LIVIVO - Search results -

Search results

Result 1 - 10 of total 41

Search options

Article ; Online: PCSK9 genetic (rs11591147) and epigenetic (DNA methylation) modifications associated with PCSK9 expression and serum proteins in CAD patients.

Shyamala, Nivas / Gundapaneni, Kishore Kumar / Galimudi, Rajesh Kumar / Tupurani, Mohini Aiyengar / Padala, Chiranjeevi / Puranam, Kaushik / Kupsal, Keerthi / Kummari, Ramanjaneyulu / Gantala, Srilatha Reddy / Nallamala, Krishna Reddy / Sahu, Sanjib K / Hanumanth, Surekha Rani

The journal of gene medicine

2021 Volume 23, Issue 8, Page(s) e3346

Abstract: Introduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) genetic polymorphisms play a significant role in cholesterol homeostasis. Therefore, we aimed to investigate the association of PCSK9 genetic variations NM_174936.3:c.137G>T (R46L, ... ...

Abstract	Introduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) genetic polymorphisms play a significant role in cholesterol homeostasis. Therefore, we aimed to investigate the association of PCSK9 genetic variations NM_174936.3:c.137G>T (R46L, rs11591147) and NM_174936.3:c.1120G>T (D374Y, rs137852912), as well as promoter DNA methylation status, with mRNA expression and circulating serum protein levels in coronary artery disease (CAD) patients. Methods: The present study includes 300 CAD cases and 300 controls from South India. Biochemical assays were performed using commercially available kits. PCSK9 rs11591147 and rs137852912 polymorphisms were analyzed by the polymerase chain reaction (PCR)-restriction fragment length polymorphism method, whereas promoter DNA methylation status and gene expression were determined using methylation specific PCR and quantitative PCR respectively. Results: The genotypic distribution of PCSK9 rs11591147 revealed that individuals with the TT-genotype and T-allele have a reduced risk for CAD. Furthermore, patients with the PCSK9 rs11591147 TT genotype have a significantly lower total cholesterol and low-density lipoprotein-cholesterol levels and also higher high-density lipoprotein-cholesterol levels than individuals with the GG genotype. Logistic regression analysis has shown that the GG and GT (p = 1.51 × 10 Conclusions: In conclusion, the present study indicates that the PCSK9 gene expression and circulating serum protein levels are not only associated with rs11591147 genotype, but also with promoter DNA methylation. Furthermore, the findings with respect to both single nucleotide polymorphism and promoter DNA methylation may open avenues for novel treatment possibilities targeting PCSK9 for CAD management.
MeSH term(s)	Adult ; Case-Control Studies ; Coronary Artery Disease/blood ; Coronary Artery Disease/etiology ; Coronary Artery Disease/genetics ; CpG Islands ; DNA Methylation ; Epigenesis, Genetic ; Female ; Gene Expression ; Genetic Predisposition to Disease ; Humans ; India ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Proprotein Convertase 9/blood ; Proprotein Convertase 9/genetics ; Protein Stability ; RNA, Messenger/blood ; RNA, Messenger/chemistry
Chemical Substances	RNA, Messenger ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-)
Language	English
Publishing date	2021-05-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1458024-x
ISSN	1521-2254 ; 1099-498X
ISSN (online)	1521-2254
ISSN	1099-498X
DOI	10.1002/jgm.3346
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5423: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Stacking herbicide detoxification and resistant genes improves glyphosate tolerance and reduces phytotoxicity in tobacco (Nicotiana tabacum L.) and rice (Oryza sativa L.).

Vennapusa, Amaranatha Reddy / Agarwal, Subham / Rao Hm, Hanumanth / Aarthy, Thiagarayaselvam / Babitha, K C / Thulasiram, Hirekodathakallu V / Kulkarni, Mahesh J / Melmaiee, Kalpalatha / Sudhakar, Chinta / Udayakumar, M / S Vemanna, Ramu

Plant physiology and biochemistry : PPB

2022 Volume 189, Page(s) 126–138

Abstract: Glyphosate residues retained in the growing meristematic tissues or in grains of glyphosate-resistant crops affect the plants physiological functions and crop yield. Removing glyphosate residues in the plants is desirable with no penalty on crop yield ... ...

Abstract	Glyphosate residues retained in the growing meristematic tissues or in grains of glyphosate-resistant crops affect the plants physiological functions and crop yield. Removing glyphosate residues in the plants is desirable with no penalty on crop yield and quality. We report a new combination of scientific strategy to detoxify glyphosate that reduces the residual levels and improve crop resistance. The glyphosate detoxifying enzymes Aldo-keto reductase (AKR1) and mutated glycine oxidase (mGO) with different modes of action were co-expressed with modified EPSPS, which is insensitive to glyphosate in tobacco (Nicotiana tabacum L.) and rice (Oryza sativa L.). The transgenic tobacco plants expressing individual PsAKR1, mGO, CP4-EPSPS, combinations of PsAKR1:CP4EPSPS, PsAKR1:mGO, and multigene with PsAKR1: mGO: CP4EPSPS genes were developed. The bio-efficacy studies of in-vitro leaf regeneration on different concentrations of glyphosate, seedling bioassay, and spray on transgenic tobacco plants demonstrate that glyphosate detoxification with enhanced resistance. Comparative analysis of the transgenic tobacco plants reveals that double and multigene expressing transgenics had reduced accumulation of shikimic acid, glyphosate, and its primary residue AMPA, and increased levels of sarcosine were observed in all PsAKR1 expressing transgenics. The multigene expressing rice transgenics showed improved glyphosate resistance with yield maintenance. In summary, results suggest that stacking genes with two different detoxification mechanisms and insensitive EPSPS is a potential approach for developing glyphosate-resistant plants with less residual content.
MeSH term(s)	3-Phosphoshikimate 1-Carboxyvinyltransferase/genetics ; Aldo-Keto Reductases ; Glycine/analogs & derivatives ; Herbicide Resistance/genetics ; Herbicides/pharmacology ; Magnesium Oxide ; Oryza ; Plants, Genetically Modified ; Sarcosine/genetics ; Shikimic Acid ; Nicotiana/genetics ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid ; Glyphosate
Chemical Substances	Herbicides ; Shikimic Acid (29MS2WI2NU) ; Magnesium Oxide (3A3U0GI71G) ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (77521-29-0) ; Aldo-Keto Reductases (EC 1.1.1.-) ; 3-Phosphoshikimate 1-Carboxyvinyltransferase (EC 2.5.1.19) ; Glycine (TE7660XO1C) ; Sarcosine (Z711V88R5F)
Language	English
Publishing date	2022-09-03
Publishing country	France
Document type	Journal Article
ZDB-ID	742978-2
ISSN	1873-2690 ; 0981-9428
ISSN (online)	1873-2690
ISSN	0981-9428
DOI	10.1016/j.plaphy.2022.08.025
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 2696: Show issues
Z 2005/727: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Stacking herbicide detoxification and resistant genes improves glyphosate tolerance and reduces phytotoxicity in tobacco (Nicotiana tabacum L.) and rice (Oryza sativa L.)

Vennapusa, Amaranatha Reddy / Agarwal, Subham / Rao Hm, Hanumanth / Aarthy, Thiagarayaselvam / Babitha, K.C. / Thulasiram, Hirekodathakallu V. / Kulkarni, Mahesh J. / Melmaiee, Kalpalatha / Sudhakar, Chinta / Udayakumar, M. / S Vemanna, Ramu

Elsevier Masson SAS Plant physiology and biochemistry. 2022 Oct. 15, v. 189

2022

Abstract	Glyphosate residues retained in the growing meristematic tissues or in grains of glyphosate-resistant crops affect the plants physiological functions and crop yield. Removing glyphosate residues in the plants is desirable with no penalty on crop yield and quality. We report a new combination of scientific strategy to detoxify glyphosate that reduces the residual levels and improve crop resistance. The glyphosate detoxifying enzymes Aldo-keto reductase (AKR1) and mutated glycine oxidase (mGO) with different modes of action were co-expressed with modified EPSPS, which is insensitive to glyphosate in tobacco (Nicotiana tabacum L.) and rice (Oryza sativa L.). The transgenic tobacco plants expressing individual PsAKR1, mGO, CP4-EPSPS, combinations of PsAKR1:CP4EPSPS, PsAKR1:mGO, and multigene with PsAKR1: mGO: CP4EPSPS genes were developed. The bio-efficacy studies of in-vitro leaf regeneration on different concentrations of glyphosate, seedling bioassay, and spray on transgenic tobacco plants demonstrate that glyphosate detoxification with enhanced resistance. Comparative analysis of the transgenic tobacco plants reveals that double and multigene expressing transgenics had reduced accumulation of shikimic acid, glyphosate, and its primary residue AMPA, and increased levels of sarcosine were observed in all PsAKR1 expressing transgenics. The multigene expressing rice transgenics showed improved glyphosate resistance with yield maintenance. In summary, results suggest that stacking genes with two different detoxification mechanisms and insensitive EPSPS is a potential approach for developing glyphosate-resistant plants with less residual content.
Keywords	Nicotiana tabacum ; Oryza sativa ; aldo-keto reductases ; bioassays ; crop yield ; genetically modified organisms ; glyphosate ; glyphosate resistance ; leaves ; meristems ; new combination ; phytotoxicity ; plant physiology ; rice ; sarcosines ; seedlings ; shikimic acid ; tobacco
Language	English
Dates of publication	2022-1015
Size	p. 126-138.
Publishing place	Elsevier Masson SAS
Document type	Article
ZDB-ID	742978-2
ISSN	1873-2690 ; 0981-9428
ISSN (online)	1873-2690
ISSN	0981-9428
DOI	10.1016/j.plaphy.2022.08.025
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 2696: Show issues
Z 2005/727: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Validation of Two-Phase Flow Model for Leachate Recirculation in Bioreactor Landfills

Krishna R. Reddy / Rajiv K. Giri / Hanumanth S. Kulkarni

Journal of Waste Management, Vol

2014 Volume 2014

Abstract: A numerical two-phase flow model is presented to determine the moisture distribution and pore water and gas pressures within unsaturated municipal solid waste (MSW) in bioreactor landfills during leachate recirculation. The numerical model used is the ... ...

Abstract	A numerical two-phase flow model is presented to determine the moisture distribution and pore water and gas pressures within unsaturated municipal solid waste (MSW) in bioreactor landfills during leachate recirculation. The numerical model used is the Fast Lagrangian Analysis of Continua (FLAC), which is based on finite difference approach. The model governing equations and mathematical formulations is briefly explained. Validation of the model is examined by simulating the published laboratory and field studies and published modeling studies. Overall, the two-phase flow model is found to produce results comparable with those of the published studies. This assures that the model can be used for the prediction of moisture distribution and for the rational design of leachate recirculation systems in bioreactor landfills.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Multidisciplinary Approach in Management of Fractured Central Incisor through Composite Plug Stabilization - A Case Report.

C, Sushil Kumar / Rao, Amit / K, Sheila / G, Hanumanth Reddy

Journal of international oral health : JIOH

2013 Volume 5, Issue 1, Page(s) 79–82

Abstract: ... K C, Rao A, Sheila K, Hanumanth R G. Multidisciplinary Approach in Management of Fractured Central ...

Abstract	Crown fracture is the most frequent type of traumatic injury in permanent dentition. Traumatized anterior teeth requires quick functional and esthetic repair. Traditionally such injuries have been restored with conventional post-core and crown techniques after endodontic treatment. This article presents an innovative technique of managing a complicate crown fracture of anterior tooth where plain orthodontic band was used for stabilization and post endodontic restoration was done with adhesively luted fiber reinforced composite post through fragment and composite plug stabilization. How to cite this article: Sushil K C, Rao A, Sheila K, Hanumanth R G. Multidisciplinary Approach in Management of Fractured Central Incisor through Composite Plug Stabilization - A Case Report. J Int Oral Health 2013; 5(1):79-82.
Language	English
Publishing date	2013-02-26
Publishing country	India
Document type	Case Reports
ZDB-ID	2617124-7
ISSN	0976-1799 ; 0976-7428
ISSN (online)	0976-1799
ISSN	0976-7428
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Understanding the application of stem cell therapy in cardiovascular diseases.

Sharma, Rakesh K / Voelker, Donald J / Sharma, Roma / Reddy, Hanumanth K

Stem cells and cloning : advances and applications

2012 Volume 5, Page(s) 29–37

Abstract: Throughout their lifetime, an individual may sustain many injuries and recover spontaneously over a period of time, without even realizing the injury in the first place. Wound healing occurs due to a proliferation of stem cells capable of restoring the ... ...

Abstract	Throughout their lifetime, an individual may sustain many injuries and recover spontaneously over a period of time, without even realizing the injury in the first place. Wound healing occurs due to a proliferation of stem cells capable of restoring the injured tissue. The ability of adult stem cells to repair tissue is dependent upon the intrinsic ability of tissues to proliferate. The amazing capacity of embryonic stem cells to give rise to virtually any type of tissue has intensified the search for similar cell lineage in adults to treat various diseases including cardiovascular diseases. The ability to convert adult stem cells into pluripotent cells that resemble embryonic cells, and to transplant those in the desired organ for regenerative therapy is very attractive, and may offer the possibility of treating harmful disease-causing mutations. The race is on to find the best cells for treatment of cardiovascular disease. There is a need for the ideal stem cell, delivery strategies, myocardial retention, and time of administration in the ideal patient population. There are multiple modes of stem cell delivery to the heart with different cell retention rates that vary depending upon method and site of injection, such as intra coronary, intramyocardial or via coronary sinus. While there are crucial issues such as retention of stem cells, microvascular plugging, biodistribution, homing to myocardium, and various proapoptotic factors in the ischemic myocardium, the regenerative potential of stem cells offers an enormous impact on clinical applications in the management of cardiovascular diseases.
Language	English
Publishing date	2012-10-30
Publishing country	New Zealand
Document type	Journal Article ; Review
ISSN	1178-6957
ISSN	1178-6957
DOI	10.2147/SCCAA.S28500
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Thinking beyond low-density lipoprotein cholesterol: strategies to further reduce cardiovascular risk.

Sharma, Rakesh K / Singh, Vibhuti N / Reddy, Hanumanth K

Vascular health and risk management

2009 Volume 5, Page(s) 793–799

Abstract: Several large statin trials and meta-analyses have demonstrated a reduction in low-density lipoprotein cholesterol (LDL-C) and cardiovascular morbidity and mortality. Some trials have also highlighted the significance of residual cardiovascular risk ... ...

Abstract	Several large statin trials and meta-analyses have demonstrated a reduction in low-density lipoprotein cholesterol (LDL-C) and cardiovascular morbidity and mortality. Some trials have also highlighted the significance of residual cardiovascular risk after treatment of LDL-C to target levels. This reflects the complex nature of residual cardiovascular risk. This residual risk is partially due to low HDL-C and high triglycerides (TG) despite achievement of LDL goals with statin therapy. The NCEP ATP III guidelines reported that low HDL-C is a significant and an independent risk factor for coronary heart disease (CHD) and is inversely related to CHD. Epidemiologic studies have also shown a similar inverse relationship of HDL-C with CHD. High-density lipoprotein cholesterol (HDL-C) may directly participate in the anti-atherogenic process by promoting efflux of cholesterol of the foam cells of atherogenic lesions. Many studies have demonstrated multiple anti-atherogenic actions of HDL-C and its role in promoting efflux of cholesterol from the foam cells. The residual risk by increased TG with or without low HDL-C can be assessed by calculating non-HDL-C and a reduction in TG results in decreased CHD.
MeSH term(s)	Biomarkers/blood ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Clofibric Acid/therapeutic use ; Drug Therapy, Combination ; Dyslipidemias/blood ; Dyslipidemias/complications ; Dyslipidemias/drug therapy ; Fatty Acids, Omega-3/therapeutic use ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hypolipidemic Agents/therapeutic use ; Niacin/therapeutic use ; Risk Assessment ; Risk Factors ; Treatment Outcome ; Triglycerides/blood
Chemical Substances	Biomarkers ; Cholesterol, HDL ; Cholesterol, LDL ; Fatty Acids, Omega-3 ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Hypolipidemic Agents ; Triglycerides ; Niacin (2679MF687A) ; Clofibric Acid (53PF01Q249)
Language	English
Publishing date	2009-09-24
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2186568-1
ISSN	1178-2048 ; 1176-6344
ISSN (online)	1178-2048
ISSN	1176-6344
DOI	10.2147/vhrm.s5684
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6066: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: New tools for prevention of restenosis could decrease the "oculo-stento" reflex.

Sturek, Michael / Reddy, Hanumanth K

Cardiovascular research

2002 Volume 53, Issue 2, Page(s) 292–293

MeSH term(s)	Angioplasty, Balloon, Coronary ; Animals ; Antibiotics, Antineoplastic/therapeutic use ; Antineoplastic Agents/therapeutic use ; Coronary Restenosis/prevention & control ; Coronary Stenosis/therapy ; Docetaxel ; Drug Implants ; Humans ; Injections, Intra-Arterial ; Models, Animal ; Paclitaxel/analogs & derivatives ; Paclitaxel/therapeutic use ; Rabbits ; Rats ; Sirolimus/therapeutic use ; Stents ; Taxoids
Chemical Substances	Antibiotics, Antineoplastic ; Antineoplastic Agents ; Drug Implants ; Taxoids ; Docetaxel (15H5577CQD) ; Paclitaxel (P88XT4IS4D) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2002-02-01
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	80340-6
ISSN	1755-3245 ; 0008-6363
ISSN (online)	1755-3245
ISSN	0008-6363
DOI	10.1016/s0008-6363(01)00567-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 565: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Aspirin and clopidogrel hyporesponsiveness and nonresponsiveness in patients with coronary artery stenting

Rakesh K Sharma / Hanumanth K Reddy / Vibhuti N Singh

Vascular Health and Risk Management, Vol 2009, Iss default, Pp 965-

2009 Volume 972

Abstract: Rakesh K Sharma1, Hanumanth K Reddy1, Vibhuti N Singh2, Rohit Sharma1, Donald J Voelker1, Girish ...

Abstract	Rakesh K Sharma1, Hanumanth K Reddy1, Vibhuti N Singh2, Rohit Sharma1, Donald J Voelker1, Girish Bhatt11Medical Center of South Arkansas, El Dorado, University of Arkansas for Medical Sciences, Little Rock, AR, USA; 2Bayfront Medical Center, St. Petersburg, University of South Florida, Tampa, FL, USAAbstract: Patients undergoing coronary artery stenting receive an antiplatelet regimen to reduce the risk of antithrombotic complications. Current guidelines recommend the use of acetyl salicylic acid (aspirin) and clopidogrel as evidenced by large clinical trials. There has been a concern about variable responses of patients to aspirin and clopidogrel which may predispose them to subacute stent thrombosis or late stent thrombosis. Up to 25% of patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) were found to have hyporesponsiveness or resistance to clopidogrel which may predispose them to recurrent events. Dual antiplatelet regimen is a standard therapy in these patients and there is always a concern about variable responses to aspirin and clopidogrel predisposing them to acute coronary syndrome (ACS). Prevalence of this hyporesponsiveness or resistance may be due to noncompliance, genetic mutations, co-morbid situations and concomitant use of other drugs. This issue is of considerable importance in the era of coronary drug eluting stents when a long-term dual antiplatelet regimen is needed. This paper is a review for clinicians taking care of such patients with hyporesponsiveness or nonresponsiveness to dual antiplatelet regimen.Keywords: aspirin, clopidogrel, acute coronary syndrome, coronary artery stenting
Keywords	Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2009-11-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Thinking beyond low-density lipoprotein cholesterol

Rakesh K Sharma / Vibhuti N Singh / Hanumanth K Reddy

Vascular Health and Risk Management, Vol 2009, Iss default, Pp 793-

strategies to further reduce cardiovascular risk

2009 Volume 799

Abstract: Rakesh K Sharma1, Vibhuti N Singh2, Hanumanth K Reddy11Medical Center of South Arkansas, El Dorado ...

Abstract	Rakesh K Sharma1, Vibhuti N Singh2, Hanumanth K Reddy11Medical Center of South Arkansas, El Dorado, University of Arkansas for Medical Sciences, Little Rock, AR, USA; 2Bayfront Medical Center, University of South Florida, St. Petersburg, FL, USAAbstract: Several large statin trials and meta-analyses have demonstrated a reduction in low-density lipoprotein cholesterol (LDL-C) and cardiovascular morbidity and mortality. Some trials have also highlighted the significance of residual cardiovascular risk after treatment of LDL-C to target levels. This reflects the complex nature of residual cardiovascular risk. This residual risk is partially due to low HDL-C and high triglycerides (TG) despite achievement of LDL goals with statin therapy. The NCEP ATP III guidelines reported that low HDL-C is a significant and an independent risk factor for coronary heart disease (CHD) and is inversely related to CHD. Epidemiologic studies have also shown a similar inverse relationship of HDL-C with CHD. High-density lipoprotein cholesterol (HDL-C) may directly participate in the anti-atherogenic process by promoting efflux of cholesterol of the foam cells of atherogenic lesions. Many studies have demonstrated multiple anti-atherogenic actions of HDL-C and its role in promoting efflux of cholesterol from the foam cells. The residual risk by increased TG with or without low HDL-C can be assessed by calculating non–HDL-C and a reduction in TG results in decreased CHD.Keywords: low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, statins, coronary heart disease
Keywords	Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2009-09-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED