multivariable analysis. When echo parameters including EF, e:e', elevated TR gradient and significant MR were added to the model, MCF less than 50% remained significantly associated with mortality. MCF was also independently associated with both death and cardiovascular hospitalization. The AUC for MCF was .66 (95% confidence interval (CI): .65-.67) while for EF the AUC was only .58 (95% CI: .57-.59), a statistically significant difference (p < .0001).
    Conclusions: Reduced MCF is independently associated with mortality in a large population referred for echocardiography.
    MeSH term(s) Humans ; Male ; Middle Aged ; Female ; Stroke Volume ; Ventricular Function, Left ; Echocardiography ; Myocardial Contraction ; Myocardium ; Prognosis ; Ventricular Dysfunction, Left
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 843645-9
    ISSN 1540-8175 ; 0742-2822
    ISSN (online) 1540-8175
    ISSN 0742-2822
    DOI 10.1111/echo.15623
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  4. Article: Mitral Regurgitation Severity Assessment after Transcutaneous Edge-to-Edge Mitral Valve Repair: Recommended Integration versus Volumetric Assessment Guidelines.

    Shekel, Efrat / Shuvy, Mony / Danenberg, Haim / Planer, David / Gilon, Dan / Leibowitz, David / Beeri, Ronen

    Journal of clinical medicine

    2023  Volume 12, Issue 19

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2023-10-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12196347
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  5. Article: The impact of aging on cardiac remodeling in chronic mitral regurgitation.

    Leibowitz, David / Zwas, Donna / Beeri, Ronen / Alcalai, Ronny / Gotsman, Israel

    Journal of geriatric cardiology : JGC

    2023  Volume 20, Issue 10, Page(s) 748–755

    Abstract: Background: Chronic mitral regurgitation (MR) is a volume overload state that causes dilatation of the left sided cardiac chambers. The presence of significant dilatation is considered an indication for mitral valve intervention, however, aging may ... ...

    Abstract Background: Chronic mitral regurgitation (MR) is a volume overload state that causes dilatation of the left sided cardiac chambers. The presence of significant dilatation is considered an indication for mitral valve intervention, however, aging may affect left ventricular (LV) remodeling independently of valvular disease. The objective of this study was to examine age-related changes in cardiac remodeling in a broad population of patients with chronic MR.
    Methods: Consecutive subjects that underwent echocardiography examinations recorded in the echocardiography database of a university-affiliated laboratory were retrieved. Subjects were categorized into none/mild, moderate or severe MR. For purposes of analysis of differences with aging, the population was divided into groups above and below 70 years of age and standard echocardiographic measurements were compared between the groups.
    Results: A total of 3492 subjects with at least moderate MR (mean age: 76 years, 52% female) were included in the study and compared to 18,250 subjects with none or mild MR. Older patients had significantly smaller LV end-diastolic diameters and volumes and significantly larger left atrial (LA) volumes when compared to the younger group. LA volume index increased in both age groups as MR severity increased, while LV end-diastolic volume increased with increasing MR only in the younger population.
    Conclusions: Cardiac remodeling in chronic MR is significantly influenced by age. Guideline based recommendations of timing of mitral valve interventions in asymptomatic MR patients, based on assessment of LA and LV remodeling, may need to take age into account.
    Language English
    Publishing date 2023-08-21
    Publishing country China
    Document type Journal Article
    ZDB-ID 2421391-3
    ISSN 1671-5411
    ISSN 1671-5411
    DOI 10.26599/1671-5411.2023.10.004
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  6. Article ; Online: Understanding the biological action of insecticides is the key to their continuous improvement.

    David, Michael / Leibowitz, Sarah / Lorsbach, Beth / Wing, Keith

    Pest management science

    2021  Volume 77, Issue 8, Page(s) 3605–3607

    MeSH term(s) Insecticides
    Chemical Substances Insecticides
    Language English
    Publishing date 2021-07-01
    Publishing country England
    Document type Editorial
    ZDB-ID 2001705-4
    ISSN 1526-4998 ; 1526-498X
    ISSN (online) 1526-4998
    ISSN 1526-498X
    DOI 10.1002/ps.6488
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  7. Article: The Diagnosis and Management of Immune Checkpoint Inhibitor Cardiovascular Toxicity: Myocarditis and Beyond.

    Gilon, Dan / Iakobishvili, Zaza / Leibowitz, David

    Vaccines

    2022  Volume 10, Issue 2

    Abstract: Recent years have brought major advancements in the use of immune therapy and specifically immune checkpoint inhibitors (ICIs) in cancer patients, with expanding indications for various malignancies resulting in the treatment of a large and increasing ... ...

    Abstract Recent years have brought major advancements in the use of immune therapy and specifically immune checkpoint inhibitors (ICIs) in cancer patients, with expanding indications for various malignancies resulting in the treatment of a large and increasing number of patients. While this therapy significantly improves outcomes in a variety of hematologic and solid tumors, the use of ICIs is associated with a substantial risk of immune-related adverse events. Cardiovascular toxicity, while not the most common side effect of ICIs, is associated with significant morbidity and mortality. It is therefore crucial for oncologists and cardiologists, as well as internists and emergency room physicians, to have a good understanding of this increasingly common clinical problem. In the present review, we discuss the cardiac aspects of ICI therapy with special emphasis on the clinical manifestations of their cardiovascular toxicity, diagnostic approaches, treatment and suggested surveillance.
    Language English
    Publishing date 2022-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10020304
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  8. Article ; Online: Mild Tricuspid Regurgitation: A Marker of Disease Burden Independently Associated with Increased Mortality.

    Gotsman, Israel / Zwas, Donna R / Elbaz Greener, Gabby / Planer, David / Amir, Offer / Leibowitz, David

    Cardiology

    2023  Volume 148, Issue 3, Page(s) 278–286

    Abstract: Introduction: Tricuspid regurgitation (TR) is a common finding which appears to be associated with a worse prognosis. There are conflicting data regarding the prognostic impact of mild TR. We examined the clinical characteristics and echocardiographic ... ...

    Abstract Introduction: Tricuspid regurgitation (TR) is a common finding which appears to be associated with a worse prognosis. There are conflicting data regarding the prognostic impact of mild TR. We examined the clinical characteristics and echocardiographic properties of subjects with TR and its impact on clinical outcome with particular emphasis on subjects with mild TR.
    Methods: Consecutive echocardiography examinations during 5 years were evaluated for TR severity and outcome including mortality and cardiovascular hospitalizations.
    Results: The study included 21,429 subjects; 45% of the subjects had mild TR, 15% had moderate TR, and 6.5% had severe TR. Primary organic TR was evident in 7% of the subjects, a percentage that increased with increasing TR severity. TR severity was incrementally associated with older subjects with an increasing number of comorbidities and echocardiographic abnormalities. 29% of the subjects died at a median follow-up duration of 8.7 years. Increasing severity of TR was independently and incrementally associated with mortality. Subjects with mild TR had a 25% increased mortality rate compared to subjects with minimal TR (HR 1.25, 95% CI: 1.12-1.39, p < 0.001) after adjustment for significant clinical parameters. TR severity was also an independent incrementally graded predictor of cardiovascular hospitalization and mortality (mild TR: HR 1.23, 95% CI: 1.12-1.34, p < 0.001).
    Conclusions: TR is associated with older and sicker patients with numerous comorbidities. TR severity is a predictor of a worse clinical outcome. Mild TR was independently associated with decreased survival. TR should be considered a marker of a disease burden with a poor prognosis.
    MeSH term(s) Humans ; Tricuspid Valve Insufficiency/diagnostic imaging ; Retrospective Studies ; Echocardiography ; Prognosis ; Comorbidity ; Severity of Illness Index
    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 80092-2
    ISSN 1421-9751 ; 0008-6312
    ISSN (online) 1421-9751
    ISSN 0008-6312
    DOI 10.1159/000530744
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  9. Article ; Online: Pulmonary Hypertension Severity in Heart Failure: Clinical Characteristics and Impact on Outcome.

    Gotsman, Israel / Abu Ghosh, Zahi / Zwas, Donna R / Amir, Offer / Leibowitz, David

    The American journal of cardiology

    2023  Volume 204, Page(s) 29–31

    MeSH term(s) Humans ; Hypertension, Pulmonary/epidemiology ; Heart Failure/complications ; Heart Failure/epidemiology ; Heart Failure/therapy ; Pulmonary Artery
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2023.07.035
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  10. Article: Left ventricular hypertrophy and chronic renal insufficiency in the elderly.

    Leibowitz, David

    Cardiorenal medicine

    2014  Volume 4, Issue 3-4, Page(s) 168–175

    Abstract: Background: The global population is aging. Cardiovascular disease is the leading cause of death in both men and women older than 65 years. In particular, elderly patients have an increased prevalence of left ventricular hypertrophy (LVH) and chronic ... ...

    Abstract Background: The global population is aging. Cardiovascular disease is the leading cause of death in both men and women older than 65 years. In particular, elderly patients have an increased prevalence of left ventricular hypertrophy (LVH) and chronic kidney disease (CKD), both of which predict increased cardiovascular morbidity and mortality. LVH and CKD frequently coexist in the elderly, and LVH is a powerful predictor of mortality in patients with end-stage renal disease.
    Key messages: Several hemodynamic factors contribute to LVH and CKD in the elderly. Increased arterial stiffness in the elderly is associated with LVH and CKD. Studies using noninvasive measures of arterial stiffening have shown a correlation between these measures and LVH in patients with CKD. Hypertensive patients with an altered circadian blood pressure pattern such as nondippers have an increased incidence of LVH and CKD. Anemia is a risk factor for LVH in patients in all stages of CKD, and studies have shown correlations between age, anemia and LV mass. Nonhemodynamic factors include chronic inflammation, increased oxidative stress, and reduced autophagy, all of which are present in the elderly. Disordered mineral metabolism in the elderly with reduced levels of vitamin D and elevated levels of parathyroid hormone and phosphorus is associated with LVH and CKD.
    Conclusions: Multiple pathophysiologic mechanisms contribute to the development of LVH and CKD in the elderly. Future research should be directed at interfering with this development and reducing the burden of cardiovascular and renal diseases in this growing population.
    Language English
    Publishing date 2014-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2595659-0
    ISSN 1664-5502 ; 1664-3828
    ISSN (online) 1664-5502
    ISSN 1664-3828
    DOI 10.1159/000366455
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