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  1. Article ; Online: Characterizing the transmission patterns of seasonal influenza in Italy: lessons from the last decade.

    Trentini, Filippo / Pariani, Elena / Bella, Antonino / Diurno, Giulio / Crottogini, Lucia / Rizzo, Caterina / Merler, Stefano / Ajelli, Marco

    BMC public health

    2022  Volume 22, Issue 1, Page(s) 19

    Abstract: Background: Despite thousands of influenza cases annually recorded by surveillance systems around the globe, estimating the transmission patterns of seasonal influenza is challenging.: Methods: We develop an age-structured mathematical model to ... ...

    Abstract Background: Despite thousands of influenza cases annually recorded by surveillance systems around the globe, estimating the transmission patterns of seasonal influenza is challenging.
    Methods: We develop an age-structured mathematical model to influenza transmission to analyze ten consecutive seasons (from 2010 to 2011 to 2019-2020) of influenza epidemiological and virological data reported to the Italian surveillance system.
    Results: We estimate that 18.4-29.3% of influenza infections are detected by the surveillance system. Influenza infection attack rate varied between 12.7 and 30.5% and is generally larger for seasons characterized by the circulation of A/H3N2 and/or B types/subtypes. Individuals aged 14 years or less are the most affected age-segment of the population, with A viruses especially affecting children aged 0-4 years. For all influenza types/subtypes, the mean effective reproduction number is estimated to be generally in the range 1.09-1.33 (9 out of 10 seasons) and never exceeding 1.41. The age-specific susceptibility to infection appears to be a type/subtype-specific feature.
    Conclusions: The results presented in this study provide insights on type/subtype-specific transmission patterns of seasonal influenza that could be instrumental to fine-tune immunization strategies and non-pharmaceutical interventions aimed at limiting seasonal influenza spread and burden.
    MeSH term(s) Child ; Humans ; Influenza A Virus, H3N2 Subtype ; Influenza, Human/prevention & control ; Italy/epidemiology ; Seasons ; Vaccination
    Language English
    Publishing date 2022-01-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-021-12426-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Efficacy of recanalization therapy for ischemic stroke: multicenter hospital network experience.

    Briganti, Francesco / Tortora, Mario / Tortora, Fabio / Elefante, Andrea / Loiudice, Giovanni / Marseglia, Mariano / Buono, Giuseppe / Rizzuti, Michele / Iodice, Rosa / Manganelli, Fiore / Diurno, Francesco / Numis, Fabio Giuliano / Ferrara, Luigi / Bruno, Carlo / Bresciani, Alessandro / Caranci, Ferdinando / Franco, Donatella / Vaiano, Carlo / D'Onofrio, Gaetano /
    Scala, Pasquale / Raucci, Rosa / Silvestro, Eufrasia

    La Radiologia medica

    2023  Volume 128, Issue 3, Page(s) 357–361

    Abstract: Purpose: Stroke is a leading cause of long-term disability with high mortality rate in the first year after the event. In Campania, mechanical thrombectomy treatment significantly increases in the last 3 years, as well as hospitals delivering acute ... ...

    Abstract Purpose: Stroke is a leading cause of long-term disability with high mortality rate in the first year after the event. In Campania, mechanical thrombectomy treatment significantly increases in the last 3 years, as well as hospitals delivering acute stroke treatments. The aim of this study is to demonstrate how a full opening of our stroke network improves stroke management and stroked patients' survival in Campania.
    Material and methods: In Federico II University Hospital of Naples acting as a HUB center of 7 peripheral SPOKE hospitals in regional territory, 68 patients with acute ischemic stroke were evaluated with NIHSS and m-RS clinical scores and neuroradiological ASPECT scores, from January 1 to December 31, 2021. At hospital discharge, NIHSS score and three months after m-RS score were re-assessed to evaluate the therapeutic effects.
    Results: Forty-two of 68 patients (63%) admitted to our hub center had ischemic acute stroke at CT evaluation; 29 patients had ASPECT score > 7 (69%), and 6 a score < 7 (14%). At admission, NIHSS score mean value was 10.75, and m-RS score mean value was 0.74. At discharge, NIHSS score mean value was 7.09. After three months, m-RS score mean value was 0.74.
    Discussion: The inter-company agreement between Federico II University and several peripheral hospitals allows an absolute and relative increase in endovascular mechanical thrombectomy and intravenous thrombolysis procedures, with a relative prevalence of mechanical thrombectomy. A regional implementation of the stroke multi-disciplinary care system is hardly needed to ensure the optimum treatment for the largest number of patients, improving patient's outcome.
    MeSH term(s) Humans ; Ischemic Stroke ; Thrombectomy/methods ; Treatment Outcome ; Stroke/diagnostic imaging ; Stroke/surgery ; Hospitals ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/surgery ; Retrospective Studies
    Language English
    Publishing date 2023-02-08
    Publishing country Italy
    Document type Multicenter Study ; Journal Article
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
    DOI 10.1007/s11547-023-01599-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Potential short-term outcome of an uncontrolled COVID-19 epidemic in Lombardy, Italy, February to March 2020.

    Guzzetta, Giorgio / Poletti, Piero / Ajelli, Marco / Trentini, Filippo / Marziano, Valentina / Cereda, Danilo / Tirani, Marcello / Diurno, Giulio / Bodina, Annalisa / Barone, Antonio / Crottogini, Lucia / Gramegna, Maria / Melegaro, Alessia / Merler, Stefano

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2020  Volume 25, Issue 12

    Abstract: Sustained coronavirus disease (COVID-19) transmission is ongoing in Italy, with 7,375 reported cases and 366 deaths by 8 March 2020. We provide a model-based evaluation of patient records from Lombardy, predicting the impact of an uncontrolled epidemic ... ...

    Abstract Sustained coronavirus disease (COVID-19) transmission is ongoing in Italy, with 7,375 reported cases and 366 deaths by 8 March 2020. We provide a model-based evaluation of patient records from Lombardy, predicting the impact of an uncontrolled epidemic on the healthcare system. It has the potential to cause more than 250,039 (95% credible interval (CrI): 147,717-459,890) cases within 3 weeks, including 37,194 (95% CrI: 22,250-67,632) patients requiring intensive care. Aggressive containment strategies are required.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Disease Notification/statistics & numerical data ; Disease Outbreaks ; Humans ; Italy/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-03-31
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2020.25.12.2000293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The early phase of the COVID-19 epidemic in Lombardy, Italy.

    Cereda, Danilo / Manica, Mattia / Tirani, Marcello / Rovida, Francesca / Demicheli, Vittorio / Ajelli, Marco / Poletti, Piero / Trentini, Filippo / Guzzetta, Giorgio / Marziano, Valentina / Piccarreta, Raffaella / Barone, Antonio / Magoni, Michele / Deandrea, Silvia / Diurno, Giulio / Lombardo, Massimo / Faccini, Marino / Pan, Angelo / Bruno, Raffaele /
    Pariani, Elena / Grasselli, Giacomo / Piatti, Alessandra / Gramegna, Maria / Baldanti, Fausto / Melegaro, Alessia / Merler, Stefano

    Epidemics

    2021  Volume 37, Page(s) 100528

    Abstract: Background: In the night of February 20, 2020, the first epidemic of the novel coronavirus disease (COVID-19) outside Asia was uncovered by the identification of its first patient in Lombardy region, Italy. In the following weeks, Lombardy experienced a ...

    Abstract Background: In the night of February 20, 2020, the first epidemic of the novel coronavirus disease (COVID-19) outside Asia was uncovered by the identification of its first patient in Lombardy region, Italy. In the following weeks, Lombardy experienced a sudden increase in the number of ascertained infections and strict measures were imposed to contain the epidemic spread.
    Methods: We analyzed official records of cases occurred in Lombardy to characterize the epidemiology of SARS-CoV-2 during the early phase of the outbreak. A line list of laboratory-confirmed cases was set up and later retrospectively consolidated, using standardized interviews to ascertained cases and their close contacts. We provide estimates of the serial interval, of the basic reproduction number, and of the temporal variation of the net reproduction number of SARS-CoV-2.
    Results: Epidemiological investigations detected over 500 cases (median age: 69, IQR: 57-78) before the first COVID-19 diagnosed patient (February 20, 2020), and suggested that SARS-CoV-2 was already circulating in at least 222 out of 1506 (14.7%) municipalities with sustained transmission across all the Lombardy provinces. We estimated the mean serial interval to be 6.6 days (95% CrI, 0.7-19). Our estimates of the basic reproduction number range from 2.6 in Pavia (95% CI, 2.1-3.2) to 3.3 in Milan (95% CI, 2.9-3.8). A decreasing trend in the net reproduction number was observed following the detection of the first case.
    Conclusions: At the time of first case notification, COVID-19 was already widespread in the entire Lombardy region. This may explain the large number of critical cases experienced by this region in a very short timeframe. The slight decrease of the reproduction number observed in the early days after February 20, 2020 might be due to increased population awareness and early interventions implemented before the regional lockdown imposed on March 8, 2020.
    MeSH term(s) Aged ; COVID-19 ; Communicable Disease Control ; Humans ; Italy/epidemiology ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-11-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2467993-8
    ISSN 1878-0067 ; 1755-4365
    ISSN (online) 1878-0067
    ISSN 1755-4365
    DOI 10.1016/j.epidem.2021.100528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Choroidal effusion and suprachoroidal hemorrhage during phacoemulsification: intraoperative management to prevent expulsive hemorrhage.

    Savastano, Alfonso / Rizzo, Stanislao / Savastano, Maria Cristina / Piccirillo, Valerio / Forte, Renato / Sbordone, Sandro / Diurno, Francesco / Savastano, Silvio

    European journal of ophthalmology

    2016  Volume 26, Issue 4, Page(s) 338–341

    Abstract: Purpose: To describe the intraoperative management of choroidal effusion (CE) or suprachoroidal hemorrhage (SCH) during cataract surgery with the phacoemulsification technique.: Methods: The study is a retrospective interventional study through which ...

    Abstract Purpose: To describe the intraoperative management of choroidal effusion (CE) or suprachoroidal hemorrhage (SCH) during cataract surgery with the phacoemulsification technique.
    Methods: The study is a retrospective interventional study through which we describe the intraoperative management adopted in 6 cases of CE or SCH during cataract surgery. The study involved 6,400 eyes (phacoemulsification) in 6 years observational time (incidence rate 0.094%). The surgical time at which these complications happened differed: nucleolus phacoemulsification in 2 eyes, cortex removal by bimanual irrigation-aspiration in 3 eyes, and intraocular lens implant for 1 eye. Once the complication was recognized, each patient was quickly moved to an extreme reverse Trendelenburg position and pharmacologically treated to manage high blood pressure, pain, and anxiety (150 mL of an 18% mannitol solution delivered in rapid infusion intravenously; 1-3 mg intravenous midazolam; 5 nifedipine sublingual drops).
    Results: In all the cases reported, the surgery was completed after resolution of the acute choroidal exudation or SCH. In the follow-up evaluation, the intraocular pressure was normal at each examination. The visual acuity of the patients was between 6/7.5 and 5/6 Snellen after 4 weeks. We observed a statistically significant reduction in endothelial cells in the 2 eyes in which the CE or SCH happened during the phacoemulsification compared with the other cases; this finding likely results from mechanical damage (p = 0.04 [95% confidence interval]).
    Conclusions: Choroidal effusion or SCH can be intraoperatively managed to avoid expulsive hemorrhage and maintain the possibility of completing the surgery.
    MeSH term(s) Aged ; Choroid Diseases/etiology ; Choroid Diseases/prevention & control ; Choroid Hemorrhage/etiology ; Choroid Hemorrhage/prevention & control ; Female ; Head-Down Tilt ; Humans ; Intraocular Pressure ; Intraoperative Complications/prevention & control ; Lens Implantation, Intraocular ; Male ; Middle Aged ; Phacoemulsification ; Retrospective Studies ; Visual Acuity
    Language English
    Publishing date 2016-06-10
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.5301/ejo.5000707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Potential short-term outcome of an uncontrolled COVID-19 epidemic in Lombardy, Italy, February to March 2020

    Guzzetta, Giorgio / Poletti, Piero / Ajelli, Marco / Trentini, Filippo / Marziano, Valentina / Cereda, Danilo / Tirani, Marcello / Diurno, Giulio / Bodina, Annalisa / Barone, Antonio / Crottogini, Lucia / Gramegna, Maria / Melegaro, Alessia / Merler, Stefano

    Euro surveill

    Abstract: Sustained coronavirus disease (COVID-19) transmission is ongoing in Italy, with 7,375 reported cases and 366 deaths by 8 March 2020. We provide a model-based evaluation of patient records from Lombardy, predicting the impact of an uncontrolled epidemic ... ...

    Abstract Sustained coronavirus disease (COVID-19) transmission is ongoing in Italy, with 7,375 reported cases and 366 deaths by 8 March 2020. We provide a model-based evaluation of patient records from Lombardy, predicting the impact of an uncontrolled epidemic on the healthcare system. It has the potential to cause more than 250,039 (95% credible interval (CrI): 147,717-459,890) cases within 3 weeks, including 37,194 (95% CrI: 22,250-67,632) patients requiring intensive care. Aggressive containment strategies are required.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #19641
    Database COVID19

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  7. Article ; Online: Potential short-term outcome of an uncontrolled COVID-19 epidemic in Lombardy, Italy, February to March 2020

    Guzzetta, Giorgio / Poletti, Piero / Ajelli, Marco / Trentini, Filippo / Marziano, Valentina / Cereda, Danilo / Tirani, Marcello / Diurno, Giulio / Bodina, Annalisa / Barone, Antonio / Crottogini, Lucia / Gramegna, Maria / Melegaro, Alessia / Merler, Stefano

    2020  

    Abstract: Sustained coronavirus disease (COVID-19) transmission is ongoing in Italy, with 7,375 reported cases and 366 deaths by 8 March 2020. We provide a model-based evaluation of patient records from Lombardy, predicting the impact of an uncontrolled epidemic ... ...

    Abstract Sustained coronavirus disease (COVID-19) transmission is ongoing in Italy, with 7,375 reported cases and 366 deaths by 8 March 2020. We provide a model-based evaluation of patient records from Lombardy, predicting the impact of an uncontrolled epidemic on the healthcare system. It has the potential to cause more than 250,039 (95% credible interval (CrI): 147,717-459,890) cases within 3 weeks, including 37,194 (95% CrI: 22,250-67,632) patients requiring intensive care. Aggressive containment strategies are required.
    Keywords COVID-19 ; Coronavirus ; Lombardy outbreak ; SARS-CoV-2 ; modelling ; Betacoronavirus ; Coronavirus Infections ; Disease Notification ; Humans ; Italy ; Pandemics ; Pneumonia ; Viral ; Disease Outbreaks ; covid19
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Potential short-term outcome of an uncontrolled COVID-19 epidemic in Lombardy, Italy, February to March 2020

    Guzzetta, Giorgio / Poletti, Piero / Ajelli, Marco / Trentini, Filippo / Marziano, Valentina / Cereda, Danilo / Tirani, Marcello / Diurno, Giulio / Bodina, Annalisa / Barone, Antonio / Crottogini, Lucia / Gramegna, Maria / Melegaro, Alessia / Merler, Stefano

    2020  

    Abstract: Sustained coronavirus disease (COVID-19) transmission is ongoing in Italy, with 7,375 reported cases and 366 deaths by 8 March 2020. We provide a modelbased evaluation of patient records from Lombardy, predicting the impact of an uncontrolled epidemic on ...

    Abstract Sustained coronavirus disease (COVID-19) transmission is ongoing in Italy, with 7,375 reported cases and 366 deaths by 8 March 2020. We provide a modelbased evaluation of patient records from Lombardy, predicting the impact of an uncontrolled epidemic on the healthcare system. It has the potential to cause more than 250,039 (95% credible interval (CrI): 147,717-459,890) cases within 3 weeks, including 37,194 (95% CrI: 22,250-67,632) patients requiring intensive care. Aggressive containment strategies are required.
    Keywords COVID-19 ; CORONAVIRUS ; LOMBARDY OUTBREAK ; SARS-COV-2 ; MODELLING ; BETACORONAVIRUS ; CORONAVIRUS INFECTIONS ; DISEASE NOTIFICATION ; HUMANS ; ITALY ; PANDEMICS ; PNEUMONIA ; VIRAL ; DISEASE OUTBREAKS ; covid19
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Eculizumab treatment in patients with COVID-19: preliminary results from real life ASL Napoli 2 Nord experience.

    Diurno, F / Numis, F G / Porta, G / Cirillo, F / Maddaluno, S / Ragozzino, A / De Negri, P / Di Gennaro, C / Pagano, A / Allegorico, E / Bressy, L / Bosso, G / Ferrara, A / Serra, C / Montisci, A / D'Amico, M / Schiano Lo Morello, S / Di Costanzo, G / Tucci, A G /
    Marchetti, P / Di Vincenzo, U / Sorrentino, I / Casciotta, A / Fusco, M / Buonerba, C / Berretta, M / Ceccarelli, M / Nunnari, G / Diessa, Y / Cicala, S / Facchini, G

    European review for medical and pharmacological sciences

    2020  Volume 24, Issue 7, Page(s) 4040–4047

    Abstract: Objective: SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2)-related pneumonia, referred to as COVID-19 (Coronavirus Disease 19), is a public health emergency as it carries high morbidity, mortality, and has no approved specific ... ...

    Abstract Objective: SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2)-related pneumonia, referred to as COVID-19 (Coronavirus Disease 19), is a public health emergency as it carries high morbidity, mortality, and has no approved specific pharmacological treatments. In this case series, we aimed to report preliminary data obtained with anti-complement C5 therapy with eculizumab in COVID-19 patients admitted to intensive care unit (ICU) of ASL Napoli 2 Nord.
    Patients and methods: This is a case series of patients with a confirmed diagnosis of SARS-CoV2 infection and severe pneumonia or ARDS who were treated with up to 4 infusions of eculizumab as an off-label agent. Patients were also treated with anticoagulant therapy with Enoxaparin 4000 IU/day via subcutaneous injection, antiviral therapy with Lopinavir 800 mg/day + Ritonavir 200 mg/day, hydroxychloroquine 400 mg/day, ceftriaxone 2 g/day IV, vitamine C 6 g/day for 4 days, and were on Non-Invasive Ventilation (NIV).
    Results: We treated four COVID-19 patients admitted to the intensive care unit because of severe pneumonia or ARDS. All patients successfully recovered after treatment with eculizumab. Eculizumab induced a drop in inflammatory markers. Mean C Reactive Protein levels dropped from 14.6 mg/dl to 3.5 mg/dl and the mean duration of the disease was 12.8 days.
    Conclusions: Eculizumab has the potential to be a key player in treatment of severe cases of COVID-19. Our results support eculizumab use as an off-label treatment of COVID-19, pending confirmation from the ongoing SOLID-C19 trial.
    MeSH term(s) Antibodies, Monoclonal, Humanized ; Betacoronavirus ; COVID-19 ; Complement Activation ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome
    Chemical Substances Antibodies, Monoclonal, Humanized ; eculizumab (A3ULP0F556)
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202004_20875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The early phase of the COVID-19 outbreak in Lombardy, Italy

    Cereda, D / Tirani, M / Rovida, F / Demicheli, V / Ajelli, M / Poletti, P / Trentini, F / Guzzetta, G / Marziano, V / Barone, A / Magoni, M / Deandrea, S / Diurno, G / Lombardo, M / Faccini, M / Pan, A / Bruno, R / Pariani, E / Grasselli, G /
    Piatti, A / Gramegna, M / Baldanti, F / Melegaro, A / Merler, S

    Abstract: In the night of February 20, 2020, the first case of novel coronavirus disease (COVID-19) was confirmed in the Lombardy Region, Italy. In the week that followed, Lombardy experienced a very rapid increase in the number of cases. We analyzed the first 5, ... ...

    Abstract In the night of February 20, 2020, the first case of novel coronavirus disease (COVID-19) was confirmed in the Lombardy Region, Italy. In the week that followed, Lombardy experienced a very rapid increase in the number of cases. We analyzed the first 5,830 laboratory-confirmed cases to provide the first epidemiological characterization of a COVID-19 outbreak in a Western Country. Epidemiological data were collected through standardized interviews of confirmed cases and their close contacts. We collected demographic backgrounds, dates of symptom onset, clinical features, respiratory tract specimen results, hospitalization, contact tracing. We provide estimates of the reproduction number and serial interval. The epidemic in Italy started much earlier than February 20, 2020. At the time of detection of the first COVID-19 case, the epidemic had already spread in most municipalities of Southern-Lombardy. The median age for of cases is 69 years (range, 1 month to 101 years). 47% of positive subjects were hospitalized. Among these, 18% required intensive care. The mean serial interval is estimated to be 6.6 days (95% CI, 0.7 to 19). We estimate the basic reproduction number at 3.1 (95% CI, 2.9 to 3.2). We estimated a decreasing trend in the net reproduction number starting around February 20, 2020. We did not observe significantly different viral loads in nasal swabs between symptomatic and asymptomatic. The transmission potential of COVID-19 is very high and the number of critical cases may become largely unsustainable for the healthcare system in a very short-time horizon. We observed a slight decrease of the reproduction number, possibly connected with an increased population awareness and early effect of interventions. Aggressive containment strategies are required to control COVID-19 spread and catastrophic outcomes for the healthcare system.
    Keywords covid19
    Publisher ArXiv
    Document type Article
    Database COVID19

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