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Article ; Online: A special role for the genotype? Some comments on Keith Baverstock: "The gene: An appraisal".

Roll-Hansen, Nils

Progress in biophysics and molecular biology

2022 Volume 172, Page(s) 82–89

Abstract: ... founded when introduced and still is. Keith Baverstock's criticism does not consider the force of the bean ...

Abstract	There is at present uneasiness about the conceptual basis of genetics. The gene concept has become blurred and there are problems with the distinction between genotype and phenotype. In the present paper I go back to their role in the creation of modern genetics in the early twentieth century. The terms were introduced by the Danish botanist and geneticist Wilhelm Johannsen in his big textbook of 1909. Historical accounts usually concentrate on this book and his 1911 paper "The Genotype Conception of Heredity." His bean selection experiment of 1900-1903 is generally assumed to be the source of his genotype theory. The present paper examines the scientific context and meaning of this experiment, how it was received, and how the genotype theory became securely established by the early 1910s. I argue in conclusion that the genotype/phenotype distinction, which provides the empirical basis for Johannsen's gene, was scientifically well founded when introduced and still is. Keith Baverstock's criticism does not consider the force of the bean selection experiment at the time and as a paradigm for following investigations of heredity.
MeSH term(s)	Genotype ; History, 20th Century ; Humans ; Phenotype ; Physicians
Language	English
Publishing date	2022-04-01
Publishing country	England
Document type	Historical Article ; Letter
ZDB-ID	209302-9
ISSN	1873-1732 ; 0079-6107
ISSN (online)	1873-1732
ISSN	0079-6107
DOI	10.1016/j.pbiomolbio.2022.03.005
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Book: Keith Richards und die Rolling Stones

Charone, Barbara / Hansen, Niko

(Fischer-Taschenbücher ; 2983)

1985

Title translation	Keith Richards <dt.>
Author's details	Barbara Charone; Aus d. Engl. von Niko Hansen
Series title	Fischer-Taschenbücher ; 2983
Language	German
Size	332 S, Ill, 19 cm
Edition	Deutsche Ausgabe
Document type	Book
Note	Diskogr. S. 329 - 332
ISBN	3596229839 ; 9783596229833
Database	Former special subject collection: coastal and deep sea fishing

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Article: COVID-19 Vaccination Among Reproductive Age Patients: An Opportunity Knocks.

Feng, Shelley / Hansen, Keith A

South Dakota medicine : the journal of the South Dakota State Medical Association

2022 Volume 74, Issue 11, Page(s) 500–501

MeSH term(s)	COVID-19 ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; Vaccination
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-01-07
Publishing country	United States
Document type	Editorial
ZDB-ID	2278073-7
ISSN	0038-3317
ISSN	0038-3317
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Article: Complementary and Alternative Treatments for Postpartum Depression.

Mammenga, Emily / Hansen, Keith A

South Dakota medicine : the journal of the South Dakota State Medical Association

2022 Volume 74, Issue 11, Page(s) 506–512

Abstract: Complementary and alternative treatments are commonly requested as treatment options for depression. This article provides a review of evidence for complementary and alternative therapies (doula support, saffron, yoga, aromatherapy, placentophagy, ... ...

Abstract	Complementary and alternative treatments are commonly requested as treatment options for depression. This article provides a review of evidence for complementary and alternative therapies (doula support, saffron, yoga, aromatherapy, placentophagy, mindfulness, probiotics and wake therapy) in the treatment of postpartum depression. The included studies, mainly randomized control trials, focus on the efficacy of these interventions as compared to standard pharmacotherapy and or no treatment.
MeSH term(s)	Aromatherapy ; Complementary Therapies ; Depression, Postpartum ; Female ; Humans ; Placenta ; Postpartum Period ; Pregnancy ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-01-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2278073-7
ISSN	0038-3317
ISSN	0038-3317
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Article ; Online: What Is New in Ovulation Induction?: Best Articles From the Past Year.

Hansen, Keith A

Obstetrics and gynecology

2019 Volume 133, Issue 2, Page(s) 376–378

Abstract: This month we focus on current research in ovulation induction. Dr. Hansen discusses five recent ...

Abstract	This month we focus on current research in ovulation induction. Dr. Hansen discusses five recent publications, which are concluded with a "bottom-line" that is the take-home message. A complete reference for each can be found on on this page along with direct links to abstracts.
Language	English
Publishing date	2019-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	207330-4
ISSN	1873-233X ; 0029-7844
ISSN (online)	1873-233X
ISSN	0029-7844
DOI	10.1097/AOG.0000000000003085
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Article: Menstrual Migraines: Diagnosis, Evidence, and Treatment.

Olson, Avery K / Hansen, Keith A

South Dakota medicine : the journal of the South Dakota State Medical Association

2022 Volume 74, Issue 12, Page(s) 570–575

Abstract: Menstrual" or "catamenial" migraine (MM) is separated into two categories in the International Classification of Headache Disorders pure menstrual migraine and menstrually-related migraine. Pure menstrual migraine is defined as a migraine occurring ... ...

Abstract	"Menstrual" or "catamenial" migraine (MM) is separated into two categories in the International Classification of Headache Disorders pure menstrual migraine and menstrually-related migraine. Pure menstrual migraine is defined as a migraine occurring exclusively on day 1 ± 2 of menstruation in at least two out of three menstrual cycles and at no other time in the cycle. Menstrually-related migraine is defined as the same but may occur at other times in the menstrual cycle, not just around menstruation. The withdrawal of estrogen has been correlated with the onset of MM, providing an opportunity for specific treatment with hormone therapies. Traditionally, MM has been treated with nonspecific treatments such as abortive and prophylactic non-steroidal anti-inflammatory drugs and triptans. While this is first line, evidence suggests that nonspecific treatments can be used in combination with specific hormone treatments. The hormone treatment recommended is either continuous combined hormonal contraceptives (CHCs) with no placebo pills or using just two days of placebo pills to avoid the estrogen withdrawal trigger. Although MM with aura is uncommon, when referring to using CHCs for MM with aura, the U.S. Medical Eligibility Criteria for Contraceptive Use 2016 categorizes MM with aura as "A condition that represents an unacceptable health risk if the contraceptive method is used." Therefore, the current recommendation is not to use CHCs with a history of menstrual migraine with aura, especially when other risk factors such as smoking are present. Other treatments such as GnRH agonists, selective estrogen receptor modulators, and bilateral oophorectomy have limited evidence.
MeSH term(s)	Contraception ; Female ; Headache ; Humans ; Menstrual Cycle ; Menstruation ; Migraine Disorders/diagnosis ; Migraine Disorders/drug therapy ; Migraine Disorders/etiology
Language	English
Publishing date	2022-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2278073-7
ISSN	0038-3317
ISSN	0038-3317
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Article: The Female Athlete Triad - What it is and Why it is Important in Primary Care.

Inman, Kristin L / Hansen, Keith A

South Dakota medicine : the journal of the South Dakota State Medical Association

2022 Volume 74, Issue 10, Page(s) 484–488

Abstract: The female athlete triad (FAT) is a disorder involving greater energy expenditure than energy consumption leading to 1) low energy availability (EA) with or without disordered eating 2) menstrual irregularities or amenorrhea and 3) low bone mineral ... ...

Abstract	The female athlete triad (FAT) is a disorder involving greater energy expenditure than energy consumption leading to 1) low energy availability (EA) with or without disordered eating 2) menstrual irregularities or amenorrhea and 3) low bone mineral density. Consequences of FAT include osteoporosis, stress fractures, increased cardiovascular risk, infertility, and negative psychological effects. The key risk factor for FAT is inadequate caloric intake when compared to the amount and intensity of exercise. All female athletes should be screened at least annually at pre-participation physicals or with signs of disordered eating, weight loss, abnormal growth or development, menstrual dysfunction, recent injuries, decreased athletic performance, or mood changes. Presence of one of the components of the triad necessitates further investigation. Treatment involves a multidisciplinary approach with increased energy intake and decreased exercise intensity being the primary goal of treatment. Understanding FAT is important for preventative medicine, as some consequences, such as infertility and loss of bone mineral density may not be reversible.
MeSH term(s)	Amenorrhea/etiology ; Bone Density ; Female ; Female Athlete Triad Syndrome/diagnosis ; Female Athlete Triad Syndrome/epidemiology ; Humans ; Osteoporosis/epidemiology ; Osteoporosis/prevention & control ; Primary Health Care
Language	English
Publishing date	2022-01-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2278073-7
ISSN	0038-3317
ISSN	0038-3317
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Article: Effects of alcohol use on sperm chromatin structure, a retrospective analysis.

Trautman, Ariadne / Gurumoorthy, Aarabhi / Hansen, Keith A

Basic and clinical andrology

2023 Volume 33, Issue 1, Page(s) 14

Abstract: Background: The evaluation of the infertile couple is often complex as multiple factors in both the male and female can contribute, including social history. Previous studies have displayed that male ethanol consumption can disturb sperm motility, ... ...

Abstract	Background: The evaluation of the infertile couple is often complex as multiple factors in both the male and female can contribute, including social history. Previous studies have displayed that male ethanol consumption can disturb sperm motility, nuclear maturity, and deoxyribonucleic acid (DNA) integrity. The main purpose of this study is to evaluate the effects of male alcohol use on sperm chromatin structure analysis (SCSA®). This study was a retrospective chart review of 209 couples that presented to a midsize infertility clinic in the Midwest and had a semen analysis and SCSA® performed. Data extracted from the electronic medical record included demographics, tobacco use, alcohol use, occupational exposures, semen analysis results, and SCSA® results (DNA Fragmentation index (DFI) and High DNA stainability (HDS)). Statistical analysis was performed on this data set to determine significance with a p-level of 0.05, with the primary input being level of alcohol use and primary outcome being the SCSA® parameters. Results: Overall, 11% of the cohort had heavy alcohol use (> 10 drinks/week), 27% moderate (3-10/week), 34% rare (0.5- < 3/week), and 28% none. 36% of the cohort had HDS > 10% (a marker of immature sperm chromatin). Level of alcohol use was not significantly associated with HDS > 10% or DFI. Heavier alcohol use was significantly associated with lower sperm count (p = 0.042). Increasing age was significantly associated with increasing DNA Fragmentation Index (p = 0.006), increased sperm count (p = 0.002), and lower semen volume (p = 0.022). Exposure to heat at work was significantly associated with lower semen volume (p = 0.042). Tobacco use was associated with lower sperm motility (p < 0.0001) and lower sperm count (p = 0.002). Conclusions: There was not a significant association between the level of alcohol use and the High DNA Stainability or DNA Fragmentation Index of sperm. Increasing age was associated with semen parameters as expected, heat exposure was associated with lower semen volume, and tobacco use was associated with lower sperm motility and density. Further studies could investigate alcohol use and reactive oxidative species in sperm.
Language	English
Publishing date	2023-06-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2732675-5
ISSN	2051-4190
ISSN	2051-4190
DOI	10.1186/s12610-023-00189-9
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Article: Tranexamic Acid in the Prevention and Treatment of Postpartum Hemorrhage: A Review.

Buchholz, Alaire / Hansen, Keith / Rodel, Rachel

South Dakota medicine : the journal of the South Dakota State Medical Association

2023 Volume 76, Issue 4, Page(s) 174–177

Abstract: Postpartum hemorrhage (PPH) continues to be one of the leading causes of maternal morbidity and mortality worldwide. The four main causes of PPH are uterine atony, lacerations, retained placenta, and bleeding diathesis. In the patient with PPH, immediate ...

Abstract	Postpartum hemorrhage (PPH) continues to be one of the leading causes of maternal morbidity and mortality worldwide. The four main causes of PPH are uterine atony, lacerations, retained placenta, and bleeding diathesis. In the patient with PPH, immediate evaluation is needed to diagnose and treat the underlying cause of hemorrhage. Uterotonic agents such as oxytocin remain first line for prevention and treatment of uterine atony. Studies have evaluated the antifibrinolytic tranexamic acid (TXA) as an adjunctive therapy in the prevention and treatment of PPH. TXA has been shown to reduce blood loss, bleeding-associated mortality, and transfusion rates in a variety of clinical settings and thus may serve a role in treating PPH. Current studies have demonstrated that TXA is an effective treatment option with limited risk of adverse events in appropriately selected patients; however, additional studies are needed to further clarify the role of TXA in the prevention of PPH.
MeSH term(s)	Pregnancy ; Female ; Humans ; Postpartum Hemorrhage/drug therapy ; Postpartum Hemorrhage/prevention & control ; Postpartum Hemorrhage/diagnosis ; Tranexamic Acid/therapeutic use ; Uterine Inertia/drug therapy ; Oxytocin/therapeutic use ; Antifibrinolytic Agents/therapeutic use
Chemical Substances	Tranexamic Acid (6T84R30KC1) ; Oxytocin (50-56-6) ; Antifibrinolytic Agents
Language	English
Publishing date	2023-08-11
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2278073-7
ISSN	0038-3317
ISSN	0038-3317
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Article ; Online: Effects of alcohol use on sperm chromatin structure, a retrospective analysis

Ariadne Trautman / Aarabhi Gurumoorthy / Keith A. Hansen

Basic and Clinical Andrology, Vol 33, Iss 1, Pp 1-

2023 Volume 15

Abstract: Abstract Background The evaluation of the infertile couple is often complex as multiple factors in both the male and female can contribute, including social history. Previous studies have displayed that male ethanol consumption can disturb sperm motility, ...

Abstract	Abstract Background The evaluation of the infertile couple is often complex as multiple factors in both the male and female can contribute, including social history. Previous studies have displayed that male ethanol consumption can disturb sperm motility, nuclear maturity, and deoxyribonucleic acid (DNA) integrity. The main purpose of this study is to evaluate the effects of male alcohol use on sperm chromatin structure analysis (SCSA®). This study was a retrospective chart review of 209 couples that presented to a midsize infertility clinic in the Midwest and had a semen analysis and SCSA® performed. Data extracted from the electronic medical record included demographics, tobacco use, alcohol use, occupational exposures, semen analysis results, and SCSA® results (DNA Fragmentation index (DFI) and High DNA stainability (HDS)). Statistical analysis was performed on this data set to determine significance with a p-level of 0.05, with the primary input being level of alcohol use and primary outcome being the SCSA® parameters. Results Overall, 11% of the cohort had heavy alcohol use (> 10 drinks/week), 27% moderate (3–10/week), 34% rare (0.5- < 3/week), and 28% none. 36% of the cohort had HDS > 10% (a marker of immature sperm chromatin). Level of alcohol use was not significantly associated with HDS > 10% or DFI. Heavier alcohol use was significantly associated with lower sperm count (p = 0.042). Increasing age was significantly associated with increasing DNA Fragmentation Index (p = 0.006), increased sperm count (p = 0.002), and lower semen volume (p = 0.022). Exposure to heat at work was significantly associated with lower semen volume (p = 0.042). Tobacco use was associated with lower sperm motility (p < 0.0001) and lower sperm count (p = 0.002). Conclusions There was not a significant association between the level of alcohol use and the High DNA Stainability or DNA Fragmentation Index of sperm. Increasing age was associated with semen parameters as expected, heat exposure was associated with lower ...
Keywords	Alcohol ; Infertility ; Sperm DNA fragmentation ; Sperm chromatin structure analysis ; Semen analysis ; SCSA ; Medicine (General) ; R5-920
Subject code	630
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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