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  1. Article ; Online: Editorial. A neurosurgery resident's response to COVID-19: anything but routine.

    Choi, Bryan D

    Journal of neurosurgery

    2020  , Page(s) 1–2

    Keywords covid19
    Language English
    Publishing date 2020-04-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2020.4.JNS201028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.135: Show issues Location:
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  2. Article ; Online: Engineering Our Future: Advancing Cell and Gene Therapy in Neurosurgery.

    Choi, Bryan D / Carter, Bob S

    Neurosurgery

    2022  Volume 68, Issue Suppl 1, Page(s) 11–16

    MeSH term(s) Genetic Therapy ; Humans ; Neurosurgery ; Neurosurgical Procedures
    Language English
    Publishing date 2022-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/NEU.0000000000001878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1424: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 539: Show issues

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  4. Article ; Online: Immunotherapy for Brain Tumors: Where We Have Been, and Where Do We Go From Here?

    Wang, Alexander F / Hsueh, Brian / Choi, Bryan D / Gerstner, Elizabeth R / Dunn, Gavin P

    Current treatment options in oncology

    2024  

    Abstract: Opinion statement: Immunotherapy for glioblastoma (GBM) remains an intensive area of investigation. Given the seismic impact of cancer immunotherapy across a range of malignancies, there is optimism that harnessing the power of immunity will influence ... ...

    Abstract Opinion statement: Immunotherapy for glioblastoma (GBM) remains an intensive area of investigation. Given the seismic impact of cancer immunotherapy across a range of malignancies, there is optimism that harnessing the power of immunity will influence GBM as well. However, despite several phase 3 studies, there are still no FDA-approved immunotherapies for GBM. Importantly, the field has learned a great deal from the randomized studies to date. Today, we are continuing to better understand the disease-specific features of the microenvironment in GBM-as well as the exploitable antigenic characteristic of the tumor cells themselves-that are informing the next generation of immune-based therapeutic strategies. The coming phase of next-generation immunotherapies is thus poised to bring us closer to treatments that will improve the lives of patients with GBM.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057351-0
    ISSN 1534-6277 ; 1527-2729
    ISSN (online) 1534-6277
    ISSN 1527-2729
    DOI 10.1007/s11864-024-01200-9
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    Zs.A 5523: Show issues Location:
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  5. Article ; Online: Labeling T Cells to Track Immune Response to Immunotherapy in Glioblastoma.

    Rhee, John Y / Ghannam, Jack Y / Choi, Bryan D / Gerstner, Elizabeth R

    Tomography (Ann Arbor, Mich.)

    2023  Volume 9, Issue 1, Page(s) 274–284

    Abstract: While the advent of immunotherapy has revolutionized cancer treatment, its use in the treatment of glioblastoma (GBM) has been less successful. Most studies using immunotherapy in GBM have been negative and the reasons for this are still being studied. ... ...

    Abstract While the advent of immunotherapy has revolutionized cancer treatment, its use in the treatment of glioblastoma (GBM) has been less successful. Most studies using immunotherapy in GBM have been negative and the reasons for this are still being studied. In clinical practice, interpreting response to immunotherapy has been challenging, particularly when trying to differentiate between treatment-related changes (i.e., pseudoprogression) or true tumor progression. T cell tagging is one promising technique to noninvasively monitor treatment efficacy by assessing the migration, expansion, and engagement of T cells and their ability to target tumor cells at the tumor site.
    MeSH term(s) Humans ; Glioblastoma/pathology ; T-Lymphocytes/pathology ; Brain Neoplasms/pathology ; Immunotherapy/methods ; Immunity
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2379-139X
    ISSN (online) 2379-139X
    DOI 10.3390/tomography9010022
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  6. Article ; Online: A Common Rule for Resection of Glioblastoma in the Molecular Era.

    Choi, Bryan D / Gerstner, Elizabeth R / Curry, William T

    JAMA oncology

    2020  Volume 6, Issue 4, Page(s) 503–504

    MeSH term(s) Brain Neoplasms ; Glioblastoma ; Humans ; Temozolomide
    Chemical Substances Temozolomide (YF1K15M17Y)
    Language English
    Publishing date 2020-02-06
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2019.6384
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  7. Article ; Online: Fluorescence and immune-cell infiltration of nonneoplastic, postbrachytherapy brain tissue in 5-ALA-guided resection of recurrent anaplastic meningioma: illustrative case.

    Ramapriyan, Rishab / Clark, Victoria E / Martinez-Lage, Maria / Hsueh, Brian / Nahed, Brian V / Curry, William T / Choi, Bryan D / Carter, Bob S

    Journal of neurosurgery. Case lessons

    2024  Volume 7, Issue 9

    Abstract: Background: 5-Aminolevulinic acid (5-ALA) fluorescence-guided surgery is a well-established technique for resecting high-grade gliomas. However, its application in meningiomas, especially those previously treated with radiation therapy, remains under ... ...

    Abstract Background: 5-Aminolevulinic acid (5-ALA) fluorescence-guided surgery is a well-established technique for resecting high-grade gliomas. However, its application in meningiomas, especially those previously treated with radiation therapy, remains under investigation.
    Observations: A 48-year-old female with recurrent anaplastic meningioma, World Health Organization grade 3, underwent a right-sided craniotomy using off-label 5-ALA as a surgical adjunct. The patient had previously undergone brachytherapy seed implantation (20 × cesium 131) for tumor management. During the surgery, a large fluorescent tumor mass adjacent to the brachytherapy-treated area was resected, and the prior brachytherapy seeds were removed. Interestingly, the surrounding brain tissue in the irradiated area showed robust 5-ALA fluorescence. Pathological examination confirmed that the fluorescent brain tissue was nonneoplastic and associated with lymphocyte and macrophage infiltration.
    Lessons: This case report presents unique 5-ALA fluorescence in nonneoplastic tissue following brachytherapy, which was found during the resection of recurrent anaplastic meningioma. This phenomenon may reflect an intricate interplay among radiation therapy, immune cells, the tumor microenvironment, and 5-ALA metabolism. Given that false-positive findings in fluorescence-guided surgery can lead to unnecessary tissue resection and increased surgical morbidity, further research is warranted to elucidate the mechanisms underlying this phenomenon and its implications for meningioma surgery.
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE23550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Commentary: The Glioma-Network Interface: A Review of the Relationship Between Glioma Molecular Subtype and Intratumoral Function.

    Choi, Bryan D / Grannan, Benjamin L / Cahill, Daniel P / Curry, William T

    Neurosurgery

    2021  Volume 88, Issue 3, Page(s) E273–E274

    MeSH term(s) Brain Neoplasms ; Glioma ; Humans
    Language English
    Publishing date 2021-01-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyaa517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1424: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 539: Show issues

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  9. Article: (R)-2-hydroxyglutarate drives immune quiescence in the tumor microenvironment of IDH-mutant gliomas.

    Richardson, Leland G / Choi, Bryan D / Curry, William T

    Translational cancer research

    2019  Volume 8, Issue Suppl 2, Page(s) S167–S170

    Language English
    Publishing date 2019-03-22
    Publishing country China
    Document type Journal Article
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr.2019.01.08
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  10. Article: IDH mutational status and the immune system in gliomas: a tale of two tumors?

    Choi, Bryan D / Curry, William T

    Translational cancer research

    2017  Volume 6, Issue Suppl 7, Page(s) S1253–S1256

    Language English
    Publishing date 2017-09-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr.2017.09.37
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