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Article ; Online: Relapsing Fever: A Rare Cause of Pediatric Fever of Unknown Origin.

Mitchell, Paul G / Natsios, Claire / Haag, Meredith B / Qin, Xuan / Vaz, Louise E

2023 Volume 62, Issue 10, Page(s) 1285–1289

MeSH term(s)	Humans ; Child ; Relapsing Fever/complications ; Fever of Unknown Origin/etiology
Language	English
Publishing date	2023-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/00099228231154129
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Zs.A 454: Show issues

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Article ; Online: How to ensure equitable research partnerships in global health.

Dutta, Madhuri / Del Pilar-Labarda, Meredith / Kpokiri, Eneyi / Thwaites, Louise / Clark, Jocalyn

BMJ (Clinical research ed.)

2023 Volume 381, Page(s) 1316

MeSH term(s)	Humans ; Global Health ; International Cooperation ; Developing Countries
Language	English
Publishing date	2023-06-09
Publishing country	England
Document type	Editorial
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.p1316
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Article ; Online: Echocardiography in the emergency assessment of acute aortic syndromes.

Meredith, E Louise / Masani, Navroz D

European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology

2009 Volume 10, Issue 1, Page(s) i31–9

Abstract: Acute aortic syndrome (AAS) is a collective term for several life-threatening acute aortic conditions: aortic dissection, intramural haematoma (IMH), penetrating atherosclerotic ulcer, and traumatic transection. Mortality from acute ascending aortic ( ... ...

Abstract	Acute aortic syndrome (AAS) is a collective term for several life-threatening acute aortic conditions: aortic dissection, intramural haematoma (IMH), penetrating atherosclerotic ulcer, and traumatic transection. Mortality from acute ascending aortic (type A) dissection increases rapidly immediately after presentation, reaching 1-2% per hour for the first 48 h. Early surgical intervention is recommended for type A aortic dissection and has been shown to improve outcome. Transthoracic echocardiography is an extremely valuable, often overlooked, clinical tool in diagnosing and assessing AAS in the emergency setting. Although diagnostic sensitivity is suboptimal, it is very useful in assessing potential high risk features or complications, such as pericardial effusion, and diagnosing potential differential conditions. A negative transthoracic echocardiography (TTE), however, does not exclude AAS. In patients with a high risk of type A dissection or IMH (identified clinically or by TTE), the safest and most rapid 'gold standard' investigation is transoesophageal echocardiography, ideally performed with the cardiac surgical team standing by. This is of particular importance in the haemodynamically unstable patient. Transoesophageal echocardiography, helical CT, and MRI have similar diagnostic accuracy and, when there is diagnostic uncertainty or no indication for immediate intervention, should be used according to clinical need, local availability, and expertise.
MeSH term(s)	Acute Disease ; Aneurysm, Dissecting/diagnostic imaging ; Aneurysm, Dissecting/mortality ; Aneurysm, Dissecting/therapy ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/mortality ; Aortic Aneurysm, Thoracic/therapy ; Blood Vessel Prosthesis Implantation/methods ; Critical Illness ; Echocardiography/methods ; Echocardiography, Doppler, Color/methods ; Echocardiography, Transesophageal/methods ; Emergencies ; Female ; Follow-Up Studies ; Humans ; Male ; Risk Assessment ; Sensitivity and Specificity ; Survival Analysis ; Syndrome ; Treatment Outcome
Language	English
Publishing date	2009-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2021408-X
ISSN	1532-2114 ; 1525-2167
ISSN (online)	1532-2114
ISSN	1525-2167
DOI	10.1093/ejechocard/jen251
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Zs.A 5614: Show issues

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Article ; Online: Emotional symptoms and inflammatory biomarkers in childhood: Associations in two Australian birth cohorts.

Journal of affective disorders

2023 Volume 344, Page(s) 356–364

Abstract: Background: An increasing body of evidence supports associations between inflammation and mental health difficulties, but the onset and directionality of these relationships are unclear.: Methods: Data sources: Barwon Infant Study (BIS; n = 500 4- ... ...

Abstract	Background: An increasing body of evidence supports associations between inflammation and mental health difficulties, but the onset and directionality of these relationships are unclear. Methods: Data sources: Barwon Infant Study (BIS; n = 500 4-year-olds) and Longitudinal Study of Australian Children (LSAC; n = 1099 10-13-year-olds). Measures: Strengths and Difficulties Questionnaire emotional symptoms at 4, 10-11 and 12-13 years, and circulating levels of two inflammatory biomarkers, high-sensitivity C-reactive protein (hsCRP) and glycoprotein acetyls (GlycA), at 4 and 11-12 years. Analysis: Adjusted quantile regression models examining cross-sectional associations between emotional symptoms and inflammation in 4-year-olds (BIS), and cross-lagged associations in 10-13-year-olds (LSAC). Results: We identified a small association between higher emotional symptoms at 10-11 years and higher GlycA levels a year later (standardised coefficient β = 0.09; 95%CI: 0.02 to 0.15). Sex-stratified analyses revealed this association was stronger for boys (β = 0.13; 95%CI: 0.04 to 0.21) than girls (β = 0.01; 95%CI: -0.09 to 0.11). These associations were not observed for hsCRP. There was little evidence of an association between higher GlycA or hsCRP at 11-12 years and emotional symptoms a year later, or cross-sectional associations between emotional symptoms and hsCRP or GlycA at 4 years. Limitations: A single time-point of biomarker collection in late childhood precluded adjustment for baseline inflammatory biomarkers. Conclusions: Our results support the direction of association from emotional symptoms to inflammation in late childhood, with potential sex differences. This adds to the body of evidence that addressing emotional symptoms in childhood is a major priority in optimising overall health throughout the life course.
MeSH term(s)	Humans ; Male ; Female ; Child ; Child, Preschool ; C-Reactive Protein/metabolism ; Longitudinal Studies ; Birth Cohort ; Cross-Sectional Studies ; Australia/epidemiology ; Biomarkers ; Inflammation/epidemiology ; Glycoproteins
Chemical Substances	C-Reactive Protein (9007-41-4) ; Biomarkers ; Glycoproteins
Language	English
Publishing date	2023-10-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2023.10.042
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Zs.A 1485: Show issues

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Article: Using molecular testing to improve the management of thyroid nodules with indeterminate cytology: an institutional experience with review of molecular alterations.

Glass, Ryan E / Marotti, Jonathan D / Kerr, Darcy A / Levy, Joshua J / Vaickus, Louis J / Gutmann, Edward J / Tafe, Laura J / Motanagh, Samaneh A / Sorensen, Meredith J / Davies, Louise / Liu, Xiaoying

Journal of the American Society of Cytopathology

2021 Volume 11, Issue 2, Page(s) 79–86

Abstract: Introduction: Molecular testing has helped clinicians and cytopathologists to further categorize indeterminate thyroid fine needle aspiration (FNA) specimens. The purpose of the present study was to evaluate the accuracy of commercially available ... ...

Abstract	Introduction: Molecular testing has helped clinicians and cytopathologists to further categorize indeterminate thyroid fine needle aspiration (FNA) specimens. The purpose of the present study was to evaluate the accuracy of commercially available molecular tests, review their effects on patient treatment, and correlate the molecular alterations with the histologic findings. Materials and methods: A pathology laboratory information system search identified thyroid FNAs performed at our institution between January 1, 2015 and June 30, 2020. The results of surgical follow-up and ancillary molecular testing were collected. We evaluated the accuracy of these tests and whether they could reduce the number of surgeries performed. Results: Our laboratory information system search identified 510 cases reported as atypia of undetermined significance, 94 as suspicious for follicular neoplasm, and 44 as suspicious for follicular neoplasm, Hurthle cell type. Of the specimens, 343 had no ancillary molecular testing, 146 were sent for ThyGenX/ThyraMIR, and 136 were sent for ThyroSeq. Of the patients without molecular testing, 50.4% had undergone follow-up surgery compared with 30.8% after ThyGenX/ThyraMIR and 38.2% after ThyroSeq testing, resulting in 38.9% and 24.2% fewer surgeries and an odds ratio of 0.04 (95% confidence interval, 0.00-0.33) and 0.14 (95% confidence interval, 0.01-0.95), respectively. For ThyGenX/ThyraMIR testing, the risk of malignancy for high and moderate to high risk alterations was 80%, 28.6% for moderate and low to moderate risk alterations, and 23.1% for low risk alterations. For ThyroSeq, the risk of malignancy was 87.5% for high risk alterations, 36.8% for intermediate to high risk alterations, 27.3% for intermediate risk alterations, and 0% for low risk alterations. The areas under the curve for ThyGenX/ThyraMIR and ThyroSeq testing were 0.65 and 0.85, respectively. Conclusions: These findings suggest that, at our institution, both ThygenX/ThyraMIR and ThyroSeq can be used to effectively stratify cytology specimens based on the risk of malignancy and reduce the number of surgeries performed at our institution.
MeSH term(s)	Biopsy, Fine-Needle/methods ; Cytodiagnosis/methods ; Humans ; Molecular Diagnostic Techniques ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/surgery ; Thyroid Nodule/diagnosis ; Thyroid Nodule/genetics
Language	English
Publishing date	2021-08-21
Publishing country	United States
Document type	Journal Article
ISSN	2213-2945
ISSN	2213-2945
DOI	10.1016/j.jasc.2021.08.004
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Article ; Online: Patient Engagement: an Assessment of Canadian Radiotherapy Programs' Current Practices, Perceived Barriers, and Facilitators.

Robin, Gabrielle / Brown, Erika / Davis, Carol-Anne / Bird, Louise / Wilson, Lianne / Halperin, Ross / Brundage, Michael / Croke, Jennifer / Harper, Cody / Giuliani, Meredith / Caissie, Amanda

Journal of cancer education : the official journal of the American Association for Cancer Education

2021 Volume 37, Issue 6, Page(s) 1834–1841

Abstract: ... to assess current patient engagement and education practices. An e-survey was sent to Canadian ROP (n = 44 ...

Abstract	Patient engagement and education have been mandated across Canadian radiation oncology programs (ROP). Guidance documents include the 2014 Canadian Association of Radiation Oncology (CARO) Radiation Therapy Patient Charter, the 2016 Canadian Partnership for Quality Radiotherapy (CPQR) Patient Engagement Guidelines (PEG) for Canadian Radiation Treatment Programs, and Accreditation Canada's 2017 refresh of Cancer Care Standards. Since little is known regarding uptake of these guidance statements, Canadian ROP were surveyed to assess current patient engagement and education practices. An e-survey was sent to Canadian ROP (n = 44). The survey focused on awareness and uptake of the CARO Patient Charter, CPQR PEG, and patient education practices. Survey development was guided by these documents and expert consensus, including CARO's Quality and Standards Patient Education/Engagement working group. Many (71%) responding ROP were familiar with the CARO Patient Charter, while 24% reported use. More than half (53%) of ROP were aware of the CPQR PEG, but approximately third (37%) had previously completed a self-audit. Most (88%) ROP view a pan-Canadian, evidence-based approach to educational materials beneficial and feasible (80%), with the majority (89%) willing to share their best practices across the radiotherapy community. Patient engagement and education are nationally mandated and supported by guidance documents. However, gaps have been identified across ROP for awareness and use of available tools, as well as uptake of their processes critical to quality of care. Understanding current practices will inform CPQR/CARO-supported pan-Canadian initiatives to optimize uptake, including development of CPQR Patient Education Guidance for Canadian Radiation Treatment Programs.
MeSH term(s)	Humans ; Radiation Oncology ; Patient Participation ; Canada ; Surveys and Questionnaires
Language	English
Publishing date	2021-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	632898-2
ISSN	1543-0154 ; 0885-8195 ; 1543-1154
ISSN (online)	1543-0154
ISSN	0885-8195 ; 1543-1154
DOI	10.1007/s13187-021-02049-4
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Zs.A 2185: Show issues

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Article ; Online: Narrowing the diagnostic gap: Genomes, episignatures, long-read sequencing, and health economic analyses in an exome-negative intellectual disability cohort.

Dias, Kerith-Rae / Shrestha, Rupendra / Schofield, Deborah / Evans, Carey-Anne / O'Heir, Emily / Zhu, Ying / Zhang, Futao / Standen, Krystle / Weisburd, Ben / Stenton, Sarah L / Sanchis-Juan, Alba / Brand, Harrison / Talkowski, Michael E / Ma, Alan / Ghedia, Sondy / Wilson, Meredith / Sandaradura, Sarah A / Smith, Janine / Kamien, Benjamin /

Turner, Anne / Bakshi, Madhura / Adès, Lesley C / Mowat, David / Regan, Matthew / McGillivray, George / Savarirayan, Ravi / White, Susan M / Tan, Tiong Yang / Stark, Zornitza / Brown, Natasha J / Pérez-Jurado, Luis A / Krzesinski, Emma / Hunter, Matthew F / Akesson, Lauren / Fennell, Andrew Paul / Yeung, Alison / Boughtwood, Tiffany / Ewans, Lisa J / Kerkhof, Jennifer / Lucas, Christopher / Carey, Louise / French, Hugh / Rapadas, Melissa / Stevanovski, Igor / Deveson, Ira W / Cliffe, Corrina / Elakis, George / Kirk, Edwin P / Dudding-Byth, Tracy / Fletcher, Janice / Walsh, Rebecca / Corbett, Mark A / Kroes, Thessa / Gecz, Jozef / Meldrum, Cliff / Cliffe, Simon / Wall, Meg / Lunke, Sebastian / North, Kathryn / Amor, David J / Field, Michael / Sadikovic, Bekim / Buckley, Michael F / O'Donnell-Luria, Anne / Roscioli, Tony

Genetics in medicine : official journal of the American College of Medical Genetics

2024 Volume 26, Issue 5, Page(s) 101076

Abstract: Purpose: Genome sequencing (GS)-specific diagnostic rates in prospective tightly ascertained exome sequencing (ES)-negative intellectual disability (ID) cohorts have not been reported extensively.: Methods: ES, GS, epigenetic signatures, and long- ... ...

Abstract	Purpose: Genome sequencing (GS)-specific diagnostic rates in prospective tightly ascertained exome sequencing (ES)-negative intellectual disability (ID) cohorts have not been reported extensively. Methods: ES, GS, epigenetic signatures, and long-read sequencing diagnoses were assessed in 74 trios with at least moderate ID. Results: The ES diagnostic yield was 42 of 74 (57%). GS diagnoses were made in 9 of 32 (28%) ES-unresolved families. Repeated ES with a contemporary pipeline on the GS-diagnosed families identified 8 of 9 single-nucleotide variations/copy-number variations undetected in older ES, confirming a GS-unique diagnostic rate of 1 in 32 (3%). Episignatures contributed diagnostic information in 9% with GS corroboration in 1 of 32 (3%) and diagnostic clues in 2 of 32 (6%). A genetic etiology for ID was detected in 51 of 74 (69%) families. Twelve candidate disease genes were identified. Contemporary ES followed by GS cost US$4976 (95% CI: $3704; $6969) per diagnosis and first-line GS at a cost of $7062 (95% CI: $6210; $8475) per diagnosis. Conclusion: Performing GS only in ID trios would be cost equivalent to ES if GS were available at $2435, about a 60% reduction from current prices. This study demonstrates that first-line GS achieves higher diagnostic rate than contemporary ES but at a higher cost.
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1455352-1
ISSN	1530-0366 ; 1098-3600
ISSN (online)	1530-0366
ISSN	1098-3600
DOI	10.1016/j.gim.2024.101076
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Zs.A 5059: Show issues

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Article ; Online: Whole exome and genome sequencing in mendelian disorders: a diagnostic and health economic analysis.

Ewans, Lisa J / Minoche, Andre E / Schofield, Deborah / Shrestha, Rupendra / Puttick, Clare / Zhu, Ying / Drew, Alexander / Gayevskiy, Velimir / Elakis, George / Walsh, Corrina / Adès, Lesley C / Colley, Alison / Ellaway, Carolyn / Evans, Carey-Anne / Freckmann, Mary-Louise / Goodwin, Linda / Hackett, Anna / Kamien, Benjamin / Kirk, Edwin P /

Lipke, Michelle / Mowat, David / Palmer, Elizabeth / Rajagopalan, Sulekha / Ronan, Anne / Sachdev, Rani / Stevenson, William / Turner, Anne / Wilson, Meredith / Worgan, Lisa / Morel-Kopp, Marie-Christine / Field, Michael / Buckley, Michael F / Cowley, Mark J / Dinger, Marcel E / Roscioli, Tony

European journal of human genetics : EJHG

2022 Volume 30, Issue 10, Page(s) 1121–1131

Abstract: Whole genome sequencing (WGS) improves Mendelian disorder diagnosis over whole exome sequencing (WES); however, additional diagnostic yields and costs remain undefined. We investigated differences between diagnostic and cost outcomes of WGS and WES in a ... ...

Abstract	Whole genome sequencing (WGS) improves Mendelian disorder diagnosis over whole exome sequencing (WES); however, additional diagnostic yields and costs remain undefined. We investigated differences between diagnostic and cost outcomes of WGS and WES in a cohort with suspected Mendelian disorders. WGS was performed in 38 WES-negative families derived from a 64 family Mendelian cohort that previously underwent WES. For new WGS diagnoses, contemporary WES reanalysis determined whether variants were diagnosable by original WES or unique to WGS. Diagnostic rates were estimated for WES and WGS to simulate outcomes if both had been applied to the 64 families. Diagnostic costs were calculated for various genomic testing scenarios. WGS diagnosed 34% (13/38) of WES-negative families. However, contemporary WES reanalysis on average 2 years later would have diagnosed 18% (7/38 families) resulting in a WGS-specific diagnostic yield of 19% (6/31 remaining families). In WES-negative families, the incremental cost per additional diagnosis using WGS following WES reanalysis was AU$36,710 (£19,407;US$23,727) and WGS alone was AU$41,916 (£22,159;US$27,093) compared to WES-reanalysis. When we simulated the use of WGS alone as an initial genomic test, the incremental cost for each additional diagnosis was AU$29,708 (£15,705;US$19,201) whereas contemporary WES followed by WGS was AU$36,710 (£19,407;US$23,727) compared to contemporary WES. Our findings confirm that WGS is the optimal genomic test choice for maximal diagnosis in Mendelian disorders. However, accepting a small reduction in diagnostic yield, WES with subsequent reanalysis confers the lowest costs. Whether WES or WGS is utilised will depend on clinical scenario and local resourcing and availability.
MeSH term(s)	Base Sequence ; Chromosome Mapping ; Exome ; Humans ; Whole Exome Sequencing ; Whole Genome Sequencing
Language	English
Publishing date	2022-08-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1141470-4
ISSN	1476-5438 ; 1018-4813
ISSN (online)	1476-5438
ISSN	1018-4813
DOI	10.1038/s41431-022-01162-2
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Zs.A 3589: Show issues

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Article ; Online: Donor heart ischemic time can be extended beyond 9 hours using hypothermic machine perfusion in sheep.

See Hoe, Louise E / Li Bassi, Gianluigi / Wildi, Karin / Passmore, Margaret R / Bouquet, Mahe / Sato, Kei / Heinsar, Silver / Ainola, Carmen / Bartnikowski, Nicole / Wilson, Emily S / Hyslop, Kieran / Skeggs, Kris / Obonyo, Nchafatso G / Shuker, Tristan / Bradbury, Lucy / Palmieri, Chiara / Engkilde-Pedersen, Sanne / McDonald, Charles / Colombo, Sebastiano M /

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

2023 Volume 42, Issue 8, Page(s) 1015–1029

Abstract: ... for clinical transplantation where longer ischemic times may be required (e.g., complex surgical cases ...

Abstract	Background: The global shortage of donor hearts available for transplantation is a major problem for the treatment of end-stage heart failure. The ischemic time for donor hearts using traditional preservation by standard static cold storage (SCS) is limited to approximately 4 hours, beyond which the risk for primary graft dysfunction (PGD) significantly increases. Hypothermic machine perfusion (HMP) of donor hearts has been proposed to safely extend ischemic time without increasing the risk of PGD. Methods: Using our sheep model of 24 hours brain death (BD) followed by orthotopic heart transplantation (HTx), we examined post-transplant outcomes in recipients following donor heart preservation by HMP for 8 hours, compared to donor heart preservation for 2 hours by either SCS or HMP. Results: Following HTx, all HMP recipients (both 2 hours and 8 hours groups) survived to the end of the study (6 hours after transplantation and successful weaning from cardiopulmonary bypass), required less vasoactive support for hemodynamic stability, and exhibited superior metabolic, fluid status and inflammatory profiles compared to SCS recipients. Contractile function and cardiac damage (troponin I release and histological assessment) was comparable between groups. Conclusions: Overall, compared to current clinical SCS, recipient outcomes following transplantation are not adversely impacted by extending HMP to 8 hours. These results have important implications for clinical transplantation where longer ischemic times may be required (e.g., complex surgical cases, transport across long distances). Additionally, HMP may allow safe preservation of "marginal" donor hearts that are more susceptible to myocardial injury and facilitate increased utilization of these hearts for transplantation.
MeSH term(s)	Animals ; Sheep ; Humans ; Heart Transplantation ; Organ Preservation/methods ; Tissue Donors ; Perfusion/methods ; Heart
Language	English
Publishing date	2023-04-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1062522-7
ISSN	1557-3117 ; 1053-2498
ISSN (online)	1557-3117
ISSN	1053-2498
DOI	10.1016/j.healun.2023.03.020
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Article: The Social Bridging Project: Intergenerational Phone-Based Connections With Older Adults During the COVID-19 Pandemic.

Noble, Louise W / Olson, Emma / Woodall, Tasha / Jones, Jeff / Smythe, Thomas / Whitlock, Cathy / Silver, Meredith / Hewitt, Lyndi / Lanou, Amy J

Gerontology & geriatric medicine

2022 Volume 8, Page(s) 23337214221083473

Abstract: Millions of Americans aged ... ...

Abstract	Millions of Americans aged 65
Language	English
Publishing date	2022-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844974-5
ISSN	2333-7214 ; 2333-7214
ISSN (online)	2333-7214
ISSN	2333-7214
DOI	10.1177/23337214221083473
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