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Article ; Online: Research progress of autoimmune diseases based on induced pluripotent stem cells.

Ren, Rutong / Jiang, Jinhe / Li, Xinxin / Zhang, Guirong

2024 Volume 15, Page(s) 1349138

Abstract: Autoimmune diseases can damage specific or multiple organs and tissues, influence the quality of life, and even cause disability and death. A 'disease in a dish' can be developed based on patients-derived induced pluripotent stem cells (iPSCs) and iPSCs- ... ...

Abstract	Autoimmune diseases can damage specific or multiple organs and tissues, influence the quality of life, and even cause disability and death. A 'disease in a dish' can be developed based on patients-derived induced pluripotent stem cells (iPSCs) and iPSCs-derived disease-relevant cell types to provide a platform for pathogenesis research, phenotypical assays, cell therapy, and drug discovery. With rapid progress in molecular biology research methods including genome-sequencing technology, epigenetic analysis, '-omics' analysis and organoid technology, large amount of data represents an opportunity to help in gaining an in-depth understanding of pathological mechanisms and developing novel therapeutic strategies for these diseases. This paper aimed to review the iPSCs-based research on phenotype confirmation, mechanism exploration, drug discovery, and cell therapy for autoimmune diseases, especially multiple sclerosis, inflammatory bowel disease, and type 1 diabetes using iPSCs and iPSCs-derived cells.
MeSH term(s)	Humans ; Induced Pluripotent Stem Cells ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Animals ; Drug Discovery ; Cell- and Tissue-Based Therapy/methods
Language	English
Publishing date	2024-04-24
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1349138
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identification of potential extracellular vesicle protein markers altered in osteosarcoma from public databases.

Zhang, Jinhe / Li, Huiyan

Proteomics. Clinical applications

2023 Volume 17, Issue 4, Page(s) e2200084

Abstract: Purpose: Extracellular vesicles (EVs) have become promising biomarkers for cancer management. Particularly, the molecular cargo such as proteins carried by EVs are similar to their cells of origin, providing important information that can be used for ... ...

Abstract	Purpose: Extracellular vesicles (EVs) have become promising biomarkers for cancer management. Particularly, the molecular cargo such as proteins carried by EVs are similar to their cells of origin, providing important information that can be used for cancer diagnostics, prognosis, and treatment monitoring. However, to date, molecular analysis on EVs is still challenging, limited by the availability of efficient analytical technologies, largely due to the small size of EVs. In this work, we developed a computational workflow for in silico identification of potential EV protein markers from genomic and proteomic databases, and applied it for the discovery of osteosarcoma (OS) EV protein markers. Experimental design: Both mRNA and protein data were computed and compared from publicly accessible databases, and top markers with high differential expression levels were selected. Results: Thirty nine markers were identified overexpressed and seven found to be downregulated. These identified markers have been found to be associated with OS on different aspects in literature, demonstrating the usability of this workflow. Conclusions and clinical relevance: This work provides a list of potential EV protein markers that are either overexpressed or downregulated in OS for further experimental validation for improved clinical management of OS.
MeSH term(s)	Humans ; Proteomics ; Osteosarcoma/genetics ; Osteosarcoma/metabolism ; Biomarkers/metabolism ; Extracellular Vesicles/genetics ; Extracellular Vesicles/metabolism ; Bone Neoplasms/genetics ; Bone Neoplasms/metabolism
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-01-03
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2261788-7
ISSN	1862-8354 ; 1862-8346
ISSN (online)	1862-8354
ISSN	1862-8346
DOI	10.1002/prca.202200084
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Article: Relationship between Nitrogen Dynamics and Key Microbial Nitrogen-Cycling Genes in an Intensive Freshwater Aquaculture Pond.

Yan, Yifeng / Zhou, Junbo / Du, Chenghao / Yang, Qian / Huang, Jinhe / Wang, Zhaolei / Xu, Jun / Zhang, Min

Microorganisms

2024 Volume 12, Issue 2

Abstract: Intensive aquaculture in high-density hybrid snakehead [ ...

Abstract	Intensive aquaculture in high-density hybrid snakehead [
Language	English
Publishing date	2024-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12020266
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Article ; Online: Rare perivascular epithelial cell tumor of the colon 18F-FDG PET/CT imaging: A case report.

Chen, Qianqian / Wang, Peiqi / Zhang, Xiao / Zhang, Jinhe

Medicine

2023 Volume 102, Issue 20, Page(s) e33802

Abstract: Rationale: Neoplasms with perivascular epithelioid cell differentiation (PEComas) are mesenchymal tumors that rarely occur in the colon. Here, we report the occurrence of a malignant PEcoma in the colon using 18F-fluorodeoxyglucose positron emission ... ...

Abstract	Rationale: Neoplasms with perivascular epithelioid cell differentiation (PEComas) are mesenchymal tumors that rarely occur in the colon. Here, we report the occurrence of a malignant PEcoma in the colon using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). Patient concerns: A 55-year-old woman was admitted to the hospital with abdominal pain for 10 days and a self-induced abdominal mass for 3 days. 18F-FDG PET/CT imaging showed a large hypermetabolic nodule and mass in the right mid-upper abdomen with heterogeneous density and a further increase in metabolism on the delayed scan. Diagnoses: PEComa of the colon. Interventions: Tumor resection was performed. Outcomes: The patient is well after 2 months of treatment, pending further follow-up. Lessons: Malignant perivascular epithelioid cell tumors originating in the colon are extremely rare, and our report suggests that PEComa should be considered as a differential diagnosis for 18F-FDG gastrointestinal malignancies. Additionally, 18F-FDG PET/CT may play a key role in the staging and extent of lesions in intestinal malignancies.
MeSH term(s)	Female ; Humans ; Middle Aged ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography/methods ; Perivascular Epithelioid Cell Neoplasms/diagnostic imaging ; Perivascular Epithelioid Cell Neoplasms/surgery ; Perivascular Epithelioid Cell Neoplasms/pathology ; Colonic Neoplasms/diagnostic imaging ; Colonic Neoplasms/surgery ; Epithelial Cells/pathology ; Radiopharmaceuticals ; Positron-Emission Tomography
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
Language	English
Publishing date	2023-06-19
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000033802
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Article ; Online: The Spatiotemporal Patterns and Driving Factors of Culture and Tourism Listed Companies in China

Wenjie Hu / Jinhe Zhang / Leying Zhou / Yi Sun

Sustainability, Vol 15, Iss 7686, p

2023 Volume 7686

Abstract: The integration of culture and tourism is the key measure for China in transforming and upgrading the tourism industry. It could promote the sustainable development by reducing the consumption of tourism resources. During the implementation of this ... ...

Abstract	The integration of culture and tourism is the key measure for China in transforming and upgrading the tourism industry. It could promote the sustainable development by reducing the consumption of tourism resources. During the implementation of this policy, culture and tourism listed companies play a leading role, as they are the major force in the cultural and tourism industry, and their spatiotemporal characteristics shows the level of development of the cultural and tourism industry and the economy in different regions. Taking the culture and tourism companies as the research objects, this paper analyzed the spatiotemporal patterns and evolution mechanism of culture and tourism listed companies over a long time scale. The results showed that: (1) the number of newly added listed companies in the cultural, tourism, and cultural and tourism categories basically showed the same change trend, and the developing process could be divided into three periods, namely embryonic (1978–1992), exploration (1992–2006) and growth (2007–2021). (2) The spatial distribution of Chinese culture and tourism listed companies developed from “single core” to “one core and multiple stars”, and gradually stabilized into a spatial pattern of “three cores”. The center of gravity was located in the southeast of China, moving from south to north in the shape of a “Z”. (3) Traffic service, government financial strength, financial environment and tourism resource endowment are the main factors affecting the spatial distribution of Chinese culture and tourism listed companies. Compared with the impact of a single influencing factor, the interactions between various factors are much stronger, especially the combinations of tourism resource endowment and another three factors, namely traffic service, communication development and economic development.
Keywords	culture and tourism listed company ; tourism ; integration of culture and tourism ; spatial distribution ; factor analysis ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	910
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Unexpected/contrary behavior of aerosol mass concentration in response to the individual components' concentration reduction in Kitakyushu, Japan.

Zhang, Xi / Murakami, Takuya / Wang, Jinhe / Aikawa, Masahide

Journal of environmental sciences (China)

2022 Volume 135, Page(s) 630–639

Abstract: In the suburbs of Kitakyushu, Japan, the inorganic aerosol mass concentration (IAM) was about 32.7 µg/ ... ...

Abstract	In the suburbs of Kitakyushu, Japan, the inorganic aerosol mass concentration (IAM) was about 32.7 µg/m
MeSH term(s)	Air Pollutants/analysis ; Particulate Matter/analysis ; Japan ; Environmental Monitoring ; Water/chemistry ; Aerosols/analysis
Chemical Substances	Air Pollutants ; Particulate Matter ; Water (059QF0KO0R) ; Aerosols
Language	English
Publishing date	2022-09-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1092300-7
ISSN	1878-7320 ; 1001-0742
ISSN (online)	1878-7320
ISSN	1001-0742
DOI	10.1016/j.jes.2022.09.024
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Article ; Online: Comparative uptake, translocation and metabolism of phenamacril in crops under hydroponic and soil cultivation conditions.

Chang, Jinhe / Gao, Kang / Li, Runan / Dong, Fengshou / Zheng, Yongquan / Zhang, Qingming / Li, Yuanbo

The Science of the total environment

2024 Volume 925, Page(s) 171670

Abstract: Many studies investigate the plant uptake and metabolism of xenobiotics by hydroponic experiments, however, plants grown in different conditions (hydroponic vs. soil) may result in different behaviors. To explore the potential differences, a comparative ... ...

Abstract	Many studies investigate the plant uptake and metabolism of xenobiotics by hydroponic experiments, however, plants grown in different conditions (hydroponic vs. soil) may result in different behaviors. To explore the potential differences, a comparative study on the uptake, translocation and metabolism of the fungicide phenamacril in crops (wheat/rice) under hydroponic and soil cultivation conditions was conducted. During 7-14 days of exposure, the translocation factors (TFs) of phenamacril were greatly overestimated in hydroponic-wheat (3.6-5.2) than those in soil-wheat systems (1.1-2.0), with up to 3.3 times of difference between the two cultivation systems, implying it should be cautious to extrapolate the results obtained from hydroponic to field conditions. M-144 was formed in soil pore water (19.1-29.9 μg/L) in soil-wheat systems but not in the hydroponic solution in hydroponics; M-232 was only formed in wheat shoots (89.7-103.0 μg/kg) under soil cultivation conditions, however, it was detected in hydroponic solution (20.1-21.2 μg/L), wheat roots (146.8-166.0 μg/kg), and shoots (239.2-348.1 μg/kg) under hydroponic conditions. The root concentration factors (RCFs) and TFs of phenamacril in rice were up to 2.4 and 3.6 times higher than that in wheat for 28 days of the hydroponic exposure, respectively. These results highlighted that cultivation conditions and plant species could influence the fate of pesticides in crops, which should be considered to better assess the potential accumulation and transformation of pesticides in crops.
MeSH term(s)	Hydroponics ; Soil ; Crops, Agricultural/metabolism ; Pesticides/metabolism ; Triticum/metabolism ; Oryza/metabolism ; Plant Roots/metabolism ; Soil Pollutants/analysis ; Cyanoacrylates
Chemical Substances	phenamacril ; Soil ; Pesticides ; Soil Pollutants ; Cyanoacrylates
Language	English
Publishing date	2024-03-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.171670
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Article ; Online: Study on the kinetics of formation process of emulsion of heavy oil and its functional group components.

Liu, Jinhe / Sun, Chengdi / Lun, Zengmin / Li, Yao / Tang, Xinyu / Zhang, Qingxuan / Yang, Pujiang

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8916

Abstract: Enhanced oil recovery (EOR) by in situ formation of oil-in-water emulsion in heavy oil cold production technology has received growing interest from the petroleum industry. We present an experimental study of emulsification of model oils prepared by ... ...

Abstract	Enhanced oil recovery (EOR) by in situ formation of oil-in-water emulsion in heavy oil cold production technology has received growing interest from the petroleum industry. We present an experimental study of emulsification of model oils prepared by heavy oil and its functional group compositions dissolved into toluene brought into contact with a surfactant solution. The effects of functional group composition, emulsifier concentration, temperature, pH and stirring speed on the emulsification rate of heavy oil was investigated. A second-order kinetic model characterizing the temporal variation of conductivity during the emulsification has been established. The results show that acidic and amphoteric fractions exhibit higher interfacial activity, larger emulsification rate constant and faster emulsification rate. With the increase of emulsifier concentration, the emulsification rate constant increase to the maximum value at a concentration of 0.05 mol/L before decreasing. Temperature increase benefits the emulsification rate and the activation energy of the emulsification process is 40.28 kJ/mol. Higher pH and stirring speed indicate faster emulsification rate. The heterogeneity of emulsions limits the accuracy of dynamic characterization of the emulsification process and the determination method of emulsification rate has always been controversial. The conductivity method we proposed can effectively evaluates the emulsification kinetics. This paper provides theoretical guidance for an in-depth understanding of the mechanism and application of cold recovery technology for heavy oil.
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-59637-9
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Article ; Online: Estimating the nonlinear response of landscape patterns to ecological resilience using a random forest algorithm

Xiaobin Ma / Jinhe Zhang / Peijia Wang / Leying Zhou / Yi Sun

Ecological Indicators, Vol 153, Iss , Pp 110409- (2023)

Evidence from the Yangtze River Delta

2023

Abstract: Ecological resilience (ER) is considered a key factor in resolving complex human and natural systems conflicts and managing risk during the period of rapid development. However, the importance of landscape patterns for ER is not given enough attention in ...

Abstract	Ecological resilience (ER) is considered a key factor in resolving complex human and natural systems conflicts and managing risk during the period of rapid development. However, the importance of landscape patterns for ER is not given enough attention in previous studies. Therefore, we selected the Yangtze River Delta region as the study area, incorporated landscape patterns into the assessment of ER and proposed the way for identifying ecological sources based on the combination of ecosystem services and landscape patterns. Combining the multidimensional ecological resilience assessment indicators system, we calculated the ER for the Yangtze River Delta region and explored the importance and nonlinear effects of landscape patterns on the ER using a random forest regression model. The results showed that the comparative analysis of ecosystem services and landscape patterns enhanced the scientificity of ecological source identification. We identified 94 ecological sources mainly in the southern of the Yangtze River Delta region, including important mountain ranges and water bodies. In addition, the ER was significantly strengthened by considering the landscape patterns. The random forest regression results indicated the nonlinear relationship between the landscape patterns and the other elements in terms of ER. This study can contribute to a comprehensive and integrated approach to the identification of ecological sources and the evaluation of ER, which can promote the conservation of regional ecological functions.
Keywords	Landscape patterns ; MSPA ; Random forest regression algorithm ; Ecological resilience ; Ecosystem services ; Yangtze River Delta region ; Ecology ; QH540-549.5
Subject code	910 ; 710
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Spatial-temporal pattern and influencing factors of tourism ecological security in Huangshan City

Jingxuan Ma / Jinhe Zhang / Feng Sun / Chenxi Zou / Tianchi Ma

Frontiers in Ecology and Evolution, Vol

2023 Volume 11

Abstract: It is of important theoretical and practical value to scientifically evaluate tourism ecological security for the sustainable development of tourist cities. The study focuses on the “characteristics of the impact factors on tourism ecological security at ...

Abstract	It is of important theoretical and practical value to scientifically evaluate tourism ecological security for the sustainable development of tourist cities. The study focuses on the “characteristics of the impact factors on tourism ecological security at different levels” of tourism ecological security that have been neglected in the previous literature. From the perspective of Compound Ecological systems theory, we built an evaluation index system for tourism ecological security in Huangshan City based on the Pressure-State-Impact-Economic-Environmental-Social (PSR-EES) model and used a combination of the entropy weight TOPSIS (Technique for Order Preference by Similarity to an Ideal Solution) method, traditional and spatial Markov chains, and panel quantile regression to analyze and characterize the spatial-temporal dynamics of security levels and driving factors. The results showed that (1) the level of tourism ecological security of the districts and counties in Huangshan City improved rapidly, but the difference was expanding. The level of tourism ecological security in the four counties was generally higher than that in the three districts. (2) In terms of the spatial-temporal dynamic evolutionary characteristics, the transfer of tourism ecological security in Huangshan City has its characteristics of stability and path dependence. Type transfers usually occur between adjacent levels. The lower the level of tourism ecological security, the higher the probability of upward transfer. A neighborhood background plays an important role in the process by which a higher neighborhood rank increases the probability of upward transfer. (3) Regarding the driving factors, environmental pollution and economic development have a negative inhibitory effect on tourism ecological security, and the negative effect decreases as the level of TES improves. The top three positive effects were government intervention and educational levels. The degree of regional greening and government intervention had greater positive marginal ...
Keywords	tourism ecological security (TES) ; dynamic evolution characteristics ; spatial Markov chains ; panel quantile regression ; Huangshan City ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
Subject code	910
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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